Osteogenesis imperfecta is a genetic disorder caused by a defect in the collagen gene that results in brittle bones that break easily from minor stress or trauma. There are four main types of OI that vary in severity from very mild to lethal in infancy. While there is no cure for OI, treatments focus on increasing bone strength through bisphosphonates and low-impact exercise, as well as surgery to repair broken bones. People with OI must manage their condition for life through precautions to avoid further fractures.

1. OsteogenesisImperfecta (OI)By Jenn Levy

2. What Causes OI?Caused by a defect in the gene that produces collagen in the boneSpecific gene defected will cause severity to the OI patient

3. TransmissionCan be transmitted through DNA from parent to childAlso can be developed by a new genetic mutationNot contagious/communicable

4. Who Can Get It?OI will develop only as an infantMay be detected at a later ageAnyone that carries the gene is more susceptible to having the disease

5. Signs and SymptomsPeople with OI will have it for lifeWeak bones prone to accidentsBlue tints to the whites of their eyesMany bone fractures from minimal forceEarly hearing lossBelow average height for ageBowed arms or legs (in most severe cases)

6. Types of OIChronic illnessFour Types of OIType I OI: normal life span, less severe bone breaks and fracturesType II OI: most severe, result in death within the first year of lifeType III OI: severe but have longer lifespans than type II, many fractures early in life, develop bone deformitiesType IV OI: moderately severe, need crutches/braces to walk

7. PreventionVisiting a genetic counselor before conceiving can help alert a couple about OI history in their familyCan not be preventedNo cures for disease, but treatments

8. TreatmentBisphosphonates treat osteoperosis, but can increase strength in bones for OI patientsCan help decrease pain in bonesSwimming is a low contact activity that can help with strengthMore severe cases: surgery for metal rod placement against bones

9. Terminal?The disease is terminal Person with OI must take precaution with every move they make for the rest of their lives