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GROUP NUMBER 5
THE PHARMACOLOGY OF LOWER RESPIRATORY
TRACT
• The lower respiratory tract includes the
following parts;
 Larynx
 Trachea
 Bronchi
 Bronchioles
 Alveolar duct
 Alveolar sac
 alveoli
• The lower respiratory infection; these are
diseases which infect the lower respiratory
tract.
The lower respiratory diseases are divided into 2
categories
Chronic obstructive pulmonary disease(COPD)
Restrictive pulmonary disease
There are 4 major diseases caused by chronic
obstructive pulmonary diseases
Chronic obstructive pulmonary disease are caused
by airway obstruction with increased airway
resistance of air flow to lung. Which are
Chronic bronchitis
Bronchiectasis
Emphysema
Asthma
• Chronic bronchitis, bronchiectasis and
emphysema cause frequent result in
irreversible lung tissue damage.
• While in asthma the lung tissue change as a
result from acute asthmatic are normally
reversible.
Restrictive pulmonary disease
This is a decrease in total lung capacity as a
result of fluid accumulation or loss of elasticity
of lung. The diseases involves;
Pulmonary edema
Pulmonary fibrosis
Pneumonitis
Lung tumors
• Thoracic deformities(scoliosis)
• Myasthenia gravis (affect thoracic mascular
wall)
THE DRUGS OF CHRONIC OBSTRUCTION
PULMONARY DISEASE
sympathomimetics drugs
Leukotrine antagonist
• Cromolyn
• mucolytics
• anticholinergic
• Glucocoticoids
• NB;Some of other drugs above can be used to
treat the restrictive pulmonary disease
BRONCHIECTASIS
Is abnormal dilation of bronchi and bronchioles
secondary to frequent infection and
inflammation.
The bronchioles become obstructed by the
break down of the epithelium of the bronchial
mucosa ,tissue fibrosis may result.
Symptoms; chronic coughing ,coughing up blood
,shortness of breath ,chest pain, and
wheezing,
EMPHYSEMA
Is progressive lungs disease causes by cigarette
smoking atmospheric contaminants or lack of
the alpha antitrytic enzymes that destroy
alveoli.
• The proteolyic enzymes are released in the
lung by bacteria.the terminal bronchioles
becomes plugged with mucus causing a loss of
the fiber and elastin network in the alveolar.
• The alveoli enlarge as many of the alveolar
walls are destroyed .air becomes trapped in
the over expanded alveoli leading to in
adequate gas {oxygen and carbondioxide}.
• Symptoms;shortness of breath
• ASTHMA
• Is a reversible obstructive airway disease of
varying severity.the symptoms are caused by
constriction of bronhiol mucous membrane and
blockage of the small bronchi with plug of mucus
.it can be triggered by factors like
allergen,infection,exercice,drugs for examples
aspirin,tobscco smoke,inhaled chemicals.
• Characterized by dyspnea,wheezing,tightness
of chest and cough.
• PNEUMONIA
• Is the inflammation of the lungs tissue
,pneumonia can either be primary or
secondary to pathological damage in the
respiratory common causes organism are
bacterial example staphylococcus
• Symptoms;high fever,dry cough,chest
pain,tachypnea,and respiratory distress
• DRUGS FOR CHRONIC OBSTRUCTIVE
PULMONARY DISEASE
• Sympathomimetic(alpha and beta adrenergic
agonist)
• Albuterol,metaproterenol,isoproterenol.
• PHARMACOKINETIC
• Metaproterenol is well absorbed from GIT.Is
protein bind percentage and half life are
unknown.it is metabolized by liver and
excreted in the urine.
• THERAPEUTIC EFFECT
• To treat bronchospasm,asthma,
• MODE OF ACTION
• Relaxation of smooth muscle of bronchi
• SIDE EFFECT
• Nervousness,tremor,restlessnes,insomnia,nau
sea,muscle cramping
• ANTICHOLINERGICS
• Help to treat asthmatic condition by dilating
the bronchioles
• Ipratropium bromide
• Has few systematics effect unlike other
anticolinergic
• When using anticholigernic agent in the
conjuction with an inhaled glucocorticor
• This caused bronchioles to dilate so the
steroid or cromolyn can be deposite in the
bronchioles.
• The combination of ibratropium and buterol
sulphate is used to treat chronic bronchitis
• MANAGEMENT OF LOWER RESPIRATORY
INFECTION
• Avoid smoking
• Oxygen therapy
• Supportive care ;lower the temperature if
>38.5 degree give paracetamol if wheezing
giving rapid acting bronchodilator (nebulized
sulbutamol)
• Avoid heavy exercise in case of asthma
• Treament of acute attacks
• Antibiotics are used to treat an acute
exacerbation and prevent reccurent infection
by suppression or eradication of existing flora.
GROUP MEMBER
• ALPHONSINA MGUMBA
• NASRA LOLO
• JENNIFER
• NICKSON PANCRAS
• MUSSAH RAMADHAN
• EMMANUEL ANDREA
• EMMANUEL NDILE

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Group number 5

  • 2. THE PHARMACOLOGY OF LOWER RESPIRATORY TRACT • The lower respiratory tract includes the following parts;  Larynx  Trachea  Bronchi  Bronchioles  Alveolar duct  Alveolar sac  alveoli
  • 3. • The lower respiratory infection; these are diseases which infect the lower respiratory tract. The lower respiratory diseases are divided into 2 categories Chronic obstructive pulmonary disease(COPD) Restrictive pulmonary disease
  • 4. There are 4 major diseases caused by chronic obstructive pulmonary diseases Chronic obstructive pulmonary disease are caused by airway obstruction with increased airway resistance of air flow to lung. Which are Chronic bronchitis Bronchiectasis Emphysema Asthma
  • 5. • Chronic bronchitis, bronchiectasis and emphysema cause frequent result in irreversible lung tissue damage. • While in asthma the lung tissue change as a result from acute asthmatic are normally reversible.
  • 6. Restrictive pulmonary disease This is a decrease in total lung capacity as a result of fluid accumulation or loss of elasticity of lung. The diseases involves; Pulmonary edema Pulmonary fibrosis Pneumonitis Lung tumors
  • 7. • Thoracic deformities(scoliosis) • Myasthenia gravis (affect thoracic mascular wall) THE DRUGS OF CHRONIC OBSTRUCTION PULMONARY DISEASE sympathomimetics drugs Leukotrine antagonist
  • 8. • Cromolyn • mucolytics • anticholinergic • Glucocoticoids • NB;Some of other drugs above can be used to treat the restrictive pulmonary disease
  • 9. BRONCHIECTASIS Is abnormal dilation of bronchi and bronchioles secondary to frequent infection and inflammation. The bronchioles become obstructed by the break down of the epithelium of the bronchial mucosa ,tissue fibrosis may result.
  • 10. Symptoms; chronic coughing ,coughing up blood ,shortness of breath ,chest pain, and wheezing, EMPHYSEMA Is progressive lungs disease causes by cigarette smoking atmospheric contaminants or lack of the alpha antitrytic enzymes that destroy alveoli.
  • 11. • The proteolyic enzymes are released in the lung by bacteria.the terminal bronchioles becomes plugged with mucus causing a loss of the fiber and elastin network in the alveolar. • The alveoli enlarge as many of the alveolar walls are destroyed .air becomes trapped in the over expanded alveoli leading to in adequate gas {oxygen and carbondioxide}.
  • 12. • Symptoms;shortness of breath • ASTHMA • Is a reversible obstructive airway disease of varying severity.the symptoms are caused by constriction of bronhiol mucous membrane and blockage of the small bronchi with plug of mucus .it can be triggered by factors like allergen,infection,exercice,drugs for examples aspirin,tobscco smoke,inhaled chemicals.
  • 13. • Characterized by dyspnea,wheezing,tightness of chest and cough. • PNEUMONIA • Is the inflammation of the lungs tissue ,pneumonia can either be primary or secondary to pathological damage in the respiratory common causes organism are bacterial example staphylococcus
  • 14. • Symptoms;high fever,dry cough,chest pain,tachypnea,and respiratory distress • DRUGS FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE • Sympathomimetic(alpha and beta adrenergic agonist) • Albuterol,metaproterenol,isoproterenol.
  • 15. • PHARMACOKINETIC • Metaproterenol is well absorbed from GIT.Is protein bind percentage and half life are unknown.it is metabolized by liver and excreted in the urine. • THERAPEUTIC EFFECT • To treat bronchospasm,asthma,
  • 16. • MODE OF ACTION • Relaxation of smooth muscle of bronchi • SIDE EFFECT • Nervousness,tremor,restlessnes,insomnia,nau sea,muscle cramping
  • 17. • ANTICHOLINERGICS • Help to treat asthmatic condition by dilating the bronchioles • Ipratropium bromide • Has few systematics effect unlike other anticolinergic • When using anticholigernic agent in the conjuction with an inhaled glucocorticor
  • 18. • This caused bronchioles to dilate so the steroid or cromolyn can be deposite in the bronchioles. • The combination of ibratropium and buterol sulphate is used to treat chronic bronchitis
  • 19. • MANAGEMENT OF LOWER RESPIRATORY INFECTION • Avoid smoking • Oxygen therapy • Supportive care ;lower the temperature if >38.5 degree give paracetamol if wheezing giving rapid acting bronchodilator (nebulized sulbutamol)
  • 20. • Avoid heavy exercise in case of asthma • Treament of acute attacks • Antibiotics are used to treat an acute exacerbation and prevent reccurent infection by suppression or eradication of existing flora.
  • 21. GROUP MEMBER • ALPHONSINA MGUMBA • NASRA LOLO • JENNIFER • NICKSON PANCRAS • MUSSAH RAMADHAN • EMMANUEL ANDREA • EMMANUEL NDILE