Gravity, or gravitation, is a natural phenomenon by which all things with mass are brought toward (or gravitate toward) one another, including planets, stars and galaxies.
Since energy and mass are equivalent, all forms of energy, including light, also cause gravitation and are under the influence of it.
On Earth, gravity gives weight to physical objects and causes the ocean tides.
the relation between force and motion id described in Newtons three laws of motion. These laws are very simple statements and enable us to describe the future (or past) motion of body if we know the forces acting on it.
This is the NCERT CBSE syllabus ppt on the topic Gravitation. It will be helpful for students studying in that class and will enable them to understand better.
Gravity Gravitation English Presentation
Tugas Fisika
Tugas Bahasa Inggris
oleh :
Kelas 12 IPA 6 SMA Negeri 1 Yogyakarta tahun 2014
Semangat!!!!!!! SUKSES
the relation between force and motion id described in Newtons three laws of motion. These laws are very simple statements and enable us to describe the future (or past) motion of body if we know the forces acting on it.
This is the NCERT CBSE syllabus ppt on the topic Gravitation. It will be helpful for students studying in that class and will enable them to understand better.
Gravity Gravitation English Presentation
Tugas Fisika
Tugas Bahasa Inggris
oleh :
Kelas 12 IPA 6 SMA Negeri 1 Yogyakarta tahun 2014
Semangat!!!!!!! SUKSES
The Braun Foundation for International ExchangeMartin Moessmer
Our Mission:
The Non-Profit Braun Foundation sees itself as a mediator for the needs of schools, universities, businesses and exchange organisations, and a facilitator for the intercultural education of (future) applicants, the further education of internationally placed employees, as well as supporting individuals and organisations in other related areas.
Our Vision:
We would like to contribute towards a mutual understanding between cultures, and develop and promote different educational and economic systems. To this end, the foundation facilitates crucial exchanges and meetings at an international level.
Our Values:
Tolerance, Integration and intercultural communication are very complex terms. The Braun Foundation brings these principles to life, and through an operational and supportive foundation business, incorporates them into our daily lives and our society.
To reach our goals and fulfill our vision we cooperate, support and interlink colleges, high-schools, state and private universities, Language Schools and Exchange organisations, NGOs, NPOs, private companies and State Organisations.
Together with the extensive and diverse Braun Foundation network we have established the International Exchange Service of the Braun Foundation (PESIE) and the International PESIE Student ID Card (IPSC).
The project "Preparation Colleges in Germany" complements the Foundation's main purposes and activities.
EUGM 2013 - Bernd Rupp (FMP) Chemical Information systems: From compound coll...ChemAxon
The FMP has developed a database of commercially available compounds which is used to design our in-house HTS collection and is additionally applied to create focused libraries. But the dramatically increase of unique compounds of one order of magnitude from less than 10 to around 30 to 40 million compounds currently and approximately hundred million compounds in the next years requires a reorganization and redevelopment of our storage and searching strategy. To manage such a massive amount of data we developed a Registration Database for registration and normalisation of vendor catalogues. This database contains the highly redundant data of the vendor catalogues and is converted in a second step into the non-redundant Unique Structure Database which represents a data warehouse combining vendor data, structural descriptors and in-house classification tools including our earlier developed ADMET- and reactivity filters as well as our in-house fragment-based fingerprints used for library design tasks. The management of both database systems is part of a new developed Java application, which handles the user management for the data upload in the Registration Database and the conversion into the Unique Structure Database. Further a first version of a Web service is in preparation. This service allows the scientist not only to search for compounds and fragments in the Unique Structure Database but also to combine such a search with the FMP tools to classify compounds for their usability in biological assays.
This theory, not so much to unify the gravitational field, but gives us a theoretical concept of the universe can be correlated, hence derives DEPENDABILITY universal, by the fact that unifies all the theories that exist, notably Einstein's general relativity and the theory of dynamic gravity of tesla, and among others.
Big Bang Theory & Other Recent Sciences || 2014 - Dr. Mahbub Khaniqra tube
RECENT SCIENCES
Big Bang, Dark Matter, Dark Energy, Black Hole, Neutrino, God Particle, Higgs Field, Graviton, Expansion of Universe, and Search for Life elsewhere in the Cosmos
The Bronze Age is a period characterized by the use of bronze, proto-writing, and other early features of urban civilization.
The Bronze Age is the second principal period of the three-age Stone-Bronze-Iron system, as proposed in modern times by Christian Jürgensen Thomsen, for classifying and studying ancient societies.
The cradle of civilization is a term referring to locations where, according to current archaeological data, civilization is understood to have emerged.
Current thinking is that there was no single "cradle", but several civilizations that developed independently; with the Fertile Crescent, Mesopotamia and Egypt, understood to be the earliest.
The Indus Valley Civilisation (IVC) was a Bronze Age civilisation (3300–1300 BCE; mature period 2600–1600 BCE) mainly in the northwestern regions of the South Asia, extending from what today is northeast Afghanistan to Pakistan and northwest India.
Along with ancient Egypt and Mesopotamia it was one of three early civilisations of the Old World, and of the three, the most widespread.
It flourished in the basins of the Indus River, which flows through the length of Pakistan, and along a system of perennial, mostly monsoon-fed, rivers that once coursed in the vicinity of the seasonal Ghaggar-Hakra river in northwest India and eastern Pakistan.
The Indigenous Aryans theory, also known as the Out of India theory, proposes that the Indo-European languages, or at least the Indo-Aryan languages, originated within the Indian subcontinent, as an alternative to the established migration model which proposes the Pontic steppe as the area of origin of the IndoEuropean languages.
The indigenist view sees the Indo-Aryan languages as having a deep history in the Indian subcontinent, and being the carriers of the Indus Valley Civilization.
This view proposes an older date than is generally accepted for the Vedic period, which is generally considered to follow the decline of Harappan culture.
The Indus Valley Civilisation (IVC) was a Bronze Age civilisation (3300–1300 BCE; mature period 2600–1600 BCE) mainly in the northwestern regions of the South Asia, extending from what today is northeast Afghanistan to Pakistan and northwest India.
Along with ancient Egypt and Mesopotamia it was one of three early civilisations of the Old World, and of the three, the most widespread.
It flourished in the basins of the Indus River, which flows through the length of Pakistan, and along a system of perennial, mostly monsoon-fed, rivers that once coursed in the vicinity of the seasonal Ghaggar-Hakra river in northwest India and eastern Pakistan.
The Kuṣaṇas started their ruling under Kujula Kadphises in central asia and centre of power was Gandhara .
The Kuṣaṇas apparently introduced the very first anthropomorphic representations of Indian gods for their coins in Gandhara, even before an iconographical canon for these deities became standardised
The Vedas are a large body of knowledge texts originating in the ancient Indian subcontinent. Composed in Vedic Sanskrit, the texts constitute the oldest layer of Sanskrit literature and the oldest scriptures of Hinduism.
Hindus consider the Vedas to be apauruṣeya, which means "not of a man, superhuman" and "impersonal, authorless".
The Indigenous Aryans theory, also known as the Out of India theory, proposes that the Indo-European languages, or at least the Indo-Aryan languages, originated within the Indian subcontinent, as an alternative to the established migration model which proposes the Pontic steppe as the area of origin of the IndoEuropean languages.
The indigenist view sees the Indo-Aryan languages as having a deep history in the Indian subcontinent, and being the carriers of the Indus Valley Civilization.
This view proposes an older date than is generally accepted for the Vedic period, which is generally considered to follow the decline of Harappan culture.
Arya is a term meaning "noble" which was used as a self-designation by Indian and Iranian or Indo-Iranian people.
The word was used by the Indic people of the Vedic period in India as an ethnic label for themselves, as well as to refer to the noble class and geographic location known as Āryāvarta where Indo-Aryan culture was based.
The closely related Iranian people also used the term as an ethnic label for themselves in the Avesta scriptures, and the word forms the etymological source of the country Iran.
The Indus Valley Civilisation (IVC) was a Bronze Age civilisation (3300–1300 BCE; mature period 2600–1600 BCE) mainly in the northwestern regions of the South Asia, extending from what today is northeast Afghanistan to Pakistan and northwest India.
Along with ancient Egypt and Mesopotamia it was one of three early civilisations of the Old World, and of the three, the most widespread.
It flourished in the basins of the Indus River, which flows through the length of Pakistan, and along a system of perennial, mostly monsoon-fed, rivers that once coursed in the vicinity of the seasonal Ghaggar-Hakra river in northwest India and eastern Pakistan.
The Vedic Vayupurana describes a battle waged among the ancient Aryans. It was as a result of this war that Anavs part of the Chandravanshi clan and Gurtar ( Guzar ) of suryabanshi had to immigrate to wester Aryabart area of modern Iran (Iran means "land of Aryans") to Tarim basin.
It was in these regions, where the fertile soil of the mountainous country is surrounded by the Turanian desert, that the prophet Zarathushtra (Zoroaster) was said to have been born and gained his first adherents. Avestan, the language of the oldest portions of the Zoroastrian Avesta, was once called "old-iranic" which is related to Sanskrit.
Chandravansi known as Sythians and Suryabanshi known as Guzar/Gusur by Tibbetian , Yuezhi by Chineese , Tocharian by Romans and Tushara by Poranic Indians.
Notes on Central Asian History during 200 BC and its effects on later history, Role of Yuezhi migration in Ancient History of Central Asia, settlement of Yuezhi after migration and various theories about current form of Ancient Yuezhi tribe: (Gurjar/Gujjar/Gujar/Gusar/Gusur/Khazar/Ughar/Gazar/Gusarova)
Notes on Central Asian History during 200 BC and its effects on later history, Role of Yuezhi migration in Ancient History of Central Asia, settlement of Yuezhi after migration and various theories about current form of Ancient Yuezhi tribe: (Gurjar/Gujjar/Gujar/Gusar/Gusur/Khazar/Ughar/Gazar/Gusarova)
Notes on Central Asian History during 200 BC and its effects on later history, Role of Yuezhi migration in Ancient History of Central Asia, settlement of Yuezhi after migration and various theories about current form of Ancient Yuezhi tribe: (Gurjar/Gujjar/Gujar/Gusar/Gusur/Khazar/Ughar/Gazar/Gusarova)
Notes on Central Asian History during 200 BC and its effects on later history, Role of Yuezhi migration in Ancient History of Central Asia, settlement of Yuezhi after migration and various theories about current form of Ancient Yuezhi tribe: (Gurjar/Gujjar/Gujar/Gusar/Gusur/Khazar/Ughar/Gazar/Gusarova)
“The stupa was one of the most characteristic remains of the Buddhist world; they are not found in Hinduism at all.
In function we may view them as a specialized type of tumulus:
They were circular in shape, with a domed top.
They were built to cover the relics of the Buddha, his earlier followers, or some other essential symbol of the Buddhist religion.
It might be recalled that the Buddha was Śākyamuni (‘Sage of the Śakyas’, i.e. the Sakas)….
To the stupas were carried offerings, often letters, while the devoted performed their rituals, walking around the shrine keeping their right shoulders (pradaksina) toward the stupa.
The stupas spread with Buddhism to China and Japan and linguistically, Sanskrit stūpa gave Prākrit thūpo which the Chinese variously treated as *tabo or *sutab/po, now simplified to tā ‘pagoda.’”
In 176 BC, the Yuezhi were driven from Tarim Besin to westward by the Xiongnu, a fierce people of Magnolia.
The Yuezhi under the leadership of the Kushanas came down from Central Asia and swept away all earlier dynasties of the Northwest in a great campaign of conquest. They established an empire which extended from Central Asia right down to the eastern Gangetic basin.
In Bactria, they conquered the Scythians and the local Indo-Greek kingdoms, the last remnants of Alexander the Great's invasion force that had failed to take India.
From this central location, the Kushan Empire became a wealthy trading hub between the peoples of Han China, Sassanid Persia and the Roman Empire.
Roman gold and Chinese silk changed hands in the Kushan Empire, at a very tidy profit for the middle-men.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
2. • Gravity, or gravitation, is a natural
phenomenon by which all things with mass are
brought toward (or gravitate toward) one
another, including planets, stars and galaxies.
• Since energy and mass are equivalent, all forms
of energy, including light, also cause gravitation
and are under the influence of it.
• On Earth, gravity gives weight to physical
objects and causes the ocean tides.
3. The gravitational attraction of the original gaseous
matter present in the Universe caused it to
begin coalescing, forming stars — and the stars
to group together into galaxies — so gravity is
responsible for many of the large scale
structures in the Universe.
Gravity has an infinite range, although its effects
become increasingly weaker on farther objects.
4. • Gravity is most accurately described by
the general theory of relativity (proposed
by Albert Einstein in 1915) which describes
gravity not as a force, but as a consequence of
the curvature of spacetime caused by the
uneven distribution of mass/energy.
• The most extreme example of this curvature of
spacetime is a black hole, from which nothing
can escape once past its event horizon, not even
light.
5. More gravity results in gravitational time dilation,
where time lapses more slowly at a lower
(stronger) gravitational potential.
However, for most applications, gravity is well
approximated by Newton's law of universal
gravitation, which describes gravity as
a force which causes any two bodies to be
attracted to each other, with the
force proportional to the product of their masses
and inversely proportional to the square of
the distance between them.
6. • Gravity is the weakest of the four fundamental
interactions of nature.
• The gravitational attraction is approximately
1038 times weaker than the strong force,
1036 times weaker than the electromagnetic
force and 1029 times weaker than the weak
force.
• As a consequence, gravity has a negligible
influence on the behavior of subatomic
particles, and plays no role in determining the
internal properties of everyday matter (but
see quantum gravity).
7. • On the other hand, gravity is the dominant
interaction at the macroscopic scale, and is
the cause of the formation, shape
and trajectory (orbit) of astronomical bodies.
• It is responsible for various phenomena
observed on Earth and throughout the
Universe; for example, it causes the Earth and
the other planets to orbit the Sun,
the Moon to orbit the Earth, the formation
of tides, the formation and evolution of the
Solar System, stars and galaxies.
8. The earliest instance of gravity in the Universe,
possibly in the form of quantum
gravity, supergravity or a gravitational singularity,
along with ordinary space and time, developed
during the Planck epoch (up to 10−43 seconds
after the birth of the Universe), possibly from a
primeval state, such as a false vacuum, quantum
vacuum or virtual particle, in a currently unknown
manner.
For this reason, in part, pursuit of a theory of
everything, the merging of the general theory of
relativity and quantum mechanics (or quantum
field theory) into quantum gravity, has become an
area of research.
9. Equivalence principle
• The equivalence principle, explored by a succession of
researchers including Galileo, Loránd Eötvös, and Einstein,
expresses the idea that all objects fall in the same way, and that
the effects of gravity are indistinguishable from certain aspects
of acceleration and deceleration.
• The simplest way to test the weak equivalence principle is to
drop two objects of different masses or compositions in a
vacuum and see whether they hit the ground at the same time.
• Such experiments demonstrate that all objects fall at the same
rate when other forces (such as air resistance and
electromagnetic effects) are negligible.
• More sophisticated tests use a torsion balance of a type
invented by Eötvös. Satellite experiments, for example STEP, are
planned for more accurate experiments in space
10. • Formulations of the equivalence principle
include:
• The weak equivalence principle: The trajectory
of a point mass in a gravitational field depends
only on its initial position and velocity, and is
independent of its composition.
• The Einsteinian equivalence principle: The
outcome of any local non-gravitational
experiment in a freely falling laboratory is
independent of the velocity of the laboratory
and its location in spacetime.
• The strong equivalence principle requiring both
of the above.
11. General relativity
• In general relativity the effects of gravitation are
ascribed to spacetime curvature instead of a
force.
• The starting point for general relativity is
the equivalence principle, which equates free fall
with inertial motion and describes free-falling
inertial objects as being accelerated relative to
non-inertial observers on the ground.
• In Newtonian physics, however, no such
acceleration can occur unless at least one of the
objects is being operated on by a force.
12. • Einstein proposed that spacetime is curved by
matter, and that free-falling objects are moving
along locally straight paths in curved spacetime.
• These straight paths are called geodesics. Like
Newton's first law of motion, Einstein's theory
states that if a force is applied on an object, it
would deviate from a geodesic.
• For instance, we are no longer following
geodesics while standing because the mechanical
resistance of the Earth exerts an upward force on
us, and we are non-inertial on the ground as a
result.
• This explains why moving along the geodesics in
spacetime is considered inertial.
13. Two-dimensional analogy of spacetime distortion generated by the mass of
an object. Matter changes the geometry of spacetime, this (curved)
geometry being interpreted as gravity. White lines do not represent the
curvature of space but instead represent the coordinate system imposed
on the curved spacetime, which would be rectilinear in a flat spacetime.
14. • Einstein discovered the field equations of general
relativity, which relate the presence of matter
and the curvature of spacetime and are named
after him.
• The Einstein field equations are a set of
10 simultaneous, non-linear, differential
equations.
• The solutions of the field equations are the
components of the metric tensor of spacetime.
• A metric tensor describes a geometry of
spacetime.
• The geodesic paths for a spacetime are calculated
from the metric tensor.
15. Solutions
Notable solutions of the Einstein field equations include:
• The Schwarzschild solution, which describes spacetime surrounding
a spherically symmetric non-rotating uncharged massive object. For
compact enough objects, this solution generated a black hole with a
central singularity. For radial distances from the center which are much
greater than the Schwarzschild radius, the accelerations predicted by the
Schwarzschild solution are practically identical to those predicted by
Newton's theory of gravity.
• The Reissner-Nordström solution, in which the central object has an
electrical charge. For charges with a geometrized length which are less
than the geometrized length of the mass of the object, this solution
produces black holes with double event horizons.
• The Kerr solution for rotating massive objects. This solution also
produces black holes with multiple event horizons.
• The Kerr-Newman solution for charged, rotating massive objects. This
solution also produces black holes with multiple event horizons.
• The cosmological Friedmann-Lemaître-Robertson-Walker solution,
which predicts the expansion of the Universe.
16. Tests of general relativity
• General relativity accounts for the
anomalous perihelion precession of Mercury.
• The prediction that time runs slower at lower
potentials (gravitational time dilation) has
been confirmed by the Pound–Rebka
experiment (1959), the Hafele–Keating
experiment, and the GPS.
17. • The prediction of the deflection of light was first
confirmed by Arthur Stanley Eddington from his
observations during the Solar eclipse of May 29,
1919.
• Eddington measured starlight deflections twice those
predicted by Newtonian corpuscular theory, in
accordance with the predictions of general relativity.
• However, his interpretation of the results was later
disputed.
• More recent tests using radio interferometric
measurements of quasars passing behind
the Sun have more accurately and consistently
confirmed the deflection of light to the degree
predicted by general relativity.
18. • The time delay of light passing close to a
massive object was first identified by Irwin I.
Shapiro in 1964 in interplanetary spacecraft
signals.
• Gravitational radiation has been indirectly
confirmed through studies of binary pulsars.
On 11 February 2016,
the LIGO and Virgo collaborations announced
the first observation of a gravitational wave.
19. • Alexander Friedmann in 1922 found that Einstein
equations have non-stationary solutions (even in
the presence of the cosmological constant).
• In 1927 Georges Lemaître showed that static
solutions of the Einstein equations, which are
possible in the presence of the cosmological
constant, are unstable, and therefore the static
Universe envisioned by Einstein could not exist.
Later, in 1931, Einstein himself agreed with the
results of Friedmann and Lemaître.
• Thus general relativity predicted that the Universe
had to be non-static—it had to either expand or
contract. The expansion of the Universe discovered
by Edwin Hubble in 1929 confirmed this prediction.
20. The theory's prediction of frame dragging was
consistent with the recent Gravity Probe
B results.
General relativity predicts that light should lose
its energy when traveling away from massive
bodies through gravitational redshift. This was
verified on earth and in the solar system
around 1960.
21. Gravity and quantum mechanics
• In the decades after the discovery of general
relativity, it was realized that general relativity is
incompatible with quantum mechanics.
• It is possible to describe gravity in the framework
of quantum field theory like the other fundamental
forces, such that the attractive force of gravity
arises due to exchange of virtual gravitons, in the
same way as the electromagnetic force arises from
exchange of virtual photons.
• This reproduces general relativity in the classical
limit. However, this approach fails at short
distances of the order of the Planck length, where a
more complete theory of quantum gravity (or a
new approach to quantum mechanics) is required.
22. Specifics:Earth's gravity
Every planetary body (including the Earth) is
surrounded by its own gravitational field, which
can be conceptualized with Newtonian physics as
exerting an attractive force on all objects.
Assuming a spherically symmetrical planet, the
strength of this field at any given point above the
surface is proportional to the planetary body's
mass and inversely proportional to the square of
the distance from the center of the body.
23. • The strength of the gravitational field is
numerically equal to the acceleration of
objects under its influence.
• The rate of acceleration of falling objects near
the Earth's surface varies very slightly
depending on latitude, surface features such
as mountains and ridges, and perhaps
unusually high or low sub-surface densities
• .For purposes of weights and measures,
a standard gravity value is defined by
the International Bureau of Weights and
Measures, under the International System of
Units (SI).
24. • That value, denoted g, is g =
9.80665 m/s2 (32.1740 ft/s2)
• The standard value of 9.80665 m/s2 is the one
originally adopted by the International
Committee on Weights and Measures in 1901
for 45° latitude, even though it has been
shown to be too high by about five parts in
ten thousand.
• This value has persisted in meteorology and in
some standard atmospheres as the value for
45° latitude even though it applies more
precisely to latitude of 45°32'33".
25. • Assuming the standardized value for g and
ignoring air resistance, this means that an object
falling freely near the Earth's surface increases its
velocity by 9.80665 m/s (32.1740 ft/s or 22 mph)
for each second of its descent.
• Thus, an object starting from rest will attain a
velocity of 9.80665 m/s (32.1740 ft/s) after one
second, approximately 19.62 m/s (64.4 ft/s) after
two seconds, and so on, adding 9.80665 m/s
(32.1740 ft/s) to each resulting velocity.
• Also, again ignoring air resistance, any and all
objects, when dropped from the same height, will
hit the ground at the same time.
26. • According to Newton's 3rd Law, the Earth itself
experiences a force equal in magnitude and
opposite in direction to that which it exerts on a
falling object.
• This means that the Earth also accelerates
towards the object until they collide.
• Because the mass of the Earth is huge, however,
the acceleration imparted to the Earth by this
opposite force is negligible in comparison to the
object's.
• If the object doesn't bounce after it has collided
with the Earth, each of them then exerts a
repulsive contact force on the other which
effectively balances the attractive force of gravity
and prevents further acceleration.
27. The apparent force of gravity on Earth is the
resultant (vector sum) of two forces:
(a) The gravitational attraction in accordance
with Newton's universal law of gravitation,
and
(b)(b) the centrifugal force, which results from
the choice of an earthbound, rotating frame
of reference.
28. The force of gravity is the weakest at the equator
because of the centrifugal force caused by the
Earth's rotation and because points on the
equator are furthest from the center of the
Earth.
The force of gravity varies with latitude and
increases from about 9.780 m/s2 at the Equator
to about 9.832 m/s2 at the poles.
29. Equations for a falling body near the
surface of the Earth
• Under an assumption of constant gravitational
attraction, Newton's law of universal
gravitation simplifies to F = mg, where m is
the mass of the body and g is a constant vector
with an average magnitude of 9.81 m/s2 on Earth.
• This resulting force is the object's weight. The
acceleration due to gravity is equal to this g.
• An initially stationary object which is allowed to
fall freely under gravity drops a distance which is
proportional to the square of the elapsed time.
30. Equations for a falling body near the
surface of the Earth
• The image on the right, spanning half a
second, was captured with a stroboscopic
flash at 20 flashes per second.
• During the first 1⁄20 of a second the ball drops
one unit of distance (here, a unit is about
12 mm); by 2⁄20 it has dropped at total of 4
units; by 3⁄20, 9 units and so on.
31. • Under the same constant gravity assumptions,
the potential energy, Ep, of a body at
height h is given by Ep = mgh (or Ep = Wh,
with W meaning weight).
• This expression is valid only over small
distances h from the surface of the Earth.
Similarly, the expression h = v2/2g for the
maximum height reached by a vertically
projected body with initial velocity v is useful
for small heights and small initial velocities
only.
32. Gravity and astronomy
• The application of Newton's law of gravity has
enabled the acquisition of much of the detailed
information we have about the planets in the Solar
System, the mass of the Sun, and details of quasars;
even the existence of dark matter is inferred using
Newton's law of gravity. Although we have not
traveled to all the planets nor to the Sun, we know
their masses.
• These masses are obtained by applying the laws of
gravity to the measured characteristics of the orbit.
In space an object maintains its orbit because of the
force of gravity acting upon it.
33. Gravity and astronomy
• Planets orbit stars, stars orbit galactic
centers, galaxies orbit a center of mass in
clusters, and clusters orbit in superclusters.
• The force of gravity exerted on one object by
another is directly proportional to the product of
those objects' masses and inversely proportional
to the square of the distance between them.
34. The earliest gravity (possibly in the form
of quantum gravity, supergravity or
a gravitational singularity), along with
ordinary space and time, developed during
the Planck epoch (up to 10−43 seconds after
the birth of the Universe), possibly from a
primeval state (such as a false
vacuum, quantum vacuum or virtual particle),
in a currently unknown manner.
36. Gravitational radiation
• According to general relativity, gravitational radiation is
generated in situations where the curvature
of spacetime is oscillating, such as is the case with co-
orbiting objects.
• The gravitational radiation emitted by the Solar
System is far too small to measure. However,
gravitational radiation has been indirectly observed as
an energy loss over time in binary pulsar systems such
as PSR B1913+16. It is believed that neutron
star mergers and black hole formation may create
detectable amounts of gravitational radiation.
• Gravitational radiation observatories such as the Laser
Interferometer Gravitational Wave Observatory (LIGO)
have been created to study the problem.
37. Gravitational radiation
• In February 2016, the Advanced LIGO team
announced that they had detected gravitational
waves from a black hole collision. On September 14,
2015 LIGO registered gravitational waves for the first
time, as a result of the collision of two black holes 1.3
billion light-years from Earth.
• This observation confirms the theoretical predictions
of Einstein and others that such waves exist.
• The event confirms that binary black hole exist. It also
opens the way for practical observation and
understanding of the nature of gravity and events in
the Universe including the Big Bang and what
happened after it
38. Speed of gravity
• In December 2012, a research team in China
announced that it had produced
measurements of the phase lag of Earth
tides during full and new moons which seem
to prove that the speed of gravity is equal to
the speed of light.
• This means that if the Sun suddenly
disappeared, the Earth would keep orbiting it
normally for 8 minutes, which is the time light
takes to travel that distance.
• The team's findings were released in
the Chinese Science Bulletin in February 2013.
39. Anomalies and discrepancies
There are some observations that are not
adequately accounted for, which may point to
the need for better theories of gravity or
perhaps be explained in other ways.
40. Extra-fast stars
• Stars in galaxies follow a distribution of
velocities where stars on the outskirts are moving
faster than they should according to the observed
distributions of normal matter.
• Galaxies within galaxy clusters show a similar
pattern.
• Dark matter, which would interact through
gravitation but not electromagnetically, would
account for the discrepancy.
• Various modifications to Newtonian dynamics have
also been proposed.
42. Accelerating expansion:
• The metric expansion of space seems to be
speeding up. Dark energy has been proposed
to explain this.
• A recent alternative explanation is that the
geometry of space is not homogeneous (due
to clusters of galaxies) and that when the data
are reinterpreted to take this into account, the
expansion is not speeding up after
all, however this conclusion is disputed.
43. Anomalous increase of
the astronomical unit:
Recent measurements indicate that planetary
orbits are widening faster than if this were
solely through the Sun losing mass by
radiating energy.
44. Extra energetic photons
• Photons travelling through galaxy clusters should
gain energy and then lose it again on the way out.
• The accelerating expansion of the Universe
should stop the photons returning all the energy,
but even taking this into account photons from
the cosmic microwave background radiation gain
twice as much energy as expected.
• This may indicate that gravity falls off faster than
inverse-squared at certain distance scales.
45. Extra massive hydrogen clouds
The spectral lines of the Lyman-alpha
forest suggest that hydrogen clouds are more
clumped together at certain scales than
expected and, like dark flow, may indicate that
gravity falls off slower than inverse-squared at
certain distance scales.