These two lectures give an overview of organic synthesis using water as a solvent. This is aimed towards final year undergraduates and graduate students in chemistry
Water is a versatile green solvent that can be used for many organic reactions. It has unique physical properties like hydrogen bonding that allow it to activate both nucleophiles and electrophiles. Reactions that were traditionally carried out in organic solvents, like Diels-Alder reactions, pericyclic reactions, reactions of carbanions/carbenium ions, radical reactions, and multicomponent reactions, have been shown to proceed faster or with better selectivity in water compared to organic solvents. The use of water as a solvent provides advantages such as environmental friendliness, safety, and cost effectiveness.
This document summarizes three methods for preparing hollow metal-organic frameworks (MOFs): 1) the exterior-template method where templates are coated with MOF shells and then removed, 2) the self-template method where intermediate products or reactants act as sacrificial templates, and 3) the two-phase interface method using gas-liquid, liquid-liquid, or solid-liquid interfaces. It also discusses using hollow MOFs for drug delivery by loading drugs through immersion or one-pot synthesis and zinc-based MOFs for delivering 5-fluorouracil.
Supramolecular chemistry is the chemistry of intermolecular bonds between two or more chemical species. It was pioneered in the late 19th century and Nobel Prizes have been awarded for its development. Supramolecular interactions include ion-ion, ion-dipole, and dipole-dipole interactions. Building blocks include macrocycles, structural units, and biologically derived units. Control relies on thermodynamics and the molecular environment. Applications include materials technology, catalysis, medicine, and other devices. Intensive research is enabling new functional materials and more effective catalysis through template-directed synthesis.
The document discusses nitration, which is the introduction of nitro groups (-NO2) into organic molecules. It can produce nitro aromatic compounds, nitro paraffinic compounds, or nitramine compounds. The main nitrating agents are mixtures of nitric acid with sulfuric acid. Nitration of aromatic compounds produces nitrobenzene and related compounds. The orientation of nitro substitution depends on the electron-withdrawing or -donating effects of substituents. Nitration of aliphatic compounds requires high temperatures and yields complex product mixtures. Process parameters like temperature, agitation, composition, and phase ratios influence nitration kinetics and yields.
Just basics of mesoporous materials!!The Break through came around 1992 by both Japanese and Mobil scientist on the soft template based synthesis of mesoporous materials
A carbene is any neutral carbon species which contains a non-bonding valance pair of electrons.
Contributed by Alison Brown & Nathan Buehler, Undergraduates, University of Utah
This document discusses metathesis reactions and their applications in organic synthesis. It begins with definitions and examples of different types of metathesis reactions including alkene, alkyne, and enyne metathesis. It then covers the key catalysts used, such as Grubbs and Schrock catalysts, as well as the 2005 Nobel Prize awarded for the development of metathesis reactions. The document concludes by outlining several important applications of metathesis in synthesizing biologically active compounds and natural products.
Water is a versatile green solvent that can be used for many organic reactions. It has unique physical properties like hydrogen bonding that allow it to activate both nucleophiles and electrophiles. Reactions that were traditionally carried out in organic solvents, like Diels-Alder reactions, pericyclic reactions, reactions of carbanions/carbenium ions, radical reactions, and multicomponent reactions, have been shown to proceed faster or with better selectivity in water compared to organic solvents. The use of water as a solvent provides advantages such as environmental friendliness, safety, and cost effectiveness.
This document summarizes three methods for preparing hollow metal-organic frameworks (MOFs): 1) the exterior-template method where templates are coated with MOF shells and then removed, 2) the self-template method where intermediate products or reactants act as sacrificial templates, and 3) the two-phase interface method using gas-liquid, liquid-liquid, or solid-liquid interfaces. It also discusses using hollow MOFs for drug delivery by loading drugs through immersion or one-pot synthesis and zinc-based MOFs for delivering 5-fluorouracil.
Supramolecular chemistry is the chemistry of intermolecular bonds between two or more chemical species. It was pioneered in the late 19th century and Nobel Prizes have been awarded for its development. Supramolecular interactions include ion-ion, ion-dipole, and dipole-dipole interactions. Building blocks include macrocycles, structural units, and biologically derived units. Control relies on thermodynamics and the molecular environment. Applications include materials technology, catalysis, medicine, and other devices. Intensive research is enabling new functional materials and more effective catalysis through template-directed synthesis.
The document discusses nitration, which is the introduction of nitro groups (-NO2) into organic molecules. It can produce nitro aromatic compounds, nitro paraffinic compounds, or nitramine compounds. The main nitrating agents are mixtures of nitric acid with sulfuric acid. Nitration of aromatic compounds produces nitrobenzene and related compounds. The orientation of nitro substitution depends on the electron-withdrawing or -donating effects of substituents. Nitration of aliphatic compounds requires high temperatures and yields complex product mixtures. Process parameters like temperature, agitation, composition, and phase ratios influence nitration kinetics and yields.
Just basics of mesoporous materials!!The Break through came around 1992 by both Japanese and Mobil scientist on the soft template based synthesis of mesoporous materials
A carbene is any neutral carbon species which contains a non-bonding valance pair of electrons.
Contributed by Alison Brown & Nathan Buehler, Undergraduates, University of Utah
This document discusses metathesis reactions and their applications in organic synthesis. It begins with definitions and examples of different types of metathesis reactions including alkene, alkyne, and enyne metathesis. It then covers the key catalysts used, such as Grubbs and Schrock catalysts, as well as the 2005 Nobel Prize awarded for the development of metathesis reactions. The document concludes by outlining several important applications of metathesis in synthesizing biologically active compounds and natural products.
IMPORTANT NAMED REACTIONS in Organic synthesis with Introduction, General Mechanism, and their synthetic application covering more than 20 named reactions in it.
Process chemistry AS PER PCI SYLLABUS FOR M.PHARMShikha Popali
pharmaceutical process chemistry is process WHERE FROM THE RESEARCH TO FINISH PRODUCT INCLUDING THE PRODUCT DEVELOPMENT AT LABORATORY LEVEL THAN PILOT PLANT WHERE THE PRODUCT IS MANUFACTURED IN 10X THAN FINAL AT 100X THAT IS SCALE UP PLANT.
more chemistry contents are available
1. pdf file on Termmate: https://www.termmate.com/rabia.aziz
2. YouTube: https://www.youtube.com/channel/UCKxWnNdskGHnZFS0h1QRTEA
3. Facebook: https://web.facebook.com/Chemist.Rabia.Aziz/
4. Blogger: https://chemistry-academy.blogspot.com/
photo redox reactions
Ultrasound In organic reaction and Supercritical Liquidsal mamun
This document discusses various applications of ultrasound and supercritical fluids in organic chemistry. It begins by defining ultrasound and describing how it is used to accelerate organic reactions by increasing reaction rates and product yields. Specific examples of heterocycle synthesis and other reaction types improved by ultrasound are provided. The document then defines supercritical fluids as substances above their critical point where distinct liquid and gas phases do not exist. Common supercritical fluids of carbon dioxide and water are noted. Applications of supercritical fluids discussed include extraction, dry cleaning, chromatography, chemical reactions, and biodiesel production.
Phase transfer catalysis involves using a catalyst to transfer a reactant from one immiscible liquid phase to another where the reaction takes place. Common phase transfer catalysts are quaternary ammonium and phosphonium salts. The catalyst forms an ion pair with the reactant anion, transporting it into the organic phase where it undergoes nucleophilic substitution or other reactions. Phase transfer catalysis allows reactions between ions and organic molecules that would otherwise not interact due to being in separate phases. It has many applications in organic synthesis and pharmaceutical manufacturing.
1) Pericyclic reactions are single-step, concerted reactions that proceed through a cyclic transition state without intermediates.
2) They are classified as electrocyclic reactions, cycloaddition reactions, cheletropic reactions, sigmatropic rearrangements, or group transfer reactions depending on the type of bonding changes that occur.
3) Examples of pericyclic reactions include the Diels-Alder reaction, electrocyclic ring openings and closings, and the Claisen rearrangement.
N-heterocyclic carbenes (NHCs) are stable species containing a carbene carbon atom adjacent to at least one nitrogen atom in a ring structure. NHCs were first synthesized in the 1960s but were not isolated until 1991. They are stable due to inductive, mesomeric, and aromatic effects. NHCs are stronger sigma donors than phosphines and provide greater stability and reactivity to transition metal complexes. They have widespread applications as ligands in catalysis due to their tunable activities and stability in air and moisture.
The document discusses ionic liquids as green solvents for organic transformations. It covers topics such as green chemistry principles, the structure and properties of ionic liquids that make them suitable green solvent replacements. Ionic liquids have applications in various organic reactions as solvents, allowing for higher yields, selectivity and easier product separation compared to conventional organic solvents. Examples of reactions discussed include Diels-Alder, Heck, hydrogenation and ring-opening reactions. Different types of ionic liquids are also summarized, including functionalized and deep eutectic solvents.
SMILES REARRANGEMENT [REACTION AND MECHANISM]Shikha Popali
The Smiles rearrangement is an intramolecular aromatic nucleophilic substitution reaction. It involves the migration of a substituent X from one carbon of an aromatic ring to another, with an aromatic substituent Y acting as the nucleophile. A specific example provided is the migration of an SO2Ar group to the ortho position of an ArO- nucleophile, activated by an adjacent nitro group. The X group is usually S, SO, or SO2, while the Y nucleophile is typically the conjugate base of OH, NH2, NHR or SH, though even CH2 has been used.
This document discusses the Shapiro reaction, which was discovered by Robert H. Shapiro in 1967. The reaction involves converting aryl sulfonyl hydrazones of aldehydes and ketones into olefins using alkyl lithium reagents, grignard reagents, or alkali metal amides at -78°C. The reaction mechanism proceeds through deprotonation, elimination, and loss of nitrogen to form alkenyl intermediates. The Shapiro reaction has been used in the total synthesis of natural products like phytocassane D and in the formation of ring B in the Nicolaou Taxol total synthesis.
Dioxygen complexes, dioxygen as ligand Geeta Tewari
This presentation describes about the preparation, properties, bonding modes, classification and applications of metal Dinitrogen Complexes. Also explains the MO diagram of molecular nitrogen.
MOF is a new class of material with lots of opportunity for future work. It is a coordination compound. Obviously MOF is a attractive subject for a group of researcher.
Electrochemical CO2 reduction in acidic media is advantageous as the loss of carbonate formation (in alkaline media) is less and the current density is also high. The main goal is to suppress the competing hydrogen evolution reaction by careful optimization of electrode-electrolyte interface design.
DIBAL-H is a commercially available selective reducing agent that can reduce esters and nitriles to the corresponding aldehydes. It is prepared by heating triisobutylaluminum, which induces beta hydride elimination to form DIBAL-H and isobutene. DIBAL-H selectively reduces esters to aldehydes at low temperatures through a tetrahedral intermediate. Hydrolytic workup of this intermediate then yields the desired aldehyde products. The document provides an introduction to DIBAL-H including its preparation, applications in organic synthesis, and how it differs from other reducing agents like LiAlH4.
BASIC DISCUSSION ABOUT THE CROWN ETHER AND CRYPTAND. INCLUDING THEIR BACKGROUND,STRUCTURE,NOMENCLATURE,CAVITY SIZE, SELECTIVITY, SYNTHESIS AND APPLICATIONS.
This document provides an overview of organometallic compounds, focusing on organolithium, organomagnesium, organozinc, and organocopper compounds. It defines organometallic chemistry as the study of chemical compounds containing carbon-metal bonds. Key applications of these compounds include forming new carbon-carbon bonds through nucleophilic addition reactions and serving as precursors for other organometallic reagents. The document discusses the structures, properties, preparations and reactions of various organometallic compounds.
The document discusses ionic liquids, which are organic salts that are liquid below 100°C. They can be used as solvents in various applications such as electrochemical devices and chemical synthesis. The document outlines the history of ionic liquids and different types including protic and aprotic ionic liquids. It also discusses the use of ionic liquids in applications like electrolytes and catalysis. Furthermore, it covers switchable ionic liquids that can change polarity and discusses their synthesis and potential to reduce solvent use. The document emphasizes the need to consider the full life cycle and disposal of ionic liquids to determine their sustainability.
Water as a solvent in microwave assisted organic synthesisPrashantChavan93
Prashant Chavan
Reserach Scholar
M.S.(Pharm) in Medicinal Chemistry
National Institute of Pharmaceutical Education and Research Mohali, Punjab (India) 160062
mcm20_prashant@niper.ac.in
IMPORTANT NAMED REACTIONS in Organic synthesis with Introduction, General Mechanism, and their synthetic application covering more than 20 named reactions in it.
Process chemistry AS PER PCI SYLLABUS FOR M.PHARMShikha Popali
pharmaceutical process chemistry is process WHERE FROM THE RESEARCH TO FINISH PRODUCT INCLUDING THE PRODUCT DEVELOPMENT AT LABORATORY LEVEL THAN PILOT PLANT WHERE THE PRODUCT IS MANUFACTURED IN 10X THAN FINAL AT 100X THAT IS SCALE UP PLANT.
more chemistry contents are available
1. pdf file on Termmate: https://www.termmate.com/rabia.aziz
2. YouTube: https://www.youtube.com/channel/UCKxWnNdskGHnZFS0h1QRTEA
3. Facebook: https://web.facebook.com/Chemist.Rabia.Aziz/
4. Blogger: https://chemistry-academy.blogspot.com/
photo redox reactions
Ultrasound In organic reaction and Supercritical Liquidsal mamun
This document discusses various applications of ultrasound and supercritical fluids in organic chemistry. It begins by defining ultrasound and describing how it is used to accelerate organic reactions by increasing reaction rates and product yields. Specific examples of heterocycle synthesis and other reaction types improved by ultrasound are provided. The document then defines supercritical fluids as substances above their critical point where distinct liquid and gas phases do not exist. Common supercritical fluids of carbon dioxide and water are noted. Applications of supercritical fluids discussed include extraction, dry cleaning, chromatography, chemical reactions, and biodiesel production.
Phase transfer catalysis involves using a catalyst to transfer a reactant from one immiscible liquid phase to another where the reaction takes place. Common phase transfer catalysts are quaternary ammonium and phosphonium salts. The catalyst forms an ion pair with the reactant anion, transporting it into the organic phase where it undergoes nucleophilic substitution or other reactions. Phase transfer catalysis allows reactions between ions and organic molecules that would otherwise not interact due to being in separate phases. It has many applications in organic synthesis and pharmaceutical manufacturing.
1) Pericyclic reactions are single-step, concerted reactions that proceed through a cyclic transition state without intermediates.
2) They are classified as electrocyclic reactions, cycloaddition reactions, cheletropic reactions, sigmatropic rearrangements, or group transfer reactions depending on the type of bonding changes that occur.
3) Examples of pericyclic reactions include the Diels-Alder reaction, electrocyclic ring openings and closings, and the Claisen rearrangement.
N-heterocyclic carbenes (NHCs) are stable species containing a carbene carbon atom adjacent to at least one nitrogen atom in a ring structure. NHCs were first synthesized in the 1960s but were not isolated until 1991. They are stable due to inductive, mesomeric, and aromatic effects. NHCs are stronger sigma donors than phosphines and provide greater stability and reactivity to transition metal complexes. They have widespread applications as ligands in catalysis due to their tunable activities and stability in air and moisture.
The document discusses ionic liquids as green solvents for organic transformations. It covers topics such as green chemistry principles, the structure and properties of ionic liquids that make them suitable green solvent replacements. Ionic liquids have applications in various organic reactions as solvents, allowing for higher yields, selectivity and easier product separation compared to conventional organic solvents. Examples of reactions discussed include Diels-Alder, Heck, hydrogenation and ring-opening reactions. Different types of ionic liquids are also summarized, including functionalized and deep eutectic solvents.
SMILES REARRANGEMENT [REACTION AND MECHANISM]Shikha Popali
The Smiles rearrangement is an intramolecular aromatic nucleophilic substitution reaction. It involves the migration of a substituent X from one carbon of an aromatic ring to another, with an aromatic substituent Y acting as the nucleophile. A specific example provided is the migration of an SO2Ar group to the ortho position of an ArO- nucleophile, activated by an adjacent nitro group. The X group is usually S, SO, or SO2, while the Y nucleophile is typically the conjugate base of OH, NH2, NHR or SH, though even CH2 has been used.
This document discusses the Shapiro reaction, which was discovered by Robert H. Shapiro in 1967. The reaction involves converting aryl sulfonyl hydrazones of aldehydes and ketones into olefins using alkyl lithium reagents, grignard reagents, or alkali metal amides at -78°C. The reaction mechanism proceeds through deprotonation, elimination, and loss of nitrogen to form alkenyl intermediates. The Shapiro reaction has been used in the total synthesis of natural products like phytocassane D and in the formation of ring B in the Nicolaou Taxol total synthesis.
Dioxygen complexes, dioxygen as ligand Geeta Tewari
This presentation describes about the preparation, properties, bonding modes, classification and applications of metal Dinitrogen Complexes. Also explains the MO diagram of molecular nitrogen.
MOF is a new class of material with lots of opportunity for future work. It is a coordination compound. Obviously MOF is a attractive subject for a group of researcher.
Electrochemical CO2 reduction in acidic media is advantageous as the loss of carbonate formation (in alkaline media) is less and the current density is also high. The main goal is to suppress the competing hydrogen evolution reaction by careful optimization of electrode-electrolyte interface design.
DIBAL-H is a commercially available selective reducing agent that can reduce esters and nitriles to the corresponding aldehydes. It is prepared by heating triisobutylaluminum, which induces beta hydride elimination to form DIBAL-H and isobutene. DIBAL-H selectively reduces esters to aldehydes at low temperatures through a tetrahedral intermediate. Hydrolytic workup of this intermediate then yields the desired aldehyde products. The document provides an introduction to DIBAL-H including its preparation, applications in organic synthesis, and how it differs from other reducing agents like LiAlH4.
BASIC DISCUSSION ABOUT THE CROWN ETHER AND CRYPTAND. INCLUDING THEIR BACKGROUND,STRUCTURE,NOMENCLATURE,CAVITY SIZE, SELECTIVITY, SYNTHESIS AND APPLICATIONS.
This document provides an overview of organometallic compounds, focusing on organolithium, organomagnesium, organozinc, and organocopper compounds. It defines organometallic chemistry as the study of chemical compounds containing carbon-metal bonds. Key applications of these compounds include forming new carbon-carbon bonds through nucleophilic addition reactions and serving as precursors for other organometallic reagents. The document discusses the structures, properties, preparations and reactions of various organometallic compounds.
The document discusses ionic liquids, which are organic salts that are liquid below 100°C. They can be used as solvents in various applications such as electrochemical devices and chemical synthesis. The document outlines the history of ionic liquids and different types including protic and aprotic ionic liquids. It also discusses the use of ionic liquids in applications like electrolytes and catalysis. Furthermore, it covers switchable ionic liquids that can change polarity and discusses their synthesis and potential to reduce solvent use. The document emphasizes the need to consider the full life cycle and disposal of ionic liquids to determine their sustainability.
Water as a solvent in microwave assisted organic synthesisPrashantChavan93
Prashant Chavan
Reserach Scholar
M.S.(Pharm) in Medicinal Chemistry
National Institute of Pharmaceutical Education and Research Mohali, Punjab (India) 160062
mcm20_prashant@niper.ac.in
This document discusses chemical reactions and different types of reactions. It begins by defining a chemical reaction as a process where the atoms in reactants are rearranged to form new substances known as products. It describes the key components of a chemical reaction as reactants, products, and activation energy. It then provides examples of the six main types of chemical reactions: synthesis, combustion, decomposition, single displacement, double displacement, and acid-base reactions. It explains the basic mechanisms and components of each type of reaction.
Phase transfer catalyst and ultrasound in organic recation .pdfMdIzarulIslam
This presentation will give a solid idea about phase transfer catalyst and ultrasound in organic chemistry. both sono_chemistry and phase transfer catalysis widely used in organic synthesis. let explore more in slide
Pericyclic reactions involve the formation and breaking of bonds in a concerted cyclic transition state. They can be classified as cycloadditions, electrocyclic reactions, sigmatropic rearrangements, cheletropic reactions, or group transfers. Examples of important pericyclic reactions discussed include the Diels-Alder reaction, 1,3-dipolar cycloadditions, Claisen rearrangement, and electrocyclic ring openings and closings. These reactions are useful in synthesis and occur in biological systems.
“Kinetics and mechanism of sulphuric acid oxidation of glycolic (ga) by selen...آفتاب حسین
This document provides an introduction to a study on the kinetics and mechanism of the oxidation of glycolic acid by selenium dioxide in an aqueous-acid medium. It discusses background information on chemical kinetics, oxidation-reduction reactions, and selenium dioxide as an oxidizing agent. Previous studies on the oxidation of various compounds like ketones using selenium dioxide are also summarized. The document lays out context for investigating the reaction kinetics and mechanism of glycolic acid oxidation.
This document summarizes heterogeneous photocatalysis research from the literature. It begins by introducing heterogeneous photocatalysis and its applications. Section II then surveys the types of photocatalytic reactions that have been observed, including oxidations, reductions, isomerizations, substitutions, condensations, and polymerizations. Section III discusses the mechanisms of photocatalysis, involving photoelectrochemistry and the roles of electron-hole pairs, oxygen, hydroxyl radicals, adsorption, and kinetics. Subsequent sections cover topics like active photocatalysts, pretreatment methods, and effects of parameters like pH, temperature, and sensitization.
This lab report summarizes a Diels-Alder reaction experiment where a diene and dienophile were reacted to produce a cycloaddition product. The product was analyzed using melting point determination, IR spectroscopy, and NMR spectroscopy. A low yield of 17.34% was obtained, which could be due to impurities as indicated by the wide melting point range of the product. The IR spectrum confirmed the presence of structural units expected in the product. While NMR analysis was unsuccessful, the evidence suggests the desired Diels-Alder reaction occurred between the diene and dienophile.
This document is a project report for an M.Sc. in Chemistry. The project involved synthesizing various functional heterocyclic compounds using a simple, eco-friendly, and cost-effective method with PEG-400 as the solvent. The report details the hypothesis, procedure, results, and schemes for synthesizing compounds like 2-(1-(4-bromophenyl)-2-(6-methylpyridin-2-yl)ethyl)malononitrile using a three component reaction with 2,6-lutidine, an aldehyde, and an activated methylene precursor in PEG-400 at 110°C for 12 hours. Monitoring by TLC and NMR spectroscopy showed the desired products were obtained.
BUBBLE COALESCENCE INHIBITION IN AQUEOUS ELECTROLYTE SOLUTIONMijul Saxena
This document presents a study on bubble coalescence inhibition in aqueous electrolyte solutions. The study investigated the transition concentrations of single and mixed inorganic electrolytes (CaCl2, NaCl, Na2SO4, MgSO4) that inhibit bubble coalescence. Experiments were conducted in a bubble column by producing pairs of air bubbles in electrolyte solutions and measuring the percentage of bubbles that coalesced. Results showed that all electrolytes inhibited coalescence below a transition concentration, with CaCl2 providing the strongest inhibition. The strength of inhibition for mixed electrolytes followed the combination of the individual electrolytes. The transition concentrations depended on ion type and combination.
The document summarizes the 2009 Ernest Orlando Lawrence Awards given by the U.S. Department of Energy to six scientists on April 28, 2010 at the National Academy of Sciences Building in Washington, D.C. The six award recipients were Joan F. Brennecke from the University of Notre Dame for her work in supercritical fluids and ionic liquids, William Dorland from the University of Maryland for his computer simulations of plasma turbulence, Omar Hurricane from Lawrence Livermore National Laboratory for advancing understanding of a nuclear weapons issue, Wim Leemans from Lawrence Berkeley National Laboratory for developing laser plasma wakefield acceleration, Zhi-Xun Shen from SLAC National Accelerator Laboratory and Stanford University for his work on strongly correlated
Pericyclic reactions involve the formation or breaking of bonds in a cyclic transition state. They include cycloadditions, electrocyclic reactions, sigmatropic rearrangements, and others. Cycloadditions like the Diels-Alder reaction involve the combination of unsaturated molecules to form a cyclic adduct. The Diels-Alder reaction between a conjugated diene and dienophile forms a cyclohexene ring. Frontier molecular orbital theory can explain the regioselectivity of cycloadditions. Examples of pericyclic reactions include the synthesis of citral via a Claisen rearrangement, Fischer indole synthesis, and Diels-Alder reactions in alkaloid and carbohydrate synthesis.
This document summarizes a computational study of the mechanism and enantioselectivity of intramolecular hydroacylation reactions catalyzed by rhodium. Potential energy surfaces were generated that identified intermediates and transition states. The pathways leading to both R and S enantiomers were examined. Substrate effects were investigated by comparing reactions of cyclopentene and cyclohexene. Future work will include analyzing geometries to explain differences in reaction energies between substrates and completing the cyclopentene reaction pathway.
Solvation can be defined as any stabilizing interaction of a solute (or solute moiety) and the solvent. These interactions can be weak, purely electrostatic, as is the case with non-polar solutes and solvents, or more significant, involving the interactions between dipole moments or between dipoles and formal charges.
Contributed by: Anton S. Klimenko (Undergraduate), Department of Chemistry, The University of Utah, 2016
Ultrasound assisted reactions can enhance chemical synthesis through cavitation effects. Piezoelectric transducers are commonly used to generate ultrasound from 20 kHz to 2 MHz. Cavitation produces localized hot spots exceeding 4000K that can drive homogeneous and heterogeneous reactions. Homogeneous reactions involve single-phase systems and produce radicals from water sonolysis. Heterogeneous reactions involve multi-phase systems and benefit from improved mixing and mass transfer. Many reactions like esterification, hydrolysis, substitution, and addition have been achieved with higher yields and faster reaction times using ultrasound.
Catalysis is the process by which the rate of a chemical reaction is increased by a substance known as a catalyst. Common catalytic reactions discussed in the document include catalytic hydrogenation, Ziegler-Natta polymerization, and the Diels-Alder reaction. Green chemistry aims to design chemical products and processes that reduce or eliminate the use of hazardous substances and is more environmentally friendly compared to traditional chemistry which may focus more on remediating pollution. The twelve principles of green chemistry provide guidelines for developing sustainable chemistry.
This document discusses multiphase reactors, which involve gas, liquid, and solid phases. It covers the construction, classification, examples, design considerations, kinetics, advantages, and applications of these reactors. Specifically, it examines slurry bubble column reactors and slurry stirred tank reactors. It provides examples of industrial processes using multiphase reactors like hydrogenation, polymerization, and Fischer-Tropsch synthesis. Rate equations are also presented to model reactions in these complex systems.
The document summarizes the career and research of Prof. Paul A. Grieco, including his education background, awards received, positions held, number of students mentored, and research interests. It provides an overview of his work developing reactions in highly polar media and applying these new methods to the total synthesis of various natural products. Examples discussed include the total syntheses of pseudotabersonine, ibogamine, eburnamonine, lycopodine, and fragments of epothilone B.
الكيمياء الحركية
Kinetic Chemistry
Chemical kinetics
حركية التفاعل أو الحركية الكيميائية هو العلم الذي يهتم ويختص بدراسة معدل التغير في سرعة التفاعلات الكيميائية والعوامل المؤثرة فيها مثل الضغط ودرجة الحرارة والتركيز وطبيعة العوامل المتفاعلة والعوامل الحفازة أو المثبطة، كما أنها تقوم بوضع نماذج رياضياتية التي توصف خواص التفاعلات الكيميائية.
Final Photocatalysis Lab Report (1) (1)Henry Hsieh
The document summarizes an experiment analyzing the effect of hydrogen peroxide concentration on the methylene blue degradation kinetic constant. When 5mL and 10mL of hydrogen peroxide were added, kinetic constants of 0.07 min-1 and 0.12 min-1 were obtained, respectively, indicating faster degradation with more hydrogen peroxide. However, decreasing kinetics from excess hydrogen peroxide was not observed due to the limited concentration range studied. Absorbance measurements and kinetic plots were used to determine the degradation constants.
Similar to Graduate lectures (Organic Synthesis in Water) (20)
The binding of cosmological structures by massless topological defectsSérgio Sacani
Assuming spherical symmetry and weak field, it is shown that if one solves the Poisson equation or the Einstein field
equations sourced by a topological defect, i.e. a singularity of a very specific form, the result is a localized gravitational
field capable of driving flat rotation (i.e. Keplerian circular orbits at a constant speed for all radii) of test masses on a thin
spherical shell without any underlying mass. Moreover, a large-scale structure which exploits this solution by assembling
concentrically a number of such topological defects can establish a flat stellar or galactic rotation curve, and can also deflect
light in the same manner as an equipotential (isothermal) sphere. Thus, the need for dark matter or modified gravity theory is
mitigated, at least in part.
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptxMAGOTI ERNEST
Although Artemia has been known to man for centuries, its use as a food for the culture of larval organisms apparently began only in the 1930s, when several investigators found that it made an excellent food for newly hatched fish larvae (Litvinenko et al., 2023). As aquaculture developed in the 1960s and ‘70s, the use of Artemia also became more widespread, due both to its convenience and to its nutritional value for larval organisms (Arenas-Pardo et al., 2024). The fact that Artemia dormant cysts can be stored for long periods in cans, and then used as an off-the-shelf food requiring only 24 h of incubation makes them the most convenient, least labor-intensive, live food available for aquaculture (Sorgeloos & Roubach, 2021). The nutritional value of Artemia, especially for marine organisms, is not constant, but varies both geographically and temporally. During the last decade, however, both the causes of Artemia nutritional variability and methods to improve poorquality Artemia have been identified (Loufi et al., 2024).
Brine shrimp (Artemia spp.) are used in marine aquaculture worldwide. Annually, more than 2,000 metric tons of dry cysts are used for cultivation of fish, crustacean, and shellfish larva. Brine shrimp are important to aquaculture because newly hatched brine shrimp nauplii (larvae) provide a food source for many fish fry (Mozanzadeh et al., 2021). Culture and harvesting of brine shrimp eggs represents another aspect of the aquaculture industry. Nauplii and metanauplii of Artemia, commonly known as brine shrimp, play a crucial role in aquaculture due to their nutritional value and suitability as live feed for many aquatic species, particularly in larval stages (Sorgeloos & Roubach, 2021).
ESR spectroscopy in liquid food and beverages.pptxPRIYANKA PATEL
With increasing population, people need to rely on packaged food stuffs. Packaging of food materials requires the preservation of food. There are various methods for the treatment of food to preserve them and irradiation treatment of food is one of them. It is the most common and the most harmless method for the food preservation as it does not alter the necessary micronutrients of food materials. Although irradiated food doesn’t cause any harm to the human health but still the quality assessment of food is required to provide consumers with necessary information about the food. ESR spectroscopy is the most sophisticated way to investigate the quality of the food and the free radicals induced during the processing of the food. ESR spin trapping technique is useful for the detection of highly unstable radicals in the food. The antioxidant capability of liquid food and beverages in mainly performed by spin trapping technique.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Unlocking the mysteries of reproduction: Exploring fecundity and gonadosomati...AbdullaAlAsif1
The pygmy halfbeak Dermogenys colletei, is known for its viviparous nature, this presents an intriguing case of relatively low fecundity, raising questions about potential compensatory reproductive strategies employed by this species. Our study delves into the examination of fecundity and the Gonadosomatic Index (GSI) in the Pygmy Halfbeak, D. colletei (Meisner, 2001), an intriguing viviparous fish indigenous to Sarawak, Borneo. We hypothesize that the Pygmy halfbeak, D. colletei, may exhibit unique reproductive adaptations to offset its low fecundity, thus enhancing its survival and fitness. To address this, we conducted a comprehensive study utilizing 28 mature female specimens of D. colletei, carefully measuring fecundity and GSI to shed light on the reproductive adaptations of this species. Our findings reveal that D. colletei indeed exhibits low fecundity, with a mean of 16.76 ± 2.01, and a mean GSI of 12.83 ± 1.27, providing crucial insights into the reproductive mechanisms at play in this species. These results underscore the existence of unique reproductive strategies in D. colletei, enabling its adaptation and persistence in Borneo's diverse aquatic ecosystems, and call for further ecological research to elucidate these mechanisms. This study lends to a better understanding of viviparous fish in Borneo and contributes to the broader field of aquatic ecology, enhancing our knowledge of species adaptations to unique ecological challenges.
hematic appreciation test is a psychological assessment tool used to measure an individual's appreciation and understanding of specific themes or topics. This test helps to evaluate an individual's ability to connect different ideas and concepts within a given theme, as well as their overall comprehension and interpretation skills. The results of the test can provide valuable insights into an individual's cognitive abilities, creativity, and critical thinking skills
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...Sérgio Sacani
Context. With a mass exceeding several 104 M⊙ and a rich and dense population of massive stars, supermassive young star clusters
represent the most massive star-forming environment that is dominated by the feedback from massive stars and gravitational interactions
among stars.
Aims. In this paper we present the Extended Westerlund 1 and 2 Open Clusters Survey (EWOCS) project, which aims to investigate
the influence of the starburst environment on the formation of stars and planets, and on the evolution of both low and high mass stars.
The primary targets of this project are Westerlund 1 and 2, the closest supermassive star clusters to the Sun.
Methods. The project is based primarily on recent observations conducted with the Chandra and JWST observatories. Specifically,
the Chandra survey of Westerlund 1 consists of 36 new ACIS-I observations, nearly co-pointed, for a total exposure time of 1 Msec.
Additionally, we included 8 archival Chandra/ACIS-S observations. This paper presents the resulting catalog of X-ray sources within
and around Westerlund 1. Sources were detected by combining various existing methods, and photon extraction and source validation
were carried out using the ACIS-Extract software.
Results. The EWOCS X-ray catalog comprises 5963 validated sources out of the 9420 initially provided to ACIS-Extract, reaching a
photon flux threshold of approximately 2 × 10−8 photons cm−2
s
−1
. The X-ray sources exhibit a highly concentrated spatial distribution,
with 1075 sources located within the central 1 arcmin. We have successfully detected X-ray emissions from 126 out of the 166 known
massive stars of the cluster, and we have collected over 71 000 photons from the magnetar CXO J164710.20-455217.
Travis Hills' Endeavors in Minnesota: Fostering Environmental and Economic Pr...Travis Hills MN
Travis Hills of Minnesota developed a method to convert waste into high-value dry fertilizer, significantly enriching soil quality. By providing farmers with a valuable resource derived from waste, Travis Hills helps enhance farm profitability while promoting environmental stewardship. Travis Hills' sustainable practices lead to cost savings and increased revenue for farmers by improving resource efficiency and reducing waste.
ANAMOLOUS SECONDARY GROWTH IN DICOT ROOTS.pptxRASHMI M G
Abnormal or anomalous secondary growth in plants. It defines secondary growth as an increase in plant girth due to vascular cambium or cork cambium. Anomalous secondary growth does not follow the normal pattern of a single vascular cambium producing xylem internally and phloem externally.
BREEDING METHODS FOR DISEASE RESISTANCE.pptxRASHMI M G
Plant breeding for disease resistance is a strategy to reduce crop losses caused by disease. Plants have an innate immune system that allows them to recognize pathogens and provide resistance. However, breeding for long-lasting resistance often involves combining multiple resistance genes
5. Background
Why water as a solvent for organic reactions?
Water is the universal solvent in Nature
Non-toxic
Non-flammable
Cheap and readily available
Can have interesting acceleration effects for certain reactions
Can be used in conjunction with some organic solvents
Applicable to a wide range of reaction types
Green Chemistry
Difficult to remove water from reactions
Solubility (not always a problem)
Not suitable for all organic reactions
Waste streams need to be treated
Pros
Cons
6. Background – Reactions using water as a solvent
Typically how have reactions been carried out using water as a solvent
7. Background – In the beginning
1828 – Friedrich Wöhler
1931 – Otto Diels and Kurt Alder
1948 – Robert Burns Woodward
Diels, O.; Alder, K. Justus Liebigs Ann. Chem. 1931, 490, 243
Woodward, R. B.; Baer, H. J. Am. Chem. Soc. 1948, 70, 1161
Wöhler, F. Annalen der Physik und Chemie. 1828, 88(2), 253
8. Background
1980 – Ronald Breslow – Columbia University
Rideout, D, Breslow, R, J. Am. Chem. Soc., 1980, 7816
Ph.D Harvard University
(R. B Woodward)
PostDoc – University of
Cambridge (Lord Todd)
Solvent k2 x 105 M-1s-1
Isooctane 5.94
Methanol 75.5
H2O 4400
Solvent k2 x 105 M-1s-1
Isooctane 1.90
Methanol 4.0
H2O 59.3
The reaction of cyclopentadiene and methyl vinyl ketone is over 700 times faster in water than in isooctane.
The corresponding reaction with acrylonitrile is only 30 times faster. Why is this?
k2 isooctane
k2 Water
= 740
k2 isooctane
k2 Water
= 31
9. Background
1996 – Jan Engberts – University of Groningen PhD. University of
Groningen
PostDoc – University of
Amsterdam
Solvent Additive k2 (M-1s-1)
Acetonitrile - 1.4 x 10-5
Water - 4.02 x 10-3
Acetonitrile Cu(NO3)2 0.472
Water Cu(NO3)2 1.11
k2 Acetonitrile
k2 Water = 287
k2 Acetonitrile
k2 Water
= 5.4
k2 Acetonitrile
k2 Water(Cu )
= 79285
Otto, S., Bertonicin F., Engberts, J.B.F.N., J. Am. Chem. Soc., 1996,118, 7702
2+
Uncatalysed Cu2+ catalysed
Reaction is accelerated 287 times faster in H2O compared to MeCN. When a Lewis acid (Cu(NO3)2) was added a large
rate acceleration observed however the reaction using water does not have a large rate acceleration as observed with the
uncatalysed reaction
Catalysis using water as a solvent possible however mechanistically can be difficult to study
10. Klign, J. E., Engberts, J.B.F.N. Nature. 2005, 435, 746
Background
2005 – K. Barry Sharpless – Scripps Research Institute
Narayan, S., Muldoon, J., Finn, M.G., et al. Angew. Chem. Int. Ed., 2005, 44, 3275
Solvent Conc (M) Time to completion
Toluene 2 > 120 h
Methanol 2 18 h
H2O 4.53 10 min
These reactions were classed as ‘on-water’ as they were seen to float on water surface
11. Background
2005 – K. Barry Sharpless
Narayan, S., Muldoon, J., Finn, M.G., et al. Angew. Chem. Int. Ed., 2005, 44, 3275
PhD. Stanford University
(E.E. Van Tamelen)
PostDoc – Stanford
University and Harvard
Solvent Reaction Time
Neat 36 h
H2O 3 h
Solvent Conc (M) Reaction
Time
Yield (%)
Toluene 1 144 79
Neat 3.69 10 82
H2O 3.69 8 81
Both reactants are liquids so there is not mixing issues
associated with neat reactions
The reaction ‘on-water’ is faster than the neat reaction.
No large rate acceleration observed with these
reactions. TSRI TSRI TSRI
12. Background – What is so significant about the rate acceleration using water?
A key aspect of the initial studies where water has been used as a solvent has focused on cycloaddition reactions.
Huisgen, R. Pure Appl Chem. 1980, 52, 2283
Huisgen, R., Seidel, H, Brüning, I, Chem. Ber. 1969, 102, 1102
Why are there large rate accelerations observed using water as a reaction solvent
and what is causing these?
The rate on going
from toluene to
ethanol only changes
by a factor of 5.6
This is because these reactions are solvent insensitive
13. Why are there large rate accelerations using water as a solvent?
Not fully understood however various theories have been put forward
14. Mechanistic Aspects – Hydrophobic Effect (Breslow)
k2 isooctane
k2 Water
= 740
k2 isooctane
k2 Water
= 31
Breslow and Rideout proposed that the rate acceleration observed for the reactions was due to the hydrophobic
effect.
Hydrophobic effect found widespread in nature and is important in
protein structure.
However this does not take into account the difference in rate between the reaction with methyl vinyl
ketone and acrylonitrile.
Rideout, D, Breslow, R, J. Am. Chem. Soc., 1980, 7816
15. Jorgensen and co-workers examined
the reaction using computational
methods and suggested that the large
accelerations observed with vinyl
ketones was due to a significant
Hydrogen bonding effects
Jorgensen calculated that the rate
acceleration was due to approximately
90% H-bonding with 10% from
hydrophobic effects
Mechanism similar to H-bonding
organocatalysis
k2 isooctane
k2 Water
= 740
k2 isooctane
k2 Water
= 31
Mechanistic Aspects – H-Bonding Effects (Jorgensen)
Rideout, D, Breslow, R, J. Am. Chem. Soc., 1980, 7816
Jorgensen, W.L., J. Org. Chem., 1994, 59, 803
PhD Harvard
University
(E.J. Corey)
H-bonding occurs with the vinyl ketone however
not with the acrylonitrile
16. Mechanistic Aspects – ‘On-water’ Effect (Sharpless and Marcus)
Toluene: >120 h
H2O: 10 mins
The ‘on-water’ is so named because the organic reactions are ‘floated’ on water
Marcus and co-workers examined this reaction from a computational aspect . The large rate accelerations were
proposed to be due to the favorable H-bonding interactions to the transition state. The H-bonding was at the oil
water/interface where a proton protrudes into the ‘oil’ phase which acts as the catalyst.
These reactions are very difficult to examine experimentally in order to explore the on-water effect.
Jung, Y, Marcus, R.A, J. Am Chem. Soc., 2007, 129, 5492
Jung, Y, Marcus, R.A, J. Chem. Phys. Cond Matt., 2010, 284117
PhD. McGill University
Nobel Prize: 1992
(Electron transfer
reactions)
17. Mechanistic Aspects – Influence on the rate of the reaction
k2 Toluene
k2 Water
= 40.9
1998 – M.R Gholami
k2 Acetonitrile
k2 Water
= 164
2004 – R.N. Butler
k2 Acetonitrile
k2 Water
= 15.3
1982 – R. Breslow
k2 Acetonitrile
k2 Water
= 211
Rideout, D, Breslow, R, J. Am. Chem. Soc., 1980, 7816
Gholami, M. R.; J. Chem. Res (S), 1999, 226
Butler, R.N. et al., J Chem. Soc Perkin Trans 2, 2002, 1807
In all of the above cases the reactants are soluble in water and the
kinetics can be measured
(‘in-water’ reactions)
18. ‘In-water’ versus ‘On-water’ – What is the difference?
‘In-water’ ‘On-water’
Water is the only reaction medium - no
organic co-solvents are used.
Reactions use insoluble substrates and
suspensions are observed.
Typically reactants are present in
concentrations >0.1M or above.
Mechanistically very difficult to study
Large rate accelerations observed can be
substrate and reaction specific.
Water is generally the reaction medium -
organic co-solvents are used to solubilise
reactants although significantly effects rate
acceleration.
Reactions use soluble substrates
Typically reactants are present in
concentrations < 0.1M or below.
Mechanistically as reactants are in solution
these are easier to study
Large rate accelerations observed can be
substrate and reaction specific.
Distinguishing between in-water and on water is very difficult however concentration of reactants and
solubility can be used as a guide
19. Mechanistic Aspects
Model Reactions using water as a solvent
Increase in rate of reaction
Increase in stereoselectivity
These can both be rationalized through various mechanisms
Exact mechanism is unknown and needs further research
21. Pericyclic Reactions – Cycloaddition reactions
Concerted reactions and solvent insensitive
Key reactions in multi-step synthesis
Highly regio- and stereospecific
Can generate up to 4 new sterocentres in one synthetic step
Large number of diene/1,3-dipoles and diene/dipolarophiles available
Wide structural diversity
Diels-Alder [4+2] Cycloaddition Reaction
Huisgen [3+2] Cycloaddition Reaction
22. Mechanistic Aspects – Influence on the stereoselectivity
Solvent Dienophile endo/exo
Cyclopentadiene (excess) Methyl vinyl ketone 3.85:1
Methyl acrylate 2.9:1
Ethanol Methyl vinyl ketone 8.5:1
Methyl acrylate 5.2:1
Water (0.15M) Methyl vinyl ketone 21.4:1
Methyl acrylate 9.3:1
Water (0.30M) Methyl vinyl ketone 18.6:1
Methyl acrylate 5.9:1
How can water be useful as a reaction solvent in organic synthesis?
1982 – Ronald Breslow
Enhancement of the endo/exo ratio and this is more pronounced in the cases of the vinyl ketones. Useful in organic
synthesis step where the endo isomer is required. Concentration of the reactants has some effect on endo:exo ratio
Breslow, R. Maitra, U, Rideout, D, Tet. Lett, 1984, 25(12), 1239
23. Pericyclic Reactions – Diels-Alder Cycloaddition reactions
Solvent Time (hr) Yield (%)
Toluene 168 Trace
Water 1 77
The cis isomer is formed however this isomerises to the trans isomer
Addition of THF, MeOH or 1,4-Dioxane causes a fall off in the rate of reaction
Reaction has excess diene present and the concentration of this is maintained at 1.0M
Increase in concentration of diene gives a fall off in rate of reaction
Reaction needs to be stirred vigorously
The use of the sodium salt adds an extra step to convert to the methyl ester
Grieco, P.A. et al, J. Org. Chem, 1983, 48, 3139
24. What about in more complex cases?
Pericyclic Reactions – Diels-Alder [4+2] cycloaddition reaction
Quassinoid natural product
R Solvent Diene conc t (h) Yield (%) endo:exo
Et Benzene 1M 288 52 0.85:1
Et H2O 1M 168 82 1.3:1
Na H2O 1M 8 83 2.0:1
Na H2O 2M 5 100 3.0:1
Grieco, P.A. et al, Tet Lett, 1983, 24, 1897
Concentration critical for these type of reactions
Significant increase in rate stereoselectivity in comparison to the reaction in organic solvents
25. Pericyclic Reactions – Diels-Alder [4+2] Intramolecular cycloaddition reaction
Solvent Temp (oC) Ratio
Toluene 90 75:25
Water 90 40:60
Reaction in water shows different selectivity
compared to toluene.
Solvent Reaction Time
Chloroform 10 days
Water 2 days
Williams, D.R. et al, Tetrahedron Lett, 1985, 26, 1362
Lovastatin
Witter, D.J., Vederas, J.C., J. Org. Chem, 1996, 61, 2613
Reaction accelerated on going from chloroform to water.
No change in stereoselectivity
Possible assembly for lovastatin core by Aspergillus terrus MF 4845
26. Pericyclic Reactions – Huisgen [3+2] cycloaddition reaction
Mechanistically identical to the Diels-Alder [4+2] cycloaddition reaction
Typically 1,3-Dipoles are highly unstable and need to be generated in-situ
There are some 1,3-dipoles that are stable at room temperature
This makes carrying out reactions using water as a reaction solvent more difficult and exploring the
mechanistic aspects
27. Pericyclic Reactions – Huisgen [3+2] cycloaddition reaction
Dipolarophile Solvent Yield endo/exo
Acetonitrile 96 3:1
Water 95 7:1
Acetonitrile 80 3:1
Water 95 16:1
Acetonitrile 65 8:1
Water 91 10:1
Unusually these 1,3-dipoles are highly stable and can be isolated and stored.
Stability is due to the electron withdrawing nature of the two cyano groups
Reaction with vinyl ketones is highly endo selective using water a a reaction solvent
(Same trend as observed with cyclopentadiene)
Azomethine ylides
Butler, R.N. et al, J. Chem. Soc. Perkin Trans 2, 2002, 1807
28. Pericyclic Reactions – Huisgen [3+2] cycloaddition reaction - Azides
Thermal cycloaddition
Cu and Ru Catalysed (CuAAC and RuAAC)
Strain Promoted cycloaddition (SPAAC) – Lecture 2
1,4 and 1,5 isomer formed in a 1:1
ratio. Need to be heated over 80oC
Cu - 1,4-isomer
Ru - 1,5-isomer
Strain of the double or triple bond of the
dipolarophiles gives rise to a rate increase for
the reaction. No metal or heat required for the
reaction.
Azide chemistry has undergone a renaissance with the advent of the CuAAC, RuAAC and SPAAC
(Sharpess, Fokin, Meldal and Bertozzi)
29. Azides Kinetics – Engberts
Pericyclic Reactions – Huisgen [3+2] cycloaddition reaction
Novartis – Rufinamide synthesis
Solvent k rel
Hexane 1
EtOH 1.6
H2O/NCP (99:1) 53.2
Solvent Temp (oC) Yield (%)
Neat 80 72
N-Heptane 80 46
EtOH 77 40
H2O 80 98
The cycloaddition reaction was found to be over 50 times faster in water than in hexane. 1% NCP was added to help
solubilise the azide
HCl is a side product of this reaction. In
organic solvents this polymerises the
chloroacrylonitrile. In water a two phase
system is observed where the HCl is dissolved
in the water layer
Engberts, J.B.F.N et al., Tet. Lett., 1995, 36, 5389
Portmann, R., WO98022423, 1998
30. Pericyclic Reactions – Huisgen [3+2] cycloaddition reaction
Synthesis of Biotin – De Clercq
Monomeric streptavidin and bound
biotin
(KD = 10-14 M)
The cycloaddition precursor was synthesized from L-cysteine.
When heated in water this undergoes cycloaddition reaction followed by elimination of N2
The seven membered ring opens up using water to form the N-benzylated biotin.
DeClercq, P. J., et al, Tetrahedron Lett., 1994, 35, 2615
31. Pericyclic Reactions – Claisen [3,3] sigmatropic rearrangement
Concerted reactions and solvent insensitive
Key reactions in multi-step synthesis
A number of different variants – N (azaClaisen), S (thiaClaisen)
Claisen
Aza-Claisen
Thia-Claisen
Typically require high temperatures which can lead to decomposition products
Substitution on the substrate can lower the activation energy for reaction.
32. In Nature
Chorismate to Prephenate- enzyme catalysed by
Chorismate mutase
kcat
= 106
kuncat
Chorismate mutase
Pericyclic Reactions – Claisen [3,3] sigmatropic rearrangement
Reaction is water at 75oC at pH 5 has a t1/2 of 10
mins
k(H2O)/k(MeOH) = 100
This Claisen rearrangement occurs at a much faster rate in
water in comparison to methanol.
This reaction occurs even without the presence of the
enzyme Chorismate mutase
Reaction with no enzyme
Andrews, P.R., et al, Biochemistry, 1973, 12, 3492
33. Pericyclic Reactions – Claisen [3,3] sigmatropic rearrangement
Brandes, E. et al., J. Org. Chem., 1989, 54, 515
Rearrangement of allyl vinyl ethers – effect of water on the rate of reaction.
R Solvent Rate
(k x 10-5s-1)
Yield
(%)
Na H2O 18 85
Na MeOH 0.79 -
Me C6H12 0.084 -
The Claisen rearrangement of the sodium carboxylate allyl vinyl ether is over 200 times faster that the corresponding
reaction in cyclohexane (methyl ester)
Rearrangement of naphthyl ethers – effect of water on the rate of reaction.
Solvent Yield (%)
Toluene 16
DMF 21
MeOH 56 (+14%)
neat 73
H2O 100
Narayan, S., Muldoon, J., Finn, M.G., et al. Angew. Chem. Int. Ed., 2005, 44, 3275
‘On-water’ reaction is faster than other polar solvents. Product
can be filtered off when water is used
No large rate accelerations observed as in the case of
quadricyclane and DEAD
34. Claisen Rearrangement
This Claisen rearrangement occurs at a much faster rate in water in comparison to toluene.
The corresponding a-anomeric reaction occurs in a similar time.
When the reaction was carried out in toluene only decomposition products were observed. The NaBH4 was added
to reduce the aldehyde.
Lubineau, A., et al, J. Chem. Soc. Perkin Trans 1, 1992, 1631
Lubineau, A. et al., Tetrahedron Lett., 1990, 31, 4147
Rearrangement of allyl vinyl ethers – effect of water solubilising groups
35. Claisen Rearrangement
Gambogin
Solvent T (oC) t (h) Conversion (%)
Ethanol 65 4 0
Methanol 65 4 0
MeOH/H2O (1:1) 65 4.0 100
MeOH/H2O (1:2) 100 0.5 100
H2O - - ppt of SM
Synthesis of Gambogin (Nicolaou)
First isolated in 1996 from
Gamboge resin from
Garcinia hamburgi
MIC (Hela) = 6.25 mg/mL
MIC (HLA) = 3.13 mg/mL
Organic co-solvent
present as reaction in
pure water causes
precipitation of the
starting material
36. Nucleophilic Ring Opening
Epoxides and aziridines are excellent synthetic intermediates
Readily converted to other functional groups such as diols, aminoalcohols and diamines
Can be done enantioselectively
Could also be described as a ‘Click’ reaction as they are highly efficient and give high yields
In Nature nucleophilic ring opening has been proposed as a key biosynthetic step in the formation of
some natural products
Epoxides
Aziridines
37. Nucleophilic Ring Opening
Cane, Celmer, Westley Proposed Mechanism
Monensin Brevetoxin
Jamison T.J. et al, Mar. Drugs, 2010, 8, 763
38. Nucleophilic Ring Opening – Epoxides (water as a nucleophile)
What happened when you heat an epoxide in water?
Monoepoxide
Bisepoxide
Qu, J et al, J Org Chem, 2008, 73, 2270
Could this be a competing pathway in epoxide ring opening with other nucleophiles in water?
39. Nucleophilic Ring Opening – Epoxides (Other nucleophiles)
Monoepoxide
No reaction occurred in either toluene or diethylether
Bonollo et al, Green Chem, 2006, 8, 960
41. Epoxide Ring Opening – Biomimetic Approach
Conditions Ratio (endo: exo)
Cs2CO3, MeOH 1:2.7
AcOH, Toluene 1.6:1
Ethylene glycol 9:1
Methanol 8:1
Water > 10:1
Brevetoxin B Ph.D Harvard University
(Stuart Schreiber)
PostDoc Harvard University
(Eric Jacobsen)
Jamison T.J. et al, Science, 2007, 317, 1189
42. Epoxide Ring Opening
Triepoxide and Bisepoxide
Where next for this methodology?
Could this be used in the synthesis of brevetoxin or larger polyether natural products such as Maitotoxin?
Jamison T.J. et al, Science, 2007, 317, 1189
43. Lecture 1 - Overview
Large rate accelerations and increase in stereoselectivites observed using water as
a reaction solvent which are not found using organic solvents.
The reasons for these accelerations are not fully understood and need further
mechanistic study
Can be applied to more complex systems
44. Organic Synthesis in Water
Emerging Areas of Research
Graduate Lecture Series
Lecture 2
Dr Anthony Coyne
(anthony.g.coyne@gmail.com)
45. Outline
Lecture 1 – Kinetics, Mechanism and Synthesis
• Background
• Mechanistic aspects
• Influence on rate of reaction
• Organic Synthesis
• Diels-Alder [4+2] cycloaddition reaction
• Huisgen [3+2] cycloaddition reaction
• Claisen rearrangement
• Epoxide ring opening
Lecture 2 – Emerging areas of research
• Recap of Lecture 1
• Organic Synthesis:
Emerging metal catalysed reactions
• Olefin metathesis
• Cyclopropanation reactions
• Chemical Biology Applications
• CuAAC reactions
• SPAAC reactions
• Sonogashira coupling
• Suzuki coupling
46. Complexity of reactions using water as a solvent
Level of
complexity
Claisen Rearrangement
(1 reactant)
Lecture 1
Diels-Alder Reaction
(2 reactants)
Lecture 1
Olefin Metathesis (Cross Metathesis)
(2 reactants and catalyst)
Lecture 2
Suzuki Reaction
(2 reactants and catalyst, ligand, base)
Lecture 2
47. Diels-Alder Reaction – Cu catalysed
Solvent Additive k2 (M-1s-1)
Acetonitrile - 1.4 x 10-5
Water - 4.02 x 10-3
Acetonitrile Cu(NO3)2 0.472
Water Cu(NO3)2 1.11
Otto, S., Bertonicin F., Engberts, J.B.F.N., J. Am. Chem. Soc., 1996,118, 7702
Reactions using catalysis are more complex to understand when water is used as a reaction
solvent
Lecture 1
Uncatalysed Reaction
Increase in rate of reaction when water is used as
the solvent
Cu catalysed Reaction
No large rate increase is observed on
changing to water as a solvent.
Lewis acid catalysis predominates?
48. Olefin Metathesis
Ruthenium Catalysts (Grubbs and Hoyveda) Robert Grubbs
Ph.D Columbia University
(Ron Breslow)
PostDoc Stanford
University
(James Collman)
Amir Hoyveda
Ph.D Yale University
(Stuart Schreiber)
PostDoc Harvard
University
(David Evans)
49. Olefin Metathesis
Ruthenium Catalysts - Modified with water solubilizing groups
In many cases catalysts have been modified where one of the ligands was appended with a water solubilizing
group.
Where the catalyst is modified using a PEG chain the molecular weight can be up to 5000 g/mol
Catalysts are only used in simple reactions and major focus of research has been focused on the catalysts and
not on reactions
Still an emerging area of research
Insoluble in water
50. Olefin Metathesis
Ring Closing Metathesis – Water soluble catalysts
Grubbs R.H et al, J. Org. Chem. 1998, 63, 9904
Solvent Catalyst
(mol%)
Conversion
(%)
MeOH 5 90
H2O 5 60
H2O 10 90
No reaction was observed with the diallylmalonate due to methylidene instability
When substituted with a phenyl ring the reaction goes in high conversion
The catalysts were shown to be stable in water over a number of days
51. Olefin Metathesis
CM and ROMP – Water soluble catalysts
Ring Opening Metathesis Polymerisation (ROMP) Cross Metathesis (CM)
Hoyveda-Grubbs type catalyst
This catalyst is highly versatile and can be used sucessfully in CM, ROMP and RCM reactions
Attempts to synthesis the phosphine derived catalyst was not possible (Grubbs I)
Grubbs R.H et al, J. Am. Chem. Soc. 2006, 128, 3509
Catalyst synthesis is straightforward
52. Olefin Metathesis
Dimerisation of Vancomycin– Grubbs I Catalyst
Nicolaou, K.C., et al, Chem.. Eur. J., 2001, 7, 3824
Using a modified Vancomycin it was possible to
homodimerise this using olefin metathesis
Typically the yields for this reaction were 30-60% with
the only product formed is the homodimer
No other side reactions observed even though there is
a large number of different functional groups on the
vancomycin scaffold
Grubbs I catalyst was used without any
modification
53. Olefin Metathesis
CM in Biological Systems
A surface cysteine residue undergoes a dethiolation to give a dehydroalanine. This can undergo
conjugate addition reactions with thiols. This can also undergo reaction with allylmercaptan to give a
double bond which is an effective substrate for olefin metathesis
No modified catalyst used,
t-Butanol needed for solubility,
Cysteine needs to be on the surface of the protein
Uses natural amino acids
Davis, B.G.; Bernardes, G.J.L, et al, J. Am Chem Soc,. 2008, 130, 9642
Davis, B.G.; Bernardes, G.J.L, et al, J. Am Chem Soc., 2008, 130, 5052
54. Metal catalysed cyclopropanation
Key Reaction
Carbenes generally unstable in water but when stabailzed by complexation to a transition metal
this increases their lifetime
Diazo compounds can be either generated in situ, synthesised or in some cases be purchased
The formation of both trans and cis cyclopropanes are passible and if a chiral ligand is used then this
reaction can be carries out enantioselectively
Cyclopropane containing natural products
55. Metal catalysed cyclopropanation
Rhodium(II) catalysed cyclopropanation – Water soluble catalysts
[Rh(OAc)2]2
Catalyst Yield (%) dr (trans/cis)
[Rh(OAc)2]2 26 1.6:1
[Rh(O2C tBu)2]2 61 1.5:1
[Rh(O2C(CH2)6Me)2]2 72 1.5:1
Water soluble catalysts gave low yields and poor
diastereoselectivity
This is due to [Rh(OAc)2]2 having a preference for
the aqueous layer and not dissolving in the
‘organic’ layer
Water insoluble catalysts gave higher yields
than water soluble catalysts
There is a biphasic system (due to 2 eq of
styrene) where the water insoluble catalysts go
into the organic layer
No change in diastereoselectivity
Wurz, R. P., Charette, A. B., Org Lett., 2002, 4, 4531
56. Metal catalysed cyclopropanation
Rhodium(II) catalysed cyclopropanation – Water soluble catalysts
Run Conversion (%) Yield (%) dr (trans/cis)
1 100 90 10:1
4 90 88 9:1
When the catalyst is recycled for a 4th time there is a negligible drop
in yield and diastereoselectivity
Water soluble catalysts gave excellent yields and trans diastereoselectivity
The porphyrin catalyst was modified using four sugar functional group which aided water solubility.
The catalyst could be recycled
Loading of 1 mol% is high as the catalyst has a molecular weight of 1450 (C73H80N4O21Ru)
Che, C-M et al., J. Am. Chem. Soc, 2010, 132, 1886
57. Metal catalysed cyclopropanation
Rhodium(II) catalysed cyclopropanation – Water soluble catalysts
55%
Uses natural amino acid
Incorporation of an alkene possible onto
Ubiquitin as lysine can be tethered using a N-
hydroxysuccinimide ester
Subsequent cyclopropanation using a diazo
modified dansyl tag carried out in 55% yield
using the water soluble Ru-porphyrin catalyst
Che, C-M et al., J. Am. Chem. Soc, 2010, 132, 1886
58. Metal catalysed cyclopropanation
From synthetic porphyrin to natural porphyrin systems
Porphyrins are found in cytochrome P450s (CYPs) which catalyse a wide range of oxidations such as
hydroxylations, epoxidations and heteroatom oxidation.
Could Iron be used as a metal for the generation of the carbene intermediate?
Carriera and co-workers showed that simple substrates can undergo cyclopropanation using iron catalyst
Typically enzymes are highly specific for substrates and how can this be overcome?
1450 Da 106169 Da (P450BM3)
Carriera, E. M et al., Org Lett, 2012, 14, 2162
59. Metal catalysed cyclopropanation
Cytochrome P450’s as cyclopropanation catalysts (Frances Arnold) B.S: Mechanical and Aerospace
Engineering (Princeton)
PhD: Chemical Engineering (Berkeley)
Post Doc: Biophysical Chemistry
(Caltech)
cis
trans
92 P450BM3 variants screened with this reaction
Catalyst Yield (%) dr (trans/cis) ee cis ee trans
P450BM3 1 63:37 27 2
H2-5-F10 59 84:16 41 63
H2A10 33 40:60 95 78
By making mutations this can greatly enhance the reactivity and selectivity of these enzymes
Amount of enzyme used needs to be reduced from 0.2 mol%
Arnold, F.H. et al., Science., 2013, 339, 307
60. Metal catalysed cyclopropanation
Cytochrome P450’ BM3 as cyclopropanation catalysts (Frances Arnold)
BM3-Hstar (T268A-C400H-L437W-V78M-L181V)
Arnold, F.H. et al., CatSciTech, 2014, 339, 307
By making five mutations this can greatly enhance
the reactivity and selectivity of these enzymes.
A noticeable mutation was on the cysteine where
this was mutated to a a histidine.This gave improved
rates for in vivo reactions
Levomilnacipran
61. Metal catalysed reactions
It is possible to carry metal-catalysed reactions using water as a reaction solvent.
These can be applied to complex reaction systems
The solubility of the catalyst/ligand combination can play a major part in the outcome of the reaction.
Typically the rate acceleration and enhanced stereoselectivity observed with pericyclic
reaction is not observed in metal catalysed reactions.
Still an emerging area of research
63. Bioorthogonal Reactions
What are bioorthogonal reactions?
The term bioorthogonal chemistry refers to a chemical reaction that can occur inside of living systems without
interfering with native biochemical processes
Carolyn Bertozzi
University of Califonia, Berkeley
Joseph Fox
University of Delaware
Scott Hilderbrandt
Harvard Medical School
Azide-Alkyne cycloadditon (CuAAC/SPAAC)
1,2,4,5-Tetrazine-Alkyne cycloaddition
Ralph Weissleder
Harvard Medical School
64. Bioorthogonal Reactions
Bioorthogonal reactions requirements
Water as a solvent
Ambient temperature
Fast reaction kinetics
Synthetically accessible functionalities
Non-toxic reagents
No cross reactivity
Stable reactants and products
Stable at physiological pH
Cell permeable reagents
65. Bioorthogonal Reactions
Solvent k rel
Hexane 1
EtOH 1.6
H2O/NCP (99:1) 53.2
Azide-Norbornene cycloaddition (Engberts)
Engberts, J.B.F.N et al., Tet. Lett., 1995, 36, 5389
Solvent k rel
Toluene 1
EtOH 2.0
H2O/tBuOH (0.95 MF) 60.9
1,2,4,5-Tetrazine-styrene cycloaddition (Engberts)
Engberts, J.B.F.N et al., J Org. Chem, 1996, 61, 2001
Key observations from kinetic studies (Lecture 1)
Cu Catalysed azide-alkyne cycloaddition
(CuAAC) Sharpless, Fokin and Meldal (2002)
Strain Promoted cycloaddition (SPAAC)
Bertozzi (2004)
Solubility is an issue
66. Bioorthogonal Reactions – SPAAC
Influence of strain on reactivity?
Significant development carried out on a number of strained cyclooctynes.
Different substitution patterns on the ring can increase the rate of reaction
However in many cases the rates of the reactions have been determined in mixed organic and aqueous solvents.
There is the question as to whether this gives an adequate indication of the rate in the biological system
Solubility is a major issue in the development of strained ring systems
Using a strained dienophile/dipolarophile can have a significant effect on the rate of reaction
67. Bioorthogonal Reactions – Azides versus Tetrazines
Not present in biological systems
Possesses orthogonal reactivity to most biological
groups
Is a small functional group (only three atoms)
Does not have appreciable reactivity with water
Triazole products are stable
Why use azide and tetrazines in bioorthogonal reactions?
Not present in biological systems
Possesses orthogonal reactivity to most biological
groups
Very fast kinetics for inverse electron demand
cycloadditions (IED)
No metals needed
Bigger functional group and needs to be stabilized
with an aryl ring
68. Bioorthogonal Reactions –Azides versus Tetrazines
Selectivity of Bioorthogonal Reactions – Inverse electron demand cycloaddition reactions
Houk, K.N., et al., J. Am Chem. Soc., 2012, 134, 17904
k2 = 0.0064 M-1s-1 k2 = 210 M-1s-1
k2 = 2.10 M-1s-1
k2 Azide
k2 Tetrazine
= 32000
1,2,4,5-tetrazine does not
react with the cyclooctyne
trans-cyclooctene reacts over 32000 faster with the 1,2,4,5-tetrazine over the azide. However in the case of
cyclooctyne no reaction was observed with 1,2,4,5-tetrazine
The difference in reactivity between azides and tetrazines with various diene/dipolarophiles means that in
biological environments more than one tag/probe can introduced using a specific bioorthogonal reaction
69. Bioorthogonal Reactions –Azides versus Tetrazines
Reactivities of Strain Promoted Dienophile/Dipolarophiles
Dienophiles reported for their reactivity towards
1,2,4,5-Tetrazines
Dipolarophiles reported for their reactivity towards azides.
(Rates are measured in MeOH or MeCN)
There has been a wide range of different dipolarophile and dienophiles discovered for the strain-promoted
bioorthogoanal reactions.
Very much an active area of research however need further reliable rate data in water as this would reflect the
rates in biological systems
King, M, Wagner, A, Bioconjugate Chem., 2014, 25, 825
70. Bioorthogonal Reactions – SPAAC
Strained dipolarophiles - PEGylation of CalB
Van Delft, F. L., et al., Chem Comm., 2010, 46 97
CalB expressed with azidohomoalanine residues (5)
with one surface exposed residue
Cyclooctyne (DIBAC) synthesized in 10 steps
Corresponding tagging carried out under Cu(I)
conditions took 1-3 days and with no full conversion
observed (CuAAC).
Under SPAAC conditions the conversion was
complete after 3 hours
Solvent k (M-1 s-1)
CD3OD 0.31
D2O 0.36
71. Bioorthogonal Reactions – Azides
Strained dipolarophiles - In vivo imaging (Glycan Trafficking)
Bertozzi, C.R., et al., Proc. Nat Acad. Sci., 2007, 104, 16793
Visualization of dynamic processes in
living cells is possible
The visualization of the azidosugar
metabolism is possible using the
fluorescent tags
Both the azide sugar and strained alkyne
do not fluoresce but upon SPAAC reaction
the localization of these in a cell can be
visualized
72. Bioorthogonal Reactions – Azides
Strained dipolarophiles - In vivo imaging (Zebrafish)
Bertozzi, C.R., et al., Science., 2008, 320, 664
Scheme From – D. A Nagib, MacMillan Group, Princeton
Metabolic labeling was observed, similar to that of mammalian cells
Interestingly there was no observed toxicity resulting from use with Ac4GalNAz or DIFO reagents.
Organic reactions using water as a solvent in a living system
73. Bioorthogonal Reactions – 1,2,4,5-Tetrazines
Tetrazines in bioorthogonal reactions - Tetradoxin
12014 Da
12222 Da
100% Conversion
(5 mins)
Fox, J.F., et al., J. Am. Chem. Soc, 2008, 130, 13518
Tetradoxin is labelled with a maleimide derived trans-cyclooctene though coupling onto a cysteine residue on the surface
of the protein
Subsequent reaction with a 1,2,4,5-tetrazine led to complete conversion in 5 mins.
Reaction can be carried out in organic sovlents, water, cell lysate with identical results
Stability of the trans-cyclooctene over prolonged time is an issue so the reaction has to be quick
74. Other Metal catalysed reactions
Palladium Catalysed Reactions – Sonogashira (GFP)
No ligand
Sonogashira coupling carried out to label alkyne encoded GFP
with a rhodamine conjugated phenyl iodide.
Pd(NO3)2 did not have any effect on the cells over 1 hour
Using a ligands gave poorer yields
This is an interesting reaction as there are only a handful of
Sonogashira reactions carried out using water as a reaction
solvent
95%
Chen et al., J. Am. Chem. Soc, 2013, 135, 7330
75. Other Metal catalysed reactions
Palladium Catalysed Reactions – Suzuki Coupling (OmpC)
OmpC contained a genetically modified p-iodophenylalanine
OmpC is a membrane protein on the surface of E.coli
This modified OmpC was reacted with a boronic acid-fluorescein which was
carried out in 1hr using the palladium catalyst.
Suzuki reactions generally have water present as a co-solvent.
Davis, B.G. et al., J. Am. Chem. Soc, 2012, 134, 800
76. Bioorthogonal Reactions – Where next?
Within 8 years from the reporting of the first ‘click’ reaction there has been the application of this
methodology in living systems
The number of reactions in the bioorthogonal toolbox is increasing however there is the need for new
reaction types
Use of natural amino acids is key
A key aspect of this methodology is the discovery of new reactions that can be carried out using
water as a solvent
2002
Sharpless
Fokin
Meldal
2007 2008 2010
77. Conclusions
Organic reactions are possible using water as a solvent.
In some cases there are large rate accelerations observed however these can
be reaction and substrate specific.
Mechanistically the rationale for these accelerations is not fully understood
In the last decade a major application of organic reactions using water as a
solvent has been to bioorthogonal chemistry
78. Not discussed in these lectures
(NDI)3
(NDI)4
AO10 Dynamic Covalent Chemistry: A Tool For Synthesis, Molecular Recognition And Understanding Systems Behavior
(2L): Professor Jeremy Sanders (January 2015)
Dynamic Covalent Chemistry
Micellar Additives
Bruce Lipshutz
University of Califonia,
Santa Barbara
80. General References
D. Burtscher, K. Grela, Angew. Chem. Int. Ed., 2009, 48,
442 (Olefin Metathesis)
S. Otto, J.B.F.N. Engberts, Org Biomol. Chem., 2003, 1(16),
2809
C-J. Li, Chem. Rev., 2005, 105, 3095–3166 (General)
A. Chandra, V.V. Fokin, Chem. Rev., 2009, 109, 725
(General)
D. Dallinger, C. Oliver Kappe, Chem Rev, 2007, 107, 2563
(Microwave synthesis in water)
U. M. Lindström, Chem. Rev, 2002, 102, 2751
(Stereoselective reactions)
M. Raj, V. K. Singh, Chem. Comm., 2009, 6687
(Organocatalysis)
J. Paradowska, M. Stodulski, J. Mlynarski, Angew. Chem.
Int. Ed., 2009, 48, 4288 (Organocatalysis)
H. Hailes, Org. Proc. Res. Dev., 2007, 11, 114 (General)
‘Organic Reactions in water’ U. Marcus Lindströhm Ed.,
Blackwell Publishing, 2007
Science of Synthesis: Water in Organic Synthesis,
Shu Kobayshi Ed, Thieme, 2012
Organic Synthesis in Water, Paul A. Grieco Ed.,
Springer, 1999.
Aqueous Phase Organometallic Catalysis – Concepts
and Applications Boy Cornlis and Wolfgang Herrmann
Ed, Wiley, 1998 G. Molteni, Heterocycles, 2006, 68(10), 2177 (Huisgen
cycloaddition reactions)
R.N. Butler, A.G. Coyne, Chem. Rev., 2010, 110, 6302
(General – in-water/on-water)
Books
B. H. Lipshutz, S. Ghorai, Green Chem, 2014, 16, 3660
(General and Stereoselective reactions)
81. Water is the solvent used by nature for biological chemistry. Considering the enormous variety of biological
pathways and the complicated molecular structures and materials, including precise arrangements of multitudes of
asymmetric centers, which are found in biological systems, It is remarkable that up until recently organic synthesis has
mainly shunned water. In recent years there has been a resurgence in the use of water as a solvent in a wide variety of
reaction types.
The aim of these two lectures will be to explore these reactions where water has been applied as a solvent. The
initial focus will be the investigation of the kinetics of these reactions where interesting rate effects have been observed.
The focus will then move onto a range of reaction types such as the Diels-Alder [4+2] and Huisgen [3+2] cycloaddition
reactions, Claisen rearrangement, epoxide ring openings, olefin metathesis and cyclopropanation reactions. The final
part of this lecture series will focus on the development and application of biorthogonal reactions where the use of water
as the solvent is crucial.
Editor's Notes
With all the solvents currently available the question is why should we consider water as a reaction solvent.
In recent years there has been a shortage of solvents –two of note is the solvent acetonitrile and for those of you who work on the first floor will have seen the recent note on the solvent cupboard for carbon tetrachloride. While these are not critical in organic synthesis in comparsion to analytical chemistry where acetonitrile is critical it is only a matter of time that we encounter solvents that are critical that are in short supply. There is also the perpective that from a green chemistry viewpoint that water is a resource that can be used
So the question is how have people typically sone reactions using water as a solvent. -
The ideal reaction