The document discusses gluten sensitivity, presenting case studies of patients who experienced symptoms like dizziness and abdominal pain but tested negative for celiac disease. It summarizes debates around whether gluten sensitivity is a real condition or whether patients' symptoms are psychosomatic. The document also outlines emerging definitions and diagnostic criteria for gluten sensitivity, differences from celiac disease, and recommendations for further research.

1. “ GLUTEN SENSITIVITY – FACT OR FICTION?”
– Harveen K (harveenk26@gmail.com)

2. AGENDA

3. GLUTEN SENSITIVITY: FACT OR FICTION?!
“Clues to Gluten Sensitivity” published in WSJ (2011)
reports case history of three patients.
“Coeliac Disease and Gluten Sensitivity” published by Food
Reaction (2009) reports case history of a 28 year old
woman.
All these patients presented with two or more
combinations of these symptoms. The All these patients were tested negative for
symptoms were dizziness, abdominal pain, coeliac disease and were sent back and no
fatigue, migraines, body aches, constipation, treatment was prescribed
and temper tantrums

4. GLUTEN SENSITIVITY: FACT OR FICTION?!
”Patients have been told if it wasn't coeliac disease, it wasn't anything. It was all in their
heads," says Cynthia Kupper, executive director of the nonprofit Gluten Intolerance Group
of North America
Were these patients reporting with too vague non-specific symptom? or it
wasn't anything?

5. GLUTEN SENSITIVITY: FACT OR FICTION?!
Dietary
Dietary
Villains..
Villains..
..
Move over fat, salt and sugar. There is a
new dietary villain in town and it’s name is
GLUTEN

6. GLUTEN SENSITIVITY: EMERGING DEFINITION
“According to the recent definition of the term gluten sensitivity at the 11th
“According to the recent definition of the term gluten sensitivity at the 11th
International Coeliac Disease Symposium in Oslo, Norway in June 2011. Gluten
International Coeliac Disease Symposium in Oslo, Norway in June 2011. Gluten
sensitivity can be indistinguishable from coeliac disease or wheat allergy based
sensitivity can be indistinguishable from coeliac disease or wheat allergy based
on symptoms alone. It has been the catch all for people who feel better gluten
on symptoms alone. It has been the catch all for people who feel better gluten
free but whose labs don’t fit them into the first two categories” (Sapone et al.,
free but whose labs don’t fit them into the first two categories” (Sapone et al.,
2011)
2011)

7. GLUTEN SENSITIVITY: SYMPTOMS
(Sapone et al., 2011)
(Sapone et al., 2011)

8. GLUTEN SENSITIVITY: DIFFERS FROM COELIAC DISEASE
– .
Volta U, De Giorgio R, 2012
Volta U, De Giorgio R, 2012

9. GLUTEN SENSITIVITY: DIAGNOSIS
The following list summarizes the theidentificationof Gluten sensitivity
The following list summarizes theidentification of Gluten sensitivity
The following list summarizes identification of gluten sensitivity:
(Sapone et al., 2011)
(Sapone et al., 2011)

10. GLUTEN SENSITIVITY: NEW UNDERSTANDING
(Volta U, De Giorgio R, 2012)
(Volta U, De Giorgio R, 2012)

11. GLUTEN SENSITIVITY: EVIDENCE-BASED MEDICAL
LITERATUTRE

12. GLUTEN SENSITIVITY: TREATMENT & PREVENTION

13. GLUTEN SENSITIVITY: TREATMENT AND PREVENTION
(WSJ, 2011)
(WSJ, 2011)

14. GLUTEN SENSITIVITY: FURTHER RECOMMENDATIONS FOR
RESEARCH

15. QUESTIONS? (Easy ones please  )

16. REFERENCES
Hadjivassiliou M, Sanders D, Grünewald RA, Woodroofe N, Boscolo S, Aeschlimann D. Gluten sensitivity: from gut to
brain. Lancet Neurol 2010; 9: 318–30
Jessica R. Biesiekierski, Newnham ED, Irvin PM, Barret JS, Haines M, Doecke DJ, Shepherd SJ, B, Jane G. Gibson PR. Gluten
Causes Gastrointestinal Symptoms in Subjects Without Coeliac Disease: A Double-Blind Randomized Placebo-
Controlled Tria . Am J Gastroenterol advance online publication, 11 January 2011; doi: 10.1038/ajg.2010.487
Sapone A, Bai J, Ciacc C, Dolinse J, HR P Green, Hadjivassiliou M, Kaukinen K, Rostami K, Sander D, Schumann M, Ullrich R,
Villalta D, Volta U, Fasano A. Spectrum of gluten-related disorders: consensus on new nomenclature and classification.
BMC Medicine 2012, 10:13 doi:10.1186/1741-7015-10-1.
Sapone A, Karen M. Lammers B, Mazzarella G, Mikhailenkoc I, Cartenìa M, Casolarob V, Fasanob A. Differential Mucosal
IL-17 Expression in Two Gliadin-Induced Disorders: Gluten Sensitivity and the Autoimmune Enteropathy Coeliac
Disease. Int Arch Allergy Immunol 2010;152:75–80 DOI: 10.1159/000260087.
Sapone A, Karen M. Lammers B, Casolaro V, Cammarota M, Giuliano T, De Rosa M, Stefanile R, Mazzarella G , Russo MI,
Esposito P, Ferraraccio F, Cartenì M, Riegler G, Magistris L, Fasano A. Divergence of gut permeability and mucosal
immune gene expression in two gluten-associated conditions: coeliac disease and gluten sensitivity. BMC Medicine
2011, 9:23 doi:10.1186/1741-7015-9-23
Volta U, Giorgio R. New understanding of gluten Sensitivity. Nature Reviews Gastroenterology & Hepatology 9, 295-299
(May 2012) doi: 10.1038/nrgastro.2012.15
Wahnschaffe U, Schulzke J, Zeitz M, Ullrich R. Predictors of Clinical Response to Gluten-Free Diet in Patients diagnosed
with diarrhoea-dominant irritable bowel syndrome. Clinical Gastroenterology & Hepatology 2007
Coeliac Disease and Gluten Sensitivity. http://www.foodreactions.org/gluten/ accessed on 25.11.2012
Clues to Gluten Sensitivity. http://online.wsj.com/article/SB10001424052748704893604576200393522456636.html
accessed on 25.11.2012