This document discusses gene interaction, which refers to how two or more genes can affect the expression of a single trait in an organism. It begins by defining gene interaction and explaining that many traits are governed by multiple genes rather than a single gene. The document then outlines different types of gene interactions, including epistatic and hypostatic interactions. It classifies epistatic gene interactions into several categories based on how the genes influence each other, such as supplementary, complementary, inhibitory, duplicate, masking, and polymeric gene interactions. Examples are provided for each category to illustrate how the interaction modifies the dihybrid or trihybrid ratios.
Basics of Undergraduate/university fellows
Complementation between two non-allelic genes (C and P) are essential for production
of a particular or special phenotype i.e., complementary factor.
Two genes involved in a specific pathway and their functional products are required
for gene expression, then one recessive allelic pair at either allelic pair would result in
the mutant phenotype.
When Dominant alleles are present together, they complement each other to yield
complementary factor resulting in a special phenotype.
They are called complementary genes.
When either of gene loci have homozygous recessive alleles (i.e., genotypes of ccPP,
ccPp, CCpp, Ccpp and ccpp), they produce identical phenotypes and change F2 ratio
to 9:7.
Basics of Undergraduate/university fellows
Complementation between two non-allelic genes (C and P) are essential for production
of a particular or special phenotype i.e., complementary factor.
Two genes involved in a specific pathway and their functional products are required
for gene expression, then one recessive allelic pair at either allelic pair would result in
the mutant phenotype.
When Dominant alleles are present together, they complement each other to yield
complementary factor resulting in a special phenotype.
They are called complementary genes.
When either of gene loci have homozygous recessive alleles (i.e., genotypes of ccPP,
ccPp, CCpp, Ccpp and ccpp), they produce identical phenotypes and change F2 ratio
to 9:7.
Gene interactions occur when two or more different genes influence the outcome of a single trait
Epistasis is a phenomenon in which the expression of one gene depends on the presence of one or more modifier genes.
A gene whose phenotype is expressed is called epistatic.
This power point presentation is designed to explain deviation of Mendelian dihybrid ratio due to interaction of genes which may be of following types
1.Two gene pairs affecting same character – 9:3:3:1
2.Epistasis, one gene hides effect of other
a) Recessive Epistasis - 9:3:4
b) Dominant epistasis - 12:3:1
3.Complementary genes - 9:7 ( 2 genes responsible for production of a particular phenotype )
4. Duplicate genes – 15:1 ( same effect given by either of two genes )
5. Polymeric gene action - 9:6:1
6. Inhibitory gene action - 13 : 3
Each interaction is typical in itself and ratios obtained are different
Gene interactions occur when two or more different genes influence the outcome of a single trait
Epistasis is a phenomenon in which the expression of one gene depends on the presence of one or more modifier genes.
A gene whose phenotype is expressed is called epistatic.
This power point presentation is designed to explain deviation of Mendelian dihybrid ratio due to interaction of genes which may be of following types
1.Two gene pairs affecting same character – 9:3:3:1
2.Epistasis, one gene hides effect of other
a) Recessive Epistasis - 9:3:4
b) Dominant epistasis - 12:3:1
3.Complementary genes - 9:7 ( 2 genes responsible for production of a particular phenotype )
4. Duplicate genes – 15:1 ( same effect given by either of two genes )
5. Polymeric gene action - 9:6:1
6. Inhibitory gene action - 13 : 3
Each interaction is typical in itself and ratios obtained are different
It's about for some interactions occurs between two genes and within a gene and how these interactions changed the phenotypic ratios of Mendelian phenotypic ratios.
Epistasis is a Greek word that means standing over .Bateson used it to describe the masking effect in 1909.
An interaction between a pair of loci in which the phenotype effect of one locus depends on the genotype at the second locus.
Genes whose phenotypes are ;
Expressed,epistatic.
Altered or suppressed hypostatic.
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3. OUTLINE
• Introduction
• Why gene interaction..?
• Types of gene interaction
• Epistatic and hypostatic gene
• Classification of epistatic gene interaction
a. Supplementary gene interaction (9:3:4)
b. Complementary gene interaction (9:7)
c. Inhibitory gene interaction (13:3)
d. Duplicate gene interaction (15:1)
e. Masking gene action (12:3:1)
f. Polymeric gene interaction (9:6:1)
4. INTRODUCTION
• Definition- The phenomenon of two or more genes affecting the expression
of each other in various ways in the development of a single character of an
organism is known as gene interaction.
• Most of the characters of living organisms are controlled/ influenced/
governed by a collaboration of several different genes.
• Mendel and other workers assumed that characters are governed by single
genes but later it was discovered that many characters are governed by two
or more genes.
• Such genes affect the development of concerned characters in various ways;
this lead to the modification of the typical dihybrid ratio (9:3:3:1) or trihybrid
(27:9:9:9:3:3:3:1).
• In gene Interaction, expression of one gene depends on
expression(presence or absence) of another gene.
5. WHY GENE INTERACTION… ?
• There may be more than two alleles for a given locus within the
population.
• Dominance of one allele over another may not be complete.
• Two or more genes may affect a single trait.
• The expression of a trait may be dependent on the interaction of
two or more genes, on the interaction of genes with non genetic
factors, or both.
6. TYPES OF GENE INTERACTIONS
• Gene interactions can be classified as-
a) ALLELIC/NON EPISTATIC GENE INTERACTION- This type of
interaction gives the classical ratio of 3:1 or 9:3:3:1.
b) NON-ALLELIC/EPISTATIC GENE INTERACTION – In this
type of gene interaction genes located on same or different
chromosome interact with each other for their expression.
7. EPISTATIC AND HYPOSTATIC GENE
• Epistatic gene:-
When a gene or locus which suppress or mask the phenotypic
expression of another gene at another locus such gene is known as epistatic
gene.
Epistatic is GREEK term and meaning is standing up.
• Hypostatic gene:-
The gene or locus which was suppressed by a epistatic gene was
called hypostatic gene.
8. CLASSIFICATION OF EPISTATIC GENE
INTERACTION
• Epistatic gene interaction is classified as follow on the basis of manner by
which concerned genes influence the expression of each other-
1. No interaction (9:3:3:1)
2. Supplementary gene interaction / Recessive Epistasis (9:3:4)
3. Complementary gene interaction (9:7)
4. Inhibitory gene interaction / Dominant Suppression (13:3)
5. Duplicate gene interaction (15:1)
6. Masking gene interaction / Dominant Epistasis (12:3:1)
7. Polymeric gene interaction / Dominant gene interaction (9:6:1)
9. 1. TYPICAL DIHYBRID RATIO (9:3:3:1)
The character is governed by two genes exhibiting FULL dominance.
10. 2. SUPPLEMENTARY GENE INTERACTION (9:3:4)
• In supplementary gene interaction, the dominant allele of one of two gene
governing a character produces phenotypic effect.
• However dominant allele of the other gene does not produce a phenotypic
effect on its own.
• But when it is present with dominant allele of the first gene it modifies the
phenotypic effect produced by that gene.
• Also known as Recessive Epistasis.
• For example:- Purple and White Grain colour in Maize.
11.
12. 3. COMPLEMENTARY GENE INTERACTION (9:7)
• The character is governed by the dominant alleles of two genes, whether
they are present in homozygous state or heterozygous state.
• In such case, the genotype aaBB, aaBb, Aabb, aabb produce one phenotype.
• Both dominant alleles when present together each other are called
complementary genes and produce a different phenotype.
• Also known as Duplicate Recessive Epistasis.
• For example:- Flower colour in Sweet pea.
13.
14. 4. INHIBITORY GENE INTERACTION (13:3)
• The character is governed by one of the two dominant genes however;
second dene has no effect of its own but stop the expression of first
dominant gene.
• When dominant allele of one gene locus in homozygous and
heterozygous condition produce the same phenotype the F2 ratio
become 13:3 instead of 9:3:3:1.
• Homozygous recessive condition inHibits phenotypic expression of other
genes so known as inhibitory gene action.
• Also known as Dominant Suppression.
• For example:- Maize Aleurone colour.
15.
16. 5. DUPLICATE GENE INTERACTION (15:1)
• The character is governed by two dominant genes whether they
are present alone or together.
• In this case the ratio becomes 15:1 instead of 9:3:3:1.
• Also known as Duplicate Dominant Epistasis.
• For example:- Awn character in Rice.
17.
18. 6. MASKING GENE INTERACTION (12:3:1)
• When out of two genes, the dominant allele of one gene(A) masked the
activity of allele of another gene(B).
• Then A gene locus is said to be epistatic to the B gene locus.
• Dominant allele A express itself only in the presence of either B or b so such
type of epistatic is known as dominant epistatic.
• The allele of hypostatic locus express only when the allele of epistatic locus
present in homozygous recessive condition.
• For example:- Fruit colour in squash gourd.