This document discusses arsenic trioxide (white arsenic). It describes its physical properties including being white, brittle, and opaque. It notes its medical uses including treating cancer and autoimmune diseases. The document also discusses its traditional Ayurvedic uses and processing into bhasma or ashes for medicinal applications. Methods of preparing arsenic trioxide bhasma are provided along with its medical indications and formulations.

1. Dr.K.J.Karthika
P.G Scholar, Department of R&B
GAVC, TPRA

3.  Crystallisation-Hexagonal,
scalenoheadral
 Colour-tin white,tarnishes quickly to grey
 Lusture-submetallic on fresh surfaces
 Streak- white
 Diaphaneity – opaque
 Cleavaga –one direction,distinct
 Fracture- uneven
 Elasticity –brittle

4.  Hardness-3.5
 Sp.gravity-5.63
 Alteration-the black tarnish which results from
exposure is a mixture of arsenic & arsenolite.
 Occurrence & mineral association-In
hydrothermal veins.Associated minerals
include ores of silver,cobalt& nickel,arsenolite
,realgar etc

5. •Second mineral drug of Sadharana rassa.
•Included by Acharya Susrutha in Dhatu visha along
with Harithala
•Identified as White arsenic or vitreous in english
•Chemically Arseneous Trioxide.
MEDICAL UTILITY
•Used to treat cancer and other condition. Induce
apoptosis of cancer cells.
•Trisenox – to treat leukemia.
•Used in auto immune diseases.
Enzyme thio-redoxin reductase is the target for arsenic.

6. OCCURRENCE
•Ores are found in European countries and parts of
China.
•In India it is found in Bihar and Kashmir along with
Iron pyrites .

7.  Hindi – Mall,Somal,Sankhiya
 Telungu – Pashanam
 Tamil,Mal – Pashaanam
 Kannada – Pasana
 English – Vitreous arsenic / Rat poison
 Latin – Arsenic oxide

8. श्ंखमूषं शंखविषं गौरीपषाणकं तथा।
दारुमूषं दारुषा दारुमॊचश्च मल्लक:।
फे नाश्मभस्मसंज्ञस्च सोमल: सम्बलं तथा।
आखुपाषाणकं चैि रासज्ञै: पररकीर्तितम्॥
(र.त.११/१३०-१३१)
Vyaktadeha, hatachoornaka, vikata,
rasabandhakara, etc.

9.  गौरीपाषाणकःपीतोविकटोहतचूणिकः।
स्फटटकाभश्चशङ्खाभोहररद्राभस्रयःस्मृताः I [R.R.S]
 Sphatikabha sveta varna uttama
 Sankhabha pandu varna madhyama
 Haridrabha pitavarna adhama
Sweta - shanka sadrusha – Artificial
Pita - dadimabha – Natural [Ay.Pr]
 Sweta – Artificial
Raktha- Natural [R.T,Yo.Ra]
 Sphatikabha is the best variety.

10. Practically in the market we can see
•Sveta
•Raktha
•Pitha
•Krisha
White is widely used for pharmaceutical preparations.

11.  पूिंपूिंगुणैःश्रेष्ठःकारिल्लीफलेक्षिपेत ्।
स्िेदयेद्धण्डिकामध्येशुद्धोभिर्तमूषकः।
[R.R.S]
 Swedana amidst karavellaphala.
 Media-Water,Karavellaswarasa [2 yama],
Meghanadarasa[1 day], Ajadugdha[1 day / 2
yama] , Godugdha,Tankana jala[1 yama]

13. विपाचचतं शङ्खविषं यत्नतष्टङ्कणाम्भसा।
गव्यदुग्धेनिा यामं शुद्चधमायात्यनुत्तमान ्॥ (र.त.११/१३७)
गिां दुग्द्धेऽथिात्िाजे कारविल्लीरसेऽथिा।
द्वियामं स्िेटदत: शुद्धो गौरीपाषाणको भिेत ्॥ (रसामृतं)
Other mediums used.
Swedana for 1 day using meghanada swarasa,
ajadugdha or aja mamsarasa.

14. Botanical NameAmaranthus spinosus L.
FamilyAMARANTHACEAE

16.  रसबन्धकरःण्स्नग्धोदोषघ्नोरसिीयिकृ त ्। [R.R.S]
On ext application ,has alkali like effect on the
body & causes sopha ,santapa& saithilya

17.  In a wide mouthed clean mud pot , spread surya
kshara 2 pala(96g).
 Ivory powder( hasti danta churna) spread on it and
that is heated till the fumes are exhausted(moisture
free) and the mixture is powdered.
 2 tola(24 g ) of this powder is taken in a small crucible
and 1 tola(12g) of shudda Gouripashna is added over it
folloed by baddition of 2 tola of the above powder.
 Sharava samputa and one lavaka puta done.
 Collect white mallabhasma with same properties as of
shudda gauripashana
[R.T 11/171-176]

18. Method 2
Shud Gauripashan(10g) + Lajavanthi kalka -> sharava
samputa -> marana using 1kg of upala when dried
Other methods
• Snihi ksheera bhavana & marana using snuhi bhasma.
•Arka ksheera bhavan and marana using arka bhasma.
•Mixed with harithala and bhavana in kumari swarasa
nad nakachikni swarasa 14 times and marana usind
ashwatha vriksha bhasma.

19.  तालिद्राहयेत्सत्त्िंशुद्धंशुभ्रंप्रयोजयेत ्। [R.R.S]
 Colour of bhasma & satwa – white

20.  आरभ्य दशमांशातु सषिपस्य प्रयत्नत
रुतीयभागपयिन्तम ् मारां मल्लस्य योजयेत ्
[R.T]
1/10 Sarshapa-1/3 sarshapa
 1/120 ratti-1/30 ratti [1-4 mg] according to the
strenght of the patient.

21.  Malla is first grounded with ardraka swarasa
added with maricha choorna in 1:100 ratio
 Mixing done thoroughly &pills of 100mg size
in which 1 mg pashana comes in each pill.
 Fatal dose is 1 ratti

22.  Mallasindoora
 Samirapannagarasa
 Chandeswara rasa

23.  With vasa satwa & kantakaarichoorna-
Swasa
 With guduchi &arkamoolachoorna-
slipadajwara
 With sunti &punarnava choorna-
vatarakta
 With lohabhasma & rasa sindoora-
rajayakshma

24.  Arsenic trioxide can be generated via many routine
processing of arsenic compounds including the
oxidation (combustion) of arsenic and arsenic-
containing minerals in air
 Large scale applications include its use as a
precursor to forestry products, in colorless glass
production, and in electronics. Being the main
compound of arsenic, the trioxide is the precursor
to elemental arsenic, arsenic alloys, and arsenide
semiconductors. Organoarsenic compounds, e.g.
feed additives (Roxarsone) and pharmaceuticals
(Neosalvarsan), are derived from arsenic trioxide