This document discusses food-drug interactions, including how food can affect drug absorption, metabolism, and excretion. It provides examples of specific foods that can interact with certain drugs in the gastrointestinal tract or liver to decrease or increase drug bioavailability. The key mechanisms of several food-drug interactions are also explained, such as how dairy products can reduce fluoroquinolone absorption by chelation or how grapefruit juice can inhibit intestinal drug metabolism. Proper management of food-drug interactions requires identifying patient risk factors, drug histories, and monitoring therapy.
discusses about the interaction of certain drugs with some food materials and explains in detail about the effect of food on absorption, distribution, metabolism and excretion. Also dicsussed about the pharmacodynamic and pharmacogenomic aspects
Nutraceuticals for Cancer, Diabetes and Cardio vascular diseases and their Me...Kratika Khede
This presentation consists of different types of foods that can be incorporated in diets to improve the health conditions in diseases -Cancer, Diabetes Mellitus and Cardio vascular diseases.
discusses about the interaction of certain drugs with some food materials and explains in detail about the effect of food on absorption, distribution, metabolism and excretion. Also dicsussed about the pharmacodynamic and pharmacogenomic aspects
Nutraceuticals for Cancer, Diabetes and Cardio vascular diseases and their Me...Kratika Khede
This presentation consists of different types of foods that can be incorporated in diets to improve the health conditions in diseases -Cancer, Diabetes Mellitus and Cardio vascular diseases.
food-drug interaction lecture on most important interactions between medications such as warfarin, tetracyclines, and other antibiotics as well as other common drugs and the effect of food on their absorption .
Drug interactions (DIs) represent an important and widely under recognized source of medication errors. Interactions between food and drugs may inadvertently reduce or increase the drug effect. Some commonly used herbs, fruits as well as alcohol may cause failure of the therapy up a point of to serious alterations of the patient’s health. The majority of clinically relevant food-drug interactions are caused by food induced changes in the bioavailability of the drug. Major side-effects of some diet (food) on drugs include alteration in absorption by fatty, high protein and fiber diets.
Underlying factors:
Classification of drug-food interactions:
Pharmacodynamic interactions
Pharmacokinetic interactions
I. Absorption interactions
II. Transport and distribution interactions
III. Metabolism interactions
IV. Excretion interactions
Grapefruit juice
Alcohol and Medication Interactions
Common Alcohol-Medication Interactions
Specific Alcohol-Medication Interactions
Foods and nutrients play a very important role in normal functioning of the body. They are helpful in maintaining the health of the individual and in reducing the risk of various diseases. Worldwide acceptance of nutraceuticals formed a relation between "nutrition" and "health" and therefore the concept of "Nutraceuticals" was evolved . In recent years, a new diet health paradigm is evolving which places more emphasis on the positive aspects of diet. The new lifestyle adopted by people today has changed the basic food habits of the latter. Consumption of the junk food has increased manifold leading to a number of diseases caused due to improper nutrition. Obesity is now recognized as a global issue. Heart disease continues to be a primary cause of death in most of the developing countries worldwide, followed by cancer, osteoporosis, arthritis and many others. Consumers being frustrated with the expensive, high-tech, disease-treatment approach in the modern medicines are seeking complementary or alternative beneficial products in the form of nutraceuticals.
Nutraceuticals are the emerging class of natural products that makes the line between food and drugs to fade .Nutraceutical is the hybrid of ‘nutrition’ and ‘pharmaceutical’. Nutraceuticals, in broad, are food or part of food playing a significant role in modifying and maintaining normal physiological function that maintains healthy human beings. The principal reasons for the growth of the nutraceutical market worldwide are the current population and the health trends. The food products used as nutraceuticals can be categorized as dietary fibre, prebiotics, probiotics, polyunsaturated fatty acids, antioxidants and other different types of herbal foods.
The nutraceuticals facilitate in combating the key health complications of the century such as obesity, cardiovascular diseases, cancer, osteoporosis, arthritis, diabetes, cholesterol etc. In whole, ‘nutraceutical’ has led to the new era of medicine and health, in which the food industry has become a research oriented sector.
DRUG INTERACTIONS (MECHANISMS OF DRUG-DRUG INTERACTIONS)N Anusha
A Drug interaction is an interaction between a drug and some other substance, such as another drug or a certain type of food, which leads to interaction that could manifest as an increase or decrease in the effectiveness or an adverse reaction or a totally new side effect that is not seen with either drug alone that can be severe enough to alter the clinical outcome.
Every time a drug is administered with any other prescription medicine, OTC products, herbs or even food we expose ourselves to the risk of a potentially dangerous interaction.
Successful treatment of hypertension is possible with limited side effects
given the availability of multiple antihypertensive drug classes. The translation of
pharmacological research to the treatment of hypertension has been a continuous
process, starting with drugs discovered 60 years ago, such as thiazide diuretics
(1958) and currently finishing with the newest antihypertensive agent available
on the market, the orally active direct renin-inhibitor aliskiren, discovered more
than 10 years ago (2000) (Laurent, 2017).
In between, there has been a continuous rate of discovery, including
spironolactone (1957), beta-blockers (propranolol, 1973), centrally acting alpha-
2 adrenergic receptor agonists (clonidine, 1970s), alpha1- adrenergic receptor
blocker (prazosin, 1975), angiotensin converting enzyme inhibitors (captopril,
1977), calcium channel blockers (verapamil, 1977), and angiotensin II receptor
blockers (losartan, 1993) (Kotchen, 2011).
Therapeutic considerations regarding the treatment of hypertension in
patients with diabetes mellitus are reviewed. Good blood pressure control is
essential in diabetic patients to prevent morbidity and mortality associated with
food-drug interaction lecture on most important interactions between medications such as warfarin, tetracyclines, and other antibiotics as well as other common drugs and the effect of food on their absorption .
Drug interactions (DIs) represent an important and widely under recognized source of medication errors. Interactions between food and drugs may inadvertently reduce or increase the drug effect. Some commonly used herbs, fruits as well as alcohol may cause failure of the therapy up a point of to serious alterations of the patient’s health. The majority of clinically relevant food-drug interactions are caused by food induced changes in the bioavailability of the drug. Major side-effects of some diet (food) on drugs include alteration in absorption by fatty, high protein and fiber diets.
Underlying factors:
Classification of drug-food interactions:
Pharmacodynamic interactions
Pharmacokinetic interactions
I. Absorption interactions
II. Transport and distribution interactions
III. Metabolism interactions
IV. Excretion interactions
Grapefruit juice
Alcohol and Medication Interactions
Common Alcohol-Medication Interactions
Specific Alcohol-Medication Interactions
Foods and nutrients play a very important role in normal functioning of the body. They are helpful in maintaining the health of the individual and in reducing the risk of various diseases. Worldwide acceptance of nutraceuticals formed a relation between "nutrition" and "health" and therefore the concept of "Nutraceuticals" was evolved . In recent years, a new diet health paradigm is evolving which places more emphasis on the positive aspects of diet. The new lifestyle adopted by people today has changed the basic food habits of the latter. Consumption of the junk food has increased manifold leading to a number of diseases caused due to improper nutrition. Obesity is now recognized as a global issue. Heart disease continues to be a primary cause of death in most of the developing countries worldwide, followed by cancer, osteoporosis, arthritis and many others. Consumers being frustrated with the expensive, high-tech, disease-treatment approach in the modern medicines are seeking complementary or alternative beneficial products in the form of nutraceuticals.
Nutraceuticals are the emerging class of natural products that makes the line between food and drugs to fade .Nutraceutical is the hybrid of ‘nutrition’ and ‘pharmaceutical’. Nutraceuticals, in broad, are food or part of food playing a significant role in modifying and maintaining normal physiological function that maintains healthy human beings. The principal reasons for the growth of the nutraceutical market worldwide are the current population and the health trends. The food products used as nutraceuticals can be categorized as dietary fibre, prebiotics, probiotics, polyunsaturated fatty acids, antioxidants and other different types of herbal foods.
The nutraceuticals facilitate in combating the key health complications of the century such as obesity, cardiovascular diseases, cancer, osteoporosis, arthritis, diabetes, cholesterol etc. In whole, ‘nutraceutical’ has led to the new era of medicine and health, in which the food industry has become a research oriented sector.
DRUG INTERACTIONS (MECHANISMS OF DRUG-DRUG INTERACTIONS)N Anusha
A Drug interaction is an interaction between a drug and some other substance, such as another drug or a certain type of food, which leads to interaction that could manifest as an increase or decrease in the effectiveness or an adverse reaction or a totally new side effect that is not seen with either drug alone that can be severe enough to alter the clinical outcome.
Every time a drug is administered with any other prescription medicine, OTC products, herbs or even food we expose ourselves to the risk of a potentially dangerous interaction.
Successful treatment of hypertension is possible with limited side effects
given the availability of multiple antihypertensive drug classes. The translation of
pharmacological research to the treatment of hypertension has been a continuous
process, starting with drugs discovered 60 years ago, such as thiazide diuretics
(1958) and currently finishing with the newest antihypertensive agent available
on the market, the orally active direct renin-inhibitor aliskiren, discovered more
than 10 years ago (2000) (Laurent, 2017).
In between, there has been a continuous rate of discovery, including
spironolactone (1957), beta-blockers (propranolol, 1973), centrally acting alpha-
2 adrenergic receptor agonists (clonidine, 1970s), alpha1- adrenergic receptor
blocker (prazosin, 1975), angiotensin converting enzyme inhibitors (captopril,
1977), calcium channel blockers (verapamil, 1977), and angiotensin II receptor
blockers (losartan, 1993) (Kotchen, 2011).
Therapeutic considerations regarding the treatment of hypertension in
patients with diabetes mellitus are reviewed. Good blood pressure control is
essential in diabetic patients to prevent morbidity and mortality associated with
preventive measures and reducing the unnecessary use of antibioticsrandzee7
Bovine respiratory disease, the most common and costly disease in the beef industry, results from complex interactions between the host, the environment, and potential pathogens. Environmental stressors play a major role in susceptibility to and transmission of disease pathogens. This module describes cost-effective preventive management measures that reduce incidence of the disease and thus the need for antimicrobial treatment. Beef practitioners play an important role in promoting these preventive measures and reducing the unnecessary use of antibiotics.
Specifically, the problem of antimicrobial resistancerandzee7
Antimicrobial resistance (AMR) is the ability of microbes like bacteria to resist the effects of an antimicrobial drug. In other words, the bacteria are either not killed or their growth is not stopped by the antimicrobial drug(s). Antimicrobial resistance is a natural phenomenon—all bacteria can evolve to develop resistance (see the Microbiology Module to learn more about bacterial resistance strategies and molecular mechanisms of resistance)—but any antibiotic use, anywhere bacteria can be found (in humans, animals, or in the environment), also can contribute to the development of resistance. Inappropriate antibiotic use in any sector is a concerning driver of resistance and is something that requires a One Health approach in order to address resistance effectively. Specifically, the problem of antimicrobial resistance cannot be solved by addressing antimicrobial use in only one sector.
According to the World Health Organisation, herbal medicines are defined as ‘finished, labelled medicinal products that contain as active ingredients aerial or underground parts of plants, or other plant material, or combinations thereof, whether in the crude state or as plant preparations.
Herbal medicines contain a combination of pharmacologically active plant constituents that are claimed to work synergistically to produce an effect greater than the sum of the effects of the single constituents
To recognize the importance of drug food interaction
To understand the effect of food on medications PK and or PD
To evaluate the clinical significance and provide a plan for management
HOW DRUGS INTERACT WITH FOOD AND NUTRIENTS ( drug-food and nutrients interact...rajabuchilumba
In order to ensure the healthy lifestyles we must understand about medication and how they relate with our food and nutrients intake.
Here!!!!
When to use food after drugs
When to use drug after food
Which drugs can be used after meal
Which drugs should be used before meal
Which drug can be used with meal
When to drink water for well healthy meal
Why we should use supplements
When to use supplements
Which food to use more for specific disease tratments.
Interaction between the food and drugs have a high effect on the success of treatment patients and on the side effects of drugs . the interaction not in all cases is bad but sometimes can improve the absorption and decrease the side effect. grapefruits interaction has received very high attention recently. Consequently, the presence of food in the digestive tract may reduce absorption of a drug. Often, such interactions can be avoided by taking the drug 1 hour before or 2 hours after eating. Like drugs, foods are not tested as comprehensively so they may interact with prescription or over the-counter drugs. therefor it is advisable for patients to follow the doctor and specialists’ guidelines to acquire greatest advantages with least food tranquilize cooperation.
A drug interaction is a situation in which a substance affects the activity of a drug, i.e. the effects are increased or decreased, or they produce a new effect that neither produces on its own.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
2. Food-Drug Interaction
A drug-food interaction occurs when your food or one of
its components and medicine interfere with one another.
Interactions can happen with both prescription and over-
the-counter medicines.
Not all medicines are affected by food. Some medicines
cannot be taken with certain types of food. The food can
cause a reaction that changes the effect of the medicine.
On the other hand, some medicines are easier to handle
when taken with food.
5. Effects of Food-Drug
Interaction in Absorption
• Drug Formulation influences the rate and extent of drug absorption.
a) Food may differentially effect the absorption of different
formulation of a single drug. For example,
Granules: absorption not influence by food intake.
Tablets: absorption (both) decreased and delayed by food intake.
b)When food delays dissolution of solid drug products, drug
absorption will also be delayed.
Foods may influence the bioavailability of drugs by
direct binding of drugs to substances in the food
by altering luminal pH, gastric emptying and intestinal transit time
through mucosal absorption , chemical interactions
6. Effects of Food-Drug
Interaction in Absorption
Water-insoluble drugs, such as spironolactone and griseofulvin
are better absorbed when taken directly after a meal.
The bioavailability of some drugs that are subject to
considerable ‘first-phase’ metabolism is increased by
simultaneous food ingestion e.g. Atenolol, metoprolol, labetolol
and nitrofurantoin.
Absorption of iron tablets is enhanced if they are taken with
fruit juice, but the tannic acid in tea tends to interfere with iron
absorption. Ingestion of food reduces the absorption of aspirin,
isoniazid.
7.
8. Effects of Food-Drug
Interaction in Metabolism
Grapefruit juice mainly inhibits the intestinal metabolism
(CYP3A4) of numerous drugs (calcium channel blockers,anti-
anxiety agents) enhancing their effects and increasing risk of
toxicity; may interfere with the absorption of other drugs. Juice
contain Naringenin which inhibits OATP.
Cruciferous vegetables(cabbage or brussels sprouts) contain
Indolic compounds which are inducers of CYP1A2 stimulate
the rate of human drug metabolism.
Rate of drug (antipyrine or theophylline) elimination (as
measured by plasma half-life) was slowest when the high
carbohydrate diet was fed and fastest during the high protein
period.
9. Effects of Food-Drug
Interaction in Excretion
Patients on low sodium diets will reabsorb more
lithium along with sodium .
Patients on high sodium diets will excrete more
lithium and need higher doses.
Some diets, particularly extreme diets, may affect
urinary pH , which affects reabsorption of acidic
and basic medications.
10. Mechanism of some Food-Drug
Interactions
Dairy products(butter , milk, cheese, yoghurt etc.)
Dairy products + Flouroquinolones /TTC
Multivalent cations found in dairy
products
Formation of insoluble chelates
Reduced Absorption
11. Mechanism of some Food-Drug
Interactions
Vitamin-K rich food( Spinach, Turnip greens , mustard
greens, Beet greens , Broccoli etc.)
Vitamin-K rich food + Warfarin
Disruption of Inhibition of Vitamin K
epoxide reductase enzyme
Synthesis of Vitamin-K dependent clotting
factors returns to normal
Increased Risk of Clot Formation
12. Mechanism of some Food-Drug
Interactions
Potassium rich foods(squash ,spinach ,lentils etc.)
Potassium rich foods + ACEi or ARB or
renin inhibitors or potassium sparing
diuretics
Lowering of Aldosterone Levels
Increased Potassium Retention
Increased Risk of Hyperkalemia
13. Mechanism of some Food-Drug
Interactions
Fiber Rich Foods(wheat , oat , sunflower seeds ,
coconut shreds , black beans , green peas etc.)
Fiber Rich Foods + Digoxin
/Amoxicillin/Levothyroxine
Fiber binds the drug within the guts
Delayed Absorption of drugs
14. Mechanism of some Food-Drug
Interactions
Grape Fruit Juice
Grape Fruit Juice + Fexofenadine
Fruit juice inhibit OATP
Decreased Absorption of Fexofenadine
Reduced therapeutic Efficacy
15. Mechanism of some Food-Drug
Interactions
Licorice
Licorice + Digoxin
Depletes Potassium Level
Enhanced Inhibition of transport of
sodium ion and potassium ion across the
membrane
Cardiac Arrhythmia
16. Mechanism of some Food-Drug
Interactions
Omega-3 fatty acid rich fish(salmon ,tuna , bluefish,
herring , menhaden, trout etc.)
Omega-3 fatty acid rich fish + Anti-platelet
drugs/Anti-coagulant drugs
Potentiation of Anti-coagulant effect
Increased Risk of Bleeding
17. Management of Food-Drug
Interaction
Identify the patient risk factors
Take complete drug history
Knowledge of action of the drug being used
Consider therapeutic alternatives
Time interval
Monitoring of therapy
Patients self-assessment