Drug interactions occur when two or more substances administered together alter their effects on the body. There are two main types of drug interactions - pharmacodynamic interactions, which involve drugs acting on the same receptors or tissues, and pharmacokinetic interactions, which alter a drug's absorption, distribution, metabolism, or excretion. Common examples of drug-drug interactions include aspirin increasing the effects of anticoagulants like warfarin and antibiotics affecting blood thinners. Food and disease can also interact with drugs. It is important for pharmacists to monitor for potential interactions and advise patients.
DRUG INTERACTIONS (MECHANISMS OF DRUG-DRUG INTERACTIONS)N Anusha
A Drug interaction is an interaction between a drug and some other substance, such as another drug or a certain type of food, which leads to interaction that could manifest as an increase or decrease in the effectiveness or an adverse reaction or a totally new side effect that is not seen with either drug alone that can be severe enough to alter the clinical outcome.
Every time a drug is administered with any other prescription medicine, OTC products, herbs or even food we expose ourselves to the risk of a potentially dangerous interaction.
DRUG INTERACTIONS (MECHANISMS OF DRUG-DRUG INTERACTIONS)N Anusha
A Drug interaction is an interaction between a drug and some other substance, such as another drug or a certain type of food, which leads to interaction that could manifest as an increase or decrease in the effectiveness or an adverse reaction or a totally new side effect that is not seen with either drug alone that can be severe enough to alter the clinical outcome.
Every time a drug is administered with any other prescription medicine, OTC products, herbs or even food we expose ourselves to the risk of a potentially dangerous interaction.
A brief description on drug and food interactions, different mechanisms,effect of food-drug interactions on pharmacokinetic systems (ADME), Management of food-drug interactions
Introduction to daily activities of clinical pharmacist.
Drug therapy monitoring,
Medication chart review
Clinical Progress
Pharmacist intervention
Detection and management of ADRs
A brief description on drug and food interactions, different mechanisms,effect of food-drug interactions on pharmacokinetic systems (ADME), Management of food-drug interactions
Introduction to daily activities of clinical pharmacist.
Drug therapy monitoring,
Medication chart review
Clinical Progress
Pharmacist intervention
Detection and management of ADRs
Dr. Surana Ajaykumar Rikhabchand
HOD and Assistant Professor,
Department of Pharmacognosy,
S.M.B.T.College of Pharmacy,
Dhamangaon, Nashik
Mb no. 09657296551
Drug food interactions in details - QAQussai Abbas
Drug interactions (DIs) represent an important and widely under recognized source of medication errors. Interactions between food and drugs may inadvertently reduce or increase the drug effect. Some commonly used herbs, fruits as well as alcohol may cause failure of the therapy up a point of to serious alterations of the patient’s health. The majority of clinically relevant food-drug interactions are caused by food induced changes in the bioavailability of the drug. Major side-effects of some diet (food) on drugs include alteration in absorption by fatty, high protein and fiber diets.
Underlying factors:
Classification of drug-food interactions:
Pharmacodynamic interactions
Pharmacokinetic interactions
I. Absorption interactions
II. Transport and distribution interactions
III. Metabolism interactions
IV. Excretion interactions
Grapefruit juice
Alcohol and Medication Interactions
Common Alcohol-Medication Interactions
Specific Alcohol-Medication Interactions
Drug interaction - Potential antimicrobial drug interaction in a hospital set...Dr. Jibin Mathew
A drug interaction is a situation in which a substance affects the activity of a drug when both are administered together. This action can be synergistic or antagonistic or a new effect can be produced that neither produces on its own
Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous molecule which exerts a biochemical or physiological effect on the cell, tissue, organ, or organism.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
5. Pharmacodynamic
Pharmacodynamic interactions are those in which the effect of one drug is
changed by the presence of another drug acting at the same biochemical or
molecular site (e.g., drug receptor or second messenger system), on the
same target organ, or on a different target but one that is associated with a
common physiological process essentially when one drug modulates the
pharmacologic effect of another by producing additive, synergistic or
antagonistic effects.
6. Conti…..
Additive effect
An effect in which two substances or actions used in
Combination produce total affect the same as the
sum of the individual effects.
synergistic effect
Interaction between two or more drug agents, entities, factors,
or substances that produces an effect greater than the sum of
their individual effects.
Antagonistic effect
Interaction of two or more drug substances such that the
action of any one of them on living cells or tissues is lessened or
diminished
7. Pharmacokinetics
Pharmacokinetic interactions are those in which one drug results in an
alteration (increase or decrease) of the concentration of another drug in the
system. Different parameters can be affected by pharmacokinetic
interactions, including a drug’s bioavailability, volume of distribution,
peak level, clearance and half-life. Such changes can lead to changes in
drug plasma concentrations and ultimately increase the risk of side effects
or diminish the efficacy of one or more drugs. Pharmacokinetic
interactions are more complicated and difficult to predict because the
interacting drugs often have unrelated actions.
8. Conti……
Bioavailability
Bioavailability is a measurement of the rate and extent to which a
drug reaches the systemic circulation.
Peak level
The highest level of drug that can be obtained in
the blood usually following multiple doses
Half life
This is the period of time required for the concentration or amount
of drug in the body to be reduced by one half.
10. Drug-Drug interactions
Drug-drug interactions occur when a drug interacts, or interferes, with
another drug. This can alter the way one or both of the drugs act in the
body, or cause unexpected side effects.
1. Aspirin+ Warfarin Synergism (excessive bleeding)
2. Antibiotic+ Blood thinner Antagonism (less effect)
3. Decongestants+ Antihypertensive Potentation (high blood pressure)
4. Codeine+ Paracetamol Addition ( increased analgesic effect)
5. Clavulanic acid+ Amoxicillin Synergism (increased antibiotic effect)
6. NSAID+ Cox 2 inhibitors Synergism (increased bleeding)
7. SSRI’S+ Vitamin K Synergism (increased bleeding)
8. Ant emetics+ Tranquilizers Unknown effect (breathing
problems)
9. H2 blockers+ PPI’S Alteration (increase ph of stomach)
10. Phenobarbital + Warfarin Antagonism (less effect)
11. Erythromycin + Warfarin Synergism ( increased bleeding)
11. Drug-Food interactions
A drug-food interaction happens when the food you eat affects the
ingredients in a medicine you are taking so the medicine cannot work the
way it should.
1. Bisphosphonates+ Any drug Reduced effectiveness of drug`
2. Benzodiazepines + grapefruit Inhabit enzymes involved in drug
metabolism
3. Digoxin + Oatmeal Decreased adsorption of drug
4. Aspirin + Milk Upset stomach
5. Acetaminophen + Alcohol Liver damage
6. MAO Inhibitors + food(tyramine) Severe headache
7. Tetracycline’s + calcium food Reduced absorption of drug
8. Warfarin + Vitamin K Reduced effect of drug
9. Celecoxib + Milk Upset stomach
10. Naproxen + fatty food Upset stomach
11. Oxycodon + Alcohol Coma , asthma
12. Caffeine + food Rapid heart beat
12. Drug-Disease interactions
1. Drug-condition interactions occur when a drug worsens or exacerbates an
existing medical condition
2. Nasal decongestants+ Hypertension Increased blood pressure
3. NSAID’S+ Asthmatic patients Air way obstruction
4. Minoxidil+ Heart failure Fluid rentation
5. Calcium channel blocker + Heart failure Negative inotropic activity
6. Nicotine + high blood pressure Increased heart rate
7. Beta blockers+ Heart failure Worsen asthma
8. Metformin + Heart failure Increased lactate level
13. Role of pharmacist in avoiding drug
interactions
Pharmacists in every practice setting need to be vigilant in monitoring for
potential drug interactions and advising patients regarding drugs proper
use, foods or beverages to avoid when taking certain medications and
about disease conditions. It is imperative for pharmacists to keep up-to-
date on potential drug-food interactions of medications, especially today’s
new drugs, so that they may counsel properly to the patient.
14. References
Pharmacology & toxicology by Mrs. S.R Kale pg 18 (2008)
British National Formulary. 46thedition, British medical association,
London;( 2003)
ASHP. ASHP guidelines on pharmacist-conducted patient education and
counseling.
Remington the science of practice of pharmacy by David. B (2006)