This document defines psychosis and its common manifestations such as delusions, hallucinations, disorganized speech and behavior, and negative symptoms. It then discusses potential differential diagnoses for psychotic manifestations including various psychiatric disorders, substance use, medical conditions, and medication side effects. The key points of assessment include evaluating the patient's history, conducting a physical and neurological exam, and assessing risk. Initial evaluations may include labs, imaging, and toxicology screens to help determine underlying causes. Management involves making a provisional diagnosis, assessing comorbidities and risk, providing stabilization if needed, and determining next steps such as admission, referral, or discharge.