This document describes using efficient global optimization applied to wind tunnel experiments to optimize flow control by plasma actuators. The optimization method uses a Kriging surrogate model and genetic algorithm to select additional sampling locations for wind tunnel runs to improve the model. Over 20 runs, it identified design variables that minimized drag for different plasma actuator configurations. Design A achieved the lowest drag by reducing flow separation with high duty cycle and modulation frequency settings. Design B also reduced drag with lower electrical energy requirements. The automated optimization successfully integrated wind tunnel experiments to efficiently optimize plasma actuator control parameters.