The document discusses the neurobiology of dementia by focusing on Bruce Willis' diagnosis. It defines dementia as the progressive decline of cognitive functions like memory and behavior. Dementia is primarily caused by neurodegenerative diseases like Alzheimer's disease which involve the loss of brain cells and accumulation of abnormal proteins. This disrupts neuronal communication and leads to cognitive impairment. Dementia affects various brain regions responsible for memory, judgment, and behavior, resulting in memory loss and changes in functioning. Progressive brain atrophy is also commonly observed in dementia patients.

1. FINAL PROJECT:
UNDERSTANDING THE BRAIN
THE NEUROBIOLOGY OF
EVERYDAY LIFE

2. INTRODUCTION:
Today, I would like to discuss a fascinating topic that
combines both neuroscience and the entertainment
industry: Bruce Willis' dementia and the neurobiology
of the disease.

3. WHAT IS DEMENTIA?
Dementia is a syndrome characterized by the progressive
decline of cognitive functions, including memory, thinking,
and behavior.
It is not a specific disease but rather a term used to
describe a range of symptoms that impact daily life.
I will explain better the disease that affects the great star
Bruce Willis
.

4. NEUROBIOLOGY OF
DEMENTIA
Dementia is primarily associated with neurodegenerative
diseases, such as Alzheimer's disease, Parkinson's disease, and
vascular dementia.
These diseases involve the progressive loss of brain cells and
the accumulation of abnormal proteins, leading to impaired
neuronal communication.
Alzheimer's disease is the most common cause of dementia.
It is characterized by the accumulation of beta-amyloid plaques
and tau tangles in the brain, disrupting cellular processes and
leading to cognitive decline.

5. NEUROTRANSMITTER
IMBALANCE
In dementia, there is often an imbalance of neurotransmitters,
the chemical messengers responsible for communication
between neurons.
Decreased levels of acetylcholine, a neurotransmitter crucial for
memory and learning, are commonly observed in dementia.

6. IMPACT ON BRAIN
REGIONS
Dementia affects various brain regions, including the
hippocampus, which is essential for memory consolidation, and
the frontal lobes, responsible for decision-making and behavior
regulation.
As these regions deteriorate, memory loss, impaired judgment,
and behavioral changes become evident.

7. IMPACT ON BRAIN
ESTRUCTURE
Progressive brain atrophy, or shrinkage, is commonly observed in
dementia.
Structural imaging techniques, such as MRI, reveal the loss of
brain tissue, particularly in areas crucial for cognitive function.

8. IMPACT ON NEURAL
NETWORKS
Dementia disrupts the intricate neural networks that underlie
cognition.
Disconnections between different brain regions impair
information processing, leading to cognitive impairments and
functional decline.

9. GENETIC FACTORS
Genetic factors play a role in some forms of dementia.
Mutations in specific genes, such as the APP, PSEN1, and PSEN2
genes in Alzheimer's disease, can increase the risk of developing
dementia.

10. Thank you for your attention. I hope I
clarified this Bruce Willis dementia or
the neurobiology of the disease.
THANK'S FOR
READING