Based on the history and investigations, what is your provisional diagnosis for this child?
Student: The provisional diagnosis is Thalassemia Major.
Thalassemia is an inherited blood disorder caused by reduced or absent amounts of hemoglobin. The key features that point to Thalassemia Major in this case are:
- Recurrent pallor and need for frequent blood transfusions since birth indicating severe anemia.
- Hepatosplenomegaly which is commonly seen in Thalassemia Major due to extramedullary hematopoiesis.
- Microcytic hypochromic anemia on blood smear examination.
- Hemoglobin electrophoresis showing