This document discusses genome database systems. It begins with an introduction to bioinformatics and genomes. It then discusses the background of genome databases, including some examples. The major characteristics of genome database systems are described as having high complex data, schema changes at a rapid pace, and complex queries. The key areas of data management in genome databases are discussed as non-standard data, complex queries, data interpretation, integration across databases, and uniform management solutions. Major research areas and applications that impact society are also summarized.
INTRODUCTION.
NCBI.
EMBL.
DDBJ.
CONCLUSION.
REFERENSE.
The National Center for Biotechnology Information (NCBI) is part of the United States National Library of Medicine (NLM), a branch of the National Institutes of Health.
The NCBI is located in Bethesda, Maryland and was founded in 1988 through legislation sponsored by Senator Claude Pepper.
The NCBI houses a series of databases relevant to biotechnology and biomedicine. Major databases include GenBank for DNA sequences and PubMed, a bibliographic database for the biomedical literature.
All these databases are available online through the Entrez search engine.
INTRODUCTION.
NCBI.
EMBL.
DDBJ.
CONCLUSION.
REFERENSE.
The National Center for Biotechnology Information (NCBI) is part of the United States National Library of Medicine (NLM), a branch of the National Institutes of Health.
The NCBI is located in Bethesda, Maryland and was founded in 1988 through legislation sponsored by Senator Claude Pepper.
The NCBI houses a series of databases relevant to biotechnology and biomedicine. Major databases include GenBank for DNA sequences and PubMed, a bibliographic database for the biomedical literature.
All these databases are available online through the Entrez search engine.
This presentation gives you a detailed information about the swiss prot database that comes under UniProtKB. It also covers TrEMBL: a computer annotated supplement to Swiss-Prot.
INTRODUCTION
WHAT IS DATA AND DATABASE?
WHAT IS BIOLOGICAL DATABASE?
TYPES OF BIOLOGICAL DATABASE
PRIMARY DATABASE
Nucleic acid sequence database
Protein sequence database
SECONDARY DATABASE
COMPOSITE DATABASE
TERTIARY DATABASE
WHY NEED?
CONCLUSION
REFRENCES
Genome annotation, NGS sequence data, decoding sequence information, The genome contains all the biological information required to build and maintain any given living organism.
Genomic databases are referred to as online repositories of genomic variants, described for a single (locus-specific) or more (general) genes or specifically for a population or ethnic group (national/ethnic).
An integrated publicly accessible bioinformatics resource to support genomic/proteomic research and scientific discovery.
Established in 1984, by the National Biomedical Research Foundation (NBRF) Georgetown University Medial Center, Washington D.C., USA.
It is the source of annotated protein databases and analysis tools for the researchers.
Serve as primary resource for the exploration of protein information.
Accessible by text search for entry and list retrieval, and also BLAST search and peptide match.
Sequence alig Sequence Alignment Pairwise alignment:-naveed ul mushtaq
Sequence Alignment Pairwise alignment:- Global Alignment and Local AlignmentTwo types of alignment Progressive Programs for multiple sequence alignment BLOSUM Point accepted mutation (PAM)PAM VS BLOSUM
In this presentation, I talk about the various tools for the submission of DNA or RNA sequences into various sequence databases. The sequence submission tools talked about in this presentation are BankIt, Sequin and Webin.
The Protein Data Bank (PDB) is a database for the three-dimensional structural data of large biological molecules, such as proteins and nucleic acids. This presentation deals with what, why, how, where and who of PDB. In this presentation we have also included briefing about various file formats available in PDB with emphasis on PDB file format
Protein Sequence, Structure, and Functional Databases: UniProtKB, Swiss-Prot, TrEMBL, PIR, MIPS, PROSITE, PRINTS, BLOCKS, Pfam, NDRB, OWL, PDB, SCOP, CATH, NDB, PQS, SYSTERS, and Motif. Presented at UGC Sponsored National Workshop on Bioinformatics and Sequence Analysis conducted by Nesamony Memorial Christian College, Marthandam on 9th and 10th October, 2017 by Prof. T. Ashok Kumar
This presentation gives you a detailed information about the swiss prot database that comes under UniProtKB. It also covers TrEMBL: a computer annotated supplement to Swiss-Prot.
INTRODUCTION
WHAT IS DATA AND DATABASE?
WHAT IS BIOLOGICAL DATABASE?
TYPES OF BIOLOGICAL DATABASE
PRIMARY DATABASE
Nucleic acid sequence database
Protein sequence database
SECONDARY DATABASE
COMPOSITE DATABASE
TERTIARY DATABASE
WHY NEED?
CONCLUSION
REFRENCES
Genome annotation, NGS sequence data, decoding sequence information, The genome contains all the biological information required to build and maintain any given living organism.
Genomic databases are referred to as online repositories of genomic variants, described for a single (locus-specific) or more (general) genes or specifically for a population or ethnic group (national/ethnic).
An integrated publicly accessible bioinformatics resource to support genomic/proteomic research and scientific discovery.
Established in 1984, by the National Biomedical Research Foundation (NBRF) Georgetown University Medial Center, Washington D.C., USA.
It is the source of annotated protein databases and analysis tools for the researchers.
Serve as primary resource for the exploration of protein information.
Accessible by text search for entry and list retrieval, and also BLAST search and peptide match.
Sequence alig Sequence Alignment Pairwise alignment:-naveed ul mushtaq
Sequence Alignment Pairwise alignment:- Global Alignment and Local AlignmentTwo types of alignment Progressive Programs for multiple sequence alignment BLOSUM Point accepted mutation (PAM)PAM VS BLOSUM
In this presentation, I talk about the various tools for the submission of DNA or RNA sequences into various sequence databases. The sequence submission tools talked about in this presentation are BankIt, Sequin and Webin.
The Protein Data Bank (PDB) is a database for the three-dimensional structural data of large biological molecules, such as proteins and nucleic acids. This presentation deals with what, why, how, where and who of PDB. In this presentation we have also included briefing about various file formats available in PDB with emphasis on PDB file format
Protein Sequence, Structure, and Functional Databases: UniProtKB, Swiss-Prot, TrEMBL, PIR, MIPS, PROSITE, PRINTS, BLOCKS, Pfam, NDRB, OWL, PDB, SCOP, CATH, NDB, PQS, SYSTERS, and Motif. Presented at UGC Sponsored National Workshop on Bioinformatics and Sequence Analysis conducted by Nesamony Memorial Christian College, Marthandam on 9th and 10th October, 2017 by Prof. T. Ashok Kumar
PowerMV is a software environment for statistical analysis, molecular viewing, descriptor generation, and similarity search.
In this presentation we will study about two modules nearest neighbor search an molecular descriptor generation.
Lyme disease, the most common vector-borne illness in the United States, is a multisystem illness caused by infection with the spirochete Borrelia burgdorferi and the body's immune response to the infection. The disease is transmitted to humans via tick bites, from infected ticks of the genus Ixodes.
Structural Bioinformatics - Homology modeling & its ScopeNixon Mendez
Homology modeling also known as comparative modeling uses homologous sequences with known 3D structures for the modelling and prediction of the structure of a target sequence
Homology modeling is one of the most best performing prediction methods that gives “accurate” predicted models.
Errors and Limitaions of Next Generation SequencingNixon Mendez
High throughput sequencing technologies has made whole genome sequencing and resequencing available to many more researchers and projects.
Cost and time have been greatly reduced.
The error profiles and limitations of the new platforms differ significantly from those of previous sequencing technologies.
The selection of an appropriate sequencing platform for particular types of experiments is an important consideration.
NGS sequencing errors focuses mainly on the following points:
1.Low quality bases
2.PCR errors
3.High Error rate
NGS has inherent limitations they are as follows :
1.Sequence properties and algorithmic challenges
2.Contamination or new insertions
3.Repeat content
4.Segmental duplications
5.Missing and fragmented genes
6.Reference index
BioPerl is an active open source software project supported by the Open Bioinformatics Foundation.
BioPerl is a product of community effort to produce Perl code which is useful in biology.
BioPerl is a collection of Perl modules
It has played an integral role in the Human Genome Project
Addressing the shortage of medical doctors in zambiaNixon Mendez
An expert system is a computer system that emulates the decision making ability of a human expert.
Zambia faces a severe shortage of medical personnel, especially medical doctors due to migration and limited number of medical schools. Rural areas are mostly affected.
Other causes of the inadequate number of trained health personnel.
Early retirement by health.
Change in careers.
Some tend to join politics.
Some specialist health workers get infected with HIV- AIDS.
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Clustering Analysis is a collection of patterns into clusters based on similarity.
Here we will discuss on the following :
Microarray Data of Yeast Cell Cycle
Clustering Analysis :-
Principal Component Analysis (PCA)
Multidimensional Scaling (MDS)
K-Means
Self-Organizing Maps (SOM)
Hierarchical Clustering
Mascot is a software package from Matrix Science that interprets mass spectral data into protein identities.
In this presentation we will study about MASCOT and also on how to use it.
Cytoscape plugins - GeneMania and CentiScapeNixon Mendez
Cytoscape is an open source software platform. It provides features for data integration, analysis and visualization.
Additional features are available in the form of apps (plugins).
These apps can be used for network analyses, molecular scripting and connection with databases.These apps are available in Cytoscape App Store.
2D-PAGE is a method is used for the separation and identification of proteins in a complex mixture using two separate dimensions that are run perpendicular to one another.
2D-DIGE is an advanced version of classical two-dimensional gel electrophoresis (2D-PAGE).
The protein samples are labeled with fluorescent dyes and then separated by 2D-PAGE.
Recently, it was reported that the forkhead box O (FoxO) transcription factor promotes human cytomegalovirus (HCMV)
replication via direct binding to the promoters of the major immediate-early (MIE) genes, but how the FoxO factor impacts HCMV
replication remains unknown. In this report, we found that human cytomegalovirus (HCMV), a beta herpesvirus member, could
dramatically induce the expression of FOXOs in the infected human fibroblasts. The induced FOXOs were recruited into the viral
replication compartments (vRC) in the nucleus, especially at the late stage of infection. Suppression of FOXO expression by RNA
interference significantly inhibited HCMV replication, and the production of progeny virus was reduced remarkably.
Mechanistically, FOXO knockdown intensively crippled viral late gene expression at the transcriptional level, while it only
marginally affected viral DNA synthesis. This study highlights how FoxO enhances HCMV gene transcription and viral replication
to promote productive infection
Bioinformatics is a science field that is similar to but distinct from biological computation, while it is often considered synonymous to computational biology.
Software Delivery At the Speed of AI: Inflectra Invests In AI-Powered QualityInflectra
In this insightful webinar, Inflectra explores how artificial intelligence (AI) is transforming software development and testing. Discover how AI-powered tools are revolutionizing every stage of the software development lifecycle (SDLC), from design and prototyping to testing, deployment, and monitoring.
Learn about:
• The Future of Testing: How AI is shifting testing towards verification, analysis, and higher-level skills, while reducing repetitive tasks.
• Test Automation: How AI-powered test case generation, optimization, and self-healing tests are making testing more efficient and effective.
• Visual Testing: Explore the emerging capabilities of AI in visual testing and how it's set to revolutionize UI verification.
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GDG Cloud Southlake #33: Boule & Rebala: Effective AppSec in SDLC using Deplo...James Anderson
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The software team must secure its software delivery process to avoid vulnerability and security breaches. This needs to be achieved with existing tool chains and without extensive rework of the delivery processes. This talk will present strategies and techniques for providing visibility into the true risk of the existing vulnerabilities, preventing the introduction of security issues in the software, resolving vulnerabilities in production environments quickly, and capturing the deployment bill of materials (DBOM).
Speakers:
Bob Boule
Robert Boule is a technology enthusiast with PASSION for technology and making things work along with a knack for helping others understand how things work. He comes with around 20 years of solution engineering experience in application security, software continuous delivery, and SaaS platforms. He is known for his dynamic presentations in CI/CD and application security integrated in software delivery lifecycle.
Gopinath Rebala
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Essentials of Automations: Optimizing FME Workflows with ParametersSafe Software
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Join us for an insightful dive into the world of FME parameters, a critical element in optimizing workflow efficiency. This webinar marks the beginning of our three-part “Essentials of Automation” series. This first webinar is designed to equip you with the knowledge and skills to utilize parameters effectively: enhancing the flexibility, maintainability, and user control of your FME projects.
Here’s what you’ll gain:
- Essentials of FME Parameters: Understand the pivotal role of parameters, including Reader/Writer, Transformer, User, and FME Flow categories. Discover how they are the key to unlocking automation and optimization within your workflows.
- Practical Applications in FME Form: Delve into key user parameter types including choice, connections, and file URLs. Allow users to control how a workflow runs, making your workflows more reusable. Learn to import values and deliver the best user experience for your workflows while enhancing accuracy.
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- Pro Tips for Success: Gain insights on parameterizing connections and leveraging new features like Conditional Visibility for clarity and simplicity.
We’ll wrap up with a glimpse into future webinars, followed by a Q&A session to address your specific questions surrounding this topic.
Don’t miss this opportunity to elevate your FME expertise and drive your projects to new heights of efficiency.
State of ICS and IoT Cyber Threat Landscape Report 2024 previewPrayukth K V
The IoT and OT threat landscape report has been prepared by the Threat Research Team at Sectrio using data from Sectrio, cyber threat intelligence farming facilities spread across over 85 cities around the world. In addition, Sectrio also runs AI-based advanced threat and payload engagement facilities that serve as sinks to attract and engage sophisticated threat actors, and newer malware including new variants and latent threats that are at an earlier stage of development.
The latest edition of the OT/ICS and IoT security Threat Landscape Report 2024 also covers:
State of global ICS asset and network exposure
Sectoral targets and attacks as well as the cost of ransom
Global APT activity, AI usage, actor and tactic profiles, and implications
Rise in volumes of AI-powered cyberattacks
Major cyber events in 2024
Malware and malicious payload trends
Cyberattack types and targets
Vulnerability exploit attempts on CVEs
Attacks on counties – USA
Expansion of bot farms – how, where, and why
In-depth analysis of the cyber threat landscape across North America, South America, Europe, APAC, and the Middle East
Why are attacks on smart factories rising?
Cyber risk predictions
Axis of attacks – Europe
Systemic attacks in the Middle East
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https://sectrio.com/resources/ot-threat-landscape-reports/sectrio-releases-ot-ics-and-iot-security-threat-landscape-report-2024/
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Cheryl Hung, ochery.com
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Neuro-symbolic is not enough, we need neuro-*semantic*Frank van Harmelen
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All of this illustrated with link prediction over knowledge graphs, but the argument is general.
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Watch this recorded webinar about real-time monitoring of application performance. See how to integrate Apache JMeter, the open-source leader in performance testing, with InfluxDB, the open-source time-series database, and Grafana, the open-source analytics and visualization application.
In this webinar, we will review the benefits of leveraging InfluxDB and Grafana when executing load tests and demonstrate how these tools are used to visualize performance metrics.
Length: 30 minutes
Session Overview
-------------------------------------------
During this webinar, we will cover the following topics while demonstrating the integrations of JMeter, InfluxDB and Grafana:
- What out-of-the-box solutions are available for real-time monitoring JMeter tests?
- What are the benefits of integrating InfluxDB and Grafana into the load testing stack?
- Which features are provided by Grafana?
- Demonstration of InfluxDB and Grafana using a practice web application
To view the webinar recording, go to:
https://www.rttsweb.com/jmeter-integration-webinar
UiPath Test Automation using UiPath Test Suite series, part 3DianaGray10
Welcome to UiPath Test Automation using UiPath Test Suite series part 3. In this session, we will cover desktop automation along with UI automation.
Topics covered:
UI automation Introduction,
UI automation Sample
Desktop automation flow
Pradeep Chinnala, Senior Consultant Automation Developer @WonderBotz and UiPath MVP
Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
3. Introduction
“Bioinformatics is an interdisciplinary field which is a
combination of many areas such as computer science,
statistics, mathematics and engineering to process
biological data ”
• What is BIOINFORMATICS ?
4. • GENOME
“The genome encodes all the information of the
Deoxyribonucleic Acid (DNA), the
macromolecule containing the genetic heritage
of each living being.”
• Increased electronically stored biological data
• Role of databases in the field of biology
5. • The study of genes and proteins has become an extremely
important area in the modern day biology and they are
better known as genomics and proteomics
• Genome databases store this information and differently
from gene databases the genome databases contain both
coding and non-coding intergenic sequences.
Background
Genome Databases
6. • Saccharomyces genome database
• Mouse genome database
• Human genome database
• European mutant mouse pathology database
• Mito Map
• Kyoto Encyclopedia of Genes and Genomes
Genome Databases
7. • High complex data
• Schema changes at a rapid pace
• Range of variability in data is high
• Complex queries
Characteristics of genome database
systems
8. • Non standard and unstructured data
• Complex query processing
• Data interpretation and meta data management
• Data integration across related databases
• Uniform data management solutions
Key Areas in Data Management in
Genome Database Systems
9. • Graph Based Genome Database Systems
• Generic genome browser
• Networked database environment for human
genome data
• The ENSEMBL genome database project
• MITOMAP
• The BIOGRID Interaction Database
• Data management for high throughput genomics
Major researches
10. • For research purposes
• Health Industry
• Study how variation in human genetics leads to
variation in response to drugs.
• Disease studies for large populations
• Drug Designing
Applications and Impact
on Society
11. • Genome database systems is one of the major research
areas in the world
• Health care, pharmaceutical organizations spend tons of
money to do researches to maintain genome databases
and implement effective and efficient tools to analyze
data.
• The main concerns in genome database systems are the
variability of the data types that they are associated with,
high throughput of genomic data, Meta data management,
data storage problem, complex query and complex
calculations are needed and data integration with different
databases
DISCUSSION
12. • Mainly the issues have occurred because of the
complexity of the data types in genome databases and
therefore the traditional relational DBMS concepts and
Object DBMS concepts are not the most suitable
concepts to tackle these issues.
• Researches have been carried out to discover novel
methods of representing data types in genome databases
• Some of the researches are targeting to identifying ways
which can be used to couple with the existing database
management systems so that only an extension is needed
for the usage.
13. • The people who use genome database systems are
scientists, academics and other people who are in the field
of genomics.
• Most of these people do not have a good knowledge in
Information Technology.
• Therefore improving the synergy between these two
fields is an important task,