This document discusses supracondylar fractures of the femur. It defines these fractures as involving the distal aspect of the femur, including the distal 8 to 15 cm. Complex classification systems exist to define the degree of comminution and displacement. Treatment goals are to restore alignment with less than 1-2mm of articular step-off and achieve stability through restored bony congruity and rigid hardware fixation. Rehabilitation involves initial non-weight bearing, active range of motion exercises, and progressing to full weight bearing over 3 months.
A fractured neck of femur (NOF) is a serious injury, especially in older people. It is likely to be life changing and for some people life threatening.
Neck of femur fractures (NOF) are common injuries sustained by older patients who are both more likely to have unsteadiness of gait and reduced bone mineral density, predisposing to fracture. Elderly osteoporotic women are at greatest risk.
Presentation on different levels of amputation of upper limb including hand amputations., thumb reconstructions, kruckenberg amputation, thumb poloicization.
Hoffa's Fracture: Diagnosis, management & New Classification System by BAGARI...Vaibhav Bagaria
Hoffa's Fracture - coronal split fracture of distal femur, its diagnosis, management strategy, a new classification and tips and tricks of management. First described Hoffa, a new classification system by Bagaria et al helps plan the surgery for these tricky fracture. The most crucial step is not to miss these fractures in ER.
A fractured neck of femur (NOF) is a serious injury, especially in older people. It is likely to be life changing and for some people life threatening.
Neck of femur fractures (NOF) are common injuries sustained by older patients who are both more likely to have unsteadiness of gait and reduced bone mineral density, predisposing to fracture. Elderly osteoporotic women are at greatest risk.
Presentation on different levels of amputation of upper limb including hand amputations., thumb reconstructions, kruckenberg amputation, thumb poloicization.
Hoffa's Fracture: Diagnosis, management & New Classification System by BAGARI...Vaibhav Bagaria
Hoffa's Fracture - coronal split fracture of distal femur, its diagnosis, management strategy, a new classification and tips and tricks of management. First described Hoffa, a new classification system by Bagaria et al helps plan the surgery for these tricky fracture. The most crucial step is not to miss these fractures in ER.
An Introduction, History, Diagnosis, Current Guidelines on Treatment of trochanteric fractures of femur. Presentation also contain an introduction of Dynamic Hip Screw and Surgical Techniques.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
This lecture is brief introduction into principles of fractures management.
The lecture presented and made by a 4th year medical student at kufa university.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
2. Definition
• A supracondylar femur fracture involves the
distal aspect or metaphysis of the femur.
• This area includes the distal 8 to 15 cm of the
femur.
• The fracture frequently involves articular
surfaces.
12/4/2008 dnbid 2
3. • Complex classification systems have been
proposed for this fracture, all of which
attempt to define the amount of comminution
and the degree of displacement of the
fracture fragments.
12/4/2008 dnbid 3
4. • Muller's update of the AO classification system is
widely accepted.
• This involves dividing the fractures into extraarticular
(type A), unicondylar (type B), and bicondylar (type
C) fractures.
• These are then subdivided into types 1 through 3 in
each group.
• In progressing from type A to C, as well as subtypes 1 to 3, the
severity of the fracture increases and the prognosis for a good
result decreases (Figures 25-1, 25-2, 25-3, and 25-4).
•
12/4/2008 dnbid 4
7. Mechanism of Injury
• In younger patients, this fracture is usually secondary
to high-energy trauma, such as being struck by
an automobile.
• These cases commonly have other associated
injuries.
• In elderly patients, this fracture is usually secondary
to low-energy trauma, such as a simple fall.
• There are usually no other associated injuries in
these cases (Figure 25-5).
12/4/2008 dnbid 7
8. Treatment Goals
• Orthopaedic Objectives
Alignment
• Restore alignment by minimizing any residual
flexion/extension or varus/valgus angulation at the
fracture site.
• Any articular step-off must be less than 1 to 2 mm in
order to decrease or delay the risk of degenerative
changes and allow for functional range of motion
and normal gait.
12/4/2008 dnbid 8
9. Stability
• Stability is best achieved by restoring bony congruity
and using hardware to rigidly fix the fracture.
12/4/2008 dnbid 9
17. Casting or Traction
• Biomechanics: Stress-sharing device.
• Mode of Bone Healing: Secondary.
12/4/2008 dnbid 17
18. • Indication: Treatments involving traction or casting are
associated with a high risk of malunion, including varus,
valgus, and rotational deformities.
• Additionally, treatment with traction requires a prolonged
period of bed rest, with its associated risks of deep venous
thrombosis, bed sores, urinary tract infections, and
pulmonary compromise.
• This conservative treatment is indicated only for the
management of severely comminuted #s or for patients who
are at high medical risk for any operative management.
(Figures 25-10 and 25-11).
12/4/2008 dnbid 18
23. Gait Cycle
• Stance Phase
Stance phase, constituting 60% of the gait cycle, is most
affected by the fracture.
• Heel Strike
The quadriceps contracts concentrically to bring the
knee to full extension. However, a knee-flexion contracture
may exist. The patellar groove may be disrupted and the glide
mechanism of the patella in the groove may be affected,
causing pain. The extensor mechanism that surrounds the
knee joint may also be compromised. Occasionally the glide
mechanism of the quadriceps is also involved, thus limiting
terminal extension (see Figure 6-1).
12/4/2008 dnbid 23
24. • Foot-Flat
Foot-flat is usually not affected; however, the quadriceps
contracts eccentrically through elongation to keep the knee
under slight tension. Muscle contraction may cause some pain
(see Figure 6-2).
• Mid-Stance
Full weight passes through the fracture site at midstance,
because there is only single-limb support. Pain may be
present (see Figure 6-3).
• Push-Off
Push-off is usually not affected. The patella lies in the
trochlear groove at this phase and may cause pain (see Figure
6-4)12/4/2008 dnbid 24
25. • Swing Phase
• The swing phase constitutes 40% of the gait cycle.
• The quadriceps contract to cause acceleration of the
tibia on the femur.
• The quadriceps glide mechanism is necessary to
allow the knee to go to full extension before heel
strike.
• The quadriceps may not be able to contract enough
to achieve full extension (see Figures 6-6,6-7, and 6-8).
12/4/2008 dnbid 25
27. Orthopaedic and Rehabilitation
Considerations
• Physical Examination
• Initially, the most important aspect to check is the
patient's neurovascular status.
• Check pulses and capillary refill, as well as sensation
and active and passive range of motion of the
extremity.
• (Do not perform passive range of motion of the knee
unless absolutely rigid fixation has been achieved.)
12/4/2008 dnbid 27
28. • Check lower extremity compartments for softness
and monitor compartment pressures if there is any
suspicion of compartment syndrome.
• Additionally, check the wound for erythema or
discharge that might indicate infection.
• If edema is present, the patient should be instructed
to elevate the extremity properly.
12/4/2008 dnbid 28
29. • Dangers
Look for compartment syndrome, especially when
popliteal vessels are injured.
• Compartment syndrome is more common with high-
energy trauma and is usually noted in the first few
hours after injury.
12/4/2008 dnbid 29
30. • Radiography
• Check radiographs for varus, valgus, and rotational
alignment at the fracture site, as compared to the
unaffected knee.
• Also check for any displacement or loss of fixation.
• Because these fractures generally involve the
metaphyseal region, which has a good blood supply,
fracture healing usually occurs within the first 3
months after injury.
12/4/2008 dnbid 30
31. • Weight Bearing
The patient is non-weight bearing on the affected
extremity for 3 months.
12/4/2008 dnbid 31
32. • Range of Motion
• Gentle active ROM exercises are prescribed to the knee,
ankle, and hip.
• If fixation is not rigid, passive ROM exercises are avoided.
• If ankle edema is present, the ankle is elevated to decrease
swelling.
• Patients are encouraged to perform active ROM exercises at
the knee joint with the goal of full extension and 60 ° to 90 °
of knee flexion.
• Patients who are noncompliant or cannot follow orders are
placed in a hinged-knee brace or cast brace to allow for
protected ROM exercises.
12/4/2008 dnbid 32
33. • Muscle Strength
No strengthening exercises are prescribed at this
point to avoid risk of fracture displacement.
• Functional Activities
• The patient is instructed in stand/pivot transfers
using crutches or a walker, with no weight-bearing on
the affected extremity.
• The patient dons pants with the affected extremity first and
doffs them from the unaffected extremity first to decrease
stress on the fracture site.
12/4/2008 dnbid 33
34. • Gait
• The patient is instructed in a two-point gait using crutches or
a walker with no weight bearing on the affected extremity
(placing the crutches first and then hopping to the crutches on level
surfaces. See Figure 6-16).
• The patient ascends stairs with the uninvolved extremity first,
followed by the fractured extremity and the crutches, and
descends stairs with the crutches first, followed by the
fractured extremity first and then the uninvolved extremity
(see Figures 6-20,6-21,6-22, 6-23, 6-24, and 6-25).
12/4/2008 dnbid 34
48. Long-Term Considerations and Problems
• At every stage of treatment, radiographs should be
obtained to evaluate for loss of reduction, because a
malunion may lead to shortening or rotational
deformities and may hasten the onset of
degenerative joint disease of the knee.
12/4/2008 dnbid 48
49. • Additionally, a loss of motion of the knee is common.
• Therefore, every attempt should be made to obtain
rigid fixation, thus allowing the patient to begin
range-of-motion exercises early in treatment.
• Patients are not permitted to participate in sports,
repetitive pounding activities, jogging, or jumping for
6 months from the time of injury.
12/4/2008 dnbid 49