Laparoscopic Low Anterior Resection for Cancer : “Pursued or just Permitted?”...Dimitris P. Korkolis
Potential Advantages of Lap TME
- Less blood loss
- Faster recovery
- Earlier return of gut function
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- Magnified view allows precise dissection (pelvic autonomics)
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Indications to CTC are increasing
CTC is recommended in all cases of unfeasibility of colonoscopy
CTC is not ready for mass screening but is ideal for screening on an individual basis.
Laparoscopic Low Anterior Resection for Cancer : “Pursued or just Permitted?”...Dimitris P. Korkolis
Potential Advantages of Lap TME
- Less blood loss
- Faster recovery
- Earlier return of gut function
- Lower morbidity and mortality
- Magnified view allows precise dissection (pelvic autonomics)
- Earlier hospital discharge
Indications to CTC are increasing
CTC is recommended in all cases of unfeasibility of colonoscopy
CTC is not ready for mass screening but is ideal for screening on an individual basis.
Similar to Feasibility of CT scan studies with triple split bolus intravenous contrast medium technique and reduced radiation dose for potential kidney donors
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Learning objectives:
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2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
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5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
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combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
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AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
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of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
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ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
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- Prix Galien International Awards Ceremony
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
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Feasibility of CT scan studies with triple split bolus intravenous contrast medium technique and reduced radiation dose for potential kidney donors
1. Original Article
einstein. 2009; 7(4 Pt 1):421-6
Feasibility of CT scan studies with triple split bolus intravenous contrast medium technique and reduced radiation dose for potential kidney donors
Viabilidade do estudo tomográfico com triplo fracionamento do contraste endovenoso e redução da dose de radiação para candidatos a doadores renais
Bruna Schmitz Serpa1, Ronaldo Hueb Baroni2, Adriano Tachibana3, Marcelo Buarque de Gusmão Funari4
A
BSTRACT
Objective: To show that it is possible to reduce the radiation dose in the examination of potential kidney donors by splitting the contrast injection followed by a single scanning, enabling evaluation of vascular structures, renal parenchyma and collecting system/ ureters, using computed tomography protocols with reduced mAs. Methods: Twenty-six potential donors were evaluated based on the following criteria: image quality, radiation dose reduction, and complications associated with the exam. The criteria were scored by two examiners, and the differences were resolved by consensus. Results: For each item assessed, 85 to 90% of studies were scored as very good or excellent with regards to image quality. There was excellent interobserver agreement, and there were no significant differences between the exams with low radiation dose compared to those with the conventional dose. No exam-related complications were observed. Conclusions: The CT scan study with triple-split bolus technique and low dose is effective for reducing the dose of radiation to potential kidney donors.
Keywords: Control over radiation exposure; Donor selection; Tissue donors; Tomography, spiral computed/methods; Tomography, spiral computed/adverse effects
RE
SUMO
Objetivo: Demonstrar que é possível reduzir a dose de radiação nos exames de candidatos a doadores renais, por meio do fracionamento do contraste injetado seguido de uma única aquisição que permita a avaliação das estruturas vasculares, parênquima renal e via excretora, e pela utilização de protocolos com redução de mAs nos aparelhos de tomografia. Métodos: Foram avaliados 26 potenciais doadores, por meio dos critérios qualidade da imagem, redução da dose e complicações associadas ao exame. Os critérios foram pontuados por dois examinadores e as disparidades foram dirimidas por consenso. Resultados: Para cada item avaliado, 85 a 90% dos estudos foram pontuados como muito bom ou excelente em relação à qualidade de imagem. Houve ótima concordância interobservador e não foram observadas diferenças significativas entre os exames com baixa dose de radiação quando comparados àqueles com dose convencional. Nenhuma complicação relacionada ao exame foi evidenciada. Conclusões: O estudo tomográfico com triplo fracionamento de contraste endovenoso e com baixa dose se mostrou eficaz para a redução da dose de radiação nos candidatos a doadores renais.
Descritores: Controle da exposição à radiação; Seleção do doador; Doadores de tecidos; Tomografia computadorizada espiral/métodos; Tomografia computadorizada espiral/efeitos adversos
INTR
ODUCTION
The current surgery of choice for kidney donors is videolaparoscopic nephrectomy. Because of visual field limitations associated with this procedure, an image exam is paramount in order to study the urinary system in details, especially the vessels of potential donor tissues(1-2).
It is fundamental to perform an anatomical evaluation of renal arteries and veins, of the kidney collecting system and parenchyma in potential renal donors, since the feasibility of donation depends on a rigorous preoperative evaluation of these structures(3-5). Figure 1 shows the anatomy of this region.
Study carried out at the Imaging Department at Hospital Israelita Albert Einstein – HIAE, São Paulo (SP), Brazil.
1 Resident of Radiology of Hospital Israelita Albert Einstein – HIEA, São Paulo (SP), Brazil.
2 PhD; Radiologist of Hospital Israelita Albert Einstein – HIAE, São Paulo (SP), Brazil.
3 Radiologist of Hospital Israelita Albert Einstein – HIAE, São Paulo (SP), Brazil.
4 PhD; Head of the Imaging Department of Hospital Israelita Albert Einstein – HIAE, São Paulo (SP), Brazil.
Corresponding author: Ronaldo Hueb Baroni – Avenida Albert Einstein, 627/701 – Morumbi – CEP 05651-901 – São Paulo (SP), Brasil – e-mail: rbaroni@einstein.br
Received on: April 3, 2009 – Accepted on: Oct 16, 2009
2. einstein. 2009; 7(4 Pt 1):421-6
422
Serpa BS, Baroni RH, Tachibana A, Funari MBG
Figure 1. Schematic view of renal anatomy, collecting system and their vessels
Figure 2. Topogram of an abdominal CT
Figure 3. Axial slices of abdominal CT in a standard urotomography protocol, characterizing the arterial, venous and excretory phases, respectively
Figure 4. Axial slice of abdominal CT in a kidney donor protocol with contrast fractioning, characterizing the arterial, venous and excretory phases in a single acquisition
Multiple detector spiral computed tomography (MDCT) is fast, not very invasive and allows replacing, with a single and better test, excretory urogram, ultrasound and arteriography. For these reasons, MDCT with a dedicated protocol (urotomography or Uro-CT) became the test of choice for preoperative evaluation of potential kidney donors(5-10). Nonetheless, the MDCT submits potential donors to high radiation doses, when compared to other methods – which is especially concerning when considering young and healthy individuals.
Thus, it is desirable to have a technique which allows for a maximum reduction in radiation dose, without significant loss in the diagnostic quality of the test within the ALARA (as low as reasonably achievable) concept.
Radiation dose automated modulation is calculated before the test, through the analysis of the abdomen topogram in two views (front and side views), as per illustrated in figure 2. the ‘low dose’ protocol, more noise is accepted in the image when compared to the ‘standard dose’ protocol.
Besides being possible to reduce the radiation dose by reducing mAs and having an automatic dose modulation in the state-of-the-art MDCT devices, they also provide the option to reduce the number of test phases – since routinely MDCT for donors is carried out in four phases (pre-contrast, arterial/cortico-medullary, venous/nephrographic and excretory).
Contrast triple splitting is based on the intravenous injection of a standard dose of iodine contrast split into four injections, seven minutes apart from each other (for the excretory phase), one minute (venous phase) and 30 seconds (arterial phase), followed by one single scan. As an example, we showed a standard urotomography test in its arterial, venous, excretory phases, respectively, in Figure 3, and the merging of these three phases by this new protocol (Figure 4).
The parameters are automatically adjusted according to the amount of background noise accepted. Thus, in
OBJECTIVE
The goal of this study was to reduce the radiation dose used in the MDCT testing of potential kidney donors, by means of a single scanning which allows physicians
3. einstein. 2009; 7(4 Pt 1):421-6
Feasibility of CT scan studies with triple split bolus intravenous contrast medium technique and reduced radiation dose for potential kidney donors
423
T
able 1. Score of image quality per anatomical structure and overall quality
C
ategory
R
enal parenchyma
A
rteries
Veins
Ureters
Bladder
C
ollecting system
G
eneral
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
2
0
0
0
0
0
0
0
3
1
0
0
8
8
6
0
4
17
2
6
11
18
7
20
5
8
24
20
7
0
13
6
0: no diagnosis; 1: poor; 2: regular; 3: good; 4: very good; 5: excellent.
Figure 5. MIP reconstruction of an exam of the renal donor protocol
to assess the arterial, venous and excretory phases, and through the mAs reduction in this acquisition.
METHODS
Twenty-six potential kidney donors who underwent CT scan for a preoperative evaluation from March 2008 to May 2009 were assessed, using the following criteria:
- image quality (a 0 to 5 scoring system, in which 0 is no diagnosis and 5 is excellent) for each structure assessed (renal parenchyma, collecting system, ureters, bladder, renal arteries and veins);
- dose reduction in relation to the conventional test.
The tests were carried out using a 64-channel Aquilion CT scan device (Toshiba, Otawara, Japan), with contrast administration in three injections, 30 ml (seven minutes before image acquisition for the excretory phase), 45 ml (one minute before image acquisition for the venous phase) and 0.6 ml/kg (30 seconds before image acquisition for the arterial phase).
In the standard dose kidney donor protocol, the mA (55) and the rotation time (0.5 s) are fixed, resulting in one mAs of 110. An acceptable noise level is established in the dose modulation and the equipment alternates the mA according to the thickness of the anatomical region irradiated.
The criteria were evaluated by two examiners. The statistical analysis was carried out using the Kappa method of interobserver agreement and a nonparametric test.
RE
SULTS
For each item assessed, most studies were scored as very good (4) or excellent (5) as far as image quality goes, as seen on Table 1.
The bladder and ureters had a lower score when compared to other parameters – however, all of them were good, very good or excellent –, probably because of the lack of maneuvers for a specific bladder study and the lack of complementary image acquisition for the ureters when not properly contrasted. Thus, even these structures were satisfactorily evaluated.
Figures 5 and 6 show acquisition through triple split contrast in one of the studies carried out by three- dimensional reconstructions, using the techniques of maximum intensity projection (MIP) and volume rendering (VR).
The Kappa value for the interobserver agreement measure obtained from the analysis was 0.752 (p < 0.001, 95% confidence interval), characterizing a good agreement between observers.
Out of 26 potential donors in this study, 11 had a reduced dose also by mAs (low dose), and 15 did the test with the regular mAs standards for an abdominal CT. An analysis was carried out on these two populations by the same image quality criteria. In order to assess potential differences between the approaches, we used the Mann- Whitney nonparametric test, using the median values, as per depicted on table 2.
4. einstein. 2009; 7(4 Pt 1):421-6
424 Serpa BS, Baroni RH, Tachibana A, Funari MBG
Both protocols were considered very good (median 4) as to diagnosis, and there was no significant diagnostic difference between them. Images from both methods are depicted on figures 7 and 8: figure 7 shows the kidney donor protocol with the standard dose, and figure 8 shows the kidney donor protocol with low dose.
The radiation measured in Sievert (Sv) – which is the equivalent dose calculated in human tissue – of a conventional urotomography in MDCT in our ward, was approximately 48 mSv. The kidney donor protocol standard dose was about 20 mSv and with low dose of approximately 14 mSv. Total dose reduction was roughly 70% when compared to a complete Uro-CT study, bringing the same necessary anatomical information for a proper preoperative planning.
DISCUSSION
Potential kidney donors require a broad preoperative assessment, including an accurate radiological exam. The anatomical information required for laparoscopic nephrectomy in live kidney donors include number, size, location and branching pattern of the kidney veins and arteries, as well as a detailed assessment of the parenchyma and renal collecting system(1-4).
MDCT proved to be an accurate alternative for surgical planning purposes. MDCT advantages include fast data acquisition, broad anatomical coverage, proper opacification of vessels and collecting system, and outstanding spatial resolution. In recent years, MDCT has been established as the method of choice for the preoperative evaluation of potential kidney donors. However, since the MDCT submits potential kidney donors (usually young and healthy individuals) to high doses of radiation, one alternative is a maximum
Figure 6. VR reconstruction of the same exam of the renal donor protocol
T
able 2. Median of image quality in the low dose and standard dose studies
T
ype of study
n
Median
Low dose
11
4.000
Standard dose
15
4.000
Figure 7. Axial slice of abdominal CT in a kidney donor protocol with the standard dose (120 kV and mAs of 110)
Figure 8. Axial slice of abdominal CT in a kidney donor protocol with low dose (120 kV and mAs of 70)
5. einstein. 2009; 7(4 Pt 1):421-6
Feasibility of CT scan studies with triple split bolus intravenous contrast medium technique and reduced radiation dose for potential kidney donors 425
radiation dose reduction without reducing diagnostic power(5,8-9,11).
Magnetic resonance angiography (angio-MRI) is a doable test modality for the preoperative evaluation of kidney donors. Recent MRI studies with gadolinium have shown high rates of accuracy – comparable to conventional angiography and to the Angio- CT regarding the assessment of live donors. Jha et al. assessed 64 patients submitted to laparoscopic nephrectomy, and reported that MRI showed arterial anomalies with an 89% sensitivity, 94% specificity, and 91% accuracy(12). Nonetheless, MRI is a more expensive test, less available, longer in duration and with a lower spatial resolution when compared to the MDCT, and it also does not detect occasional small stones in the collecting system(10,12).
ALARA means as low as reasonably achievable, and it is a radioprotection concept applicable to numerous radiological methods. Part of the principle assumes that there is no safe radiation dose, and all the noxious biological effects increase as dose increase, regardless of how small it is. Therefore, it is important to keep radiation doses in the lowest possible limit, especially when considering young and healthy patients(13).
Thus, it would be ideal to have a method that reduced to a minimum the radiation dose used in the test, without any significant loss of quality. Numerous studies have been carried out testing protocols, adjusting image acquisition parameters or trying fewer phases. Some groups, such as Kawamoto et al. and Foley, described methods eliminating one of the phases: venous and excretory, respectively, nonetheless with critics from many authors because of a greater difficulty in characterizing some structures(14-15).
The most promising recent study in this context used a protocol called Split Bolus. With the goal of reducing the radiation dose received by patients submitted to urotomography to investigate hematuria, Chow et al. proposed the use of two tomographic image acquisitions: before and after contrast injection. The studies were carried out with the contrast volume to be injected (120 ml) being divided into two doses as follows: the first, 40 ml at 2 ml/s, and the second was 80 ml, also injected at 2 ml/s. The interval between injections was four minutes, with a 120-second delay after the second dose, thus allowing visualization of the nephrographic and excretory phases at the same time(16). However, in this protocol there is no arterial phase study, since the idea is to diagnose the cause of hematuria. Thus, this protocol leaves much to be desired in those cases when it is necessary to carry out an arterial anatomy study, as is the case with kidney donors.
Aiming to meet this demand, this study suggests a protocol with three different iodine contrast injection turns (triple-split), and each is responsible for contrasting each of the systems one intends to study. Thus, with one single post-contrast tomographic image acquisition, one can obtain a simultaneous contrasting of the arterial, venous and collecting systems and, at the end of the test, one can achieve a proper study of the entire anatomy necessary for surgical planning, thus reducing the dose of ionizing radiation employed.
Another way to reduce the radiation dose for potential donors is by modulating the CT radiation dose. From the conventional Uro-CT to the triple-split protocol there was a 58% drop in the radiation dose, by only reducing the number of phases in the test. From the triple-split protocol to the triple-split with dose modulation protocol there was an additional 23% reduction in the radiation dose. In total, this study was able to reduce approximately by 70% the radiation dose when compared to a complete Uro-CT study, producing the same necessary anatomical information for a proper preoperative evaluation.
The present study has numerous limitations. First, we were unable to obtain surgical anatomy confirmation. Another limitation was the small sample size in this preliminary study. There was no matching of potential donor groups submitted to the protocols with standard dose and low dose of radiation. We believe further studies with a larger sample and surgical confirmation of the findings must be conducted in order to corroborate the results obtained in this investigation.
C
ONCLUSION
This study showed that contrast triple split MDCT with mAs reduction is an effective technique to reduce the preoperative radiation dose used to assess kidney donors, without significant loss of image quality.
RE
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11. Rydberg J, Kopecky KK, Tann M, Persohn SA, Leapman SB, Filo RS, et al. Evaluation of prospective living renal donors for laparoscopic nephrectomy with multisection CT: the marriage of minimally invasive imaging with minimally invasive surgery. Radiographics. 2001;21 Spec No:S223-36.
12. Jha RC, Korangy SJ, Ascher SM, Takahama J, Kuo PC, Johnson LB. MR angiography and preoperative evaluation for laparoscopic donor nephrectomy. AJR Am J Roentgenol. 2002;178(6):1489-95.
13. McCollough CH, Bruesewitz MR, Kofler JM. CT dose reduction and dose management tools: overview of available options. Radiographics. 2006;26(2): 503-12.
14. Foley WD. Renal MDCT. Eur J Radiol. 2003;45 Suppl 1:S73-8.
15. Kawamoto S, Lawler LP, Fishman EK. Evaluation of the renal venous system on late arterial and venous phase images with MDCT angiography in potential living laparoscopic renal donors. AJR Am J Roentgenol. 2005;184(2): 539-45.
16. Chow LC, Kwan SW, Olcott EW, Sommer G. Split-bolus MDCT urography with synchronous nephrographic and excretory phase enhancement. AJR Am J Roentgenol. 2007;189(2): 314-22.