Expo day: Digital Artefacts (BrainBaseline), HeartMath, Sleep Genius, The Alzheimer’s Research and Prevention Foundation

Sponsors
Expo Day Agenda
Afternoon
1-1:30am. Digital Artefacts
(BrainBaseline)
1:45-2:15pm. HeartMath
2:30-3pm. Sleep Genius
3:15-3:45pm. The Alzheimer’s Research
and Prevention Foundation

Joan Severson
201 East Washington Street
Suite 1302
Iowa City, IA 52240
Phone: (319) 431-3278
Email: joan@digitalartefacts.com
October 29, 2014
BrainBaseline
http://www.brainbaseline.com
Copyright Digital Artefacts 2014

BrainBaseline
BrainBaseline’s Broad Objectives
• Develop a global platform that integrates cognitive performance measures with
lifestyle and biometric information to track brain health over time
• Provide consumers, clinicians, pharmaceutical companies, and health care and
wellness communities a better understanding of brain health and function across
the lifespan.
• Inform and educate consumers on evidence-based behavioral interventions to
provide life-long cognitive health and wellness.
• Accelerate discovery and reduce the cost of research, clinical trials, and clinical
interventions.

BrainBaseline
BrainBaseline Platform
BrainBaselineTM is designed as a modular platform that aggregates health and
behavioral measures through embedded content and third party API integration. The
cornerstone of the application is our suite of over 40 cognitive tasks, which allow us to
determine the relationship between cognitive performance and other aspects of an
individual’s behavior or physical health. We present this information to users in a way that
is appealing and easy to understand; effectively, BrainBaseline is an education and
research platform that provides users with an engaging means of understanding,
testing, and improving their cognitive health.

BrainBaseline
BrainBaseline 2.0 Platform Overview
Lifestyle Activity Brain Drive Biometrics
What makes BrainBaselineTM 2.0 unique is the ability to combine these measures to
provide holistic snapshots of an individual’s psychological, physical and cognitive health,
providing this information to users in a way that allows them to better understand how
their brain health is linked to their behavior.

BrainBaseline
Components of BrainBaseline 2.0
User Dashboard:
The user dashboard acts as a hub that provides users with an
overall snapshot of their current behavioral, cognitive, and
lifestyle status in the form of summary scores and performance
trend lines. The data are populated dynamically and can be
adjusted instantly to provide social motivation, with users
being allowed to see how their status in each domain
compares to other anonymous users of the application in,
e.g., their age group or location, as well as connecting with
friends or family to compare scores against others in their social
network.

BrainBaseline

BrainBaseline
User Information: (lifestyle, demographics)
In the user information module, users answer a series of demographic
questions, including, age, gender, income level, education, and
geographic location, in addition to questions related to their preferred
leisure activities, overall level of activity. Other specific questionnaires or
self-report measures can be integrated on the basis of project-specific
requirements.

BrainBaseline
Cognitive Testing:
The cognitive testing module is the cornerstone of the BrainBaseline
application. The tests are mapped to specific cognitive domains, are brief
(individual tests take between 1 and 4 minutes), and are diverse in order
to maximize both user engagement and data quality. Furthermore, the
diversity and wide-ranging nature of BrainBaseline’s tests provide added
sensitivity to cognitive change, allowing more accurate detection of
decrements or improvements in cognition.

Over 40 testing
instruments
Attention
Working Memory
Executive Function
Motor Coordination
Spatial Processing
Speed of Processing
Verbal Recall
Fine Motor
Fatigue
BrainBaseline
CONFIDENTIAL October 21, 2014

BrainBaseline
Activity:
The activity module is a hub for users to monitor and aggregate
information about their level of activity and sleep, and allows them to set
activity and sleep goals that let them visualize and incentivize lifestyle
changes that lead to optimal physical and cognitive health. Current
functionality allows users to either self-report activity and sleep data, or
integrate directly with their FitBit, Jawbone UP, and Body Media trackers
for automated aggregation of these data.

BrainBaseline
Biometrics:
The Biometrics module allows users to aggregate biometric information
such as weight, blood pressure, heart rate, or blood-glucose level over
time. Users are able to set specific goals related to target levels of specific
biometric variables (e.g., blood pressure) as well as trend this information
over time.

BrainBaseline
Driving behavior tracking :
A unique aspect of the BrainBaseline platform is the ability to obtain
measures of complex driving behavior and use this information as an
additional ‘real-world’ data point with which to assess a subject’s overall
cognitive health.
The behavioral tracking module integrates with BrainBaseline’s
DriveMonitor mobile phone application, which uses GPS, accelerometer,
and video data to measure basic drive information (e.g., overall time on
road, miles/km driven) as well as detecting and marking unsafe driving
behaviors such as sudden stops or drastic swerves. These data can be
sent to the behavioral tracker, where subjects can monitor this information
over time to observe relationships between specific cognitive behaviors
and real world driving behaviors.

BrainBaseline
Medication tracking :
Future development is planned to support integration of medication
reminders, as well as tracking of prescription/over the counter
pharmaceutical use and dosage over time.

BrainBaseline
1 Million self administered consumer based tests by 2015

BrainBaseline
BrainBaseline 2.0 Platform Overview
BrainBaseline 2.0 is a scalable platform capable of integrating data from many varying
systems, developed both internally and externally, into cognitive profiles for varying
populations ranging from individual users up to groups based on activity, biometrics,
demographics and other factors. The platform itself focuses on data security, reliability
and extensibility.
BrainBaseline integration with Apple HealthKit and Electronic Health Records
Electronic
Health
Records

In conjunction with UCSD department of psychiatry we
have received NIH funding to develop an iPad-based
screening measure for HIV-associated neurocognitive
disorders.
• Screening takes 10 minutes to complete
• Self administered in clinic waiting room
• Automated scoring and reporting
• Aggregated data
• HIPPA compliant infrastructure
• Multiple language support, native iOS development
• Global Research sties
• US, Japan, South Africa
BrainBaseline
Clinical Screening Instruments

BrainBaseline
Why are we building the BrainBaselineTM platform
“If you could give people information and tools that would delay the onset of cognitive
impairment by a few years, you would be doing much to improve individuals’ quality of life
as
well as improving society.”
Debra Cherry, PhD
Alzheimer’s Association

HeartMath:
Creating a Fundamental Shift in Human
Health and Well-Being
Catherine Calarco
SVP/CMO HeartMath Inc.
ccalarco@heartmath.com
www.heartmath.com

The Problem: Stress
• One Third of Americans Extremely Stressed. APA Survey 10/07
• Workplace Stress is as bad for your heart as high
cholesterol.JAMA 2007;298:1652-1660.
• For 11,119 workers in 52 countries, heart disease was directly related
to work stress. Rosengren A, Hawken S, Ounpuu S, et al. Lancet. 2004;364:953-962.
• People with high stress have 46% higher health costs. JOEM, Vol. 40,
Number 10, October 1998.
Stress impacts all aspects of life, resulting in sleep
disorders, obesity and pain – issues that are tied to
chronic disease and morbidity.
JOEM, Vol. 40, Number 10, October 1998

HeartMath Proven Solutions
• HRV and Coherence Digital Health Technologies
• Training programs for Health Professionals, Coaches/Mentors,
Military and Organizations
• Non-Profit Research Institute and Education Programs
“HeartMath gave me a venue that allowed me to change my life.” –
Vietnam veteran, Lt. Col. Harrison Jack
“It is the most powerful tool I have found to reduce stress quickly in my
life.” – Tammi Johansen Evans
11/6/2014 HeartMath Template 34

Our Solution: Using HRV Technology to Lower Stress
• HRV is a measure of the naturally occurring beat-to-beat changes in the heart.
• HeartMath IP measures HRV in real time to determine “coherence”, a very efficient
physiological state where the heart, the brain and nervous system work are in synch
• Greater coherence reduces stress and empowers sustained behavior change.
Incoherence: Frustration, Anxiety, Worry, Irritation
Impairs
Performance
and Wellness
Coherence: Positive Emotions Appreciation, Love, Care
Promotes
Optimal
Performance
and Wellness
©2014 HeartMath Inc

A Brief History of HeartMath
• Founded 1991, non-profit research center to study links
between stress, brain/heart function, health and
performance.
• Published more than 80 studies on cardiovascular health,
cognitive performance, health care utilization, staff
retention, PTSD
• Developers of award-winning mobile stress reduction
technology solutions.
• 20 years evidence of sustained reduction of stress and
stress-related conditions
• Over 360,000 Customers, in 85 Countries
36

HRV and Coherence:
• HRV proven & used in medical practice for decades
• Increase in recent research studies and publications
• Palo Alto Longevity Prize selects HRV as a criteria for
success
• Increase demand for product and services
• Kaiser, Sabre, Huffington Post, Samsung and others select
HeartMath as leader in HRV and Coherence training
• HeartMath was listed as one of the Top 10 Companies to
Watch in 2013 in a new market trends report by SharpBrains.
@2014 HeartMath Inc 37

Coherence Significantly Improves Brain Function
• Increased ability to self-regulate (Bradley, 2010; Bedell 2010)
• 40% improvement in long-term memory (Lloyd, 2010)
• 24% improvement in short-term memory (Lloyd, 2010)
• Increased ability to focus (Lloyd, 2010; Ginsberg, 2010)
• Increased ability to process information (Ginsberg, 2010)
• Faster reaction times (McCraty, 2010)
• Higher test scores (Bradley, 2010)
• Improved ability to learn (Bradley, 2010)

Improvements in Physical Symptoms of Stress
Before and six weeks after taking the HeartMath Program
33%6 44%6
43%6
Percentage of individuals responding often or always
63%6
44%6
44%6
(N=5692)

Retail Pharmacy Chain: Reduction in Medical Errors
N = 222 pharmacists
Retail pharmacy chain knew stress was affecting medication errors
“incident rate”.
One day HeartMath workshop and emWave provided to all pharmacists,
with 2-hour follow up.
Results:
Significant reductions: fatigue, anxiety, depression, anger, resentfulness,
stress symptoms, morale issues, time pressure and stress.
40-71% reduction in medication errors.
Exit survey reported 100% “extremely satisfied” with the program.
Based on these results, won ISFP award for safe medication practice.
©2014 Institute of HeartMath

Heart Rate Variability Indicators
• We have the most HRV when we are young and it steadily
declines as we age.
• Below-normal HRV for your age is a strong and
independent predictor of future health problems, including
all-cause mortality.
• HRV is an important indicator of psychological resiliency
and ability to handle stress.
• Higher levels of HRV are associated with superior mental
performance on tasks requiring executive functions.

The Heart-Brain Relationship
• The heart has its own complex
nervous system: the “heart brain.”
• The heart sends far more information
to the brain than the brain sends to
the heart.
• Heart signals especially affect the
brain centers involved in strategic
thinking, reaction times and self-regulation.

Heart Rate Variability:
The Heart’s Rhythm and Measuring Coherence

Coherence Affects Physical and Mental Performance
• Heart signals affect the brain centers involved in emotional perception, decision making,
reaction times, social awareness and the ability to self-regulate.
Coherence
Facilitates Brain
Function
Incoherence
Inhibits Brain
Function

HEART RATE (BPM)
A Police Officer During a Domestic
Violence Scenario
Encounters angry man
Scenario
Clock Time
Officer uses
Shift and Reset

Research Showing Increased HRV and Baseline Shift
Resting HRV baselines
before and after four
months of practicing
HeartMath techniques.

HRV Reflects ANS Activity
Ambulatory HRV Recording
Coherence Technique
Restful sleep
Dreaming

Recent Research
• Heart Coherence Training Combined with Back School in Patients
with Chronic Non-specific Low Back Pain: First Pragmatic Clinical
Results
Remko Soer • Dafne Vos • Bert Hofstra •Michiel F. Reneman
Appl Psychophysiol Biofeedback Published online Oct 2, 2014
• Dynamic correlations between heart and brain rhythm during
Autogenic meditation
Dae-Keun Kim, Kyung-Mi Lee, Jongwha Kim, Min-Cheol Whang and Seung Wan Kang
Front. Hum. Neurosci., 31 July 2013
“Nearly all of my patients’ ratings of pain decrease after a session with the
emWave® desktop. Essentially, it helps patients step aside from their pain.”
Michele Barr, Senior Therapeutic Recreational Specialist
North Carolina Jaycee Burn Center
University of North Carolina Hospitals
11/6/2014 48

How to Achieve Benefits
• Practice Daily for 6 weeks and then at least 5-7x per week
• Train 10- 15mins in the morning and evening
• Use Quick Coherence Technique
• Track Success and Gain Awards
• Work with a Coach, Trainer or Health Professional
11/6/2014 49

HeartMath Technologies
Inner Balance™ App for iDevices

emWave2®
emWave® Pro

Thank You for Your Attention
Connect with HeartMath to learn more
live@heartmath.com

Colin House
CEO
(435) 655-1511
colin@sleepgenius.com

Hearing, the sensory system which
remains highly active during sleep
Cochlea and Vestibular Apparatus

Experts
Decades of Research, Neuroscience, Sleep, Music and Sound

Proprietary Technology
Neurosensory
Algorithms
Unique to Sleep Genius
Activates your vestibular system which triggers a
motion induced sensation, like a baby being rocked
to sleep.
Multi-Band
Binaural Beats
Unique to Sleep Genius
Engages multiple regions of your brain to entrain
and maintain sleep by matching the waveforms that
characterize all four stages of sleep.
Pink Noise
Originally Produced
Creates a sonic wall which blocks out distracting
noises as well as lowering activity in your brain’s
arousal centers .
Psychoacoustic
Music
Originally Composed
Originally and scientifically composed music with
low frequency, tone and tempo to induce and
maintain sleep.

60
Sleep Genius App
• “FEATURED” by Apple
dozens of times
• Attained #1 Health &
Fitness App
• 100% Viral…Zero Marketing

Sleep Genius Premium
Personalized Sleep Reporting

66
Samsung Partnership
• GEAR 2 + GEAR FIT Integration
o Announced at MWC
o Sleep Program + Revive Cycle Alarm

Thank You!
Colin House
Sleep Genius
colin@sleepgenius.com
sleepgenius.com

Dharma Singh Khalsa, M.D.
President/Medical Director
Alzheimer’s Research and Prevention
Foundation
drdharma@alzheimersprevention.org
www.alzheimersprevention.org
BEME
Kirtan Kriya
A Limitless Dimension
In Alzheimer’s
Prevention

Brain Longevity®:
Creating a Lifetime of Peak
Mental Performance
What is the biggest obstacle?

1. Chronic Stress
2. Lack of self-knowledge
The biggest obstacle to peak mental
performance and optimal cognitive
function is a combination of untreated and
unbalanced Early Life Stress and Adult
Stress

The impact of a lifetime of stress is
decreased brain function:
1.  Memory
2.  Mood
3.  Cellular and genetic health
4. Mind/body/spirit imbalance
Time Doesn’t Heal, it Only Conceals

Stress Increases Risky Behavior
1. Poor dietary choices
2. Too tired to exercise
3. Too exhausted to use cognitive training
4. No time to meditate (perception)
5. PSWB non existent
6. Unconscious Compulsive Self-Defeating
Behavior (blind spots activated)

Stress Increases Risk Factors
1. Memory Loss
2. Anxiety / Depression
3. Anger
4. Insomnia
5. Heart Disease
6. Diabetes
7. Immune Dysfunction
8. GI Issues
9. Unhappy
10.Loss of Spiritual Direction

The Benefits of BEME/KK
in 12 Min/Day:
Fast, Precise, Powerful, Deep
1. Can be easily learned and practiced at home with a CD
2. Less stress
3. Prevents and reverses memory loss
4. Improves attention, concentration, and focus
5. Better mood, less depression and anxiety
6. More mental and physical energy
7. Enhanced cellular, genetic health
8. PSWB enhanced
Research papers available at
http://www.alzheimersprevention.org/research

How KK Works
Degree of representation of the
different muscles of the body in the
motor cortex. (From Penfield and
Rasmussen. The Cerebral Cortex of
Man. A Clinical Study of Localization
of Function. New York. Macmillan
Co. 1968.)
The Meridian Points of the
Upper Palate

Before After
Kirtan Kriya
Khalsa, D. Newberg, A: Nuclear Medicine Communications, Sept. 2009

Up
Posterior Cingulate Gyrus
Khalsa, D.S., Newberg, A. Jl of Nuclear Med Communication 2009

Changes in the Anterior Cingulate Gyrus
PFC
Pre-Program
Baseline
Post-Program
Baseline
Ant Cingulate
Ant Cingulate
PFC

BEME KK and GCBF
Before After

What is PWB?
The newest aspect of meditation research
1. Acceptance
2. Independence
} Reduction
3. Mastery
of Risk
4. Personal Growth
Factors
5. Positive Relationships 6. Purpose/ Mission  Mild Cognitive Impairment and
Alzheimer’s Risk

What is SWB?
Discover Your Best Self
1. Patience
2. Altruism
3. Compassion
4. Surrender
5. Peace of Mind
When you move beyond yourself, you might find peace of mind is
waiting there.
~ George Harrison
Within You and Without You
Sgt. Pepper’s Lonely Hearts Club Band. The Beatles, 1968

Ongoing ARPF Research
1. UWVA- KK & MCI
2. UCLA- KK & MCI
3. FINGER Study
4. Looking for partners:
a. Technology arena
b. Independent/assisted living arena
c. Others – all doors open

Moving Beyond Memory
And In The End…
Spirit and Wisdom

BEME KK
Easy and Fun
Only 12 Minutes a Day
High Compliance
No Further Training Required

Take Kirtan Kriya Home
1. Self-led12-minute KK meditation now possible
2. Anyone can practice it
3. Best time to do it is first thing in the morning
4. CD and MP3 available for a $20 donation
5. Includes simple instructions
6. It’s easy, enjoy!
www.alzheimersprevention.org Store page
drdharma@alzheimersprevention.org

THANK YOU FOR JOINING US!
Next…
1. Today: Relax, enjoy 
2. Tomorrow: Join private LinkedIn Group
3. Monday: Access Summit Recordings

215 Participants in 17 Countries

 To learn more, visit SharpBrains.com

Expo day: Digital Artefacts (BrainBaseline), HeartMath, Sleep Genius, The Alzheimer’s Research and Prevention Foundation

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