This document provides an overview of esophageal motility disorders. It describes the anatomy and physiology of normal esophageal function, including peristalsis. Esophageal motility disorders are classified as either relaxation disorders like achalasia or contraction disorders. Achalasia is characterized by impaired LES relaxation and absent peristalsis. It can be classified into 3 subtypes based on manometry findings. Treatment involves medications, botulinum toxin injections, or pneumatic dilatation of the LES. Manometry, particularly high-resolution manometry, is the gold standard for diagnosing esophageal motility disorders.
Different esophageal disorders are discussed in this lecture. The learning objectives are to understand:
The anatomy and physiology of the oesophagus and their relationship to disease.
The clinical features, investigations, and treatment of benign and malignant disease with particular reference to the common adult disorders.
Topics include: Surgical anatomy, Physiology, Symptoms, Investigations, Congenital lesions: TOF and Atresia, Benign tumours, Cancer of oesophagus, Foreign bodies,Oesophageal perforation, Gastro-oesophageal reflux diease, Hiatal hernia,
Oesophageal motility disorders: achalasia and diffuse spasm, Oesophgeal diverticula.
and Others.
Different esophageal disorders are discussed in this lecture. The learning objectives are to understand:
The anatomy and physiology of the oesophagus and their relationship to disease.
The clinical features, investigations, and treatment of benign and malignant disease with particular reference to the common adult disorders.
Topics include: Surgical anatomy, Physiology, Symptoms, Investigations, Congenital lesions: TOF and Atresia, Benign tumours, Cancer of oesophagus, Foreign bodies,Oesophageal perforation, Gastro-oesophageal reflux diease, Hiatal hernia,
Oesophageal motility disorders: achalasia and diffuse spasm, Oesophgeal diverticula.
and Others.
một trong những rối loạn vận động của thực quản, co thắt tâm vị không nguy hiểm tới tính mạng như các bệnh mãn tính không lây, hiểm nghèo, ... nhưng lại ảnh hưởng đáng kể đến sinh hoạt của cá nhân mang căn bệnh này ...
I give this lecture in the Function and Dysfunction course for first-year veterinary students. The fluoroscopic videos of a vomiting dog was very well received.
Medical Physiology of the GIT:
Mucosa, principles of GIT function, afferent sensory innervation, GI reflexes, motility throughout the GI system, control of stomach emptying, coordination of motility, GI secretions, Gastric events following ingestion of a meal......
Cellulose (C 6 H 10 O 5) n is one of the most ubiquitous organic polymers on the planet. It is a significant structural component of the primary cell wall of green plants, various forms of algae and oomycetes. It is a polysaccharide consisting of a linear chain of several hundred to many thousands of β(1 → 4) linked d-glucose units. There are various extraction procedures for cellulose developed by using different processes like oxidation, etherification and esterification which convert the prepared celluloses in to cellulose derivatives. Since it is a non-toxic, biodegradable polymer with high tensile and compressive strength, it has widespread use in various fields such as nanotechnology, pharmaceutical industry, food industry, cosmetics , textile and paper industry, drug-delivery systems in treating cancer and other diseases. Micro-crystalline cellulose in particular is among the most frequently used cellulose derivatives in the food, cosmetics, pharma industry, etc. and is an important excipient due to its binding and tableting properties, characterized by its plasticity and cohesiveness when wet. Bacterial cellulose's high dispensability, tasteless and odourless nature provides it with lot of industrial applications. Currently, about half of the waste produced in India contains about 50% cellulose which can be used productively. This chapter deals with the chemistry of cellulose, its extraction and its properties which help various industries to make the most of it.
MATATAG CURRICULUM: ASSESSING THE READINESS OF ELEM. PUBLIC SCHOOL TEACHERS I...NelTorrente
In this research, it concludes that while the readiness of teachers in Caloocan City to implement the MATATAG Curriculum is generally positive, targeted efforts in professional development, resource distribution, support networks, and comprehensive preparation can address the existing gaps and ensure successful curriculum implementation.
Normal Labour/ Stages of Labour/ Mechanism of LabourWasim Ak
Normal labor is also termed spontaneous labor, defined as the natural physiological process through which the fetus, placenta, and membranes are expelled from the uterus through the birth canal at term (37 to 42 weeks
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How to Build a Module in Odoo 17 Using the Scaffold MethodCeline George
Odoo provides an option for creating a module by using a single line command. By using this command the user can make a whole structure of a module. It is very easy for a beginner to make a module. There is no need to make each file manually. This slide will show how to create a module using the scaffold method.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
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students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
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• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
Biological screening of herbal drugs: Introduction and Need for
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Acetabularia Information For Class 9 .docxvaibhavrinwa19
Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
it describes the bony anatomy including the femoral head , acetabulum, labrum . also discusses the capsule , ligaments . muscle that act on the hip joint and the range of motion are outlined. factors affecting hip joint stability and weight transmission through the joint are summarized.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
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Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
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5. Peristalsis
Esophageal peristalsis results from sequential contraction of circular muscle, which
serves to push the ingested food bolus toward the stomach. Esophageal longitudinal
muscle may also play a role in peristalsis.
Swallow-induced peristalsis is called primary peristalsis.
Peristalsis elicited by esophageal distention is called secondary peristalsis.
Peristaltic contractions are always preceded by inhibition that, in the case of primary
peristalsis, is called deglutitive inhibition.
Peristalsis in the striated muscle part of the esophagus is dependent on central
mechanisms, involving sequential activation of vagal lower motor neurons in the vagal
nucleus ambiguus.
Peristalsis in the smooth muscle of the esophagus is dependent on both central and
peripheral mechanisms.
7. Central Neural control forswallowing
The central mechanism involves
patterned activation of the
preganglionic neurons in the dorsal
motor nucleus of the vagus that
project onto inhibitory and excitatory
neurons in the esophageal myenteric
plexus.
8. Medullary Swallowingcentre
The DSG contains the generator neurons
involved in triggering, shaping, and
timing the sequential or rhythmic
swallowing pattern.
The VSG contains the switching neurons,
which distribute the swallowing drive to
the various pools of motoneurons
involved in swallowing.
The esophageal circuit may involve
a DSG, a VSG, and the motor or
preganglionic nuclei receives information
from the periphery, from the cerebral
cortex, and from various supramedullary
structures.
9. Peripheral Neural control ofswallowing
The peripheral mechanism involves regional
differences in the inhibitory and excitatory
intramural nerves and intrinsic properties of
the muscle.
Intramural inhibitory nerves act by releasing
nitric oxide (NO) and vasoactive intestinal
peptide, whereas the excitatory nerves
release acetylcholine and substance P.
10. Central and Enteric nervouscoordination
in EsophagealSmoothMuscles
The nerve fibers that innervate the smooth muscle of the lower esophagus have their
cell bodies in enteric ganglia. Peristalsis in Smooth Muscle is also coordinated from the
CNS.
The enteric ganglia of the smooth muscle esophagus are directly innervated by pre-
enteric neurons of the dorsal motor nucleus of the vagus, and lesion of this nucleus
impairs the motility patterns of the smooth muscle esophagus .
The vagus is involved in relaxing the lower esophageal sphincter (LES), to allow
passage of food, through a descending inhibitory reflex that relaxes the sphincter when a
bolus of food enters the last part of the esophageal body and its intraluminal pressure is
raised.
The reflex relaxation is inhibited by cooling the vagus nerve However, sphincter
relaxation still occurs in response to distension following vagal block, indicating that a
local reflex can be elicited
11. Smooth muscles: Circularand
Longitudinal musclefunction
Circular smooth muscle (CSM) generates radial closure pressure to create a local
peristaltic closure
Longitudinal smooth muscle (LSM) contracts before circular smooth muscle (CSM)
contraction and ends after it resulting in Local Longitudinal Shortening (LLS)
The mechanical function of LLS is to reduce the level of pressure required to maintain
closure. The combined physiological and mechanical consequences of LLS are to
reduce circular muscle fibre tension and power, by as much as 1/10 that would be
required for peristalsis without Longitudinal Muscle layer.
12. PrimaryPeristalsis
Primary peristalsis is initiated by motor neurons located in swallowing center of the
brainstem. Once contractile activity starts in the esophageal body it may be modulated
by both the central nervous system and locally mediated influences.
This intrinsic regulation of peristalsis is controlled either by regional differences of the
muscle cells in excitability (myogenic control) or the enteric nervous system (neurogenic
control).
This is compounded with Gravitational action.
The peristaltic wave travels at 2cm/s to 5 cm/s.
13. SecondaryPeristalsis
activated by esophageal distention.
This can occur physiologically by food left behind after the primary peristaltic
wave has passed, or by refluxed contents from the stomach. House Keeping
reflex.
Unlike primary peristalsis, secondary peristalsis is not accompanied by
deglutition with associated pharyngeal and upper esophageal sphincter motor
function.
19. Velocity and Pressureof Peristalticwaves
The peristaltic velocity averages
3 cm/sec in the upper esophagus,
5 cm/sec in the mid-esophagus,
2.5 cm/sec distally.
Peak pressures average
53+/-9 mmHg in the upper esophagus,
35+/-6 mmHg in the mid portion , and
70+/-12 mmHg in the lower esophagus
20. Duration and Amplitude of Peristalticwaves
The duration and amplitude of individual pressure waves also varies along the
esophagus.
The duration of the wave is shortest in the proximal esophagus (approximately
2 seconds) and longest distally (approximately 5 to 7 seconds).
21. Variablesinfluencing Peristalsis
These parameters can be influenced by a number of variables including bolus
size, viscosity, patient position (e.g., upright vs. supine), and bolus
temperature.
large bolus elicits stronger peristaltic contractions that migrate distally at a
slower rate than a small bolus.
Warm boluses tend to enhance, whereas cold boluses inhibit the amplitude of
peristaltic contractions.
These alterations are likely mediated by local neuromuscular reflexes as well
as by vagovagal reflexes.
27. Important HRManometryParameters
The pressure topographic measurements used are
•integrated relaxation pressure (IRP)
•distal contractile integral (DCI)
•contractile deceleration point (CDP)
•distal latency (DL)
28. Integrated RelaxationPressure
IRP, defined as the mean pressure for the 4 seconds of maximal deglutitive relaxation in
the 10-second window starting with deglutitive upper esophageal sphincter (UES)
relaxation, is the best metric to differentiate between normal and impaired EGJ
relaxation
29. Post-Deglutitive esophagealcontraction
•CDP- represents the inflection point in the contractile front propagation velocity in the distal
esophagus.
•DL- represents the interval between UESrelaxation and the CDP.It is considered an important
metric indicating the integrity of the inhibitory pathway in the distal esophagus.Avalue less
than 4.5 secondsdefines apremature contraction, indicative ofspasm.
•DCI - describes the vigor of the distal esophageal contraction. It is measured asthe “volume” of
the esophagealcontraction spanningfrom the transition zoneto the EGJ.
30. DCI
TheDCIis the product of the integral of the amplitude exceeding 20 mm Hg,the duration, and
the length of the contractile segment between the transition zoneand the EGJ.
Amplitude xDuration xLength
Cutoff values defining different diagnostic categories depend on the type of HRMhardware and
software used. DCIin normal subjects rangesbetween 450 and 8000 mm Hg-s-cm.
Hypercontractility is defined by aDCIgreater than 8000 mm Hg-s-cm.ADCIranging between
100 and 450 mm Hg-s-cmdefines weak peristalsis, whereas aDCIlower than 100 mm Hg-s-cm
identifies failed peristalsis.
31. Pathogenesisof Esophagealmotility
disorders
Poorly understood- post viral and genetics hypothesised.
Achalasia – loss of intrinsic Ganglion cells
at esophageal body- loss Ach containing Nerves – loss of peristalticcontraction
at LES- loss of inhibitory Neurons secreting NO and VIP - loss of relaxation
In spasmodic disorders – loss of imbalance between excitatory and inhibitory post
ganglionic pathways mostly in distal esophagus
32.
33. Clinical Featuresof RelaxationDisorders
Dysphagia for solids or/ and liquids
ChokingandAspiration
Dyspepsia
Chestpain
Epigastricpain
Odynophagia
Weight loss / persistentDehydration
Watch for Skinchangesin Scleroderma
43. Swallowprovocation test
a thin tube inserted through the nose into the oropharynx area followed by injection ofa
small volume of water
measure the time from injection to start of swallowing reflex.
Average time in healthy individuals was 1.7 seconds when using 0.4 mL of
distilled water at normal temperature, and 3 seconds or longer isconsidered
abnormal.
IThis test allows the assessment of sensory input and motor output in the pharynx in the
absence of influence of the oral phase, and therefore can assess the risk of silent
aspiration.
This method requires some experience of tube insertion.
52. HRManometry isGold Standard for
EsophagealMotility Disorders
HRM is coupled with sophisticated algorithms to display the manometric data as pressure
topography plots, esophageal contractility is visualized with isobaric conditions among
sensors indicated by isocoloric regions on the pressure topography plots. Clouse plots
y-axis represents the axial length of the esophageal
body, with the pharynx and upper esophageal
sphincter (UES) at the top of the graph and the
esophagogastric junction (EGJ) and proximal
stomach at the bottom.
x-axis represents time.
Pressure is represented as color, with “hot” colors
(red, orange) representing higher pressures and
“cool” colors (green, blue) depicting lower pressures.
53.
54.
55.
56.
57. IRP– Relaxation- LESrelaxation after 4sof Wet Swallow
DCI-Contraction – Vigour of Swallow
DL– inhibitory ability of DistalEsophagus
CDP-propagation of wave in DistalEsophagus
58.
59. AchalasiaCardia
Increases with age, with 65-85 years ; can affect adults of all age groups.
males =females,
genetic etiology : The triple-A syndrome (Allgrove disease) is a rare condition presenting with
achalasia, alacrima, adrenocorticotropic hormone (ACTH)–resistant adrenal insufficiency, and
neurologic disturbances.
60. ClinicalFeatures
Progressive dysphagia to both solids and liquids is the most common presenting
symptom (90%),
followed by regurgitation of undigested food (76% to 91%),
respiratory complications (nocturnal cough [30%] and aspiration [8%]),
chest pain (25% to 64%),
heartburn (18% to 52%), and
weight loss (35% to 91%)
61. Endoscopicfindings
in the more advanced stage of achalasia include a dilated esophagus containing
retained saliva or food residue, stasis changes in the mucosa, and occasionally the
presence of candidiasis
early on endoscopic findings may be unremarkable.
The puckered appearing gastroesophageal junction presents with mild resistance when
attempting to intubate the stomach.
The feeling of a stronger resistance should raise suspicion for pseudoachalasia, and the
need for further evaluation.
Careful inspection of the gastroesophageal junction (GEJ) and cardia, including a
retroflex view, should help exclude infiltrating lesions.
62. BariumStudies
Typical findings on barium esophagram in advanced disease are a dilated esophagus
with food and contrast retention, lack of peristaltic stripping waves, and a narrowed GEJ
(the so-called bird beak).
Time barium esophagram (TBE) - to assess esophageal emptying
This simple technique involves drinking a large bolus of barium in an upright position
and obtaining a radiograph after 1 and 5 minutes and assessing the height of the barium
column in the esophagus
Lack of adequate reduction in the height of the barium column after therapy is
associated with higher risk of treatment failure during follow-up of ballon dilatation or
myotomy.
63. Manometry
impaired lower esophageal sphincter (LES) relaxation + apersiatalsis, in the absence
of obstructive lesions involving the gastroesophageal junction.
Esophageal pressure topography has allowed for the classification of achalasia into
three variants on the basis of the contractile pattern of the esophagealbody.
Type I achalasia (classic achalasia), no contractile activity is detected and no significant
pressurization is within the esophageal body.
Type II achalasia, swallowing water results in panesophageal pressurization,
Type III achalasia (spastic/vigorous achalasia) is associated with premature
contractions (characterized by short distal latency)
64. AchalasiaTypeI
UESopened
Aperistalsis in body
LESnot relaxed
Bolus accumulation in lower end
Type I achalasia (classic)Median IRP>15 mm Hg;
100% failed peristalsis (DCI <100 mm Hg•s •cm);
premature contractions with DCI<450 mm Hg•s
•cm satisfy criteria for failedperistalsis
67. FLIP
Functional lumen imaging probe (FLIP),hasdetected esophageal contractile activity in achalasianot
seenwith the standard thin intraluminal manometriccatheter
68. Medical Management
NITRATES and CALCIUM CHANNEL BLOCKERS
Isosorbide dinitrate 5 mg, taken 10 to 15 minutes before meals
Nifedipine sublingually, at a dose of 10 to 30 mg - 30 to 45 minutes before meals.
Limited symptomatic response and side effects such as hypotension, dizziness,
and headaches
BOTULINUM
injected into the LES endoscopically by a sclerotherapy needle, at a total dose of
100 U, usually divided in four aliquots, injected to the four quadrants of the LES,
just above the squamocolumnar junction.
relapse is observed in approximately 50% of patients by 1 year, and repeat injections
are required
69. PneumaticDilatation
comes in three sizes (30, 35, and 40 mm diameters).
positioned across the LES, commonly under fluoroscopic control and with the aid of a
guidewire, and is inflated with air to forcefully stretch the LES muscle.
The balloon is kept inflated for about 15 to 60 seconds, while straightening of the
balloon waist at the level of the LES is observed.
Following dilation, patients are evaluated by a Gastrografin study followed by a barium
esophagram to exclude esophageal perforation.
Graded dilation, starting with the smallest diameter, is the recommended approach,with
symptomatic and radiographic assessment within 4 to 6 weeks after treatment,
70.
71.
72. Esophagealstents
Diameter varied between 20 and 30 mm, and
stents were removed after 6 or 30 days,
respectively. Follow-up of up to 36 months
showed good remission rates with low
morbidity related to stent migration in a few
patients. This treatment modality may be
attractive in high-risk patients, but further data
are needed for better assessment of its role
73. Heller’sMyotomy
•Ernest Heller, a German surgeon did first cardiomyotomy based on Gottstein’s idea
through abdominal approach. He did myotomies at both anterior and posterior walls. It
is an extramucosal oesophagomyotomy. Double myotomies.
•many modifications were tried on this procedure.
•. Groeneveldt modified it as only anterior myotomy which was popularised by Zaaiijer
(1923).
•Myotomy facilitates gravity induced swallowing. Incidence of reflux oesophagitis is very
high (20%) and so partial or often total Nissen’s fundoplication is added to prevent reflux.
Pressure of the lower oesophageal sphincter (LES) is completely reduced but not
eliminated by myotomy.
74. Abdominal approach
• Patient is in head up (reverse Trendelenburg)
position.
• self-retaining retractor is placed. Sternal self-
retaining chain retractor is better if available.
• Left lobe is mobilised by placing surgeon’s left
hand over the left lobe retracting it below and
towards right.
• Left triangular ligament is divided using cautery
and scissor.
• Thus left lobe is mobilised and retraced by folding
it inwards to expose hiatus fairly adequately.
• Wet mop should be placed under the retractor to
avoid injury to left lobe of liver during retraction.
• Stomach is displaced below by downward
traction by first assistant using fingers or
Babcocks.
• Peritoneal reflection over the OG junction is lifted
using long dissecting forceps and using long
curved scissor it is cut horizontally to push it
upwards towards hiatus.
• Anterior left vagus should be safeguarded, gently
dissected and kept aside using smooth sling
75. Entire abdominal oesophagus is mobilised using right index finger with blunt dissection.
Dissection facilitates separation of the abdominal oesophagus from behind away from aorta.
Mobilised lower oesophagus is hooked with right index finger and long gauze or tape or infant
feeding tube or Penrose drain is passed around
Phrenooesophageal membrane is divided to allow the dissection into the peritoneum. Right
pleura may get injured while dividing this membrane/ligament and so care should be taken to
avoid it. Oesophagus is dissected by blunt and sharp dissection further upwards across the
hiatus
Oesophagus is held under tension by giving traction on the sling. Constriction part can be felt
with this method. Using left index finger lower oesophagus is encircled; longitudinal incision is
made on the anterior left lateral aspect of the oesophagus over the muscle; both longitudinal and
circular muscles are cut; mucosa can be visualised
76. Both muscles are cut even though only circular muscle is hypertrophied and thickened due to the
disease. Careshould be taken not to injure it. Using right angles Mixter forceps dissectionbetween
mucosaand muscular layers is carried out upwards creating separation; separated muscle is cut
using curved scissor; bipolar cautery can be used for small bleeder with care to avoid injury to
mucosa.
77. Cranially myotomy is done 8-10 cm. Often ametal clip is placed
at this point for future identifi cation of uppermost point of
myotomy. Upper myotomy should go to the proximal 2 cmdilated
segment of oesophagus. Myotomy is also done downwards over
the stomach wall for lessthan 1 cm. It should never exceed more
than 1cm.
Edgeof the cut musculature is held using dissecting forceps and
using fi ne scissor it is raised from the deeper mucosal plane for
half the circumference. It prevents from muscle reuniting again
leading to stenosis. Raisingof the muscle is done on bothedges.
Metal clip is also placed over the lowermost cut edge foridentifi
cation. 200 ml methylene blue instillation is done to check for
perforation.
78. Dor anterior fundoplication: Here right margin of the fundus is sutured to left margin of the
oesophagus; front part of fundus is sutured to right margin of the oesophagus; 2nd row is
also sutured to right crus. It is useful after Heller’s cardiomyotomy if perforation of
oesophagus has occurred.
80. POEM
The principles of POEM procedure are
(1) mucosal incision and submucosal access
(2) submucosal tunnel creation
(3) esophageal myotomy, and
(4) mucosal incision closure.
POEM is usually performed in the operating room under generalAnesthesia
81. Indications for POEM
• classic achalasia,
•complicated achalasia (like a
dilated “sigmoid” esophagus and
failure of previous myotomy),
• as well as other spastic
esophageal motility disorders.
Contraindications to POEM
• severe pulmonary disease,
• coagulopathy, and
•prior interventions that compromise
esophageal mucosal integrity like
an endoscopic mucosal resection,
radiofrequency ablation, and
radiation therapy.
82. A submucosal bleb is created in the mid-
esophagus using saline solution mixed with
indigo carmine.
A 1.5–2 cm longitudinal mucosal incision is
made with an endoscopic submucosal dissection
knife.
The submucosal space is dissected, and the
submucosal tunnel is extended until passing
LES and at least 2–3 cm into the stomach
Subsequently, an anterior or posterior myotomy
of the inner circular muscle bundles is performed
starting 2 cm distal to the mucosal entry point
and extending distally 2–3 cm into the gastric
cardia.
After completion of the myotomy, the
gastroscope is introduced into the esophageal
lumen, and smooth passage into the stomach
through the GEJ is confirmed.
The mucosal incision site is closed using
endoscopic clips.
84. EGJoutflow obstruction
characterized by impaired EGJ relaxation in the presence of preserved peristaltic
contractions
Esophagogastric junction outflow obstruction (achalasia in
evolution)Median IRP >15 mm Hg; sufficient evidence of
peristalsis such that criteria for types I-III are not met
Botox injections alleviate symptoms temporarily, and
hydrostatic balloon dilation may provide long-term
symptomatic relief.
Surgery is indicated for patients who fail to respond to
interventional treatments and those with significant
symptoms.
A laparoscopic modified Heller esophagomyotomy is the
operation of choice. In patients with normal esophageal
motility, a partial antireflux procedure (e.g., Dor or
Toupet fundoplication) is added
85. Diffuse EsophagealSpasm
The basic pathology is related to a motor abnormality of the esophageal body thatis
most notable in the lower two thirds of the esophagus.
Muscular hypertrophy and degeneration of the branches of the vagus nerve in the
esophagus have been observed. As a result, the esophageal contractions arerepetitive,
simultaneous , and of high amplitude.
chest pain and dysphagia mimic those of angina.
Patients will complain of a squeezing pressure in the chest that may radiate to thejaw,
arms, and upper back.
Regurgitation of esophageal contents and saliva is common but acid reflux is not.
However, acid reflux can aggravate the symptoms.
86. Workup
The classic picture of the corkscrew esophagus or pseudo-diverticulosis on an
esophagram is caused by the presence of tertiary contractions and indicates advanced
disease.
The classic manometry findings in DES are simultaneous multipeaked contractions of
high amplitude (>120 mm Hg) or long duration (>2.5 seconds).
These erratic contractions occur after more than 10% of wetswallows.
Because of the spontaneous contractions and intermittent normal peristalsis, standard
Manometry may not be enough to identify DES.
88. Medical management
•If dysphagia is a component of a patient’s symptoms, steps must be taken to eliminate
trigger foods or drinks from the diet.
•If reflux is a component, acid suppression medications are helpful.
•Nitrates, calcium channel blockers, sedatives, and anticholinergics may be effectivein
some
•Peppermint may also provide temporary symptomatic relief.
•Bougie dilation of the esophagus up to 50 or 60 Fr provides relief for severe dysphagia
and is 70% to 80% effective.
•Botulinum toxin injections have also been tried with some success, but the results are
not sustainable.
90. NutcrackerEsophagus
esophagus with hypertensive peristalsis or high-amplitude peristaltic contractions. all
ages, with equal gender predilection,
most common of all esophageal hypermotility disorders.
Like DES, the pathophysiologic process is not well understood. It is associated with
hypertrophic musculature that results in high amplitude contractions of the
esophagus and is the most painful of all esophageal motility disorders.
Patients with nutcracker esophagus present in a similar fashion to those with
DES and frequently complain of chest pain and dysphagia. Odynophagia is also
noted, but regurgitation and reflux are uncommon.
An esophagram may or may not reveal any abnormalities, depending on how
well “behaved” the esophagus is during the examination.
91. Hypercontractile esophagus (jackhammer)At least 2
swallows with DCI >8000 mm Hg•cm •s
Ambulatory monitoring can help distinguish this
disorder from DES. This is of critical importance because
a subset of DES patients with dysphagia can
be helped with esophagomyotomy, but surgery is of
questionable value in patients with a nutcracker
esophagus.
Calcium channel blockers, nitrates, and antispasmodics
may offer temporary relief during acute spasms.
Bougie dilation may offer some temporary relief of
severe discomfort but has no long-term benefits.
Patients with nutcracker esophagus may have triggers
and are counseled to avoid caffeine, cold, and hot
foods.
92. Ineffective peristalsis
contraction abnormality of the distal esophagus and is usually associated with
GERD. It may be secondary to inflammatory injury of the esophageal body
because of increased exposure to gastric contents.
Dampened motility of the esophageal body leads to poor acid clearance in the
lower esophagus. Once altered motility is present, the condition appears to be
irreversible.
symptoms of IEM are mixed, but patients usually present with symptoms of reflux
and dysphagia. Heartburn, chest pain, and regurgitation are noted.
A barium esophagram demonstrates nonspecific abnormalities of esophageal
contraction but will not further distinguish IEM from other motor disorders.
93. Diagnosis made by manometry. IEM is defined
by greater than 50% of swallows being deemed
ineffective (distal contractile integral <450 mm
Hg).
best treatment of IEM is prevention, which is
associated with effective treatment of GERD
95. References
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Endocrinology: The Microbiota-Gut-Brain Axis in Health and Disease. Advances inExperimental
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Yasushi SUZUKI
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