The CS 3800 gives you a whole new experience in acquiring impressions: Freedom. Freedom from cables; freedom to pursue your preferred workflow; freedom to pay only for what you use; and freedom to interact with partners, how you prefer, when you prefer. Plus, as the result of a renewed collaboration with Studio F. A. Porsche, the CS 3800 displays a timeless, ergonomic design that ensures a high- performance scanning experience.
• High-performance wireless intraoral scanner for optimal mobility
• One of the lightest and most compact intraoral scanners on the market
• Fast and smooth scanning thanks to a large and deep field of view
• Easier for you and end-to-end workflows provide a seamless user experience
SPOTLIGHT ON THE PREMIUM CHANNEL – AcuFocusHealthegy
Presentation from OIS@ASCRS 2016
Nick Tarantino, OD, Chief Global Clinical & Regulatory Affairs Officer
Video Presentation:
https://www.youtube.com/watch?v=Nc4T9u62rBQ&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw&index=34
Total corneal astigmatism in older adults taking into account posterior corne...Álvaro Rodríguez-Ratón
PURPOSE: To study the composition of corneal astigmatism in older adults, evaluating the difference made by the inclusion of posterior corneal astigmatism in a ray tracing calculation of total corneal astigmatism.
SETTING: Ophthalmology clinic.
METHODS: One hundred consecutive patients aged between 60 and 80 years were included in a prospective descriptive study. Their right eye was analysed by an integrated Placido disk and rotating Scheimpflug camera topographer (CSOTM Sirius). Several parameters were measured: anterior corneal astigmatism (ACA) and posterior corneal astigmatism (PCA), total astigmatism based on anterior topographic data (simK) and total corneal astigmatism (TCA) by merging anterior and posterior astigmatism using ray tracing.
RESULTS: Mean ACA was 1.51 diopters (D) and PCA was 0.38D. ACA was aligned 47% with-the-rule and PCA 87% against-the-rule. Cases with against-the-rule ACA showed low magnitude correlation between anterior and posterior surfaces. TCA had a mean deviation of 0.30D @ 3 over SimK in a vector calculation. Eighteen percent (18%) of cases differed by 0.50 D or more between SimK and TCA magnitude, and 53% had 10 or more degrees of axis discrepancy, the difference being higher at lower magnitudes of astigmatism.
CONCLUSIONS: Anterior WTR astigmatism tends to be compensated by posterior ATR astigmatism in older patients. Nevertheless, the high number of cases largely justifies the use of tomographic technology that takes into account the posterior corneal surface for managing individual total corneal astigmatism.
FULL ARCH CBCT SCANS
Extended field of view up to 12 cm x 10 cm—best for full arch scans
VERSATILE 2D/3D SYSTEM Versatile 4-in-1 system ideal for expanding treatment capabilities
ARTIFACT-FREE, HIGH RESOLUTION IMAGES High-resolution 3D images with limited artifacts and noise
OUTSTANDING IMAGE QUALITY
Outstanding 2D/3D images thanks to the latest premium technology
ULTRA-COMPACT DESIGN
Ideal for practices that want to expand their capabilities without expanding their footprint
POWERED WITH CS IMAGING VERSION 8
Provides you with one-stop access to all your images and CAD/CAM data
Indian Dental Academy: will be one of the most relevant and exciting training center with best faculty and flexible training programs for dental professionals who wish to advance in their dental practice,Offers certified courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic Dentistry, Periodontics and General Dentistry.
As Carestream Dental’s most successful 3D unit, the CS 8100 3D
is now available with an optional cephalometric imaging module.
A multi-functional, 4-in-1 imaging solution, the new CS 8100SC 3D blends award-winning 2D panoramic technology, powerful CBCT imaging, and 3D model scanning with the world’s fastest cephalometric scanning capabilities. In turn, you gain access to the tools you need to build your practice through a single imaging system that covers virtually all of your everyday imaging needs.
ULTRA-COMPACT DESIGN
Slim and elegant, the CS 8100SC 3D fits practically anywhere. At just 1.8 m wide, the unit is one of the smallest cephalometric units and features an open design that Is built for comfort.
MULTI-FUNCTIONAL SYSTEM
In addition to diagnostic imaging, the CS 8100SC 3D allows you to obtain precise digital 3D models for optional applications, including orthodontics, implant planning or CAD/CAM restorations.
The CS 3800 gives you a whole new experience in acquiring impressions: Freedom. Freedom from cables; freedom to pursue your preferred workflow; freedom to pay only for what you use; and freedom to interact with partners, how you prefer, when you prefer. Plus, as the result of a renewed collaboration with Studio F. A. Porsche, the CS 3800 displays a timeless, ergonomic design that ensures a high- performance scanning experience.
• High-performance wireless intraoral scanner for optimal mobility
• One of the lightest and most compact intraoral scanners on the market
• Fast and smooth scanning thanks to a large and deep field of view
• Easier for you and end-to-end workflows provide a seamless user experience
SPOTLIGHT ON THE PREMIUM CHANNEL – AcuFocusHealthegy
Presentation from OIS@ASCRS 2016
Nick Tarantino, OD, Chief Global Clinical & Regulatory Affairs Officer
Video Presentation:
https://www.youtube.com/watch?v=Nc4T9u62rBQ&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw&index=34
Total corneal astigmatism in older adults taking into account posterior corne...Álvaro Rodríguez-Ratón
PURPOSE: To study the composition of corneal astigmatism in older adults, evaluating the difference made by the inclusion of posterior corneal astigmatism in a ray tracing calculation of total corneal astigmatism.
SETTING: Ophthalmology clinic.
METHODS: One hundred consecutive patients aged between 60 and 80 years were included in a prospective descriptive study. Their right eye was analysed by an integrated Placido disk and rotating Scheimpflug camera topographer (CSOTM Sirius). Several parameters were measured: anterior corneal astigmatism (ACA) and posterior corneal astigmatism (PCA), total astigmatism based on anterior topographic data (simK) and total corneal astigmatism (TCA) by merging anterior and posterior astigmatism using ray tracing.
RESULTS: Mean ACA was 1.51 diopters (D) and PCA was 0.38D. ACA was aligned 47% with-the-rule and PCA 87% against-the-rule. Cases with against-the-rule ACA showed low magnitude correlation between anterior and posterior surfaces. TCA had a mean deviation of 0.30D @ 3 over SimK in a vector calculation. Eighteen percent (18%) of cases differed by 0.50 D or more between SimK and TCA magnitude, and 53% had 10 or more degrees of axis discrepancy, the difference being higher at lower magnitudes of astigmatism.
CONCLUSIONS: Anterior WTR astigmatism tends to be compensated by posterior ATR astigmatism in older patients. Nevertheless, the high number of cases largely justifies the use of tomographic technology that takes into account the posterior corneal surface for managing individual total corneal astigmatism.
FULL ARCH CBCT SCANS
Extended field of view up to 12 cm x 10 cm—best for full arch scans
VERSATILE 2D/3D SYSTEM Versatile 4-in-1 system ideal for expanding treatment capabilities
ARTIFACT-FREE, HIGH RESOLUTION IMAGES High-resolution 3D images with limited artifacts and noise
OUTSTANDING IMAGE QUALITY
Outstanding 2D/3D images thanks to the latest premium technology
ULTRA-COMPACT DESIGN
Ideal for practices that want to expand their capabilities without expanding their footprint
POWERED WITH CS IMAGING VERSION 8
Provides you with one-stop access to all your images and CAD/CAM data
Indian Dental Academy: will be one of the most relevant and exciting training center with best faculty and flexible training programs for dental professionals who wish to advance in their dental practice,Offers certified courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic Dentistry, Periodontics and General Dentistry.
As Carestream Dental’s most successful 3D unit, the CS 8100 3D
is now available with an optional cephalometric imaging module.
A multi-functional, 4-in-1 imaging solution, the new CS 8100SC 3D blends award-winning 2D panoramic technology, powerful CBCT imaging, and 3D model scanning with the world’s fastest cephalometric scanning capabilities. In turn, you gain access to the tools you need to build your practice through a single imaging system that covers virtually all of your everyday imaging needs.
ULTRA-COMPACT DESIGN
Slim and elegant, the CS 8100SC 3D fits practically anywhere. At just 1.8 m wide, the unit is one of the smallest cephalometric units and features an open design that Is built for comfort.
MULTI-FUNCTIONAL SYSTEM
In addition to diagnostic imaging, the CS 8100SC 3D allows you to obtain precise digital 3D models for optional applications, including orthodontics, implant planning or CAD/CAM restorations.
Faster and more confident diagnosis:
• True anatomical details
• Distortion free images, 1:1 anatomical accuracy • Eliminate doubts from 2D exams
Predictability in surgery, improved treatment quality Increased productivity and autonomy
• In-office 3D exams– limit patient visits Improved communication
• Show patients images that are easier to understand Increased treatment plan acceptance.
The advantages at a glance
• Affordable three-in-one solution– 3D, 2D panoramic and optional cephalometric imaging
• Highest resolution (76 μm), low dose 3D images
• Flexible 3D programs– from local exams to full-arch exams
• Compatible with guided surgery systems
What Exactly is PDIP?
PDIP is an acronym for “Prothetic Dental Implant Planning” Traditionally with CBCT implant planning software, you have had to place the implant and then work out how to get your abutment and crown in the correct position. With PDIP you position the crown and then place the implant in the best position to accommodate the crown. However the latest version of PDIP take this a stage further and integrates the SMOP, BlueSkyBio and coming soon may other guided systems.
360 Visualise can help you with hardware, calibration, clinical training and software support.
Aakash Eye Hospital is one of the largest eye hospital in Ahmedabad, Visnagar and Bharuch. our expertise in Cataract Surgery ,Glaucoma, Bladeless Lasik Surgery, Squint Surgery, Pterygium, eye Treatment and Conjunctivitis Treatment
Make one-appointment restorations a reality in your practice
Expand your chairside restorative treatment options and deliver aesthetic, accurate and durable restorations. It’s never been easier with the CS 3100. Combining the top-of-the-line CS 3600 with exocad Chairside CAD software, the CS 3100 delivers the optimal HD chairside user experience for aesthetic restorations.
RESTORATIVE VERSATILITY
CS 3100 offers four distinct fabrication options, including milling, grinding, carving and thrilling, and delivers hybrid resin, ceramic and zirconia restorations—ideal for full contour crowns and bridges, inlays, onlays and veneers.
WORKFLOW PROFICIENCY
Efficient digital workflow speeds treatment, improves case acceptance rates and drives practice productivity.
PRECISION MILLING FOR OPTIMAL AESTHETICS
The CS 3100 features a 4-axis brushless motor and an exceptionally precise Jäger spindle capable of grinding at speeds up to 100,000 rpm.
USER-FRIENDLY FUNCTIONALITY
Users simply transfer the crown design to the mill, insert the block (and, if needed, a new bur), close the door and push start.
STATE-OF-THE-ART SOFTWARE
Smart Milling Queue Management in exocad Chairside CAD software enables you to prepare multiple restorations, one after another, while the automated block selection reduces user error.
QUIET, COMPACT DESIGN
The CS 3100’s small footprint enables you to place it anywhere in the practice—even chairside due to its quiet, vibration-free milling. No compressed air, water supply or drain needed, resulting in easy installation and maintenance.
• Automated 4 tool size changer delivers optimal anatomical results
• Intuitive touch-screen display provides a simplified user experience
• Unique carving mode expedites milling times
• Future-proof system capable of adapting to new materials
• Clever mounting, with milling parts separated from the control part, eliminates contamination of electronic components
• Robust, durable technology ensures long-term precision milling
SPOTLIGHT ON THE PREMIUM CHANNEL - Abbott Medical OpticsHealthegy
Presentation from OIS@ASCRS 2016
Leonard Borrmann, Divisional VP, R&D
Video Presentation:
https://www.youtube.com/watch?v=02VOUB17Xp8&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw&index=38
Brief introduction to the latest innovations that are used at dentistry, where equipment used are fully digitized and computerized, with the differences between using conventional methods and digital equipment in dentistry.
Main equipment to be discussed are dental imaging systems and CAD/CAM systems
This presentation gives a brief overview of the current intra oral scanner market as of October 2018. Comparisons of accuracy and a brief overview of some of the software packages available to allow you to go to guide.
360 Visualise: Last year 360 Visualise sold more CBCT in the UK than any other company. Our first scanning centre in Ilkley was the first independent CBCT referral centre outside of London and we now scan over 3000 patients each year. This experience gives us a unique insight into the clinical needs and processes of the dental profession and what can be achieved with new software packages.
New processes are quickly developing enabling implant dentists to quickly scan, plan and print implant drilling guides using third-party applications such as SMoP & BlueSkyBio. The price of these services has reduced dramatically over the past year and with increased competition is set to continue to improve and become more accurate and efficient.
Working with so many dentists and labs, 360 Visualise are in a unique position to support you and your 3D scanner as this incredible technology continues to evolve over the coming years.
Aakash Eye Hospital is one of the largest
eye hospital in Ahmedabad, Visnagar and Bharuch.
our expertise in Cataract Surgery ,Glaucoma, Bladeless Lasik Surgery,
Squint Surgery, Pterygium, eye Treatment and Conjunctivitis Treatment.
STREAMLINED CAD/CAM RESTORATIONS
• More procedures, in fewer steps and all in your practice
• 3-step scan, design, mill process
• Comfortable workflow for both you and your patients
• Open system to better meet your practice needs
The presentation gives you an overview of the digital impression as well as intraoral scanners. Trios 3 of 3Shape was specifically discussed in the presentation.
Faster and more confident diagnosis:
• True anatomical details
• Distortion free images, 1:1 anatomical accuracy • Eliminate doubts from 2D exams
Predictability in surgery, improved treatment quality Increased productivity and autonomy
• In-office 3D exams– limit patient visits Improved communication
• Show patients images that are easier to understand Increased treatment plan acceptance.
The advantages at a glance
• Affordable three-in-one solution– 3D, 2D panoramic and optional cephalometric imaging
• Highest resolution (76 μm), low dose 3D images
• Flexible 3D programs– from local exams to full-arch exams
• Compatible with guided surgery systems
What Exactly is PDIP?
PDIP is an acronym for “Prothetic Dental Implant Planning” Traditionally with CBCT implant planning software, you have had to place the implant and then work out how to get your abutment and crown in the correct position. With PDIP you position the crown and then place the implant in the best position to accommodate the crown. However the latest version of PDIP take this a stage further and integrates the SMOP, BlueSkyBio and coming soon may other guided systems.
360 Visualise can help you with hardware, calibration, clinical training and software support.
Aakash Eye Hospital is one of the largest eye hospital in Ahmedabad, Visnagar and Bharuch. our expertise in Cataract Surgery ,Glaucoma, Bladeless Lasik Surgery, Squint Surgery, Pterygium, eye Treatment and Conjunctivitis Treatment
Make one-appointment restorations a reality in your practice
Expand your chairside restorative treatment options and deliver aesthetic, accurate and durable restorations. It’s never been easier with the CS 3100. Combining the top-of-the-line CS 3600 with exocad Chairside CAD software, the CS 3100 delivers the optimal HD chairside user experience for aesthetic restorations.
RESTORATIVE VERSATILITY
CS 3100 offers four distinct fabrication options, including milling, grinding, carving and thrilling, and delivers hybrid resin, ceramic and zirconia restorations—ideal for full contour crowns and bridges, inlays, onlays and veneers.
WORKFLOW PROFICIENCY
Efficient digital workflow speeds treatment, improves case acceptance rates and drives practice productivity.
PRECISION MILLING FOR OPTIMAL AESTHETICS
The CS 3100 features a 4-axis brushless motor and an exceptionally precise Jäger spindle capable of grinding at speeds up to 100,000 rpm.
USER-FRIENDLY FUNCTIONALITY
Users simply transfer the crown design to the mill, insert the block (and, if needed, a new bur), close the door and push start.
STATE-OF-THE-ART SOFTWARE
Smart Milling Queue Management in exocad Chairside CAD software enables you to prepare multiple restorations, one after another, while the automated block selection reduces user error.
QUIET, COMPACT DESIGN
The CS 3100’s small footprint enables you to place it anywhere in the practice—even chairside due to its quiet, vibration-free milling. No compressed air, water supply or drain needed, resulting in easy installation and maintenance.
• Automated 4 tool size changer delivers optimal anatomical results
• Intuitive touch-screen display provides a simplified user experience
• Unique carving mode expedites milling times
• Future-proof system capable of adapting to new materials
• Clever mounting, with milling parts separated from the control part, eliminates contamination of electronic components
• Robust, durable technology ensures long-term precision milling
SPOTLIGHT ON THE PREMIUM CHANNEL - Abbott Medical OpticsHealthegy
Presentation from OIS@ASCRS 2016
Leonard Borrmann, Divisional VP, R&D
Video Presentation:
https://www.youtube.com/watch?v=02VOUB17Xp8&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw&index=38
Brief introduction to the latest innovations that are used at dentistry, where equipment used are fully digitized and computerized, with the differences between using conventional methods and digital equipment in dentistry.
Main equipment to be discussed are dental imaging systems and CAD/CAM systems
This presentation gives a brief overview of the current intra oral scanner market as of October 2018. Comparisons of accuracy and a brief overview of some of the software packages available to allow you to go to guide.
360 Visualise: Last year 360 Visualise sold more CBCT in the UK than any other company. Our first scanning centre in Ilkley was the first independent CBCT referral centre outside of London and we now scan over 3000 patients each year. This experience gives us a unique insight into the clinical needs and processes of the dental profession and what can be achieved with new software packages.
New processes are quickly developing enabling implant dentists to quickly scan, plan and print implant drilling guides using third-party applications such as SMoP & BlueSkyBio. The price of these services has reduced dramatically over the past year and with increased competition is set to continue to improve and become more accurate and efficient.
Working with so many dentists and labs, 360 Visualise are in a unique position to support you and your 3D scanner as this incredible technology continues to evolve over the coming years.
Aakash Eye Hospital is one of the largest
eye hospital in Ahmedabad, Visnagar and Bharuch.
our expertise in Cataract Surgery ,Glaucoma, Bladeless Lasik Surgery,
Squint Surgery, Pterygium, eye Treatment and Conjunctivitis Treatment.
STREAMLINED CAD/CAM RESTORATIONS
• More procedures, in fewer steps and all in your practice
• 3-step scan, design, mill process
• Comfortable workflow for both you and your patients
• Open system to better meet your practice needs
The presentation gives you an overview of the digital impression as well as intraoral scanners. Trios 3 of 3Shape was specifically discussed in the presentation.
Richard L. Lindstrom, MD's "Thoughts on Corneal and Lens based Refractive Surgery to Enhance Near Vision in the USA: 2015" presentation from OIS@ASCRS 2015
Th e use of premium IOLs requires more specifically than standard monofocal IOLs a thorough clinical and para clinical examination using modern equipments.
We will only mention micro-incision premium IOLs that are used
in our daily practice. All information regarding the characteristics of all available and especially multifocal IOLs are available in the SFO 2012 Report on presbyopia
Biometry is the method of measuring various dimensions of the eye, its components and their inter-relationship. Using these data to calculate the idol intraocular lens power. In 1949, 29th November, Harold Ridley implanted the first IOL but his patient had a refractive surprise of -20 D spherical equivalents.
So, It was long way to travel to refined the out comes. Classic keratometry is based on anterior corneal surface measurements.
Whereas this directly measure the anterior and posterior corneal surface to obtain Total keratometry(TK).
Telecentric keratometry of the anterior corneal surface + swept source OCT of the posterior corneal surface= TOTAL KERATOMETRY.
TK measurements are compatible with existing IOL constants plus two exclusive formulas: barrett true K with TK for post LVC eyes and Barrett TK toric.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
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Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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7. The average amount of higher order aberrations present for a 7.5mm pupil was equivalent to the wave-front error produced by less than ¼ of defocus.
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9. Why Now? High Precision Preoperative Biometry Curvature of the Cornea (Keratometry) Axial Length / Length of the Eye (biometry) Estimate IOL Position IOL Dependent (Design, Material, etc.) Surgeon Technique Dependent (Optimization Formula) Calculate IOL Power Now More Accurate Now More Accurate Now More Accurate
10. Choosing an IOL Power Actual Study Patient: JLOS375 Preoperative Measurements IOL Power Options
12. Actual Study Patient: JLOS375 New Standard: Expanded IOL Power Increments Choosing an IOL Power
13. The Softec HD PS eliminates a MAJOR accuracy variable. Actual Study Patient: JLOS375 Physician Choice Choosing an IOL Power
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17. Standard Outcomes However current industry standards 9,10,11 for postoperative refractive error (diopters from target) are as follows: 9 Gale RP, et al. Eye . 2009; 23:149-152. 10 Zaidi FH, et al. Br J Ophthalmol. 2007; 91: 731-736. 11 Lundstr ӧ m M, Stenevi U, Thorburn W. Acta Ophthalmol Scand . 2002; 80; 248-257. 0.5 D Defocus 1.0 D Defocus 4mm pupil diameter, Aspheric IOL 4mm pupil diameter, Aspheric IOL ~50% within 0.50 D of target ~80% within 1.00 D of target
18. Cumulative Target vs. Achieved Refraction * * Clinical trial data on file at Lenstec, Inc. ~50% ~70% ~80% ~95% Percent n=305 n=306 n=295 n=291 8 Sites New Standard
19. Cumulative Target vs. Achieved Refraction * Percent * Data on file at Lenstec, Inc. 12 Month Postoperative Data; 1 Clinical Trial Site (n=10/group)
20. Cumulative Uncorrected Visual Acuity * * Data on file at Lenstec, Inc. Percent Industry Standard: 93% 20/40 or better BEST CORRECTED Driving vision 12 Month Postoperative Data; 1 Clinical Trial Site (n=10/group)
21.
22. More Precise IOL Tighter tolerances & smaller lens increments = more accurate results More accurate results -> improved postoperative visual acuity. High Precision New Standard Softec HD PS ± 1.00 D = 80% ± 0.50 D = 50% ± 0.25 D = 40% ± 0.75 D = 85% ± 1.00 D = 95% ± 0.50 D = 70% Industry Standard
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25. MNREAD is used with normal or low vision patients to assess the reading performance/speed with different print sizes
26. 74% 99% Percent of Cases 20/20 20/25 20/32 92% 100% 20/40 37% 20/16 Percent of Cases PRINT SIZE (logMAR)
27. MNREAD Functional Vision Testing Bilateral Implantation at 1 Year Tetraflex vs. Monofocal Control Tetraflex Control Denotes statistical significance * * * * * 20/20 20/25 20/32 20/40 20/16 20/50 20/63
28. MNREAD Functional Vision Testing Bilateral Implantation Stability of Tetraflex Reading 1 Year 2 Years 6 Months 20/20 20/25 20/32 20/40 20/16 20/50 20/63
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30. MNREAD Functional Vision Testing Bilateral Implantation at 1 Year Tetraflex vs. crystalens Tetraflex crystalens Denotes statistical significance * * * * * 20/20 20/25 20/32 20/40 20/16 20/50 20/63
31. MNREAD Functional Vision Testing Bilateral Implantation at 1 Year Tetraflex vs. Control vs. Crystalens Tetraflex crystalens Denotes statistical significance Control * * * * * 20/20 20/25 20/32 20/40 20/16 20/50 20/63
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36. Your standard IOL is likely to be the greatest source of refractive error.
Editor's Notes
Take back to slide showing difference between 0.0 D, 0.25 D and 0.50 D defocus. Clinical Trial data on 18-25D range.
All patients in 18-25 D range (PS series). All patients contralaterally implanted Tecnis in one eye & Softec in other eye. Monovision patient excluded (n=1). One patient with with Amblyopia excluded (n=1). Softec HD PS Mean = 0.18 +/- 0.11 Tecnis Mean = 0.27 +/- 0.18 Note: Small Sample Size
Note: For Softec UCVA ≠20/20 to 20/25 in 90% of cases (like target v achieved ≤0.25 D) due to pc fibrosis (4 mild cases). One patient is 20/40. He/she was 20/20 at 3-6 Month visit -> PCO.
All comparisons being made between the Tetraflex and 3-piece Collamer monofocal control IOL were tested for statistical significance using the Wilcoxon Two-sample or Mann-Whitney U-Test. The null hypothesis was that the value produced by the Tetraflex lens was either the same as or worse than (lower value) that produced by the control lens; thus 1-sided tests were used to test for the Tetraflex value being better (higher) than that of the control. MNRead functional vision testing was administered binocularly to bilaterally implanted Tetraflex and Control cases at 1 year postoperatively. Reading speed in Words per Minute in a semi-logarithmic scale is given on the Y Axis while Print size in Snellen equivalents of LogMAR values is given on the X-Axis. The graphs are similar up to a print size of 20/80 vision and then the controls begin to lose the ability to read in terms of reading speed relative to the Tetraflex IOL. The Tetraflex was statistically significantly better than the controls at print sizes of 20/63 (p=0.02), 20/50 (p=0.004), 20/40 (p=0.006), 20/32 (p<0.001), and 20/25 (p=0.001). Note that even at the 20/40 print size which is smaller than classified advertising text or telephone directory print, the reading speed with the Tetraflex IOL averages about 49 words per minute compared to only 23 words per minute for the control IOL. No patient in the control group could read the 20/25 line so the reading speed is zero after 20/32.
This graph compares the currently available 6 month, 1 year, and 2 year Tetraflex MNREAD data demonstrating no significant loss of reading ability between 6 months and 2 years postoperatively.
Tetraflex cases were enrolled as part of the U.S. FDA clinical trial. A consecutive series of Crystalens cases that returned to the practices collecting MNRead data from our clinical trial who were between 1 to 1.5 years postoperatively were also enrolled. As can be seen above, the Crystalens and Tetraflex cases were of similar age, similar follow-up and had similar visual potential (greater than 20/20 on average). All Crystalens cases were model 5.0.
All comparisons being made between the Tetraflex and Crystalens were tested for statistical significance using the Wilcoxon Mann-Whitney U-Test. The null hypothesis was that the value produced by the Tetraflex lens was the same as that produced by the Crystalens; thus 2-sided tests were used to test for the Tetraflex value compared to that of the Crystalens. MNRead functional vision testing was administered binocularly to bilaterally implanted Tetraflex and Crystalens cases at an average of 13-14 months post-operatively. Reading speed in Words per Minute in a semi-logarithmic scale is given on the Y Axis while Print size in Snellen equivalents of LogMAR values is given on the X-Axis. The graphs are similar from larger print sizes down to a print size of 20/63 vision and then the Crystalens patients begin to lose the ability to read in terms of reading speed relative to the Tetraflex patients. The Tetraflex was statistically significantly better than the Crystalens at print sizes of 20/63 (p=0.004), 20/50 (p=0.002), 20/40 (p=0.001), 20/32 (p=0.003) and 20/25 (p=0.001). Note that even at the 20/40 print size which is smaller than classified advertising text or telephone directory print, the reading speed with the Tetraflex IOL averages about 52 words per minute compared to only 25 words per minute for the Crystalens IOL. While one usually thinks of good reading vision as the ability to read 20/20 or 20/25 print sizes, it has recently been pointed out that commonly read print objects such as telephone directory, stock quotations, or newspaper print are all larger than 20/40 print. 1 Richter-Mueksch, et al. have suggested that reading the 20/50 line would be a good criterion for reasonable reading performance. 2 Sanders D, Sanders M. Near Visual Acuity for Everyday Activities with Accommodative and Monofocal Intraocular Lenses. J Refract Surg 2007;23:747-51. Richter-Mueksch S, Weghaupt H, Skorpik C, Velikay-Parel, Radner W. Reading performance with a refractive multifocal and a diffractive bifocal intraocular lens. J Cataract Refract Surg 2002,28:1957-63.
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