The document summarizes research on the IC-8TM small-aperture intraocular lens. Optical modeling shows it extends the depth of focus compared to monofocal and bifocal lenses. Clinical data from patients found it provided a broad range of clear vision from near to far, with minimal visual symptoms. The IC-8TM lens can be implanted using standard cataract surgery techniques and allows for posterior segment assessments and procedures.

1. IC-8™ Small-Aperture
Intraocular Lens
Nicholas Tarantino, O.D.
Chief Clinical and Regulatory
Officer

2. Depth of Focus Comparison
Optical Modeling, 3.0 mm Pupil
IC-8™Small Aperture IOL Extended Depth of Focus (TC -0.75D)
Standard Mono-focal
0.0 D -0.5 D -1.0 D -1.5 D -2.0 D -2.5 D
20/50
20/40
20/30
20/20
20/10
20/50
20/40
20/30
20/20
20/10
20/50
20/40
20/30
20/20
20/10
2
Diffractive Bi-focal
0.0 D -0.5 D -1.0 D -1.5 D
(66 cm)
-2.0 D
(50 cm)
-2.5 D
(40 cm)
0.0 D -0.5 D -1.0 D -1.5 D -2.0 D -2.5 D

3. IC-8™ IOL Extends Depth of Focus
• Defocus curve results from IC-8 IOL patients demonstrate broad range of
vision across near, intermediate and far distances versus a monofocal IOL
• Mean post-op MRSE at their last follow-up was -0.14 D +/- 0.52
Data courtesy of Robert Ang, MD
-0.20
-0.10
0.00
0.10
0.20
0.30
0.40
0.50
0.60
0.70
0.80
0.90
1.00
1.10
Acuity(LogMAR)
Defocus Lens Power
Simulated Monofocal IOL Ang 6M (n=8)
Far Near
20/25
20/40

4. Forgiving Design
• Combining with a small amount of myopia further extends depth of
focus
• If refractive target is missed, patient still achieve good range from
near
Data courtesy of Robert Ang, MD
-0.20
-0.10
0.00
0.10
0.20
0.30
0.40
0.50
0.60
0.70
0.80
0.90
1.00
1.10
Acuity(LogMAR)
Defocus Lens Power
Simulated Monofocal IOL Ang 6M (n=8)
Far Near
20/25
20/40

5. Near Visual Acuity
Uncorrected and Target Corrected
• Mean achieved UCNVA in the IC-8™ eye is J2, with refractive target
correction to -0.75 D mean improves to J1
• 89% of eyes achieved J1 or better TCNVA
22%
89%
100% 100%
89%
100% 100% 100%
0%
20%
40%
60%
80%
100%
>=J1 >=J2 >=J3 >=J5
Uncorrected & Target Corrected
Near Visual Acuity
UCNVA IE TCNVA IE
Data courtesy of Robert Ang, MD (n=9)
TCNVA: Visual acuity tested at -0.75 DS

6. Intermediate and Distance Acuity
Uncorrected and Target Corrected
• Mean achieved UCIVA, TCIVA, UCDVA and TCDVA in the IC-8™ eye is
20/20
• 100% of patients achieved 20/25 TCIVA and TCDVA
44%
67%
100% 100%
78%
100% 100% 100%
0%
20%
40%
60%
80%
100%
>=20/20 >=20/25 >=20/32 >=20/40
Uncorrected & Target Corrected
Intermediate Visual Acuity
UCIVA IE TCIVA IE
Data courtesy of Robert Ang, MD (n=9)
TCIVA and TCDVA: Visual acuity tested at -0.75 DS
67%
78%
100% 100%
56%
100% 100% 100%
0%
20%
40%
60%
80%
100%
>=20/20 >=20/25 >=20/32 >=20/40
Uncorrected & Target Corrected
Distance Visual Acuity
UCDVA IE TCDVA IE

7. Reported Visual Symptoms Remain Low
• Comparison between eyes shows similar scores for
all symptoms ratings
Data courtesy of Robert Ang, MD (n=9)
QUESTIONAIRE:
Patients were asked to
rate the presence of
visual symptoms on a
scale of 0 to 7
(0=None, 7=Severe)
None
Severe
0
1
2
3
4
5
6
7
Subjective Symptoms
IC-8 Eye (IE) vs. Fellow Eye (FE)
Month 12 FE
Month 12 IE

8. No Surgical Adaptation Needed
• Personal cataract removal technique
acceptable
– Choice of manual or femtosecond
laser-created incisions, capsulotomy
and lens fragmentation
• In the bag lens placement same as any
standard IOL:
– Haptics at 6 and 12 o’clock
• To date no centration issues experienced
with any version of the lens

9. Ocular Assessment & Posterior Segment
Procedures Possible
• Imaging through the IOL mask central
aperture is possible minimal differences
noted between IC-8 IOL and fellow monofocal
IOL implanted eyes1 (Visual field, fundus
photography, and retinal OCT)
• Technicians reported ocular assessments
were successful and required no different
instructions for IC-8 IOL eyes
• Vitreoretinal surgery in eyes implanted with
the IC-8 IOL can be performed with ease and
good visibility2,3
1- Data courtesy of Dr. Amadeo Veloso
2- Results from a an animal study conducted by Dr. Barry Kupperman is Professor of Ophthalmology and Biomedical Engineering;
Chief, Retina Service; Vice-Chair, Clinical Research, Ophthalmology at UC Irvine School of Medicine
3-Personal experience in one patient form Professor Burkhardt Dick, MD
Fellow Eye
IC-8 IOL Eye
Images courtesy of Prof. Günther Grabner

10. Summary
– Reliably extends depth of focus
– Provides excellent visual acuity across all distances
– Is forgiving of refractive misses
– Tolerant to 1.50 D of astigmatism
– Has a low-level of visual symptoms
– Requires no surgical adaptation
– Is free of centration issues
– Allows posterior segment ocular assessments and
secondary procedures post implantation

11. THANK YOU
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