My personal selection of highlights from the #ePharma 2015 summit in NYC. The topics ranged from wearables to innovation to population health and emerging pharma business models. The highlights are from 25-26 Feb 2015
Presentation of the EUSOMII/ESOI annual meeting in Valencia, Oct. 2016, about the impact of new communication tools on the communication between radiologists, clinicians and patients
Understanding Mental Health Apps — Neurotech SF presentationSteven Chan, MD MBA
What does the mental health app and psychiatry informatics landscape look like? A brief 15-minute look given at Neurotech SF conference at UCSF Mission Bay, by Steven Chan — University of California, Davis researcher and resident physician — on barriers, challenges, and near-term solutions on psychology, psychotherapeutics, and digital mental health.
Presentation of the EUSOMII/ESOI annual meeting in Valencia, Oct. 2016, about the impact of new communication tools on the communication between radiologists, clinicians and patients
Understanding Mental Health Apps — Neurotech SF presentationSteven Chan, MD MBA
What does the mental health app and psychiatry informatics landscape look like? A brief 15-minute look given at Neurotech SF conference at UCSF Mission Bay, by Steven Chan — University of California, Davis researcher and resident physician — on barriers, challenges, and near-term solutions on psychology, psychotherapeutics, and digital mental health.
May 2013 NHS Choices satisfaction surveyNHSChoices
Report of web survey that measures NHS Choices site user's satisfaction with their visit on that day. The survey includes, reasons for visit, whether people found what they wanted, experience of using the search functionality on the site.
Digital Health Revolution and the Opportunity for Dietitians to Lead Viable Synergy LLC
This is a presentation that was given at the 96th Annual Conference of the Ohio Academy of Nutrition and Dietetics conference on May 18, 2017. During the session we discussed the rise of digital health and its impact and role in health and healthcare delivery. Innovative software, hardware, and communication solutions were described and use cases discussed. Innovative programs and services being provided by dietitians in our region and around the world were highlighted.
The pairing of large tablets with smartphones has important implications for news organizations.
Nearly 9 in 10 large tablet owners also use smartphones according to the latest mobile media survey from the Donald W. Reynolds Journalism Institute. Only 4 in 10 smartphone owners said they also used large tablets.
Insights into patient preferences on telemedicine, wearables
and post-discharge care - We asked more than 2,000 Americans how they currently connect with healthcare providers. Their answers may surprise you - This survey was conducted online within the United States by Harris Poll on behalf of Salesforce from June 8-10, 2016, among 2,025 U.S. adults ages 18 and older, among whom 1,736 have health insurance and a primary care doctor. This online survey is not based on a probability sample, and therefore no estimate of theoretical sampling error can be calculated. For complete survey methodology, including weighting variables, please contact Joel Steinfeld at jsteinfeld@salesforce.com.
Wearable Health, Fitness Trackers, and the Quantified SelfSteven Tucker
The vision and reality of individualised health and wellness achieved through tracking personal data. An introduction to the scope of the problems followed by the advent of the Quantified Self. Then a pictorial view of trackers, gadgets, #ehealth, and #mHealth devices. This leads the audience to a clear understanding of how we can digitise behaviour and biology to achieve wellness and prevent disease in the 1st place. Overall, there is an underlying influence of the impact of exponential technologies in numerous fields with an increasing force in healthcare.
Creating greater value for people with diabetes: the case of digitalization i...Milena Saleh
Creating great value for people with diabetes: the case of digitalization in diabetes, presentation at 10th Digital Pharma Europe, Milena Saleh.
The presentation reviews recent diabetes technology & healthcare model innovations and provides a framework for assessment of successful interventions.
Passive data collection entails active patients: Refocusing the UX lens in cl...Medullan
Presented at the PanagoraPharma Clinical Trials & IoT Forum, November 7, 2016.
Sensor technology and connected devices promise a wealth of real-world data for clinical trials without participants seemingly needing to effort. But it’s wrong to conflate the notion of passive data collection with passive patient behavior. Trial subjects need to accept sensor technology and allow it into their lives. Successful trials using IoT connected devices require renewed focus on the user experience, considering how patients, many who may be digitally naïve, adopt and use connected devices. Even when data is collected passively, IoT trials require participants to be engaged, which has significant implications for the design of trials.
2019-06-04 Learnings and key success factors digital medical devices Milena S...Milena Saleh
Digital medical devices and virtual clinics are making inroads in diabetes management. The presentation reviews two such solutions, and discusses the critical elements for success and key learnings - what are the benefits and incentives for stakeholders, and what is needed to change current behaviours and attitudes.
Edelman Health Barometer 2008: Health Influence in the Era of Public Engagement
Edelman Health Barometer 2010 (http://www.slideshare.net/edelmaninc/edelman-health-engagement-barometer-2010)
Social media for tracking disease outbreaks–way of the future By.Dr.Mahboob a...Healthcare consultant
Traditional disease surveillance relies on data obtained from doctors, hospitals or laboratories through formal reporting systems. This yields valid and accurate data about emerging outbreaks and the impact of control strategies such as vaccinations. But it’s often not timely. Digital data are now publicly available from many sources. People talk about epidemics on social media using key words such as “fever” and “infection” before they are officially identified.
A surveillance system for detecting outbreaks of Ebola using Twitter, for example, could set geospatial tags for specific locations such as the African continent. It could search for a cluster of terms on the Twittersphere such as “haemorrhage”, “fever”, “virus”, “Ebola”, “Lassa” (an illness that can be confused with Ebola).
A system trying to identify influenza could mine terms that reflect visits to the doctor, purchase of tissues, paracetamol or aspirin from pharmacies, sick leave from work, as well as terms specific to the clinical syndrome of influenza.
May 2013 NHS Choices satisfaction surveyNHSChoices
Report of web survey that measures NHS Choices site user's satisfaction with their visit on that day. The survey includes, reasons for visit, whether people found what they wanted, experience of using the search functionality on the site.
Digital Health Revolution and the Opportunity for Dietitians to Lead Viable Synergy LLC
This is a presentation that was given at the 96th Annual Conference of the Ohio Academy of Nutrition and Dietetics conference on May 18, 2017. During the session we discussed the rise of digital health and its impact and role in health and healthcare delivery. Innovative software, hardware, and communication solutions were described and use cases discussed. Innovative programs and services being provided by dietitians in our region and around the world were highlighted.
The pairing of large tablets with smartphones has important implications for news organizations.
Nearly 9 in 10 large tablet owners also use smartphones according to the latest mobile media survey from the Donald W. Reynolds Journalism Institute. Only 4 in 10 smartphone owners said they also used large tablets.
Insights into patient preferences on telemedicine, wearables
and post-discharge care - We asked more than 2,000 Americans how they currently connect with healthcare providers. Their answers may surprise you - This survey was conducted online within the United States by Harris Poll on behalf of Salesforce from June 8-10, 2016, among 2,025 U.S. adults ages 18 and older, among whom 1,736 have health insurance and a primary care doctor. This online survey is not based on a probability sample, and therefore no estimate of theoretical sampling error can be calculated. For complete survey methodology, including weighting variables, please contact Joel Steinfeld at jsteinfeld@salesforce.com.
Wearable Health, Fitness Trackers, and the Quantified SelfSteven Tucker
The vision and reality of individualised health and wellness achieved through tracking personal data. An introduction to the scope of the problems followed by the advent of the Quantified Self. Then a pictorial view of trackers, gadgets, #ehealth, and #mHealth devices. This leads the audience to a clear understanding of how we can digitise behaviour and biology to achieve wellness and prevent disease in the 1st place. Overall, there is an underlying influence of the impact of exponential technologies in numerous fields with an increasing force in healthcare.
Creating greater value for people with diabetes: the case of digitalization i...Milena Saleh
Creating great value for people with diabetes: the case of digitalization in diabetes, presentation at 10th Digital Pharma Europe, Milena Saleh.
The presentation reviews recent diabetes technology & healthcare model innovations and provides a framework for assessment of successful interventions.
Passive data collection entails active patients: Refocusing the UX lens in cl...Medullan
Presented at the PanagoraPharma Clinical Trials & IoT Forum, November 7, 2016.
Sensor technology and connected devices promise a wealth of real-world data for clinical trials without participants seemingly needing to effort. But it’s wrong to conflate the notion of passive data collection with passive patient behavior. Trial subjects need to accept sensor technology and allow it into their lives. Successful trials using IoT connected devices require renewed focus on the user experience, considering how patients, many who may be digitally naïve, adopt and use connected devices. Even when data is collected passively, IoT trials require participants to be engaged, which has significant implications for the design of trials.
2019-06-04 Learnings and key success factors digital medical devices Milena S...Milena Saleh
Digital medical devices and virtual clinics are making inroads in diabetes management. The presentation reviews two such solutions, and discusses the critical elements for success and key learnings - what are the benefits and incentives for stakeholders, and what is needed to change current behaviours and attitudes.
Edelman Health Barometer 2008: Health Influence in the Era of Public Engagement
Edelman Health Barometer 2010 (http://www.slideshare.net/edelmaninc/edelman-health-engagement-barometer-2010)
Social media for tracking disease outbreaks–way of the future By.Dr.Mahboob a...Healthcare consultant
Traditional disease surveillance relies on data obtained from doctors, hospitals or laboratories through formal reporting systems. This yields valid and accurate data about emerging outbreaks and the impact of control strategies such as vaccinations. But it’s often not timely. Digital data are now publicly available from many sources. People talk about epidemics on social media using key words such as “fever” and “infection” before they are officially identified.
A surveillance system for detecting outbreaks of Ebola using Twitter, for example, could set geospatial tags for specific locations such as the African continent. It could search for a cluster of terms on the Twittersphere such as “haemorrhage”, “fever”, “virus”, “Ebola”, “Lassa” (an illness that can be confused with Ebola).
A system trying to identify influenza could mine terms that reflect visits to the doctor, purchase of tissues, paracetamol or aspirin from pharmacies, sick leave from work, as well as terms specific to the clinical syndrome of influenza.
HAS 22 Day 2: Healthcare Analytics’ Biggest Party Wraps UpHealth Catalyst
Day 1 of HAS 22 may have looked like a hard act to follow, but Day 2 did not disappoint! From early risers for the fun run/walk to a full day of keynotes, featured speakers, breakout sessions, and more, summit attendees learned new ways to look at data and analytics, how we relate to information and each other, and new perspectives for making the healthcare ecosystem–and world at large–a better place.
Perfecting the art of medical hypnosis as an alternative to traditional anesthesia, learnings from Sodexo's International Leaders' Survey, addressing the challenges and opportunities created by the multi-generational workforce in hospitals, improving transport services to increase efficiency, news around the world.
Judy Starts to Cross the Autoimmune AbyssDrBonnie360
Content and Visual Design by Tiffany Simms
Bringing the Lonely Voices of Autoimmune Disease back to Stanford Medicine X 2015, DrBonnie360 describes an autoimmune journey through Judy's Story.
Judy finds hope in patient power, new data sharing and collaboration, and turning data into insights.
Expanded version of a short panel presentation on the subject of mHealth. My point was that mHealth has meaning only in the larger context of an important reality: the best quality care depends on having the best information, so THAT is what we need to be thinking about.
A presentation by Brian D Sites at the 2017 meeting of the Scandinavian Society of Anaestesiology and Intensive Care Medicine.
All available content from SSAI2017: https://scanfoam.org/ssai2017/
Delivered in collaboration between scanFOAM, SSAI & SFAI.
From surviving to thriving: cancer’s next challengePwC Russia
Рак-диагноз, который никто не хочет услышать. Приуроченный к Всемирному дню борьбы с раком отчет PwC рассказывает об историях тех, кто пережил этот страшный период жизни и не сдался.
McGovern Award Lecture - American Medical Writers AssociationGary Schwitzer
The McGovern Award is given by the American Medical Writers Association for "preeminent contributions to medical communications." It was presented at the AMWA annual conference, in Memphis, October 9, 2014.
A patient perspective on the Five Year Forward View, pop up uni, 2pm, 3 septe...NHS England
Expo is the most significant annual health and social care event in the calendar, uniting more NHS and care leaders, commissioners, clinicians, voluntary sector partners, innovators and media than any other health and care event.
Expo 15 returned to Manchester and was hosted once again by NHS England. Around 5000 people a day from health and care, the voluntary sector, local government, and industry joined together at Manchester Central Convention Centre for two packed days of speakers, workshops, exhibitions and professional development.
This year, Expo was more relevant and engaging than ever before, happening within the first 100 days of the new Government, and almost 12 months after the publication of the NHS Five Year Forward View. It was also a great opportunity to check on and learn from the progress of Greater Manchester as the area prepares to take over a £6 billion devolved health and social care budget, pledging to integrate hospital, community, primary and social care and vastly improve health and well-being.
More information is available online: www.expo.nhs.uk
Can you teach an old doc new tricks? Techonomy Bio 2015W2O Group
Greg Matthews' presentation at the Techonomy Bio confernce 2015 in Mountain View, CA (http://techonomy.com/conf/bio15/). Introduces the context of the global health ecosystem.
Consumer Attitudes About Comparative EffectivenessMSL
Evidence as an essential—but insufficient—ingredient for medical decision-making. Presentation to the National Comparative Effectiveness Summit by Chuck Alston, SVP and Director of Public Affairs at MSLGROUP Washington, DC on September 16, 2013.
Infographics of The Big 5 Tech Giants recent Digital Health Journey's (Amazon, Apple, Facebook, Google and Microsoft). Hyperlinks to all Digital Health news content at each milestone. Presentation is downloadable and should be a useful reference
A 3+ Year Review of 12 StartUp Health Companies ProgressGary Monk
On 10/26/15 I met 12 StartUp Health companies at the Cleveland Clinic. This annotated presentation shows where these companies are today in terms of activity and funding status. Some encouraging reading (See slide 15 summary)
85% of clinical trials fail to recruit enough patients, 80% fail to finish on time. A key issue is 70% of patients live more that 2 hours from the study site. Wearable devices can support the collection of real world data in the patients home as well as create novel endpoints
Its 2019 - Should Pharma Still Be Scared of Digital?Gary Monk
Updated deck with 2018 ABPI data on UK breaches to the code of practice by Pharma and how much of role did digital play?
One of Pharma's biggest fears when it comes to adopting digital and new technology, is fear of regulations and compliance. To see how much of an issue this really is, breaches of the ABPI code of practice were analyzed over 2017 & 2016, across all channels. The results are interesting...
An Analysis of the Mobile Search Habits of Americans. What are the proportion of searches performed on mobile devices across the most popular categories? How does healthcare and pharma stack up in terms of consumers searching on mobile?
Mobile Searches in Healthcare - 2018 UPDATEGary Monk
An updated and annotated presentation of analysis of mobile searches in healthcare across a range of medical conditions. The findings show a significant increases across the board, over the last 3 years and some interesting findings. The original presentation had over 2000 views
It's 2018, Should US Pharma still be Scared of Digital?Gary Monk
Follow up analysis of the breaches to the US FDA OPDP regulations by Pharma, looking at the reasons why and digital channels employed. Do Pharma really have an issue using digital from a compliance perspective?
Its 2018... Should Pharma Still be Scared of Digital?Gary Monk
One of Pharma's biggest fears when it comes to adopting digital and new technology, is fear of regulations and compliance. To see how much of an issue this really is, breaches of the ABPI code of practice were analyzed over 2017 & 2016, across all channels. The results are interesting...
Virtual and Augmented Reality in HealthcareGary Monk
An overview of some of the latest examples of where Virtual Reality, Augmented Reality and Mixed Reality are impacting healthcare in a dramatic way. There are numerous examples across a range of conditions.
Note: A number of these examples are featured in more detail in the health section of the following book:
The Fourth Transformation: How Augmented Reality & Artificial Intelligence Will Change Everything (Scoble & Israel)
Wikipedia Health Landscape - Top Health ConditionsGary Monk
This is an update of research into a previous SlideShare looking at the use of Wikipedia to research health conditions and diseases. There is also an interview with top Wikipedia editor Dr James Heilman
Technology versus Cancer (How can technology help?)Gary Monk
There is a lot of cancer ‘moonshotting’ going on but what are the main ways that technology can help the fight against cancer?
This presentation is focused on how technological hardware, software, data, algorithms, artificial intelligence and wearables can help win the war against cancer. Emerging technology promises so much particularly when it comes to the battle against cancer.
Top 10 Health Trends at CES 2016 - Havas HealthGary Monk
The Top 10 health related trends at CES 2016. The trends are wide ranging from Fitness to Automotive This deck gives you the health trends to watch, with some specific future use cases and some that are very relevant now. For questions, more information or discussion please get in touch!
Health Tech & Health Care - A Shiny Future? Gary Monk
Health innovations including wearables, sensors, big data analytics and 'behavior changing' applications and devices are ubiquitous. These technologies promise so much yet are they really benefiting the healthcare consumer? And what does the future look like? This presentation highlights some real world examples of this technology in use today and some insights into what the future may hold. This presentation on Health Technology was presented at the @BrightTALK event on 10th Dec. 2015
Highlights of some key sessions I attended at SXSW 2015. The bias is towards innovation and healthcare. How to set up your business for success, think differently, leverage new technology and engage your customers.
18 Interesting Health Technology StartupsGary Monk
An overview of 18 interesting health technology startups. Some are more successful than others, some are in a relatively crowded space. Slides contain an overview and insights into these emerging healthtech companies
Consumer Electronics Show 2015 - A healthcare summaryGary Monk
A summary of the latest health technology, advances in remote medicine and pharma cases from the 2015 Consumer Electronics Show (CES) in Las Vegas. Outputs from the health exhibition and digital health sessions
Analysis in the rise of mobile search in Healthcare and Pharma over the last 2 years. All analysis via google, over the last 8 quarters. Trends across 10 interesting and common diseases are analyzed.
Wikipedia Pharma Disease Analysis in EU5 CountriesGary Monk
Wikipedia Pharma Disease Analysis in EU5 Countries (Spanish, German, French, English, Italian. A review of the most viewed disease pages in English and a comparison with the other languages. The analysis looks at relative page views for the Top 5 diseases and how active the editors are, with recommendations for healthcare companies considering editing.
An analysis of Pharma Wikipedia disease pages. This looks at the common pharma disease pages on Wikipedia, including how often they are viewed and edited. It analyses the top editors of these disease pages that are of interest to Pharma companies. Editing disease pages by Pharma companies, in the right way, is a potentially lower risk route than prescription medicine pages. This is a useful analysis for anyone working in healthcare and interested in editing Wikipedia.
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2. Introduction
Some unofficial images and highlights from the
#epharma 2015 conference in New York City,
with some personal commentary and opinion
3. Before we start…
Opinions are mine
I have not been sponsored by the organizers (iir
usa) although they kindly allowed me to publish
photos
My interpretations of the speakers messages
may differ from their intended ones!
4. Paul Ivans
Evolution road consulting
Paul gave an overview of the
healthcare landscape, highlighting the
lack of physician autonomy
He referenced the Merck – Practice
Fusion example of population health
in vaccines. See article here
5. Thought Leader Panel
Monique Levy (left) held the view that the golden days
of patient empowerment are over. The patient may
have unprecedented access to information but
physicians have less control. Other members of the
panel had a more optimistic view
Panelists L-R, Monique Levy, Craig Kemp, Jeremy Shepler, Tom McCourt, Jonathan
Gordon
6. Thought Leader Panel
The panel debated if barriers to innovation were
cultural or structural. I personally believe both!
‘Look across the patient journey, locate the major pain
point and focus there’ was my favorite piece of advice
7. Thomas Goetz
IODINE
Iodine is the ‘Tripadvisor’ of (legal)
drugs, replete with valuable patient
feedback or as pharma would call
them ‘Adverse Events’
It will take a forward thinking Pharma
Co to partner with him but surely this
sort of feedback is what the industry
needs?
You can find the site here
8. Value Discussion Panel
This discussion on how to offer value to customers was focused on the incremental such as
using Key Account Teams. There was a view that the pharma sales rep would be around for a
long time to come. I don’t believe this unless the role radically changes. Defenders may say
the death of the pharma rep has been looming since the early 1990’s
Panelists L-R, Bill Paquin, Erin Curcio, Heather Gervais (obscured), Nolan Castillo
9. My GI Health
• Apparently the ‘UBER for GI’
• A video showing the journey of a stool made
‘pleasant’ post lunch viewing
• An interesting digestion tracker was referenced
that measures digestive sounds
• The importance of ‘Thick Data’ as well as ‘Big
Data’
• See My GI Health here
Tom McCourt (Ironwood) and Brennan Spiegel (UCLA)
10. Physician
Networks
• Oncologists don’t tend to
interact with each locally
due to competition
• Where you train as a
doctor influences who will
connect and respond to
you
• PCPs tend to connect
locally and specialists
across the country
• Some doctors are
influential nodes, others
are ‘bridging connectors’
between specialties
• Doctors salaries vary
across the country. New
York cardiologists are
some of the poorest (if
$450k a year counts as
poor..)
Craig Kemp (Merck Vaccines) & Nate Gross MD (Doximity)
11. John Mangano
comScore Inc
John presented some very
interesting stats on wearables.
Mobile phones have 4x the
market penetration of health
tracking wearables. Are these
the future? He highlighted the
recent news wearables and
smartphones have equal
efficacy in tracking health
I can’t share his slide deck but if
you ask him very nicely maybe
he will..
12. Sarah Krüg
Cancer 101
The quote I took away was
‘Experience Based Medicine is
as important as Evidence
Based Medicine’
A great presentation despite
technical challenges, I am sure
she must have taken improv
classes
13. Peter Dannenfelser
Janssen Pharmceuticals
A plucking great presentation. Pete’s
description of innovation via his bass guitar
struck a chord with the audience (Sorry!)
His main focus was getting the basics right
in pharma marketing, being open to
transformation yet not being consumed by it
He highlighted only 23% of pharma
websites are mobile enabled
I am of the view Pharma needs to think big
when it comes to innovation but hard to
argue with Pete that they need to do the
basics right first
He highlighted social community
management will be the next focus for
innovation. I agree with him, just can’t
believe it has taken the industry so long
14. Jeremy Shepler
Novo Nordisk
Ask-Screen-Know is a Novo program that
aims to support all patients with diabetes
whether diagnosed or not, through
screening and support to staying in
control
Novo’s branded products do not benefit
proportionately from this activity so it is
very much a wellness service unrelated to
the product (please don’t make me say
Beyond The Pill!)
Most channels are digital although some
are traditional to cater for an ‘older’
audience
Interesting partnership with Michael
Stevens (V Sauce – You Tube) to educate
around Diabetes
15. Meet your future boss
The rising stars of pharma innovation
This panel of rising stars shared their opinons on innovation as well as citing some interesting
cases from inside and outside of their companies (take outs on the next slide)
Panelists L-R, David Kopp(Healthline), Erika Jurrens(GSK), Annie Singer(BMS), Ryan Billings(AZ), Greg Cohen(UCB)
16. Meet your future boss
The rising stars of pharma innovation
• My favorite example was the branded NEXIUM Facebook page. It goes where other
companies won’t and allows comments! Importance of understanding the audience (in this
case mostly women over 40) and having an informed content strategy
• Highlighted was the UCB sponsored Epilepsy community on Facebook and how a disease
state summit of patients and caregivers provided insights for a mentorship program
• Also highlighted was the ‘patient centric’ UCB Cares and how social listening is helping
understand what patients need
• Interesting BMS ‘Tell Your Story’ program where patients can submit their experiences.
Example for Yervoy
• The overall feeling from the panel on ‘wearables’ was they are over hyped and not accurate.
As an agency you would have to convince these guys any ‘new innovation’ is a key
component of an integrated program
17. Greg Barrett
Daiichi Sankyo
Greg discussed a pilot initiative in
conjuction with Partners Healthcare
It is in the area of Atrial Fibrillation
where Daiichi have a product
At the core is a ‘mobile application
focused on coaching and educating
AF patients’