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Suicidal inhibition These HIV protease inhibitors act by binding irreversibly to the active site of the viral protease enzyme, rendering it unable to function. This mechanism is known as suicidal inhibition. The key aspects are: - They bind irreversibly to the active site - Rendering the enzyme unable to function - This is considered suicidal inhibition The other proposed inhibition types (competitive, non-competitive, uncompetitive) do not accurately describe this mechanism.












































































