The EMPHASIS program is a 5-year initiative funded by the Big Lottery Fund, UK, that aims to reduce the vulnerability of key mobile populations to HIV/AIDS along mobility routes between Bangladesh/India and Nepal/India. The program will deliver interventions at source, transit, and destination points and generate evidence to influence regional policies relating to safe mobility. Key objectives include demonstrating effective models for HIV prevention, care, and support for mobile populations and enhancing partners' capacity. The program will work in source areas in Nepal and Bangladesh, transit areas along the borders, and destination areas in major Indian cities. Initial activities include mapping populations, stakeholder analyses, and building common understanding among partners.