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Drugs cold supply chain presentation
- 1. 3RD INTERNATIONAL CONFERENCEON SUPPLY CHAIN Implementation of Total Quality Management Tools in Cold Supply Chains: The Case of Drugs Theodoros Athanasiadis Dimitrios Aidonis Petros Ieromonachou
- 2. 3RD INTERNATIONAL CONFERENCEON SUPPLY CHAIN Detection of potential problems that may occur in drugs cold supply chain Understanding, evaluation and implementation of corrective actions in order to eliminate or delete them. Improvement of supply chain management by engaging of principles and tools involved in TQM Main Scope
- 3. Main scope 3RD INTERNATIONALCONFERENCE ON SUPPLY CHAIN TQM SCM Drugs cold supply chain •Vaccines •Insulins •Inhalers •New biotechnological products
- 4. 3RD INTERNATIONAL CONFERENCEON SUPPLY CHAIN Drugs peculiarities •Sort period of life •Globalization-long distances •Many products are very expensive or too cheap •Large amount of generics •High sensitivity •Absolute necessity •Regulations, laws (local, international) •(WHO W. H., Guide to good storage practices for pharmaceuticals, 2003 •WHO W. H., Model Guidance for the Storage and Transport of Time and Temperature-Sensitive Pharmaceutical Products, 2010 •ΕΜΕΑ 2007 (Declaration of storage conditions in the product infοrmation of medicinal products) •Guidelines of 5 November 2013 on Good Distribution Practice of medicinal products for human use (2013/C 343/01)
- 5. 3RD INTERNATIONAL CONFERENCEON SUPPLY CHAIN Structure of the Study-Research •Structure of Drugs Supply Chain in Greece •Analysis of operations of Supply Chain (Flow Chart) •Detection of faults and problems ( FTA) •Research Methodology •Research Data analysis •FMEA – ( RPN, problems evaluation) •Corrective actions
- 6. 3RD INTERNATIONAL CONFERENCEON SUPPLY CHAIN Manifacturer-distributor Consumer Pharmacy-Hospital-Insurance co. Wholesaler Pre-wholesaler Wholesaler Drugs Supply Chain Structure in Greece
- 7. 3RD INTERNATIONAL CONFERENCEON SUPPLY CHAIN Seller Transporter Customer`` Start Specification of storage requirements Comply with standards Stop of procedure Storage Temperature recording Filling forms Is process under control? Rejection Specification of packaging requirements Packaging Is process under control? Pick up and transfer by transporter Specification of transportin requirements Check and recording of temperature Filling forms Comply with transporting standards? Pickup from customer Unpackanging andstorage Send reference to supplier End No YES YES NO YES NO NO YES Drugs cold supply chain Flow Chart
- 8. Cold supply chainfailure Sellers Failure Distributors Failure Customers failure or 3RD INTERNATIONAL CONFERENCE ON SUPPLY CHAIN Cold supply chain failure Inappropriate equipment Inappropriate handling Inappropriate planning or Drugs Cold Supply Chain: FTA
- 9. Refrigerating machines • Non-regular maintenance • Badusage • Inappropriate maintenance • Inappropriate tools • Not qualified workers Metric system temperature control failure • Damaged instruments • Non calibrated equipments • Non regular measurements • Faults measurements • Absence of software Handling problems • Lack of knowledge • Not clear instructions • Loading- uploading problems • Workers negligence Transportation means and procedures • Inappropriate vehicles • Non-regular maintenance • Inappropriate maintenance • Irresponsible workers • Maintenance by unskilled people Planning and design of procedures • Long distances • Often stop of vehicles • Wrong planning • Non separation of products • Lack of communication 3RD INTERNATIONAL CONFERENCE ON SUPPLY CHAIN Main causes of problems in drugs cold supply chain
- 10. Research Methodology Questionnaire Research Period : 1-28 February 2015 Email, Fax, Post, Couriers Community pharmacists, Drugs wholesalers, Pharmaceutical companies 3RD INTERNATIONAL CONFERENCE ON SUPPLY CHAIN
- 11. Διπλωματική εργασία-Αθανασιάδης Θεόδωρος 6% 17% 35% 36% 6% Possibilityto appear very much very likely less likely unlikely 3RD INTERNATIONAL CONFERENCE ON SUPPLY CHAIN 90% consider problems as serious 58%consider problems are likely to occur Less than10% consider problems are unlikely to occur 31% 34% 25% 8% 2% Problems severity Research Data Analysis
- 12. Probability toappear 000 010 020 030 040 050 060 1 2 3 4 5 machines problems metric system handling transpostation structure >30% 3RD INTERNATIONAL CONFERENCE ON SUPPLY CHAIN Research Data Analysis
- 13. 3RD INTERNATIONAL CONFERENCEON SUPPLY CHAIN 33.3% consider moderate or little possibility to detect >40% 000 010 020 030 040 050 060 uncertain less possib. moderate pos. quit certain certain machines problems metric system handling transpostation structure 4% 13% 18% 37% 28% Possibility of detection uncertain little pos. moderatte pos quite certain certain Research Data Analysis
- 14. 3RD INTERNATIONAL CONFERENCEON SUPPLY CHAIN 000 010 020 030 040 050 060 very much very likely less likely unlikely non-regular maintenance bad usage inapropriate maintenance inappropriate tools inapropriate workers Percentage distribution of causes that create problems in refrigerating machines 000 010 020 030 040 050 very much very likely less likely unlikely damaged instruments non calibrated equipment non regular messurments fauls messurements absence of software Percentage distribution of handling problems causes 000 010 020 030 040 050 very much very likely less likely unlikely lack of knowledge not clear instructions loading problems workers negligence Percentage distribution of handling problems causes Research Data Analysis
- 15. 3RD INTERNATIONAL CONFERENCEON SUPPLY CHAIN 000 005 010 015 020 025 030 035 040 045 050 very much very likely less likely unlikely inapropriate vehicles non regular maintenance inapropriate maintenance maintenance by incompeted people irresposnible workers Percentage distribution of transportation problems causes >67% 000 005 010 015 020 025 030 035 040 045 050 very much very likely less likely unlikely long distnces often stop of vehicles wrong planning products separation communication Percentage distribution of inadequate planning >67% >75% Research Data Analysis
- 16. 3RD INTERNATIONAL CONFERENCEON SUPPLY CHAIN Probable problem Severity Probability Detect ability RPN Problems in machines 4,03 2,69 1,74 18,90 Failure of metric system 3,52 2,28 2,08 16,65 Handling errors 3,97 3,31 2,44 32,02 Problems in transportation 3,90 3,13 2,44 29,70 Inadequate plans 3,77 2,64 2,72 27,06 FMEA: Main Problems categories
- 17. 3RD INTERNATIONAL CONFERENCEON SUPPLY CHAIN Process step Potential Failure Mode Potential Failure Effect SEV Potential Causes OCC Current Process Controls DET RPN Inadequate planning Omissions Products demolition 3,77 No separation of products 3,23 Re-evaluation 2,72 33,12 Handling Ignorance of procedures Products demolition 3,97 Loading- unloading problems 3,28 Inspection 2,44 31,77 Inadequate planning Omissions Products demolition 3,77 Lack of communication 3,05 Re-evaluation 2,72 31,28 Inadequate planning Omissions Products demolition 3,77 Faults in routes 3,05 Re-evaluation 2,72 31,28 Handling Ignorance of procedures Products demolition 3,97 negligence 3,21 Inspection 2,44 31,09 Process step Potential Failure Mode Potential Failure Effect SEV Potential Causes OCC Current Process Controls DET RPN Refrigerating machines Stop of procedure Products demolition 4.03 Conservation by wrong people 2.95 Inspection 1.74 20.69 Metric system Wrong temperature estimation Products demolition 3.52 Wrong measurement 2.74 Check 2.08 20.09 Metric system Wrong temperature estimation Products demolition 3.52 Not calibrated instruments 2.67 Check 2.08 19.71 Metric system Wrong temperature estimation Products demolition 3.52 Damaged instruments 2.67 check 2.08 19.52 Refrigerating machines Stop of procedures Products demolition 4.03 Use of improper tools 2.74 Inspection 1,74 19.21 FMEA: Main causes of problems in Drugs Cold supply chain
- 18. 3RD INTERNATIONAL CONFERENCEON SUPPLY CHAIN CORRECTIVE ACTIONS Leadership Strategic planning Funding increase Employees involvement Business culture Information and uncertainty Costumers Focus Structural changes Inventory management
- 19. 3RD INTERNATIONAL CONFERENCEON SUPPLY CHAIN CORRECTIVE ACTIONS Clear designed procedures Communication Intervention of administration Employees involvement Internal evaluation Occurrence Detection √ √ √ √ √ √ √ √ √ √
- 20. 3RD INTERNATIONAL CONFERENCEON SUPPLY CHAIN Thank you for your attention!!!
Editor's Notes
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