The document discusses solid lipid nanoparticles (SLNs), which are submicron colloidal carriers composed of a single lipid core matrix that is solid at body temperature. SLNs can incorporate both hydrophilic and hydrophobic drugs in their solid lipid core. They offer advantages like controlled drug release, stability, biocompatibility and protection of incorporated drugs. However, SLNs also have disadvantages like poor drug loading capacity and potential drug expulsion during storage. The document provides details on the structure, production methods and applications of SLNs.

1. DR. K.N.M.I.P.E.R.
MODINAGAR
SOLID LIPID
NANOPARTICLE(SLNs)
Presented by
ALOK SINGH
B.Pharm 3rd
year
1507850005

2. NANOPARTICLES
 Nanoparticles are particles between 1 and
100 nanometres (nm) in size with a surrounding
interfacial layer.
 The interfacial layer is an integral part of
nanoscale matter, fundamentally affecting all of
its properties.
 The interfacial layer typically consists of ions,
inorganic and organic molecules.
 Organic molecules coating inorganic
nanoparticles are known as stabilizers, capping
and surface ligands.

3. TYPES OF NANOPARTICLES
 Polymeric Micelles
 Nanosuspension and Nanocrystals
 Ceramic NPs
 Liposomes
 Niomoses
Solid-Lipid Nanoparticles
 Dendrimers
 Magnetic Nanoparticles

4. DIFFERENT NANOPARTICLES

5. SOLID LIPID NANOPARTICLE
 Solid-lipid Nanoparticles (SLNs) are submicron
colloidal carriers composed of a single lipid core
matrix that is solid at body temperature, and is
coated with a surfactant acting as stabilizer.
 A solid lipid nanoparticle is typically spherical with -an
average diameter between 10 and 1000 nanometers.
 Solid lipid nanoparticles possess a solid lipid core
matrix that can solubilize lipophilic molecules.
 The lipid core is stabilized by surfactants (emulsifiers).
 The term lipid is used here in a broader sense and
includes Mono , Di and Triglycerides, fatty
acids , steroids and waxes .
 All classes of emulsifiers have been used to stabilize the

6. STRUCTURE

7. TYPES OF SOLID LIPID NANOPARTICLES
SLNs can be divided into 3 basic types on the basis of drug
loading:-
I. Type-1(homogeneous matrix model)
II. Type-2(drug enriched shell model)
III.Type-3(drug enriched core model)
drugdrug

10. 1. HIGH PRESSURE HOMOGENIZATION

12. ADVANTAGES
 The SLNs bypass liver and spleen filtration.
 Controlled release of the incorporated drug can be achieved
for up to several weeks .
 SLN formulations stable for even three years has been
developed.
 The feasibility of incorporating both hydrophilic and
hydrophobic drugs .
 The carrier lipids are biodegradable and hence safe .
 Generally less toxic as compared to some polymeric
nanoparticles because physiological and biocompatible lipids
are used .
 Protecting the labile and sensitive drugs from chemical,
photochemical or oxidative degradation, due to
immobilization of drug molecules by solid lipids .

13. DISADVANTAGES
 Poor drug loading capacity.
 Drug expulsion during storage.
 Low capacity to load Hydrophilic drugs due to
partitioning effect during production procss.
 Particle growth.

14. USES/APPLICATIONS OF SLNS