This document provides an overview of the anatomy, physiology, and common diseases of the esophagus. It begins with the learning objectives which are to understand the anatomy/physiology and clinical features of benign and malignant esophageal diseases. It then covers topics such as surgical anatomy, physiology, symptoms, investigations, congenital anomalies, foreign bodies, perforations, gastroesophageal reflux disease, hiatal hernia, motility disorders, and diverticula.
Different esophageal disorders are discussed in this lecture. The learning objectives are to understand:
The anatomy and physiology of the oesophagus and their relationship to disease.
The clinical features, investigations, and treatment of benign and malignant disease with particular reference to the common adult disorders.
Topics include: Surgical anatomy, Physiology, Symptoms, Investigations, Congenital lesions: TOF and Atresia, Benign tumours, Cancer of oesophagus, Foreign bodies,Oesophageal perforation, Gastro-oesophageal reflux diease, Hiatal hernia,
Oesophageal motility disorders: achalasia and diffuse spasm, Oesophgeal diverticula.
and Others.
Different esophageal disorders are discussed in this lecture. The learning objectives are to understand:
The anatomy and physiology of the oesophagus and their relationship to disease.
The clinical features, investigations, and treatment of benign and malignant disease with particular reference to the common adult disorders.
Topics include: Surgical anatomy, Physiology, Symptoms, Investigations, Congenital lesions: TOF and Atresia, Benign tumours, Cancer of oesophagus, Foreign bodies,Oesophageal perforation, Gastro-oesophageal reflux diease, Hiatal hernia,
Oesophageal motility disorders: achalasia and diffuse spasm, Oesophgeal diverticula.
and Others.
Carcinoma esophagus is the common cause for dysphagia for solids. These patients usually present too late to do any definitive curative surgical procedure.
Carcinoma esophagus is the common cause for dysphagia for solids. These patients usually present too late to do any definitive curative surgical procedure.
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2. LEARNING OBJECTIVES
To understand:
The anatomy and physiology of the
oesophagus and their relationship to
disease.
The clinical features, investigations, and
treatment of benign and malignant disease
with particular reference to the common
adult disorders.
4. SURGICAL ANATOMY
The oesophagus is a fibromuscular tube 25 cm long.
Occupying the posterior mediastinum.
Extending from the cricopharyngeal sphincter to the
cardia of the stomach.
4 cm of this tube lies below the diaphragm.
The musculature of the upper one third is mainly
striated, giving way to smooth muscle below.
It is lined by squamous epithelium except the lower 3
cms which are lined by specialized mucosa.
8. PHYSIOLOGY
To transfer food from the mouth to the stomach.
Sequential contraction of oropharyngeal musculature
+ simultaneous closure of nasal and respiratory
passages+ opening of the cricopharyngeal sphincter.
Involuntary peristaltic wave in the body of oesophagus
then sweeps food bolus downwards.
Through a relaxed gastro-oesophageal sphincter zone
into the stomach.
The upper sphincter is normally closed at rest to
prevent regurgitation. Failure of it to relax on
swallowing may cause propulsion diverticulum.
9. PHYSIOLOGY
At the lower end of the oesophagus there is a
physiological sphincter which together with other
anatomical mechanisms prevent reflux of gastric acid
and bile.
The tone of this sphincter is influenced by
gastrointestinal hormones, anti-cholinergic drugs and
smoking.
The displaced sphincter loses its tone and permits
reflux to occur.
The normal GOJ is 3-4 cm long and has a pressure of
30 cm H2O.
10. SYMPTOMS
Difficulty in swallowing described as food or fluid
sticking ( oesophageal dysphagia). Must rule out
malignancy.
Pain on swallowing ( odynophagia). Suggest
inflamation and ulceration.
Regurgitation or reflux ( heartburn). Common in
gastro-oesophageal reflux disease ( GORD).
Chest pain; difficult to distinguish from cardiac pain.
Loss of weight, anaemia, cachexia and change of voice
are other important symptoms.
11. INVESTIGATIONS
Radiography.
plain CXR, contrast oesophagography ( barium or
gastrographin swallow) and CT scan of chest.
Endoscopy: rigid and flexible oesophagoscopy.
Endosonography: endoscopic ultrasonography.
Oesophageal manametry: to diagnose oesophageal
motility disorders.
24-hour pH monitoring: the most accurate method for
the diagnosis of gastro-oesophageal reflux.
17. CONGENITAL ABNORMALITIES
Atresia with or without tracheo-
oesophageal fistula.
Stenosis-rare.
Short oesophagus with hiatus hernia.
Dysphagia lusoria ( compression by an
abnormal artery).
18. TYPES OF TOF
IT SHOULD BE SUSPECTED IN ALL CASES OF HYDRAMNIOS,
A CONDITION WHICH IS PRESENT IN 50% OF CASES OF ATRESIA.
RECOGNITION WITHIN FORTY-EIGHT HOURS OF BIRTH,
AND SUBSEQUENT SURGICAL CORRECTION, IS THE
ONLY HOPE OF SURVIVAL.
20. FOREIGN BODIES IN OESOPHAGUS
Adults as well as children are prone to ingest FBs.
Varieties of FBs have been encountered. The most
common impacted material is food.
Dysphagia, odynophagia and drooling of saliva.
Plain X- ray +_ contrast study to confirm diagnosis.
Removal should be done as early as possible.
Complications: perforation of oesophagus, aspiration,
fistula formation with aorta.
Removal is by rigid or flexible oesophagoscopy.
Surgery may be needed for sharp or impacted FBs
which fail to be extracted by endoscopy.
22. PERFORATION OF OESOPHAGUS
Potentially lethal complication due to mediastinitis
and septic shock.
Numerous causes, but may be iatrogenic.
Surgical emphysema is virtually pathognomonic.
Treatment is urgent; it may be conservative or surgical,
but requires specialized care.
May be spontaneous ( due to barotrauma): Borehaave
syndrome; is the most serious form of perforation
because of large volume of material that is released
under pressure into the mediastinum and pleura. It is
caused by vomiting against a closed glottis, sometimes
following labour or weight lifting. The tear is in the
weakest point in the lower third.
23. PERFORATION OF OESOPHAGUS
Instrumentation is by far the most common cause of
perforation.
Diagnostic upper GI endoscopy has a rate of 1: 4000
perforation rate.
Therapeutic endoscopy has a rate of 1: 400 perforation
rate.
Diagnosis is based on clinical features, plain x-ray,
contrast study and CT scan.
Prompt and thorough investigations is the key to
management.
25. Management Options in Perforation of the Oesophagus
Factors that favour non-
operative management
Factors that favour operative
Repair
Small septic load.
Minimal cardiovascular
upset.
Perforation confined to
mediastinum.
Perforation by flexible
endoscope.
Perforation of cervical
oesophagus.
Large septic load.
Septic shock.
Pleura breached.
Boerhave,s synrome.
Perforation of abdominal
oesophagus.
26. INGESTION OF CORROSIVE AGENTS
Corrosives such as
sodium hydroxide (
caustic soda) or
sulphuric acid may be
ingested accidentally or
intentionally causing
chemical burn of
oesophagus.
Severe strictures may
develop.
27. MANAGEMENT
The management in the acute stage is
controversial.
Nothing by mouth, steroids to reduce fibrosis and
parenteral nutrition. Followed by careful
oesophagoscopy.
Dilatation may be helpful for short strictures.
Long strictures are better managed surgically.
Surgical options include: replacement of
oesophagus by stomach, colon or jujenum.
32. Leiomyomas
Account for two thirds of all benign tumours of the
oesophagus.
Symptoms: dysphagia occurs when leiyomyomas
exceed a diameter of 5 cm as they grow within the
muscular wall, leaving the overlying mucosa intact.
Diagnosis: Dysphagia, barium swallow and
oesophagoscopy.
Biopsy is contraindicated.
33. Leiyomyoma
The characteristic radiographic finding of an esophageal leiyomyoma
on barium esophagogram, a smooth concave filling defect, created
by a well- defined lesion, with sharp, intact mucosal shadow with
abrupt angle where the tumour meets the normal esophageal wall.
34. Surgical treatment
Enucleation: in symptomatic patients, the
tumour is enucleated from the oesophageal wall
without violating the mucosa.
A limited oesophageal resection is indicated if the
tumour lies in the lower oesophagus and can not
be enucleated.
35. Benign intraluminal tumours
Oesophagoscopy is performed to confirm the
diagnosis and to rule out malignancy.
Surgical treatment:
Oesophagotomy, removal of the tumour, and repair of
the oesophagomyotomy.
Endoscopy should not be used to remove these tumours
because of the possibility of oesophageal perforation.
36. Malignant Tumours
Incidence:
in the US, the incidence of oesophageal
carcinoma ranges from 3.5 in 1 million for whites
to 13.5 in 100,000 for blacks.
The highest incidence of oesophageal carcinoma
is noted in the Hunan Chinese population with as
many as 130 in 100,000 inviduals affected.
37. Aetiology
The exact cause is unknown.
Associated factors are:
tobacco use, excessive alcohol ingestion,
nitrosamines, poor dental hygiene, and hot
beverages.
Premalignant conditions:
Achalasia
Barrett,s oesophagus.
38. Pathology
Squamous cell carcinoma is the most common form.
Adenocarcinoma, the next commonest, is the type
that occurs in patients with Barrett,s oesophagus.
Rare tumours include mucoepidermoid carcinoma
and adenoid cystic carcinoma.
Tumour spread: direct invasion, lymphatic and
haematogenic spread.
39. DIAGNOSIS
History: dysphagia and weight loss.
Contrast study.
CT: depth of invasion, lymphatic spread and distant
metastases.
Oesophagoscopy: for tissue diagnosis.
Endoscopic ultrasonography: depth of invasion and
staging.
Bronchoscopy: for proximal lesions to exclude invasion
of the bronchial tree.
40. TREATMENT
Surgery provides the only cure.
Operative mortality is less than 5%.
Types: Ivor-Lewis op.
Transhiatal oesophagectomy.
Left thoraco-abdominal approach.
Radiotherapy and chemotherapy: either as adjuvant
to surgery or as a primary treatment option.
Paliative Treatment for inoperable cases: stenting.
41.
42.
43. GASTRO-OESOPHAGEAL
REFLUX
This is a common condition affecting 80% of
population.
LES is a physiological sphincter normally has
an intra-abdominal position. Loss of LES
pressure results in gastric reflux.
Oesophageal motility causes refluxed
secretions to be cleared by oesophageal
peristalsis.
Gastric secretions, gastric acid, pepsin and bile
reflux produce severe oesophagitis.
44. DIAGNOSIS
Symptoms: substernal pain, heartburn and
regurgitation.
Manometry: decreased LES pressure.
Oesophagoscopy: oesophagitis.
24-hr pH monitoring: increased acidity.
Cineradiography: correlates the amount of reflux via
motion pictures.
45. TREATMENT
MEDICAL:
PPI, H2- receptor antagonists, cisapride and
metoclapramide increasing rate of gastric
emptying, antacids, weight reduction, abstinence
from smoking and alcohol and elevation of the
head of bed at night.
SURGERY:
Antireflux operations: Nissen fundoplication, Belsey
Mark IV op and Hill repair.