This document provides a detailed overview of the anatomy and physiology of the esophagus. It describes the relations, layers, blood supply, nerve supply, lymphatic drainage and musculature of the esophagus. It discusses the swallowing process and peristalsis. It also covers clinical topics such as perforation of the esophagus, its diagnosis and treatment. Instrumental perforation is identified as the most common cause. The principles of non-operative and surgical management of perforations are outlined.
he peritoneum is the serous membrane that lines the abdominal cavity. It is composed of mesothelial cells that are supported by a thin layer of fibrous tissue and is embryologically derived from the mesoderm.
The esophagus is a muscular tube that connects the pharynx to the stomach.
It begins in the neck where it is continuous with the laryngopharynx at the pharyngo-esophageal junction.
The esophagus consists of striated (voluntary) muscle in its upper third, smooth (involuntary) muscle in its lower third, and a mixture of striated and smooth muscle in between.
he peritoneum is the serous membrane that lines the abdominal cavity. It is composed of mesothelial cells that are supported by a thin layer of fibrous tissue and is embryologically derived from the mesoderm.
The esophagus is a muscular tube that connects the pharynx to the stomach.
It begins in the neck where it is continuous with the laryngopharynx at the pharyngo-esophageal junction.
The esophagus consists of striated (voluntary) muscle in its upper third, smooth (involuntary) muscle in its lower third, and a mixture of striated and smooth muscle in between.
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4. Relations…
• Right side- mediastinal pleura & terminal
part of azygous vein
• Left side- left subclavian artery, aortic
arch, thoracic duct, mediastinal pleura
• When esophagus pierces the diaphragm,
it is accompanied by two vagi, branches
of left gastric artery & lymphatic vessels.
• In abdomen – left lobe of liver anteriorly
& left crus of diaphragm posteriorly.
5. Constrictions
I – Pharyngo-esophageal junction
-15cm from incisor teeth.
II- Aortic arch and left bronchus
crosses esophagus
anteriorly- 25cm from
incisor teeth.
III- Esophagal hiatus 40cm
from incisor
6. Clinical importance of constrictions of
esophagus
• Common site for lodgment of foreign body
• Common site for stricture formation after corrosive ingestion
• Common site for carcinoma of esophagus
• Difficult sites for passage of esophagoscope.
7. Length of the Esophagus
• The distance between the cricoid cartilage and the gastric orifice.
• In adults, it ranges from 22 to 28 cm, 3 to 6 cm of which is located in
the abdomen.
• length of the esophagus is related to the subject's height rather than
sex.
• Cervical – 5cm
• Thoracic -18-20cm
• Abdomen – 2-4cm
8. Blood supply
• Upper 1/3 – inferior thyroid
artery
• Middle 1/3 – direct branches
from aorta.
• Lower 1/3 – left gastric artery
10. Nerve supply (Extrinsic)
• Esophageal plexus – formed by
vagus nerves by joining with
sympathetic nerves below the
root of lungs.
• LARP- left vagus anteriorly
• Right vagus posteriorly
11. Nerve suply
• Extrinsic –vagus
• Intrinsic –
• Auerbach /myentric plexus - between longitudinal and circular muscle
• Peristalsis
• Meissner’s plexus- at submucosal level – for secretion
• Meissner’s submucosal plexus is sparse in the esophagus.
• The parasympathetic nerve supply is mediated by branches of the
vagus nerve
• that has synaptic connections to the myenteric (Auerbach’s) plexus.
13. Diameter of the Esophagus
• The esophagus is the narrowest tube in the intestinal tract.
• At rest, the esophagus is collapsed; it forms a soft muscular tube .
• Flat in its upper and middle parts, with a diameter of 1.6 cm.
• The lower esophagus is rounded, and its diameter is 2.4 cm.
14. Musculature
• The musculature of the upper
esophagus & UES is striated.
• This is followed by a transitional zone
of both striated and smooth muscle.
• proportion of the smooth muscle.
progressively increasing.
• In the lower half of the esophagus,
there is only smooth muscle.
• It is lined throughout with squamous
epithelium.
16. Periesophageal Tissue, Compartments, and
Fascial Planes
• Unlike the general structure of the digestive tract, the esophageal
tube has neither mesentery nor serosal coating.
• Its position within the mediastinum and a complete envelope of
loose connective tissue allow the esophagus extensive transverse and
longitudinal mobility.
• The esophagus may be subjected to easy blunt stripping from the
mediastinum.
17. Clinical relevance
• The connective tissues in which the esophagus and trachea are
embedded are bounded by fascial planes,
• the pretracheal fascia anteriorly and
• the prevertebral fascia posteriorly.
• In the upper part of the chest, both fascia unite to form the carotid
sheath.
18. Tunica Adventitia
• This thin coat of loose
connective tissue envelops the
esophagus.
• connects it to adjacent
structures,
• contains small vessels, lymphatic
channels, and nerves.
19. Tunica Muscularis
• The tunica muscularis coats the lumen
of the esophagus in two layers :
• the external muscle layer parallels the
longitudinal axis of the tube,
• the muscle fibers of the inner layer
are arranged in the horizontal axis.
• For this reason, these muscle layers
are classically called longitudinal and
circular, respectively.
20. Tela Submucosa
• The submucosa is the connective tissue layer that lies between the
muscular coat and the mucosa.
• It contains a meshwork of small blood and lymph vessels, nerves, and
mucous glands.
• The duct of deep esophageal glands pierce the muscularis mucosae.
21. Tunica Mucosa
• The mucous layer is composed of three components:
• the muscularis mucosae,
• the tunica / lamina propria, and
• the inner lining of nonkeratinizing stratified squamous epithelium .
23. Physiology
• The musculature of the esophagus = predominantly striated at the
level of the UES and proximal 1 to 2 cm of the esophagus.
• mixed striated = smooth muscle transition zone spanning 4 to 5 cm
• Entirely smooth muscle structure = in the distal 50% to 60% of the
esophagus, including the LES
24. SWALLOWING PROCESS
• Normal human subjects swallow on average 500 times a day.
• The act of swallowing can be divided into three stages:
1. the oral (voluntary) stage,
2. the pharyngeal (involuntary) stage, and
3. the esophageal stage.
• These stages are a continuous process closely coordinated through
the medullary swallowing centers.
25. Esophageal Stage
• The esophageal stage of swallowing starts once the food is transferred
from the oral cavity through the UES into the esophagus.
• This active process is achieved by contractions of the circular and
longitudinal muscles of the tubular esophagus and coordinated relaxation
of the LES.
• Esophageal peristalsis is controlled by afferent and efferent connections of
the medullary swallowing center via the vagus nerve (cranial nerve X).
26. • The vagus nerve carries both stimulating (cholinergic) and inhibitory
(noncholinergic, nonadrenergic) information to the esophageal
musculature.
• In addition to the central nervous system control, the myenteric
(Auerbach) plexus
• plays a major role in coordinating peristalsis in the smooth muscle portion of
the distal esophagus.
27. Esophageal peristalsis
• Esophageal peristalsis is the result of sequential contraction of the
circular esophageal muscle.
• Three distinct patters of esophageal contractions have been
described:
1. Primary peristalsis
2. Secondary peristalsis
3. Tertiary contractions.
28. Primary peristalsis
• Primary peristaltic contractions are the usual form of the contraction
waves of circular muscles that progress down the esophagus;
• they are initiated by the central mechanisms that follow the voluntary
act of swallowing.
• During primary peristalsis, the LES is relaxed, starting at the initiation of
swallowing and lasting until the peristalsis reaches the LES.
29. Secondary peristalsis
• Secondary peristaltic contractions are the contraction waves of the
circular esophageal muscle occurring in response to esophageal
distention.
• They are not a result of central mechanisms.
• The role of secondary peristaltic contractions is to clear the
esophageal lumen of ingested material not cleared by primary
peristalsis or material that is refluxed from the stomach.
• Tertiary contractions are primarily identified during barium x-ray
studies and represent non-peristaltic contraction waves that leave
segmental indentations on the barium column.
30. LES
• Normal LES resting pressure ranges from 10 to 45 mm Hg above the
gastric baseline level.
• The function of the LES is to
• prevent gastroesophageal reflux and
• to relax with swallowing to allow movement of ingested food into the
stomach.
31. Perforation of the oesophagus
• Causes -
1. usually iatrogenic (at therapeutic endoscopy) or
2. due to ‘barotrauma’ (spontaneous perforation).
3. Pathological perforation- rare
4. Penetrating injury
32. Barotrauma (spontaneous perforation, Boerhaave syndrome)
• This occurs classically when a person vomits against a closed glottis.
• The pressure in the oesophagus increases rapidly, and the oesophagus
bursts at its weakest point in the lower third, sending a stream of material
into the mediastinum and often the pleural cavity as well.
• The condition was first reported by Boerhaave , who reported the case of a
grand admiral of the Dutch fleet who was a glutton and practised auto
emesis.
33. Boerhaave syndrome…
• Most serious type of perforation
• because of the large volume of material that is released under pressure.
• mediastinitis
• Barotrauma has also been described in relation to other pressure
events when the patient strains against a closed glottis (e.g.
defaecation, labour, weight-lifting).
34. Diagnosis of spontaneous perforation
• history
• severe pain in the chest or upper abdomen following a meal or a bout of drinking.
• shortness of breath
• O/E-
• rigidity on examination of the upper abdomen, even in the absence of any peritoneal
contamination.
• D/D
• myocardial infarction,
• perforated peptic ulcer or
• pancreatitis if the pain is confined to the upper abdomen.
35. Boerhaave syndrome…
1. Chest x-ray - confirmatory
• air in the mediastinum, pleura or peritoneum.
2. A contrast swallow or
3. CT scan
36. Pathological perforation
• Free perforation of ulcers or tumors of the oesophagus into the
pleural space is rare.
• Erosion into an adjacent structure with fistula formation is more
common.
• Aerodigestive fistula is most common and usually encountered in
primary malignant disease of the oesophagus or bronchus.
• Covering the communication with a self-expanding metal stent is the
usual solution.
39. Diagnosis of instrumental perforation
• History and physical signs may be useful pointers to the site of
perforation.
1. Cervical perforation:
• pain localised to the neck,
• hoarseness,
• painful neck movements and
• subcutaneous emphysema.
40. 2. Intrathoracic and intra-abdominal perforations,
(more common),
• Immediate symptoms and signs
• chest pain,
• haemodynamic instability,
• oxygen desaturation .
• evidence of subcutaneous emphysema, pneumothorax or
hydropneumothorax.
41. Treatment of oesophageal perforations
• Perforation of the oesophagus usually leads to mediastinitis.
• The loose areolar tissues of the posterior mediastinum allow a rapid
spread of gastrointestinal contents.
• Aim of treatment
• limit mediastinal contamination and
• prevent or deal with infection.
42. Decision between operative and non-operative
management rests on four factors
1. the site of the perforation (cervical versus thoraco-abdominal
oesophagus);
2. the event causing the perforation (spontaneous versus
instrumental);
3. underlying pathology (benign or malignant);
4. the status of the oesophagus before the perforation (fasted and
empty versus obstructed with a stagnant residue).
43. Non-operative treatment of Instrumental
perforations
• Cervical oesophagus - are usually small perforation and can nearly
always be managed conservatively.
• The development of a local abscess is an indication for cervical
drainage preventing the extension of sepsis into the mediastinum.
44. Indication for non-operative management
(thoraco-abdominal perforation)
• when the perforation is detected early and prior to oral alimentation.
• absence of
• crepitus,
• diffuse mediastinal gas,
• Hydro-pneumothorax or pneumo-peritoneum;
• mediastinal containment of the perforation with no evidence of widespread
extravasation of contrast material;
• no evidence of ongoing luminal obstruction or a retained foreign body.
• patients who have remained clinically stable despite diagnostic delay.
46. Indication of Surgical management
• unstable with sepsis or shock;
• have evidence of a heavily contaminated mediastinum, pleural space
or peritoneum;
• have widespread intra-pleural or intra-peritoneal extravasation of
contrast material.
47. Surgery
• direct repair,
• the deliberate creation of an external fistula or,
• rarely, oesophageal resection with a view to delayed reconstruction.
• Direct repair
• if the perforation is recognised early (within the first 4–6 hours) and the extent
of mediastinal and pleural contamination is small.
• After 12 hours, the tissues become swollen and friable , primary repair
not possible.
48. MALLORY–WEISS SYNDROME
• Forceful vomiting may produce a mucosal tear at the cardia rather
than a full perforation.
• In Boerhaave’s syndrome, vomiting occurs against a closed glottis,
and pressure builds up in the oesophagus.
• In Mallory– Weiss syndrome, vigorous vomiting produces a vertical
split in the gastric mucosa, immediately below the squamo-columnar
junction at the cardia in 90 per cent of cases.
• In only 10 per cent is the tear in the oesophagus.