This document provides information about DNA replication through a series of slides. It begins with introductory slides on DNA and key figures like Rosalind Franklin. It then covers the process of DNA replication through slides discussing initiation, elongation, and termination. Enzymes involved like DNA polymerase, ligase, and helicase are explained. The importance of DNA replication for cell division and protein production is highlighted. Multiple choice questions assess learning and students rate their understanding of the learning objectives.

2. HOW TO THINK LIKE A
SCIENTIST?
WELCOME TO SCIENCE 10
AN HOUR OF DNA
EXPLORATION

5. Direction: Identify the
images that is
projected in your
screen, write and
submit your answer
within 10 seconds.

6. ROSALIND
FRANKLIN

7. WATSON AND CRICK
MODEL OF DNA

8. NUCLEOTIDES

9. NITROGENOUS
BASES

10. DEOXYRIBONUCLE
IC ACD

12. 3 (6) + 12 = (20 – 5) * 2
LET’S TRY THIS!
Let’s pick one

13. Let’s spin it.

14. DNA REPLICATION

15. A. IDENTIFY THE ENZYMES INVOLVE IN
REPLICATION;
B. EXPLAIN THE PROCESS OF REPLICATION BY
DRAWING A SIMPLE FLOWCHART; AND
C. RELATE THE IMPORTANCE OF DNA
REPLICATION IN BUILDING PROTEIN AND IN
REAL LIFE SITUATION.

16. REPLICATION FACTS
•DNA has to be copied before a cell
divides
•DNA is copied during the S or synthesis
phase of interphase
•New cells will need identical DNA strands

17. Mitosis
-prophase
-metaphase
-anaphase
-telophase
G1 G2
S
phase
interphase
DNA replication takes
place in the S phase.
(G8)
Nucleus of eukaryotes (G7)

18. DNA REPLICATION

19. DNA REPLICATION

20. ON INITIATION…

21. ON INITIATION…

22. ON INITIATION…

23. ON INITIATION…
Enzymes
(G8)

24. ON INITIATION…

25. ON INITIATION…
•As the 2 DNA strands open at the origin,
Replication Bubbles form
•Prokaryotes (bacteria) have a single bubble
•Eukaryotic chromosomes have MANY bubbles
Bubbles Bubbles

26. DNA REPLICATION

27. ON ELONGATION…
DNA
pol III

28. ON ELONGATION…

29. ON ELONGATION…

30. ON ELONGATION…

31. ON ELONGATION…

32. ON ELONGATION…

33. DNA REPLICATION

34. ON TERMINATION…

35. ON TERMINATION…

36. ON TERMINATION…

37. ON TERMINATION…

38. ON TERMINATION…

39. DNA REPLICATION SIMULATION
•https://rb.gy/ru1l6

40. DRAGGABLE ENZYMES
Helicas
e
Topoisomera
se
SSBPs
DNA
POLYMERAS
E III
DNA
PRIMAS
E
DNA
POLYMERASE I
LIGAS
E
INITIATION
ELONGATIO
N
TERMINATIO
N
ZIPPER
UNZIP

41. How does DNA replication is
related to skin injury?
Name picker

42. How does radiation affect
DNA replication?
Name picker

43. How does DNA used in
forensic investigation?
Name picker

44. Complete the
following three
separate
statement.
Activity : 3-2-1
Countdown
3 things you didn’t
know before…
2 things you
learned this day…
1 thing you want to
start doing with
what you have
learned
Name picker

45. Multiple-choice questions
Directions: Choose the letter of the correct answer.
1. Which enzyme is responsible for unwinding the double helix
during DNA replication?
A) Primase
B) Helicase
C) DNA polymerase
D) Ligase

46. 2. During DNA replication, which strand is synthesized
continuously in the 3’ to 5’ direction?
A) Leading strand
B) Lagging strand
C) Both strands are synthesized continuously
D) Neither strand is synthesized continuously

47. 3. Which enzyme is responsible for adding RNA
primers to the template strand during DNA
replication?
A) Primase
B) Helicase
C) DNA polymerase III
D) Ligase

48. 4. Which direction does DNA polymerase III
synthesize new strands during DNA replication?
A) 3' to 5'
B) 5' to 3'
C) Both directions simultaneously
D) It depends on the location of the origin of
replication

49. 5. Which enzyme is responsible for joining
Okazaki fragments during DNA replication?
A) Primase
B) Helicase
C) DNA polymerase III
D) Ligase

50. 6. What is the function of DNA polymerase I during DNA
replication?
A) Synthesizes new DNA strands
B) Removes RNA primers and replaces them with DNA
nucleotides
C) Joins Okazaki fragments
D) Unwinds the double helix

51. 7. Which enzyme is responsible for proofreading newly
synthesized DNA strands during replication?
A) Primase
B) Helicase
C) DNA polymerase III
D) DNA polymerase I

52. 8. Which direction does the lagging strand synthesize new
strands during DNA replication?
A) 3' to 5'
B) 5' to 3'
C) Both directions simultaneously
D) It depends on the location of the origin of replication

53. 9. What is the function of topoisomerase during DNA
replication?
A) Unwinds the double helix
B) Adds RNA primers to the template strand
C) Prevents supercoiling of DNA
D) Joins Okazaki fragments

54. 10. What is DNA replication?
A. The process of creating a new DNA molecule from an
existing one
B. The process of creating a new RNA molecule from a DNA
template
C. The process of creating a protein from a DNA template
D. The process of breaking down a DNA molecule into its
component parts

55. Rate yourself from 1 (lowest) to 10 (highest) on how far you
have attained the learning targets.
1.I can describe DNA and DNA replication.
2.I can identify/recognize the enzymes and their roles in
DNA replication.
3.I can discuss/tell the value of DNA replication.
4.I can show/explain the importance of DNA replication.

56. ASSIGNMENT
Using your ZIPGRADE ID and code, log in to Zipgrade
student portal (https://www.zipgrade.com/student/) and
answer the posted assignment for the day