The document defines and describes the structure and function of nails. It discusses that nails are composed of keratin and line the tips of fingers and toes. The nail has several parts including the nail matrix that produces nail cells, nail bed, and cuticle. Nails grow at a rate of about 0.1 mm per day and various factors can influence growth rate. The document outlines common nail disorders and the importance of proper nail care including trimming nails regularly and using moisturizers.
Experience the benefits of professional nail care with the manicure and pedicure services at Signature Day Spa, Carmel, CA. Give an ultra comfort to your nails.
This is our IT coursework presentation, designed and edited by me. I super like this, and miss my coursemate so much :')
Presenter:
1. Venisri A/P Vijayakumar
2. Vidhya A/P Jeeva
3. Wong Ying Ying
4. Ting Chiou Yun
Experience the benefits of professional nail care with the manicure and pedicure services at Signature Day Spa, Carmel, CA. Give an ultra comfort to your nails.
This is our IT coursework presentation, designed and edited by me. I super like this, and miss my coursemate so much :')
Presenter:
1. Venisri A/P Vijayakumar
2. Vidhya A/P Jeeva
3. Wong Ying Ying
4. Ting Chiou Yun
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
Instructional materials include the main knowledge that students will encounter, acquire and apply. I applied different instructional material like power point presentation to make the class more interactive and also. I used different design to caught the attention of my students. I used also visual aids with image it helps my learners to retain the lessons for a longer time. With these, it provides the students clear understanding about the topic and concept. We are in the 21st century, therefore as a future educator, we must know how to keep up with the use of different educational tools to make the flow of my lesson more relevance and attractive.
Nail Structure and Nail Diseases ( Abigail Delas Alas).pdfabigaildelasalas70
Instructional materials include the main knowledge that students will encounter, acquire and apply. I applied different instructional material like power point presentation to make the class more interactive and also. I used different design to caught the attention of my students. I used also visual aids with image it helps my learners to retain the lessons for a longer time. With these, it provides the students clear understanding about the topic and concept. We are in the 21st century, therefore as a future educator, we must know how to keep up with the use of different educational tools to make the flow of my lesson more relevance and attractive.
Objective
Definition
Animal welfare board of India
Experimentation on animals
Committee for experimentation on animals
Power of entry and inspection
Power to prohibit experiments on animals
penalties
Objectives of the Drugs and Cosmetics Act
Definitions
DRUGS TECHNICAL ADVISORY BOARD (DTAB)
GOVERNMENT ANALYST
Drug Inspectors
Regulatory provisions relating to import of cosmetics
Offences & penalties
Loan license
Requirements pertaining to labeling of cosmetics
References
A glycogen storage disease (GSD, also glycogenosis and dextrinosis) is a metabolic disorder caused by an enzyme deficiency affecting glycogen synthesis, glycogen breakdown, or glucose breakdown, typically in muscles and/or liver cells.
PREPARATION AND IN-VITRO EVALUATION OF ITRACONAZOLE LOADED NANOSPONGES FOR T...Mahewash Sana Pathan
Itraconazole is an imidazole derivative and used for the treatment of local and systemic fungal infections. It is a BCS Class II drug having very low solubility in water i.e. 1-4ng/ml. The oral use of Itraconazole is not much recommended as it has many side effects. The present research has been undertaken with the aim to develop a topical hydrogel formulation of Itraconazole loaded nanosponges to increase the solubility, permeability and stability of itraconazole. Itraconazole loaded nanosponge was prepared by emulsion solvent diffusion method by using different concentrations of ethyl cellulose as a polymer, Polyvinyl alcohol as surfactant and dichloromethane as cross linking agent. Physical characteristics of the nanosponges as well as the drug entrapment efficiency, percentage drug content, Percent yield, drug polymer compatibility, solubility studies of the nanosponges were investigated. Particle size analysis and surface morphology of nanosponges were performed. The scanning electron microscopy of nanosponges showed that they were spherical in shape and spongy in nature. Drug entrapment efficiency was found to be in the range of 42.75 % to 73.10 %. The optimized nanosponge formulation was loaded into hydrogel using carbopol 940 and studied for pH, viscosity, in vitro drug release. Of the nanosponge formulations prepared, F4 was found to show drug release of 70.62%. It was concluded that Itraconazole nanosponge hydrogel may have increased solubility and drug release
The safe use of medicines is perhaps the single most important criteria that any regulatory authority within a given country has to ensure in order both to protect the public health and the integrity of its health care system. For the same purpose pharmacovigilance was established. According to WHO, Pharmacovigilance is the science and activities related to the collection, detection, and assessment of ADR’s. It promotes the systematic, rational use and assures the confidence for the safety of drugs. It improves patient care and safety. Significance of pharmacovigilance is growing as the patients or consumers have become more responsive about the advantage and hazard of medicines. Pharmacovigilance is a complex process and a robust system is essential to undertake the activity. A good pharmacovigilance system will identify the hazard aspects in the short period of time. This review article tries to explain the some basic principles, history and developments, methods and some scope of this developing field i.e. Pharmacovigilance in India.
Presentation include chapter solubility of drugs from second yr B-Pharm
Solubility, solubility expression, solute solvent interactions, solubility parameters, solvation and dissolution, factors affecting solubility, solubility of gases in liquids, liquids in liquids, fractional distillation, azeotropes, dissolution and drug release and diffusion.
Cosmetics regulatory: includes Regulatory provision relating to manufacture of cosmetics, Schedule M (II) of D & C rule 1945 deals with requirements for the factory premises for the manufacture of cosmetic, requirement of plant & equipment, conditions of licencing, regulatory provision on sale of cosmetics, loan licence, Regulatory provision relating to import of cosmetics, offences & penalties, List of amending Act and adaptation orders.
Pharmacovigilance is defined as, The pharmacological science and activities concerned with the detection, assessment, understanding and prevention of adverse reactions to medicines or Pharmacovigilance is the name given to the mechanisms and controls that together map and ensure the safety of a medicine throughout its life span – from test tube to patient.
Challenges in herbal formulation
Steps in herbal drug formulation
Types of conventional herbal formulations
Liquid herbal dosage forms
Solid herbal dosage forms
Other herbal dosage forms
Novel dosage form
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
3. NAIL
Nail is a plate of keratin that lines on the
tips of the fingers and toes & produced by living
skin cells in the finger.
OR
A nail is a horn-like envelope
covering the tips of the fingers and toes in most
primates and a few other mammals.
It is composed largely of keratin, a hardened
protein.
The average growth rate for nails is 0.1 mm each
day. 3
4. FUNCTIONS OF NAILS
1. Protection
2. enhancing the sensitivity of the fingertip
3. extended precision grip
4. cutting or scraping actions
4
6. PARTS OF NAIL
1. Lanula:
The whitish half moon at the base of
the nail.
2. Cuticle:
The cuticle is the semi-circular
layer of non-living, almost invisible
dead skin cells that "ride out on”
and cover the back of the visible
nail plate
Overlapping epidermis around
the nail. 6
7. 3. Free edge:
The portion of the nail that extends
past the end of the matrix bed.
4. Nail plate:
The actual nail, made of translucent
keratin.
100 layers of nail cells.
7
8. 5. Matrix (matrix unguis,
keratogenous membrane, nail
matrix, or onychostroma)
The hidden part of the nail unit
under the cuticle.
Produces keratin cells that
make up the nail plate.
Contains nerves, lymph and
blood vessels.
The width and thickness of the
nail plate is determined by the
size, length, and thickness of
the matrix. 8
9. 6. The nail sinus (sinus unguis) is where the nail root is i.e.
the base of the nail underneath the skin. It originates
from the actively growing tissue below the matrix.
7. Hyponychium is slightly thickened layer of skin
underneath free edge.
8.The onychodermal band is the seal between the nail
plate and the hyponychium. It is just under the free edge,
in that portion of the nail where the nail bed ends.
9.Together, the eponychium and the cuticle form a
protective seal.
10.The nail wall (vallum unguis) is the cutaneous fold
overlapping the sides and proximal end of the nail.
9
10. 11. Nail bed:
skin underneath the nail plate.
Deeper dermis & epidermis, attached by tiny
longitudinal grooves called matrix crests.
12. Specialized ligaments.
10
11. GROWTH OF NAILS
Fingernails require three to six months to re-grow
completely, and toenails require twelve to eighteen
months.
Actual growth rate is dependent upon age, sex,
season, exercise level, diet, and hereditary factors.
The growing part of the nail is under the skin at the
nail's proximal end under the epidermis, which is
the only living part of a nail.
Rate increases dramatically in last trimester of
pregnancy.
11
12. NAIL DISORDERS
1. onychatrophia:
It is an atrophy or wasting away
of the nail plate which causes it
to lose its luster, become smaller
& sometimes shed entirely.
Can caused by injury to the nail
matrix or by internal disease.
12
13. 2.Leuconychia or white spots:
Caused by tiny bubbles of air
that are trapped in the nail
plate layers due to trauma.
This condition may be
hereditary & no treatment is
required.
13
14. 3. Pterygium:
It is an outgrowth of the cuticle
which sticks to the surface
of nail plate.
14
15. 4. Brittle nails:
A vertical splitting or separation
of the nail plate layers at the
free edge of the nail plate.
Caused due to over exposure
to water & chemical solvents.
15
16. 5. Bruised nails:
Condition in which a blood clot
forms under the nail plate, forming
a dark purplish spot.
16
18. CARE OF NAILS
The care of nails is referred to as Manicuring .
Manicure preparations include:
Nail lacquer/enamel/paint/varnish
Enamel remover
Powder polish
Nail cream
Nail bleach
Cuticle remover
Cuticle softener
18
19. NAIL LACQUERS :
“Nail lacquers are viscous
preparations intended
to decorate nails for fingers and
toes”.
ENAMEL REMOVERS
Nail removers / nail cleansers are
defined as the mixture of
solvents containing small
amounts of fat intended to
remove the nail enamel.
19
20. Pharmaceutical nail lacquer
Rehydrating nail hardener
Nail strengthener
Nail rebuilder
Almond cuticle extract with ginseng extract
20
21. The best way to care for nails is to trim them regularly.
Nails can dry out, just like skin. They can also peel,
break, and be infected.
Toe infections, for instance, can be caused or
exacerbated by dirty socks, specific types of aggressive
exercise (long distance running), tight footwear, and
walking unprotected in an unclean environment.
Common organisms causing nail infections include
yeasts and molds (particularly dermatophytes).
Nail tools used by different people may transmit
infections.
Standard hygiene and sanitation procedures avoid
transmission. In some cases, gel and cream cuticle
removers can be used instead of cuticle scissors.
21
23. CONCLUSION:
Nails even serve as defense to the fingers and toes
from any mechanical injury hence nail care by using
manicures is utmost important.
It is vital to maintain well hydrated and moisturized
nails.
Oil based nail conditioners should be used which
improves flexibility & reduce water loss.
23