This study analyzed prenatal diagnosis and termination of pregnancy data for birth defects in Hunan, China between 2015-2018. Over half of birth defects were diagnosed prenatally, with the average gestational age at diagnosis being 25 weeks. Rural areas and older mothers had higher rates of prenatal diagnosis and termination following diagnosis compared to urban areas and younger mothers. Conditions with the highest rates of prenatal diagnosis and termination included conjoined twins, chromosomal abnormalities, and central nervous system defects.
According to the International Federation of Gynaecology and Obstetrics (FIGO), prolonged pregnancy is defined as any pregnancy that exceeds 42wks (294 days) from the first day of the LMP in a woman with regular 28-day cycles.
Obstetrical Ultrasound• Introduced in the late 1950’s ultrasonography is a safe, non- invasive, accurate and cost-effective means to investigate the fetus• Computer generated system that uses sound waves integrated through real time scanners placed in contact with a gel medium to the maternal abdomen• The information from different reflections are reconstructed to provide a continuous picture of the moving fetus on the monitor screen
Prenatal Assessment of Gestational Age - Case Presentation Nawras AlHalabi
Prenatal Assessment of Gestational Age - Case Presentation
تقدير عمل الحمل، حالة سريرية.
Faculty of Medicine of Syrian Private University
كليّة الطّبّ البشريّ في الجامعة السّوريّة الخاصّة
20-12-2015
Antenatal care is the routine health control of presumed healthy pregnant women without symptoms (screening), in order to diagnose diseases or complicating obstetric conditions without symptoms and to provide information about lifestyle, pregnancy and delivery.
Gynaecology - Early Pregnancy ComplicationMichelle Fynes
What to expect during the course of her care (including expectant management), such as the potential length and extent of pain and/or bleeding, and possible side effects. This information should be tailored to the care she receives.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
2. INTRODUCTION
The diagnosis of pregnancy traditionally has been
made from history and physical examination.
Important aspects of the menstrual history must be
obtained. The woman should describe her usual
menstrual pattern, including date of onset of last
menses, duration, flow, and frequency
13. • Detection of HCG in maternal serum and urine is evident only
8- 10 days after conception
• HCG is detectable in the serum of approximately 5% of patients
8 days after conception and in more than 98% of patients by day
11
• Diagnostic levels in Urine seen only about 23-24 days after
conception. Levels peak at 10-12 weeks' gestation and then
plateau before falling
17. • Intra decidual gestational sac is identified as early as 29
– 35 days of gestation
• Gestational sac & yolk sac -5 menstrual weeks
• Fetal pole and cardiac activity – 6 weeks
• Embryonic movements -7 weeks
• Doppler effect of USG can pick heart rate reliably by
10th week.
20. ABDOMINAL EXAMINATION
INSPECTION: – Linea nigra extending from symphysis
pubis to ensiform cartilage 20th week…
STRIAE ( both pink and white) visible in the lower
abdomen more towards the flanks
PALPATION: –
Fundal height – increased with progressive enlargement of
the uterus.
21. Auscultation
• Auscultation of FHS as early as 20-24 weeks by Pinard
stethoscope
• Auscultation of funic/fetal souffle due to rush of blood
through the umbilical artery
• Auscultation of uterine souffle (soft blowing and systolic
murmur heard low own at the sides of the uterus)
synchronous with the maternal pulse
22. INVESTIGATIONS
• SONOGRAPHY: – Routine sonography at 18 – 20
weeks permits a detailed survey of fetal anatomy,
placental localisation and the integrity of the cervical
canal.
• RADIOLOGIC: – 16TH WEEK – FETAL SKELETAL SHADOW.
24. • AMENORRHOEA PERSISTS – Enlargement of the abdomen leading to
discomfort to the patient (palpitation or dyspnoea following
exertion)
• LIGHTENING: 38th week sense of relief of the pressure
symptoms due to engagement of the presenting part.
• Frequency of micturition reappears – Fetal movements are more
pronounced.
• SIGNS: – Cutaneous changes are more prominent with increased
pigmentation and striae. Uterine shape – from cylindrical to
spherical beyond 36th week
25. •FUNDAL HEIGHT (distance between the
umbilicus and ensiform cartilage)
• Junction of the upper and middle third at 32 weeks.
• Level of ensiform cartilage at 36th week
• Comes down to 32 week level at 40th week
because of the engagement of the presenting part.
26. SYMPHYSIS FUNDAL
HEIGHT
– Upper border of the fundus located by
ulnar border of the left hand and point is
marked.
– Distance between the upper border of
the symphysis pubis up to the point
marked is measured in centimetre
27.
28. SIGNS OF PREVIOUS CHILDBIRTH
• Breast become more flabby
•Abdominal wall is more lax and loose. There
may be presence of silvery white striae and
linea alba.
•Uterine wall is less rigid and the contour of
the uterus is broad and round, rather than
ovoid.
29. • Perineum is lax and evidence of old scarring
from previous perineal laceration or
episiotomy may be found
•Vagina is more roomy.
•Cervix: Nulliparous cervix is conical with a
round external os. In parous women, it
becomes cylindrical
30. ESTIMATION OF GESTATIONAL AGE AND PREDICTION OF
EXPECTED DATE OF DELIVERY(EDD)
Gestational age is about 280 days calculated
from the first day of the last normal menstrual
period (LMP). Accurate LMP is the most
reliable parameter for estimation of gestational
age.
33. •Second trimester by BPD, HC, AC and FL
measurement. Most accurate when done between 12
and 20 weeks (variation ± 8 days).
To add 20 weeks since the measurement of fetal
parameters for anomaly scan (18-20 weeks).
Third trimester-less reliable, variation ± 16 days.
34. • SUMMARY:-
Today we discuss about diagnosis of pregnancy according their trimester. We also
discuss about differential diagnosis, previous birth sign, expected date of delivery.
• CONCLUSION
The diagnosis of pregnancy can be made by several methods. Normocyclic
women who present with amenorrhea and typical history and physical exam
findings have the classic presentation and can be diagnosed with a viable
intrauterine pregnancy if they progress appropriately.
35. RESEARCH ABSTRACT
• Objective: The aim of this study was to analyse the characteristics of
the prenatal diagnosis (PD) of birth defects (BDs) and termination of
pregnancy (TOP) for fetal anomalies and to suggest perinatal
management.
• Methods: BD surveillance data were collected from 52 registered
hospitals in Hunan between 2015 and 2018. The PD and TOP rates of
BDs were calculated to examine the associations between infant sex,
maternal age, and region.
36. Results:
From 2015 to 2018, a total of 18 931 fetuses with BDs
were identified, of which 10 299 fetuses (54.4%) were
diagnosed prenatally and 9343 pregnancies (90.7% among
PDs and 49.3% among BDs) were terminated. The mean
gestational age at diagnosis for fetuses with BDs was 25.1 ±
5.9 weeks and showed a downward trend over the study
period. The average PD rate of the BDs was higher in rural
areas than in urban areas (58.1% vs 50.3%), higher for
female than male fetuses (57.25% vs 48.92%), and higher
for mothers older than age 35 than for those younger
(58.62% vs 53.69%).
37. The average TOP rate of fetuses with BDs in rural areas
was higher than that in urban areas (91.99% vs 89.12%)
and decreased with increasing maternal age
( x2trendxtrend2 = 7.926, P = .005). The five BDs with the
highest PD rates were conjoined twins (100%),
anencephaly (97.87%), congenital hydrocephalus
(97.66%), chromosomal malformation (96.07%), and
encephalocele (95.54%). The five BDs with the highest
TOP rates among the PDs were conjoined twins (100%),
exstrophy of the urinary bladder (100%), chromosomal
malformation (98.09%), encephalocele (98%), and
anencephaly (97.28%).
38. •Conclusions: More than half of BDs were diagnosed
prenatally, with the majority diagnosed at less than 28
gestational weeks. The TOP rates following PD in Hunan
Province were high, especially for rural and younger
mothers. The findings suggest a need for high-quality,
targeted counselling following PD.
•Conducted On: 10 June 2020