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Dengue Virus
 Dengue viruses are spread to people through the bite of an infected Aedes species (Aedes aegypti or Aedes albopictus)
mosquito which also spread Zika, chikungunya, and other viruses.
 Dengue is common in more than 100 countries around the world.
 Each year, up to 400 million people get infected with dengue. Approximately 100 million people get sick from
infection, and 22,000 die from severe dengue.
 It belongs to single positive-stranded RNA virus of the family Flaviviridae; genus Flavivirus.
 Five serotypes of the virus have been found.
Transmission:
 Through Mosquito Bites
 From mother to child
 Through infected blood, laboratory, or healthcare setting exposures
Diseases:
 Dengue fever
 Dengue hemorrhagic fever
 Dengue shock syndrome
Prevention:
 Prevention depends on control of and protection from the bites of the mosquito that transmits it.
 A vaccine to prevent dengue (Dengvaxia®) is licensed and available in some countries for people ages 9-45
years old. The World Health Organization recommends that the vaccine only be given to persons with
confirmed prior dengue virus infection.
 The DENV genome is about 11000 bases of positive-sense, single stranded RNA (ssRNA) that codes for three
structural proteins (capsid protein C, membrane protein M, envelope protein E) and seven nonstructural
proteins (NS1, NS2a, NS2b, NS3, NS4a, NS4b, NS5). It also includes short noncoding regions on both the 5' and
3' ends.
Target:
 The NS2B-NS3 protease is essential for the Dengue Virus (DENV) replication process.
 The protease is highly conserved between the four Dengue virus serotypes.
 The NS2b-NS3 protease has a catalytic triad (His51, Asp75, Ser135) in the active site.
DenguePro.pptx
DenguePro.pptx
DenguePro.pptx

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DenguePro.pptx

  • 1. Dengue Virus  Dengue viruses are spread to people through the bite of an infected Aedes species (Aedes aegypti or Aedes albopictus) mosquito which also spread Zika, chikungunya, and other viruses.  Dengue is common in more than 100 countries around the world.  Each year, up to 400 million people get infected with dengue. Approximately 100 million people get sick from infection, and 22,000 die from severe dengue.  It belongs to single positive-stranded RNA virus of the family Flaviviridae; genus Flavivirus.  Five serotypes of the virus have been found. Transmission:  Through Mosquito Bites  From mother to child  Through infected blood, laboratory, or healthcare setting exposures Diseases:  Dengue fever  Dengue hemorrhagic fever  Dengue shock syndrome Prevention:  Prevention depends on control of and protection from the bites of the mosquito that transmits it.  A vaccine to prevent dengue (Dengvaxia®) is licensed and available in some countries for people ages 9-45 years old. The World Health Organization recommends that the vaccine only be given to persons with confirmed prior dengue virus infection.
  • 2.  The DENV genome is about 11000 bases of positive-sense, single stranded RNA (ssRNA) that codes for three structural proteins (capsid protein C, membrane protein M, envelope protein E) and seven nonstructural proteins (NS1, NS2a, NS2b, NS3, NS4a, NS4b, NS5). It also includes short noncoding regions on both the 5' and 3' ends.
  • 3.
  • 4. Target:  The NS2B-NS3 protease is essential for the Dengue Virus (DENV) replication process.  The protease is highly conserved between the four Dengue virus serotypes.  The NS2b-NS3 protease has a catalytic triad (His51, Asp75, Ser135) in the active site.