Define ionophore and describe how the compound A23187 affects intrac.pdf

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Define ionophore and describe how the compound A23187 affects intracellular Ca2+ levels in sperm and the capacitation process. Solution Ionophore are small hydrophobic lipid soluble molecule that disolve in lipid biolayer and increase their permeability to specific inorganic ions . Ionophores shield the charge of the ions to be transported, enabling it to penetrate the hydrophobic interior of the lipid bilayer. there are two kind of ionophores. 1. Mobile ion channels It transports the K+ ions down its electrochemical gradient eg.(Valinomycin ) 2. channel formers - In membrane it form channel. the channel permits the passage of water and univalent cations but not anions eg. (gramisidin). The molecule metioned in the question is a Protein-Tyrosine Kinase (HCK) which involves in various signaling events capacitation is also one of them.The capacitation depends on PKA activation mediated by the Ca2+ and HCO3-dependent soluble adenylyl cyclase. It has been suggested that Ca2+ is transported into the cell by the sperm-specific Ca2+ channel (CatSper) and HCO3 by the Na+/HCO3 cotransporter..

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A hypothesis is presented which suggests that the cardiac L-type calcium channel opens in a stochastic fashion as the calcium channel protein complex moves around in the lipid of the outer leaflet of the sarcolemma. Opening occurs when there is release of calcium ions that are bound in the polarised state to anionic phospholipid of the inner leaflet, the release being a consequence of proton penetration into the sarcolemma upon depolarisation.

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In what ways does interferon eliminate pathogens? Solution Interferons are a group of proteins called cytokines produced by white blood cells, fibroblasts, or T-cells as part of an immune response to a viral infection or other immune trigger. IFNs are released by host cells in response to the presence of pathogens. Interferons do not directly kill viral or cancerous cells; they boost the immune system response and reduce the growth of cancer cells by regulating the action of several genes that control the secretion of numerous cellular proteins that affect growth. The type I IFNs (IFN- and ) instruct infected cells to die by apoptosis. During apoptosis the virus is prevented from replicating and apoptosis also halts the spread of the infection..

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In 2006 you joined a group of 20 Richland College graduates to start a company that provides innovative tutoring and educational services You are responsible for all accounting activities. After applying to the Secretary of State in Austin, Shannon’s Tutoring Corporation (STC)received its corporate charter and began business as a Texas Corporation on December 1, 2006. During the first month of business the following Transactions occurred. You must analyze each transaction’s effect on the Accounting Equation and Prepare the Income Statement, Statement of Retained Earnings and the Balance Sheet for the Year ended 12/31/2006. 12/01/06 STC began business by investing $50,000 in exchange for 10,000 shares of Common Stock. 12/1/06 STC Paid $12,000 for 1 year of rent for the 12 month period beginning December 1, 2006 through November 30, 2007. (Hint: Prepaying rent in advance creates an Asset called Prepaid Rent ) 12/1/06 STC received $18,000 cash in advance from the Texas School System and signed a contract to provide monthly tutoring services to students from December 2006 through May of 2007. 12/02/06 STC purchased a Computer System for $35,000 cash. 12/09/06 STC earned & received $1,000 in cash by providing tutoring services. 12/12/06 STC Billed the RISD $2,500 for tutoring services performed at their school. Payment has not been received. 12/12/06 STC Purchased $500 of Supplies on Account. 12/21/06 STC Paid $400 Wages to employees. 12/23/06 STC Received $1,500 Cash from RISD for services billed on 12/12/06(#6). 12/29/06 STC Paid a $300 Utility Bill. 12/01/06 STC began business by investing $50,000 in exchange for 10,000 shares of Common Stock. 12/1/06 STC Paid $12,000 for 1 year of rent for the 12 month period beginning December 1, 2006 through November 30, 2007. (Hint: Prepaying rent in advance creates an Asset called Prepaid Rent ) 12/1/06 STC received $18,000 cash in advance from the Texas School System and signed a contract to provide monthly tutoring services to students from December 2006 through May of 2007. 12/02/06 STC purchased a Computer System for $35,000 cash. 12/09/06 STC earned & received $1,000 in cash by providing tutoring services. 12/12/06 STC Billed the RISD $2,500 for tutoring services performed at their school. Payment has not been received. 12/12/06 STC Purchased $500 of Supplies on Account. 12/21/06 STC Paid $400 Wages to employees. 12/23/06 STC Received $1,500 Cash from RISD for services billed on 12/12/06(#6). 12/29/06 STC Paid a $300 Utility Bill. Solution Answer Accounting Equation: Total Assets = Capital/Equity + Liabilities Note: After every transaction, A column = B column Date Tran saction no Total Assets = Equity + Liabilities TOTAL (B) Cash Fixed Assets Supplies Accounts Receivables Prepaid Rent TOTAL(A) = Common Stock + Advance from Customer 12-01-2006 1 50000 50000 = 50000 + 50000 TOTAL 50000 50000 = 50000 + 50000 12-01-2006 2 -12000 11000 -1000 = -1000 + -1000 TOTAL 38000 11000 49000 = 49000 + 49000 12-01-20.

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If the leader has been dealing with the follower appropriately by using an S4 leadership style and the follower suddenly begins performing at Performance Readiness® level R3, what should the leader do? (10 points) Solution the leader has to approach the follower and ask him to do it in a right way only. otherwise the total efforts are going to be spoil. even the other people will suffer with one mistake by one person in the team..

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How does the structure of vertebrae aid in their function? Solution The vertebral column or the back bone is the main part of the axial skeleton performing the function of support. It comprises of 33 vertebrae,each of them having specific function and structure. Vertebrae are made up of building blocks of spines,stacked one upon the other with a disc between them.the disc provides cushion and help in the absorption of shock /load and absorbs energy. The vertebrae are further classified into the following types based on their loction : Cervical spine: it is the uppermost part of the verebral column made up of 7 vertebrae labelled as c1 to c7 from the top. Rotation of the neck is brought about by the two vertebrae. The c1 or the atlas connects the head and the rest of the spine. C2 or the axis has a bony process called the odontoid process which fits within a hole in the atlas to allow the rotation of the neck.The first spinal curve is located at the cervical spine , bent slightly inward and called the lordotic curve.The cervical spine has opening in each vertebral body that allows the blood vessels to carry blood the blood to the brain. Thoraicic spine : It is made up of 12 veretbrae labelled as T1 -T12 in the thoraicic region or the chest region.The vertebral curve is bent outwards like backward C and is called the kyphotic curve.This region shows less motion and hence subjected to less wear and tear. Lumbar spine: Has 5 vertebrae L1-L5 connects the spine and the pelvis. .Bear maximum weight of the body and have the largest vertebrae.The cuve is bent inward . The paired facets , joints on the c\\back are aligned in such a way that they allow the flexion and extension but not rotation. Sacrum lies below the lumbar and is made up of many number of fused small bone and forms the base of the spine and the back of pelvis. This is followed by the coccyx or the tail bone made up of sevral small bones. All the vertebrae are made up of : vertebral body: which is cylindrical,bony with discs to absorb shock.Carries most of the weight. spinous processes: Posterior or the rear portions of the vertebrae. Laminae : two small plates that join in the back of the vertebrae. Pedicels:short thick bones on either side of the vertebrae which help in the attachment of the muscles and tendons. pedicels :Short bumpy backward projecting structures from the upper part. transverse processes: bony projections on either side of the vertebra where the laminae join the pedicles which help in the Muscles and ligaments attachment of Muscles and ligament to the spine— These are the spinal joints, the areas on the spine where one vertebra comes into contact with another. facet joints— these are the spinal joints, the areas on the spine where one vertebra comes into contact with another.allow vertebrae to move against one another allow felxibility and movement.help us in bending forward and backward and also side to side.the spinal canal allows the spinal cord and the nerves to .

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Explain the security implications of HIPPA requirements for hospital networks. your responce should be 300 words Solution HIPAAstands for Health Insurance Portability and Accountability Act. Passed in 1996 HIPAA is a federal law that sets a national standard to protect medical records and other personal health information. The rule defines \"protected health information\" as health information that: 1. Identifies an individual and 2. Is maintained or exchanged electronically or in hard copy. If the information has any components that could be used to identify a person, it would be protected. The protection would stay with the information as long as the information is in the hands of a covered entity or a business associate. HIPAA Security Rules The portion of the HIPAA law that most impacts technology interests is the section on Administrative Simplification (Title II, Subtitle F). Administrative Simplification seeks to force uniform standards in the electronic interchange of health information (through the Transaction Rule) and also mandates guidelines for the security (Security rules) and privacy (Privacy rules) of that information whether in transit or stored. The HIPAA Security regulations apply to that protected health information that is electronically maintained or used in an electronic transmission1 . Administrative Simplification is divided in to Transaction, Security and Privacy Rules. The HIPAA Security rules are divided into four sections: · Administrative Safeguards · Physical Safeguards · Security Services · Security Mechanisms Administrative safeguards deal with those administrative policies, procedures and practices that are used by a covered entity to handle protected health information. These generally take the form of written policies and procedures that are practiced in normal day-to-day operations. Physical safeguards deal with physical access to data and facilities within that contain protected health information. Security services and security mechanisms specifically address technical systems, networks and applications that possess or transmit protected health information. The HIPAA Security rules mandate that if healthcare information (also referred to in the HIPAA text as protected health information) is stored or processed electronically, then the security rule applies to that covered entity. This would seem to exempt pure paper-based operations from the Security rules, but even these organizations likely use fax technology, which is covered by the HIPAA security rule. Accordingly, there are very few healthcare organizations that will escape the grasp of the HIPAA regulations as very few are entirely paper-based. HIPAA Security rules essentially resemble a collection of the recommended best practices for security management and operations. For this reason, if the healthcare organization has already adopted sound security practices, the HIPAA-compliance effort should be minimal. Given that Security is not a prime conc.

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Explain briefly about the major enhancements in ARM processor architecture compared to conventional RSIC computational model. Solution ARM: • ARM stands for Advanced RISC Machine based on the RISC. • It has high code density, low power consumption & low silicon area. • It is a load-store architecture, data processing through registers and does not involve changes directly within memory and it gives good speed vs power consumption ratio. RISC features Instructions: Lower number of instructions compared to CISC. The compiler or programmer synthesizes complicated operations by combining several simple instructions. Each instruction is a fixed length to allow the pipeline to fetch future instructions before decoding the current instruction. Pipeline: The processing of instructions is broken down into smaller units that can be executed in parallel by pipelines. Ideally the pipeline advances by one step on each cycle for maximum throughput. Instructions can be decoded in one pipeline stage. There is no need for an instruction to be executed by a mini-program called microcode as on CISC processors. Fixed number of instruction cycles: Most instructions single cycle. Registers: RISC have a large number of general purpose registers while CISC have special purpose registers. In RISC any register can contain either data or an address. Registers act as the fast local memory store for all data processing operations. Load-store architecture -The processor operates on data held in registers. Separate load and store instructions transfer data between the register bank and external memory. Memory accesses are costly, so separating memory accesses from data processing pro-vides an advantage because you can use data items held in the register bank multiple times without needing multiple memory accesses. In contrast, with a CISC design the data processing operations can act on memory directly. ARM feature improvements over RISC Variable cycle execution for certain instructions-Not every ARM instruction executes in a single cycle. For example, load-store-multiple instructions vary in the number of execution cycles depending upon the number of registers being transferred. The transfer can occur on sequential memory addresses, which increases performance since sequential memory accesses are often faster than random accesses. Inline barrel shifter leading to more complex instructions-The inline barrel shifter is a hardware component that preprocesses one of the input registers before it is used by an instruction. This expands the capability of many instructions to improve core performance and code density. ARM has enhanced the processor core by adding a second 16 bit instruction set called Thumb. This thumb instruction permits the ARM core to execute either 16 bit or 32 bit instructions. The 16 bit instructions improve code density by about 30 percent compare to 32 bit instructions of fixed length. Conditional execution-An instruction is only executed when a specific.

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Chapter Cellular Structure and Function Wor which consist of fatty acids and alcohol. The phos- The plasma membrane composed mainly of phospholipids, d bilayer As shown in the figure and the tails pholipids in the plasma membrane are tails. bead \"loves\" water the head and two the membrane. whereas below, each a on the interior of ne cell because water aydophobic). The water-hating tails are tars are hand, point outwards, either the cytoplusm or dhe nuid surrounds if they the other of heads pass the plasma hydrophilic, on exterior Mtolecules that are b can easily membrane. Molecule that are water-loving like the hating like the interior the cause they are through de plasma least rot without help pass Phospholipid molecule Phospholipld bilayer Hydrophilic head Hydrophobic tails hydrophobic, or waterhating, interior The phospholipid bilayer consists of two layers of phospholipids 0eft), with a depicted on the and a hydrophilic, or water-loving, esterior, Asingle phospholipid molecule is Other Molecules in the Plasma Membrane molecules in The plasma membrane also contains other molecules primarily other lipids and proteins. The green the figure above, for example, are the lipid Molecules of cholesterol belp the plasma membrane keep its shape. Many of the proteins in the plasma membrane assist other substances in crossing the membrane. Euensions of the Plasma Membrane plasma membrane may haveextensions, such as whip like nagelt or ke cilia. In single-celled organisms. the membrane estensions may belp organisms move. In multicellular organisms, the extensions have other For example, the cilia the particles the mouth and Dose. Mung cells sweep foreign and mucustoward What is the plasma membrane? 2. What is the meaning of semipen nneabiliry? Solution 1). What is the plasma membrane? The plasma membrane is a membrane that encloses the cell organelles of a cell. It separates the cell interior and the outside environment. The plasma membrane is semi-permeable membrane that allows selective entry and exit to charged ions and organic molecules. It provides protection to the cell. 2). What is the meaning of semi-permeability? Semi-permeability is the quality of a membrane to allow passage of some particles through it while restricting the flow of others. The plasma membrane is composed of two layers of phospholipid molecules which have polar phosphate head on the either sides and two non-polar lipid tails embedded inside. Due to this structure, the hydrophilic molecules can not pass through the membrane. Besides, the membrane has transmembrane proteins that may act as channels to allow the passage of specific molecules through them with or without any expense of energy..

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Ellen died with the following property: house in joint tenancy with her husband, stocks owned individually, a bank account held individually, and household goods. What schedules must her executor complete? Ellen died with the following property: house in joint tenancy with her husband, stocks owned individually, a bank account held individually, and household goods. What schedules must her executor complete? Solution Schedules B, C, E, F of form 706 Schedule B - Stocks and bonds Schedule C - Mortgages, notes and cash (bank account) Schedule E - Jointly owned Property (house in joint tenancy with her husband) Schedule F - Miscellaneous Property (Household Goods).

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Ed Norton, a city maintenance worker, is inspecting a sewer line. To access the sewer line he removes a manhole cover and climbs into the sewer line. City policy requires that protective barriers be placed around any open manholes but Ed is in a hurry so instead he sets out a warning sign and leaves the flashing yellow light on over his truck. Betsy is walking along the street texting with her boyfriend. Not watching where she is going Betsy falls into the manhole and suffers serious injuries. Betsy sues Ed in negligence. 6.Assume that Betsy suffered $50,000 in damages. Discuss the contributory fault defenses that Ed might assert and how the suit would be resolved under the different approaches. Solution In such a case, the fault is with both the parties. Ed should highlight the contributory negligence. Contributory Negligence addresses a way to allocate fault between parties when it is not clear that whose fault is it. If you are negligent, and your negligence causes another person to become injured, then you are legally responsible for paying damages. The concept of contributory negligence is used to characterize conduct that creates an unreasonable risk to one\'s self. The idea is that an individual has a duty to act as a reasonable person. When a person does not act this way and injury occurs, that person may be held entirely or partially responsible for the resulting injury, even though another party was involved in the accident. Ed was at fault because he did not put a protective barrier around the open manholes. But if Betsy had been paying attention to the open manhole, she would not have sufferred injuries. Betsy was not cautious adn is at fault. So Ed definitely does not owe $50,000 in damanges. He owes less than $50,000 (may be 50% or more)..

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Can -1^ (1/4) be expressed in terms of i Solution To express (-1)^1/4 and (-1)^(1/6) interms of i. We know that i= (-1)^(1/2) or i^2 = -1. -1 = cos pi +sinpi = cos(2n+1)pi +isin(2n+1)pi Therefore (-1)^1/4 = Cos(2n+1)pi/4+sin(2n+1)pi)/4 = cos(2n+1)pi/2+isin(2n+1)pi/2 , for n = 0,1,2... 1/2^(1/2) +i/sqrt2 , -1/2^(1/2) +i/2^1/2) , -1/2^1/2) -i/2^(1/2) and (1/2^(1/2) +i/2^(1/2). (-1)^1/6 = {cos(2npi+1) +isin(2npi+1)}^(1/6) = cos(2n+1)pi/6 +isin(2n+1)pi/6. for n = 0,1,2,3,.. = (1/2)*3^(1/2) +i(1/2) , i , -(1/2)3^(1/2 ) +i/2 , (1/2)*3^(1/2)-i/2, -i , (1/2)3^(1/2) - i ,.

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digestive disorders of the GI tract Solution The two common digestive disorders of the GI tract are, 1). Peptic ulcer disease (PUD) is a lesion of the mucosal layer n the stomach or duodenum that may be caused by pathogenic bacteria or pepsin and other gastric acids. The most common causes of peptic ulcers include the infection caused by the bacterium Helicobacter pylori or H. Pylori, medications that disturb the gastric mucosa, psychological pressures and irregular food habits that result in improper acid secretions that damages gastric mucosa. 2). Gastro esophageal reflux disorder (GERD) is a physiological abnormality in which the acidic contents of stomach reflex into esophagus. The causes of GERD include weakened lower esophageal sphincter, impaired acid clearance in the stomach due to unhealthy food habits and pregnancy, infection with H.pylori and stress. Heart burn and acid indigestion are the common symptoms of GERD..

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Describe how a prioritized set of system requirements is developed in the traditional system development life cycle (SDLC). Solution in a tradition sdlc life cycle the system requirements is developed in the following way step1:it first check or evaluate the system and identify the deficiencies.so to evaluate the system they will interview the user of the respected system and discussion will be done with the supporting person step2:afer the evaluation is done then the new system requirements are defined.

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Consider the equation 1 ? 2x = sin x. (a) Use the Intermediate Value Theorem to prove that this equation has a root in the interval (0, pie/4). Check all the criterions in the IVT. (b) Use a graphing calculator to find an interval of length 0.01 that contains this root. Explain how to obtain this interval. Solution (a)f(x)=sinx+2x-1 Notice that, f(0) < 0 and f(pi/4) > 0 Therefore, by the Intermediate Value theorem there exists a zero in the interval [0, pi/4]. Now, is this the only root? f\'(x) = cos x+2 for all x. Therefore, f(x) is strictly increasing and therefore, the root we found above is the ONLY root..

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A binary encoded signal has a bit-rate of Rb = 28 kbps. An Alternate Mark Inversion line-code is used to encode these bits for baseband transmission over copper wire. What would be the transmission bandwidth required to transmit this signal? B = 112 kHz B = infinity B = 28 kHz B = 56 kHz B = 14 kHz B = 7 kHz Solution Speed or bit rate = nfs = Rb Bandwidth minimum is Rb/2 Bandwidth maximum is Rb Normally bandwidth consider to be half of speed Bandwidth = 28/2 Bandwidth = 14 kbps.

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15.) What kind of reaction occurs between Sudan III and hydrophobic substances? Solution Biological Molecules contain specific chemical structures called functional groups, which can be distinguished by biochemical tests, such as Benedict\'s Iodine, and Sudan III/IV.The Sudan III/IV test is used to detect the hydrocarbon chains of lipids. Sudan is a red, non-polar, dye that forms hydrophobic interactions with the hydrocarbon chains of lipids. Alternatively, the Brown Bag test can also be used to identify lipids due to the oily nature of hydrocarbon chains..

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1.) a.What was the original definition of a virus before it could be seen with electron microscopy? Why is that definition no longer functionally useful? What is the current definition of a virus? b.What are the differences between cellular organisms (i.e., eukaryotes & prokaryotes) and viruses? Can antibiotics be used to treat viral infections? Interferons? Why or why not? Why are some more recently discovered viruses challenging some of these paradigms, especially the one that classifies viruses as non-living? Explain. Solution Ques-1: 1.) What was the original definition of a virus before it could be seen with electron microscopy? Why is that definition no longer functionally useful? What is the current definition of a virus? Answer: According to degeneracy hypothesis, viruses were considered as small cells that can live as parasites in other cells. The other definition of viruses before they were seen under electron microscopy is that the viruses are evolved from macromolecules such as protein and nucleic acid at the time of cells initially appeared on Earth. at the same time as cells first appeared on earth. These definitions are not worked because these viruses are not complete cells because they do not have conspicuous nucleus or cell membrane or any morphological cellular features when observed under electron microscope. Therefore, the new definition of virus has proposed that these are technically living species and it is a small in size composed of virion and a segment of nucleic acid covered by a protein coat referred as capsid often infectious in host cell.

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1.Is the following discrete or continuous, number of brothers a person has? 2.Is the following a statistic or parameter? I asked 4 of the 12 people in our family, if this weekend would be a good time for the birthday party? Solution 1) number of brothers is clearly discrete as it only takes point values (integers) rather than a continous range. 2) This is a statistic because it is description of a sample.

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1. What two types of ICMP messages are received at the sending host executing the traceroute program? 2. True or false: When an OSPF route sends its link state information, it is sent only to those nodes directly attached neighbors. Explain. 1. What two types of ICMP messages are received at the sending host executing the traceroute program? 2. True or false: When an OSPF route sends its link state information, it is sent only to those nodes directly attached neighbors. Explain. 2. True or false: When an OSPF route sends its link state information, it is sent only to those nodes directly attached neighbors. Explain. Solution (1).The two types of messages are received at the srending host executing the traceroute programm is as follows: 1.Port unreachable 2.Time exceeded i.e TTL=0 (2).Answer:True Reason:it utilizes the IP multicast to send link state updates .it confirms little processing on routers which are not concentrating on OSF packets..

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