An autopsy (post-mortem examination, obduction, necropsy, or autopsia cadaverum) is a surgical procedure that consists of a thorough examination of a corpse by dissection to determine the cause, mode and manner of death or to evaluate any disease or injury that may be present for research or educational purposes.
An autopsy (post-mortem examination, obduction, necropsy, or autopsia cadaverum) is a surgical procedure that consists of a thorough examination of a corpse by dissection to determine the cause, mode and manner of death or to evaluate any disease or injury that may be present for research or educational purposes.
Starvation is defined medically in two parts that is: The act or process of starving and the condition of being starved, while ‘Neglect’ is defined as – to fail to give due care, attention, or time to someone an adult/ a child especially.
Death occurring in the course of nature and from natural causes (as age or disease) as opposed to accident or violence.Death is the permanent cessation of all biological functions that sustain a living organism. Phenomena which commonly bring about death include aging, predation, malnutrition, disease, suicide, homicide, starvation, dehydration, and accidents or major trauma resulting in terminal injury. In most cases, bodies of living organisms begin to decompose shortly after death
Starvation is defined medically in two parts that is: The act or process of starving and the condition of being starved, while ‘Neglect’ is defined as – to fail to give due care, attention, or time to someone an adult/ a child especially.
Death occurring in the course of nature and from natural causes (as age or disease) as opposed to accident or violence.Death is the permanent cessation of all biological functions that sustain a living organism. Phenomena which commonly bring about death include aging, predation, malnutrition, disease, suicide, homicide, starvation, dehydration, and accidents or major trauma resulting in terminal injury. In most cases, bodies of living organisms begin to decompose shortly after death
Difference between Apoptosis versus Necrosis and Types of Necrosis.pptxRukhshanda Ramzaan
Apoptosis Versus Nercosis
Apoptosis Necrosis
Predefined cell suicide or programmed cell death. Natural physiological Process. Involve one cell at a time. Cell shrinkage (Dense eosinophilic cytoplasm) Pyknosis (Condensation) and Karyorrhexis (fragmentation) of nuclear material Formation of membrane blebs and apoptotic bodies
Phagocytosis of apoptotic bodies by Macrophages
Caspase dependent pathway
No Inflammation (no immune response) Premature, unprogrammed cell death always pathological. Involve many cells Cell Swelling (Swelling of endoplasmic reticulum and mitochondria) and membrane blebs Pyknosis (condensation), Karyorrhexis (Fragmentation) and Karyolysis (lysis)of the nucleus. Breakdown of the plasma membrane, organelles (enzymatic digestion), leakage of cellular contents
Increased eosinophilia, Accumulation of Myelin figures (whorled precipitated Phospholipids)
Initiate Inflammation (Strong immune response)
Difference between reversible and irreversible cell injury,Mechanism of cell ...Rukhshanda Ramzaan
Cell Injury: Any change resulting in loss of the ability to maintain the normal or adapted homeostatic state.
Agents that cause cell injury
• Hypoxia / Ischemia (loss of blood supply)
• Microbial
• Parasitic
• Chemical
• Physical
• Trauma
• Genetic
• Nutritious
• Environmental
Types of Cell injury
Reversible Cell Injury
Pathologic changes that can be reversed in mild cellular injury when the stimulus is removed. Cell injury is reversible only up to a certain point otherwise it will be irreversible.
Changes in reversible cell injury
Cellular Swelling: Due to accumulation of intracellular water and endoplasmic reticulum & mitochondria.
Clumping of chromatin.
Irreversible Cell injury
Pathologic changes that are permanent and cause cell death, they cannot be reversed to normal state.
Changes in irreversible cell injury
Irreversible injury is marked by severe mitochondrial vacuolization, extensive damage to plasma membranes, detachment of ribosomes from the granular endoplasmic reticulum (ER). Injury to lysosomal bodies leads to leakage of lysosomal enzymes into the cytoplasm and condensation, fragmentation and lysis of nuclei.
Cellular Response to cell Injury and Cellular Adaptations .pptxRukhshanda Ramzaan
Cellular Adaptations
ability of cells to respond to various types of stimuli and adverse environmental changes
Atrophy(decrease in cell size)
Hypertrophy(increase in cell size)
Hyperplasia(increase in cell number)
Metaplasia(change in cell type): Replacement of one differentiated cell type with another mature differentiated cell type that is not normally present in that tissue.
Dysplasia (increase in abnormal cell): Dysplasia is not cancer, but it may sometimes become cancer.
Terminologies used in Disturbances of Cell Growth which are not adaptations
Agenesis refers to the failure of an organ to develop during embryonic growth and development
Hypoplasia is the underdevelopment or incomplete development of a tissue or organ. It is technically not the opposite of hyperplasia (too many cells). Hypoplasia is a congenital condition, while hyperplasia generally refers to excessive cell growth later in life.
Aplasia is a birth defect where an organ or tissue is wholly or largely absent. It is caused by a defect in a developmental process.
Introduction to Pathology and how to describe a LesionRukhshanda Ramzaan
Introduction to general Veterinary Pathology, Gross examination description, How to describe lesion while doing Gross/ macroscopic examination, Postmortem lesion description at basic leve
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
2. Death
• Death is the permanent, irreversible cessation of all biological
functions that sustain a living organism. The remains of a previously
living organism normally begin to decompose shortly after death.
• Clinical signs and stages of death
1. Respiratory arrest (no breathing)
2. Cardiac arrest (no pulse)
3. Brain death (no neuronal activity)
3. Post-mortem changes
• The stages that follow shortly after death are:
• Pallor mortis, paleness which happens in the first 15–120 minutes
after death. Pallor mortis results from the collapse of capillary
circulation throughout the body.
• Algor mortis, the reduction in body temperature following death. This
is generally a steady decline until matching ambient temperature.
External factors can have a significant influence.
4. • Rigor mortis, the limbs of the corpse
become stiff (Latin rigor) and difficult to
move or manipulate.
• After death, aerobic respiration in an
organism ceases, depleting the source of
oxygen used in the making of adenosine
triphosphate (ATP). ATP is required to
cause separation of the actin-myosin cross-
bridges during relaxation of muscle. When
oxygen is no longer present, the body may
continue to produce ATP via anaerobic
glycolysis. When the body's glycogen is
depleted, the ATP concentration
diminishes, and the body enters rigor
mortis because it is unable to break those
bridges.
5. • Rigor Mortis, used to determine the time of
death.
• Starts within 2 hours after death.
• Stiffness starts in the head (eyelids) and
gradually works its way down the legs.
• The body is at the most rigid state after 12
hours.
• Stiffness disappears after 36 hours.
• It may remain up to 48 hours depending on
body weight and ambient temperature.
• Stiffness occurs because skeletal muscles are
unable to relax and remain contracted.
6. • Livor mortis, or hypostasis, is a
settling of the blood in the lower, or
dependent, portion of the body,
causing a purplish red discoloration of
the skin.
• Livor mortis starts in 20–30 minutes,
but is usually not observable by the
human eye until two hours after
death. The size of the patches
increases in the next three to six
hours, with maximum lividity
occurring between eight and twelve
hours after death.
7. • Putrefaction is the fifth stage of death,
following pallor mortis, algor mortis, rigor
mortis, and livor mortis. Putrefaction
(rotting), refers to the enzymatic
decomposition of organic material (tissue)
with production of foul-smelling
compounds (eg H2S, NH3) especially by
saprophytic / putrefactive bacteria.
• Postmortem emphysema occurs when
saprophytic bacteria produce gas, causing
gaseous distention of G-I tract, organs and
body cavities.
8. Stages of Decomposition
• A corpse decomposes in
predictable ways.
• Within 2 days after death:
• Cell autolysis begins
• Green and purplish color
occurs
• Skin takes marble appearance
• Face becomes discolor
• After 4 days:
• Skin blisters
• Abdomen swells
• Within 6 to 10 days:
• Corpse bloats
• Chest and abdomen burst and
collapse
• Fluids leak
• Eyeballs and other tissues
liquefy
• Skin sloughs off
• Decomposition = Rotting