This document discusses death and different types of death. It defines death as the permanent loss of vital functions and introduces the new concept of brain death. It describes three types of death: somatic, molecular, and brain death. Somatic death is the irreversible stoppage of circulation, respiration, and brain functions. Molecular death is death at the cellular level, which can continue for hours after circulation stops. Brain death can be cortical, brain stem, or whole brain. Brain stem death is the loss of vital centers controlling respiration and consciousness. Criteria for determining brain death include the Philadelphia protocol, Minnesota criteria, and Harvard criteria, which evaluate responsiveness, breathing, movements, reflexes, and EEG results.

2. Points to be discussed are
What is death
Types of death
Brain death

3. DEATH
 Tenatology is the study of all aspects of death
 Historically death was considerd as spontaneous
stoppage of heart & lung function
 New concept is of brain death, irreversible loss of
cerebral function
 According to registration of births &deaths act,death is
the permanent disappearance all evidences of life at
any time after birth

4. TYPES OF DEATH
Somatic death
Molecular death

5. SOMATIC DEATH
 It is the complete and irreversible stoppage of
circulation, respiration and brain functions
 It is important in resuscitation and organ
transplantation
 As long as circulation of oxygenated blood is
maintained to brain stem, life exists
 A person who cannot survive upon withdrawal of
artificial maintenance is dead

6. MOLECULAR DEATH
Death of cells & tissues individually
Takes place usually one to two hours after stoppage of
vital functions
Individual cell live on their residual oxygen for variable
time after circulation stopped
Nervous tissues die rapidly
Vital centers of brain loss in about five minutes
Muscles live up to one to two hours

7. ANOXIA
 According to Gordon stoppage of vital functions
depends upon tissue anoxia
 Anoxia means lack of oxygen
1.Anoxic anoxia
2.Anaemic anoxia
3.Stagnant anoxia
4.Histotoxic anoxia

8.  Anoxic anoxia
Oxygen cannot reach blood, because lack of
oxygen in lungs
occurs
a)from contaminated atmosphere
b)From mechanical interference with passage
of air into or down the respiratory tract
Eg.smothering,choking,hanging or exposure to
fumes wells and tanks

9.  Anaemic anoxia
Oxygen carrying capacity reduced
eg: acute massive haemorrhages,poisoning by carbon
monoxide, chlorates,nitrates,coaltar derivatives
 Stagnant anoxia
Impaired circulation results in a reduction of
oxygen delivery to tissues eg:heart failure,embolism
and shock

10.  Histotoxic anoxia
Enzymatic processes by which oxygen in blood
is used by the tissues are blocked
Eg: Acute cyanide poisoning

11. BRAIN DEATH
 3 Types
1.cortical/cerebral death
2.Brain stem death
3.Whole brain death

12. BRAIN STEM DEATH
 Here cerebrum intact
 Loss of vital centers control respiration,
 Loss of ascending reticular activating system that
sustain consciousness
 Person become irreversibly comatose& incapable of
spontaneous breathing
 Can be produced by raised intracranial pressure,
cerebral edema,intracranal hemorrhages

13. CORTICAL DEATH
 Here brain stem intact
 Respiration continues
 Total loss of power of perception by senses
 Deep coma is produced by cerebral hypoxia, toxic
conditions or brain injury

14. WHOLE BRAIN DEATH
 Permanent cessation of functions of cerebrum
cerebellum & brain stem

15. CRITERIA FOR DETERMINING BRAIN
DEATH
Philadelphia protocol
Minnesota criteria
Harvard criteria

16. PHILADELPHIA PROTOCOL
Determined on basis of
 Lack of responsiveness to internal and external
environment
 Absence of spontaneous breathing movements for 3
minutes, in absence of hypocarbia
 No muscular movements with generalized flaccidity
 No reflexes and responses
 Falling arterial pressure without support by drugs or other
means
 Isoelectric EEG recorded spontaneously and during tactile
& auditory stimulation

17. MINNESOTA CRITERIA
Known but irreperable intracranial tension
No spontaneous movements
Apnoea
Absence of brain stem reflexes
All findings remain unchanged for at least 12 hours

18. HARVARD CRITERIA
 Unreceptivity & unresponsivity
No movements
Apnoea
Absence of elicitable reflexes
Isoelectric EEG

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