60 years of Kariba Dam: implications for downstream water qualityDAFNE project
Presentation held at the 12th Institute of Biogeochemistry and Pollutant Dynamics (IBP) PhD congress on 26 April 2019. The IBP PhD congress is a unique platform for doctoral students of our institute to present and share their research work, to build network, and to interact among each other outside the normal day-to-day environment.
Sustainable Management of the Nexus in Transboundary Systems DAFNE project
The presentation took place at the Resource Nexus Policy & Cluster Workshop on 27th November 2018 in Brussels that was organized by DAFNE, SIM4NEXUS and MAGIC at EASME premises. Read more about the workshop here: https://dafne.ethz.ch/2018/12/11/resource-nexus-policy-cluster-workshop-27th-november-brussels/
Protection and Sustainable Use of the Dinaric Karst Aquifer System (DIKTAS)
International Roundtable on Protection and Sustainable Use of Trans-boundary Waters in South East Europe, 15-16 December 2011, Zagreb, Croatia
60 years of Kariba Dam: implications for downstream water qualityDAFNE project
Presentation held at the 12th Institute of Biogeochemistry and Pollutant Dynamics (IBP) PhD congress on 26 April 2019. The IBP PhD congress is a unique platform for doctoral students of our institute to present and share their research work, to build network, and to interact among each other outside the normal day-to-day environment.
Sustainable Management of the Nexus in Transboundary Systems DAFNE project
The presentation took place at the Resource Nexus Policy & Cluster Workshop on 27th November 2018 in Brussels that was organized by DAFNE, SIM4NEXUS and MAGIC at EASME premises. Read more about the workshop here: https://dafne.ethz.ch/2018/12/11/resource-nexus-policy-cluster-workshop-27th-november-brussels/
Protection and Sustainable Use of the Dinaric Karst Aquifer System (DIKTAS)
International Roundtable on Protection and Sustainable Use of Trans-boundary Waters in South East Europe, 15-16 December 2011, Zagreb, Croatia
The use of spatial data in policy development and reviewIIED
These slides, presented by Sarah Darrah from the UN Environment Programme World Conservation Monitoring Centre at the Mainstreaming biodiversity workshop in Sogakope, Ghana, in November 2016, look at how spatial data can be used as a tool to support mainstreaming.
Darrah acknowledges that lack of access to data, and a lack of expertise in using spatial data, can be barriers to using this information for mainstreaming, but where there are existing research and data collection programmes and exchange of information between institutions, then spatial information can be a valuable.
She illustrates this using an example from the Lake Victoria basin, looking at the potential impacts of agricultural development on biodiversity.
More information: www.iied.org/nbsaps
This session targets GFW partners working at a national level and those interested in increasing the relevance of GFW for national/local stakeholders. Discussion topics include: How are GFW partners working to “nationalize” GFW data and technology to support forest management, law enforcement, land use planning, and reporting on forest-related commitments? What more can be done to facilitate these efforts?
Navigating the Marine Geophysical Data Life CycleVicki Ferrini
I gave this presentation at the University of New Hampshire's Center for Coastal and Ocean Mapping on April 18, 2014 describing the marine geophysical data life cycle and a variety of resources available to help investigators navigate the world of data management, as well as efforts focused on optimizing high-quality publicly available data.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
1. Geert-Jan Nijsten - IGRAC
21 May 2014
Windhoek
Stampriet – Kalahari/Karoo Aquifer Case Study
Technical Seminar on Project Implementation
Dealing with data
Information Management System
Processing & Harmonisation
Team cooperation
2. Set-up of the presentation
1. Information Management System
2. Data processing and harmonisation
3. Internal communication
4. But it can be an information management system for
interpreted data and documents
to support transboundary management
What will the GGIS NOT be ?
5. Purpose of Information Management System
• Collect, store, visualise and share
structured information
in order to:
• Support transboundary groundwater
governance
• Allow replication of the assessment
6. • Indicators
• Parameters/variables
• Tabular data
• Thematic maps
• Background maps
• Documents
• Images
And:
• Meta information
What types of information can be stored?
Projections
(WaterGap)
8. Actors and roles in Data Flow
GGIS
National
Experts (NE)
Regional
coordinat
ors (RC)
IGRAC -
UNESCO
• Data &
information
collection
• Data
processing
and
harmonisation
• Create visuals
• Coordinate &
assist NE
• Facilitate
Transboundary
cooperation,
data
harmonisation
and creation of
visuals
• IMS
Development
and maintenance
• Guidelines and
data protocols
• Technical
assistance to
NE’s
• Global
Groundwater
Information
System
Management
tool for
consultative
body
10. Structured data
Standardised
formats:
• Digital maps
• Tables (excel)
• Text
Data collection
• Paper maps
• Paper reports
Text, tabular data,
images, maps
•Digital data
Tables, maps, reports
Data Processing
From ‘raw’ data to consistently structured data
14. 1 TBA
2 Countries
• Countries need consensus
on delineation of TBA
2 data sets
• National data
sets may differ in
format
Harmonised
data
• Harmonised TBA map,
based on national data sets.
Harmonisation – map information
Transboundary
aquifer
For example information on
Aquifer productivity (Namibia) and
Groundwater potential (Botswana)
15. WHO
1993
Botswana, 2000
Guide-
line
Value
Class 1
Ideal
Class 2
Acceptable
Class 3
Max.
Allowable
mg/l mg/l mg/l mg/l
Namibia, 1991 South Africa, 2006
Group A
Excellent
Group B
Good
Group C
Low
Health
Risk
Group D
Unsuitable
Class I
Operational
Class II
Max allowable for
limited duration
mg/l mg/l mg/l mg/l mg/l mg/l
Harmonisation – Agree on classifications
16. Data processing & Harmonisation
Agree on:
• classifications (suitability for water consumption, land use types, water use
types, stratigraphy, etc. etc.)
• map scale and map projection
• areal sub-divisions for reporting (eg report per local municipality
or per district?)
• units
• table formats
• report format
• additions/modifications to the methodology (eg: Groundwater
community management)
• ….
• ….
17. Harmonisation
May 2014
Stampriet ?!
October 2013
Stampriet
Kalahari-Karoo
South East Kalahari
Karoo Basin
Harmonisation is all about developing a
common language and terminology
18. 18
Project workflow / tasks
1. Data collection (incl. data entry and digitising of
relevant information)
2. Taking stock (which data are available and which
not) and fine-tuning of methodology
(data & indicators)
3. Structuring of data (data processing)
4. Harmonising data in a consistent way
across the aquifer
5. Producing outputs: Indicators, thematic
maps, overview tables, illustrative graphs, conceptual
model, assessment report
