cyclotron that accelerate the charge particles prior their bombardment to the target nuclei.
it is developed by E.O.Lawrence & he was awarded by nobel prize in this work. it accelerate the particle from 1MeV to the more than 100 MeV.
it contains the electric & magnetic system to accelerate the charge particles.
electric field acts horizontally & magnetic field act vertically.
particle moves in spiral path and its energy , radius & velocity increases.
after that it moves out of window ( diflactor plate) n hit the target.
n then the nuclear reaction starts.
it is used to treat cancer.
produce positrons emission isotopes for PET imaging.
it do not accelerate the neutrons, electrons & positive charge with higher mass.
A particle accelerator
Sends charged particles, which constantly accelerate through a ‘Dee’, through a circular path until they are (most likely) directed towards a designated target for a specific purpose
This PPT contains all about cyclotron. That is introduction, history, types, uses, construction, working and limitations of cyclotron. This PPT also contains derivation and formula for cyclotron. Pictorial presentation is understandable for higher secondary school student. Although it is for Bachelor's level.
A particle accelerator
Sends charged particles, which constantly accelerate through a ‘Dee’, through a circular path until they are (most likely) directed towards a designated target for a specific purpose
This PPT contains all about cyclotron. That is introduction, history, types, uses, construction, working and limitations of cyclotron. This PPT also contains derivation and formula for cyclotron. Pictorial presentation is understandable for higher secondary school student. Although it is for Bachelor's level.
This kind of Van de Graaff generator is made up of:
• A motor
• Two rollers
• A belt
• Two brush assemblies
• An output terminal (usually a metal or aluminum sphere)
The strong negative charge from the roller now begins to do two things:
1. It repels the electrons near the tips of the lower brush assembly.
2. It begins to strip nearby air molecules of their electrons.
Applications:
1. It is used to generate x-rays, which is widely used in medicine field.
2. It is used in atom smasher’s, which is used in research purposes.
3. It found applications in physics, medicine, and astro physics.
This kind of Van de Graaff generator is made up of:
• A motor
• Two rollers
• A belt
• Two brush assemblies
• An output terminal (usually a metal or aluminum sphere)
The strong negative charge from the roller now begins to do two things:
1. It repels the electrons near the tips of the lower brush assembly.
2. It begins to strip nearby air molecules of their electrons.
Applications:
1. It is used to generate x-rays, which is widely used in medicine field.
2. It is used in atom smasher’s, which is used in research purposes.
3. It found applications in physics, medicine, and astro physics.
In your previous class you have already studies about the structure of an atom but some of the exception you can learn here in this chapter how the structure of an atom is fully defined
The evolution of radiation treatment planning and delivery, with innovative techniques (3DCRT, IMRT, IGRT, IGBT), particle therapy allowing for better definition of target and sensitive structure volumes and more precise quantification of dose, has introduced more complexity into the evaluation of radiation effects on OARs.
maldi & ldi , main difference, how they help in ionization peocess & how they actually ionize the sample in mass spectrometry. their applications, significance & limitations.
Solvents & their impact on environmentWishal Butt
A solvent is a substance that dissolves a solute resulting in a solution.
most of the solvents are combustible, often highly volatile and extremely flammable and they should always be handled with care.
An organic solvent containing oxygen as part of the molecular structure.
EXAMPLE:-
alcohols, glycol ethers, ketones, esters, and glycol ether.
USES
These solvents are widely used in paints, inks, pharmaceuticals, perfumes, adhesives, cosmetics, detergents, and food processing.During the synthesis of such solvents like alcohol, the residue of molasses is disposed off out of the industry containing microbes, may contaminate the soil & water.
Alcohol poisoning
Respiratory depressions
Low rate of metabolism by abnormal liver.
Loss of electrons by an atom, ions or molecule during a chemical reaction & increase its oxidation state.
Gain of electrons by an atom , ion or molecule during a chemical reaction & decrease in its oxidation state
The reactions which involves both reduction process & complementary oxidation process called redox reaction.
The term ‘complement’ refers to set of serum proteins that cooperate in both innate and adaptive immune system to eliminate blood tissue pathogens.
It was 1st identified as heat labile component of serum.
Major effectors of hormonal branch of immune system.
Paul Ehrlich in Berlin independently carried out similar experiments & coined the term COMPLEMENT, defining it as ‘’ the activity of blood serum that completes the action of antibody.’’
In later years it was revealed that the action of complement is basically the result of interaction of large & complex group of proteins.Most of the components of complement system are synthesized in liver by hepatocytes, epithelial cells of gastrointestinal & genitourinary tracts.
it consist up of 15% of globular proteins fraction in plasma & combined conc. Is about 3 mg/ml.
These are the glycoproteins distributed among blood plasma & cell membrane.After activation several components interact in regulated cascade to carry out no. of basic functions…..
Lysis if cells .( bacteria , virus)
Opsonization, that promote phagocytosis of particulate antigens.
Activation of inflammatory response.
Immune clearance.
Chemotaxis.
Lysis refers to the breaking down of the cells' membrane , by viral, enzymic, or osmotic mechanisms that compromise its integrity.
A fluid containing the contents of lysed cells is called a "lysate".
Cell lysis is used to break open cells to avoid shear forces that would denature or degrade sensitive proteins and DNA.
Paired
Retroperitoneal
Partially protected by the 11th and 12th ribs
Right slightly lower due to liver
Surrounded by renal capsule
Adipose capsule
Renal fascia
The primary route in which the body eliminates substances .
The main function of the kidney is the excretion of body wastes and harmful chemicals into the urine. uropoiesis
The functional unit of the kidney responsible for excretion is the nephron.
Each kidney contains about one million nephrons.
Kidney excrete by urine formation & release, & it consist up of following steps.
Glomerular / ultra filtration
Selective reabsorption
Tubular secretion
Detoxification is the body’s process of removing toxic substances.
Detoxification is not a food, or diet, or a pill - it is an ongoing, VITAL process that your body does (all on its own) in order to survive.
It happens 24/7, 365 days of the year. Not just for a few days or weeks prescribed to “do a detox”.
Your main detoxification organs are the liver and kidneys.
The bowels and urinary tract are extensions of these organs as wastes exit your body.
Industrial production of lactic acid & monosodium glutamateWishal Butt
Widely occurring organic acid
Applications in industry, food , textile, pharmaceutical
White in solid
Extremely soluble
DISCOVERY:-
In 1780 discovered by a Swedish chemist SCHEELE by sour milk.
1839, FERMY from sugar , milk , starch , dextrin.
1857 , PASTEUR, discovered that it is not a component of milk , but a metabolite that certain microorganisms produced by fermentation.Monosodium glutamate (MSG, also known as sodium glutamate) is the sodium salt of glutamic acid,
one of the most abundant naturally occurring non-essential amino acids.
It is commonly known as Ajinomoto.
It is found naturally in tomatoes, cheese and other foods.
It is used in the food industry as a flavor enhancer.
The movement ( migration) of the dispersion medium of colloidal solution , under the influence of electrical field, when dispersed particles are prevented from moving is known as ELECTROOSMOSIS.
It is basically a drying technique .
It is used to dewatering a substance or a colloidal solution electrically.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
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Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
2. INTRODUCTION:-
Device used to accelerate
the charged particles to
high energies without the
use of high voltage.
It is capable of generating
particles energies between
1MeV to more than 100
MeV.
Accelerate charged
particles e.g. proton,
deuterons etc., using
electric & magnetic fields.
4. PRINCIPLE:-
it is cross magnetic and
electric field which
combinedly increases the
velocity of a charge particle.
Cyclotron works on the
principle that a charged
particle moving normal to a
magnetic field experiences
magnetic Lorentz force due
to which the particle moves
in a circular path.
the force which is exerted by
a magnetic & electric field on
a moving charge particle.
8. ION SOURSE:-
Provide ions ( proton , deuterons)
which have to be accelerated.
PIG ( penning ion gauge) generate
ions to be accelerated.
Inject ions in the center of Dees.
9. DEES:-
Two flat hollow
semicircular ,electrodes
made up of highly
conductive metals.
Electrodes inside the
cyclotrons.
Fluttering positive &
negative charges.
Increase the velocity of
ion.
11. RF OSCILLATOR:-
Radiofrequency oscillator
pulls the ions out the ionic
source.
It is connected to the Dees
at high frequency &
voltage.
Push & pull the ion around
the cyclotron.
Accelerate the particles to
the specified energy
before its bombardment.
12. TARGET:-
Targets are located
outside the cyclotrons.
High energy particle ,
beam of proton hit the
nucleus & cause
nuclear reaction.
Target material can be
a gas , liquid or solid.
Target
Ionic beam
13. WORKING:-
a positive ion of charge q and mass m is emitted
from the source, accelerated towards the Dee
having a negative potential at that instant of time.
Due to the normal magnetic field, the ion
experiences magnetic Lorentz force and moves in
a circular path.
By the time the ion arrives at the gap between the
Dees, the polarity of the Dees gets reversed.
Hence the particle is once again accelerated and
moves into the other Dee with a greater velocity
along a circle of greater radius.
14. Thus the particle moves in a spiral path of
increasing radius and when it comes near the
edge, it is taken out with the help of a deflector
plate (D.P).
The particle with high energy is now allowed to
hit the target T.
15.
16. CALCULATIONS:-
Mass of ion = m
Charge of ion = e
Velocity = V
magnetic field = H
Centripetal force = HeV
Centrifugal force = mV²/ r
17.
18.
19. APPLICATIONS:-
high-energy beams used for
experiment in nuclear
physics, where high energy
collisions are required.
Cyclotrons can be used in
particle therapy to treat
cancer.
Cyclotron beams can be
used to bombard other
atoms to produce short-lived
positron emitting isotopes
suitable for PET imaging .
20. LIMITATIONS:-
Maintaining a uniform
magnetic field over a large
area of the Dees is difficult.
Cyclotron cannot accelerate
electrons because electrons
are of very small mass.
A cyclotron cannot be used to
accelerate neutral particles.
It cannot accelerate positively
charged particles with large
mass due to the relativistic
effect.