This document discusses plasma therapy as a potential cure for COVID-19. It explains that convalescent plasma therapy has been used to treat SARS, MERS, and H1N1, with satisfactory efficacy and safety. Doctors in Delhi, India are trying to implement convalescent plasma therapy to treat COVID-19 patients, having already tested it on four patients. The document also outlines some research gaps regarding COVID-19 such as whether certain mutations enhance host cell entry or diagnosing the virus from field samples.

1. #SCIENCE #ADDA
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CURE
COVID-19

2. GRAPHICAL PRESENTATION OF SOURCE, SPREAD AND CURE OF CORONA
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3. PLASMA THERAPY TO CURE COVID 19
Convalescent plasma (CP) therapy, a classic adaptive immunotherapy, has
been applied to the prevention and treatment of many infectious
diseases for more than one century. Over the past two decades, CP
therapy was successfully used in the treatment of SARS, MERS, and
2009 H1N1 pandemic with satisfactory efficacy and safety.
Dr. Shiv Kumar Sarin & Dr. Minu bajpai (AIIMS, DELHI) is trying to
implement it in Delhi hospital. Four patients teste already.
Important Note:
If you think you have been exposed to novel coronavirus (COVID-19), and have developed any
symptoms (cough, fever or difficulty breathing), call the Govt. of India helpline 1075 or
the state helpline numbers for assistance.
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4. PLASMA THERAPY
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5. WORKING IMAGE OF MECHANISM
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6. RESEARCH GAP
 It is not yet clear whether this mutation is common in Group 4 viral
isolates from different geographical regions.
 whether this mutation enhances host cell entry.
 Viral isolation from field samples is rarely successful.
 Reverse genetics recovery of recombinant virus is labour intensive and
expensive.
 Development diagnostic-test kits
 Development of potential drugs.
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7. COMMON THINGS TO KNOW
 People may be sick with the virus for 1 to 14 days before developing symptoms. The
most common symptoms of coronavirus disease (COVID-19) are fever, tiredness, and
dry cough.
 Most people (about 80%) recover from the disease without needing special treatment.
 More rarely, the disease can be serious and even fatal. Older people, and people with
other medical conditions (such as asthma, diabetes, or heart disease), may be more
vulnerable to becoming severely ill.
People may experience:
cough
fever
tiredness
difficulty breathing (severe cases)
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8. REFERENCES
 Letko, M., Marzi, A. and Munster, V., 2020. Functional assessment of cell entry and receptor usage
for SARS-CoV-2 and other lineage B betacoronaviruses. Nature microbiology, 5(4), pp.562-569.
 of the International, C.S.G., 2020. The species Severe acute respiratory syndrome-related
coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nature Microbiology, p.1.
 Duan, K., Liu, B., Li, C., Zhang, H., Yu, T., Qu, J., Zhou, M., Chen, L., Meng, S., Hu, Y. and Peng,
C., 2020. Effectiveness of convalescent plasma therapy in severe COVID-19 patients. Proceedings
of the National Academy of Sciences.
 COVID-19 | MyGov.in
 http://virological.org/
 https://google.com/covid19-map/?hl=en
THANK YOU #SCIENCE
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