- Climate-smart agriculture is presented as a guideline for successful agriculture in Tanzania. - Agriculture is the mainstay of Tanzania's economy, employing most citizens and contributing most to food production, but smallholder farmers are experiencing impacts of climate change. - The guideline provides climate-smart practices and technologies for different agricultural zones to help farmers build resilience to climate change through adaptation and mitigation. - Roles for government, NGOs, private sector, and farmers are outlined to implement and scale up climate-smart agriculture through approaches like training, partnerships, and demonstration projects.