This document provides information on COVID-19 including what it is, its epidemiology, transmission, clinical presentation, investigations, management, and prevention. It describes COVID-19 as a novel coronavirus that is transmitted between people and causes respiratory illness. Symptoms can range from mild to severe and include fever, cough, and shortness of breath. Diagnosis involves PCR testing of respiratory samples. Current recommendations for prevention include hand washing, social distancing, and self-isolation when sick.
COVID-19 : Introduction,Nomenclature,Incubation Period,Structure,Symptoms,Transmission,Flowchart,Diagnosis,Treatment,Drugs under testing,Prevention,Importance of Social Distancing,Effects in Lungs,Effects in Other organs,Replication,Severity,Stages,Comparison,Facts.
Features, Evaluation and Treatment Coronavirus (COVID-19)
The WHO and other organizations have issued the following general recommendations:
Avoid close contact with subjects suffering from acute respiratory infections.
Wash your hands frequently, especially after contact with infected people or their environment.
Avoid unprotected contact with farm or wild animals.
People with symptoms of acute airway infection should keep their distance, cover coughs or sneezes with disposable tissues or clothes and wash their hands.
Strengthen, in particular, in emergency medicine departments, the application of strict hygiene measures for the prevention and control of infections.
Individuals that are immunocompromised should avoid public gatherings.
Patients and families should receive instruction to:
Avoid close contact with subjects suffering from acute respiratory infections.
Wash their hands frequently, especially after contact with sick people or their environment.
Avoid unprotected contact with farm or wild animals.
People with symptoms of acute airway infection should keep their distance, cover coughs or sneezes with disposable tissues or clothes and wash their hands.
Immunocompromised patients should avoid public exposure and public gatherings. If an immunocompromised individual must be in a closed space with multiple individuals present, such as a meeting in a small room; masks, gloves, and personal hygiene with antiseptic soap should be undertaken by those in close contact with the individual. In addition, prior room cleaning with antiseptic agents should be undertaken and performed before exposure. However, considering the danger involved to these individuals, exposure should be avoided unless a meeting, group event, etc. is a true emergency.
Strict personal hygiene measures are necessary for the prevention and control of this infection.
Novel corona virus (COVID-19) its cause, symptoms and treatmentMedical Knowledge
In this SlideShare, you can learn about the pandemic Novel Corona Virus (COVID-19) and also seek knowledge about,
1. What is Coronavirus?
2. Types of the Coronavirus.
3. Transmission of Coronavirus.
4. Prevention of Coronavirus.
5. Treatment of Coronavirus.
6. Diet in Coronavirus.
7. Symptoms of Coronavirus.
8. How Coronavirus get its name?
9. What is MERS_COVID & SARS_COVID?
To download the PowerPoint of this click below:
https://drive.google.com/open?id=1s35dGMbsaO8WT2RG8NudOBc4lF2u5JXyH0MVQWpiaXk
To view the video tutorial click below:
https://youtu.be/sKVFN250l_Q
The Corona virus pandemic has costed a lot of lives through out the world.
Here are some in formations about what is known so far.
It includes cause, Spread, Signs and Symptoms.
it also has the ongoing myths about corona virus.
COVID-19 (coronavirus disease 2019) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), previously known as 2019 novel coronavirus (2019-nCoV), a strain of coronavirus. The first cases were seen in Wuhan, China in December 2019 before spreading globally. The current outbreak was recognized as a pandemic on 11 March 2020.
The non-specific imaging findings are most commonly of atypical or organizing pneumonia, often with a bilateral, peripheral, and basal predominant distribution. No effective treatment or vaccine exists currently (March 2020).
In this PowerPoint presentation you can get data about every aspect of COVID-19 disease.I gave every minute important detail in short form so that you can easily get that. Coronavirus disease spread globally and WHO called it as a Pandemic Disease on March 11,2020. in India it is on stage 2,please its my request to everyone stay at Home..Don't Go outside...Government provide everything which is of daily use...Don't Panic...Stay Safe..Stay At Home...Quarantine yourself for somedays.
COVID-19 : Introduction,Nomenclature,Incubation Period,Structure,Symptoms,Transmission,Flowchart,Diagnosis,Treatment,Drugs under testing,Prevention,Importance of Social Distancing,Effects in Lungs,Effects in Other organs,Replication,Severity,Stages,Comparison,Facts.
Features, Evaluation and Treatment Coronavirus (COVID-19)
The WHO and other organizations have issued the following general recommendations:
Avoid close contact with subjects suffering from acute respiratory infections.
Wash your hands frequently, especially after contact with infected people or their environment.
Avoid unprotected contact with farm or wild animals.
People with symptoms of acute airway infection should keep their distance, cover coughs or sneezes with disposable tissues or clothes and wash their hands.
Strengthen, in particular, in emergency medicine departments, the application of strict hygiene measures for the prevention and control of infections.
Individuals that are immunocompromised should avoid public gatherings.
Patients and families should receive instruction to:
Avoid close contact with subjects suffering from acute respiratory infections.
Wash their hands frequently, especially after contact with sick people or their environment.
Avoid unprotected contact with farm or wild animals.
People with symptoms of acute airway infection should keep their distance, cover coughs or sneezes with disposable tissues or clothes and wash their hands.
Immunocompromised patients should avoid public exposure and public gatherings. If an immunocompromised individual must be in a closed space with multiple individuals present, such as a meeting in a small room; masks, gloves, and personal hygiene with antiseptic soap should be undertaken by those in close contact with the individual. In addition, prior room cleaning with antiseptic agents should be undertaken and performed before exposure. However, considering the danger involved to these individuals, exposure should be avoided unless a meeting, group event, etc. is a true emergency.
Strict personal hygiene measures are necessary for the prevention and control of this infection.
Novel corona virus (COVID-19) its cause, symptoms and treatmentMedical Knowledge
In this SlideShare, you can learn about the pandemic Novel Corona Virus (COVID-19) and also seek knowledge about,
1. What is Coronavirus?
2. Types of the Coronavirus.
3. Transmission of Coronavirus.
4. Prevention of Coronavirus.
5. Treatment of Coronavirus.
6. Diet in Coronavirus.
7. Symptoms of Coronavirus.
8. How Coronavirus get its name?
9. What is MERS_COVID & SARS_COVID?
To download the PowerPoint of this click below:
https://drive.google.com/open?id=1s35dGMbsaO8WT2RG8NudOBc4lF2u5JXyH0MVQWpiaXk
To view the video tutorial click below:
https://youtu.be/sKVFN250l_Q
The Corona virus pandemic has costed a lot of lives through out the world.
Here are some in formations about what is known so far.
It includes cause, Spread, Signs and Symptoms.
it also has the ongoing myths about corona virus.
COVID-19 (coronavirus disease 2019) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), previously known as 2019 novel coronavirus (2019-nCoV), a strain of coronavirus. The first cases were seen in Wuhan, China in December 2019 before spreading globally. The current outbreak was recognized as a pandemic on 11 March 2020.
The non-specific imaging findings are most commonly of atypical or organizing pneumonia, often with a bilateral, peripheral, and basal predominant distribution. No effective treatment or vaccine exists currently (March 2020).
In this PowerPoint presentation you can get data about every aspect of COVID-19 disease.I gave every minute important detail in short form so that you can easily get that. Coronavirus disease spread globally and WHO called it as a Pandemic Disease on March 11,2020. in India it is on stage 2,please its my request to everyone stay at Home..Don't Go outside...Government provide everything which is of daily use...Don't Panic...Stay Safe..Stay At Home...Quarantine yourself for somedays.
Rekha Dehariya (M.Sc nursing 1st year) Bhopal Nursing College, Bhopal
Covid -19 has effected broud number of people all over the world. the health education is necessary to aware people about it.
This Powerpoint presentation is on Covid-19. It includes the origin of Covid 19, features, figures in the world, role of common people, role of Government, art of living due to lockdown, outcomes and lessons of Covid-19 and lockdown, and how to tackle such situations in future.
Its a small presentation about corona virus. Hope you will get an idea about it. Its not detail its just to give an overview of the virus and its mode of transmission. Preventive measures are also discussed.
This is a presentation for all the people who are unaware about COVID-19.
COVID-19 = Corona Virus Disease 2019. Please like and share my presentation.
Presentation by:-
C. S. Nelson
VI - E
D.A.V Boys Senior Secondary School.
D.A.V Group of School.
coronavirus disease (COVID-19),origin,epidemiology,risk factors and causes,mode of transmission,pathophysiology,signs and symptoms,management,comlication,preventive measures
Everything we need to know about COVID-19PrincessExtra
These slides is uploaded for information and as a partial requirement of Philippine Women's University in Master of Nursing (MAN); Subject: Nursing Practicum
Rekha Dehariya (M.Sc nursing 1st year) Bhopal Nursing College, Bhopal
Covid -19 has effected broud number of people all over the world. the health education is necessary to aware people about it.
This Powerpoint presentation is on Covid-19. It includes the origin of Covid 19, features, figures in the world, role of common people, role of Government, art of living due to lockdown, outcomes and lessons of Covid-19 and lockdown, and how to tackle such situations in future.
Its a small presentation about corona virus. Hope you will get an idea about it. Its not detail its just to give an overview of the virus and its mode of transmission. Preventive measures are also discussed.
This is a presentation for all the people who are unaware about COVID-19.
COVID-19 = Corona Virus Disease 2019. Please like and share my presentation.
Presentation by:-
C. S. Nelson
VI - E
D.A.V Boys Senior Secondary School.
D.A.V Group of School.
coronavirus disease (COVID-19),origin,epidemiology,risk factors and causes,mode of transmission,pathophysiology,signs and symptoms,management,comlication,preventive measures
Everything we need to know about COVID-19PrincessExtra
These slides is uploaded for information and as a partial requirement of Philippine Women's University in Master of Nursing (MAN); Subject: Nursing Practicum
Coronaviruses are a large family of viruses that are known to cause illness ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS).
A novel coronavirus (COVID-19) was identified in 2019 in Wuhan, China. This is a new coronavirus that has not been previously identified in humans. im mentioned in this ppt about Coronavirus disease symptoms, transmission, mechanism, treatment, diagnosis etc.
what is COVID-19 or corona virus.
CAUSE OF CORONA VIRUS
RISK ASSESSMENT OF SARS-COV-2
CASE FATALITY RATIO
RISK MITIGATION
Administrative controls, self care and testing
Case fatality ratio of Covid-19, Sars and Mers
Review on strategies to counteract sars cov-2 by anti-inflammatory and anti-o...sagapolarajini
Therefore, exploring the repurposing of natural compounds may provide alternatives against COVID19. Several nutraceuticals have a proven ability of immune- boosting, antiviral, antioxidant, anti-inflammatory effects. These include Zn, vitamin D, vitamin C, curcumin, cinnamaldehyde, probiotics,
selenium, lactoferrin, quercetin, etc. Grouping some of these phytonutrients in the right combination
in the form of a food supplement may help to boost the immune system, prevent virus spread, preclude the disease progression to severe stage, and further suppress the hyperinflammation providing both
prophylactic and therapeutic support against COVID-19
Covid-19 is an infectious disease caused by SARS-CoV-2. mechsnism, pathogenesis and causes, transmission,symptoms and therapeutic strategies
Published by karuna raghuwanshi,M.pharma II semester (pharmaceutics),Pharmacy department.
corona is a pandemic disease in the world so many people are died because of this disease, it's not coming in a particular structure. it's having a different type of structure . how to prevent this disease maintain social distance, maintain hand hygiene, wear masks .nowady vaccines are available covishield ,covaxin, Pfizer, sputnik vaccine etc...this mainly helpful to prevent the corona
covid-19 disease or novel corona virus disease or sars-cov 2 information includes all about virology,patho physiology, taxonomy of virus, taxonomy of intermediary host pangolin,and preventive measures needed to be followed by public etc, in a most possible concised manner illustrated in this presentation.
detailed information about COVID_19 and Corona Viruses how it would be transmitted and all the preventive measures
information about the vaccine of corona virus
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
1. Dr.Rajni Sharma
Mahamana Pandit Madan Mohan
Malviya Cancer Centre, Varanasi
Department of Atomic Energy, (Government of India)
2. What is COVID-19
The virus responsible for COVID-19, SARS-CoV-2, is in the species SARS-
like corona viruses.
At 125 nm, it is slightly larger than influenza, SARS and MERS viruses.
It is almost certainly a descendant from a bat corona virus of which
there are many.
The closest is a virus that originated from the Rhinolophus bat which is
> 96% homologous with the current SARS-CoV-2 virus. It is only 79%
homologous with the original SARS CoV .
3. EPIDEMIOLOGY
In December, 2019, Wuhan city, the capital of Hubei
province in China, became the centre of an outbreak
of pneumonia of unknown cause. By Jan 7, 2020,
Chinese scientists had isolated a novel coronavirus,
severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2; previously known as 2019-nCoV), from
these patients with virus-infected pneumonia,1 which
was later designated coronavirus disease 2019 (COVID-
19) in February, 2020, by WHO.
4. The novel Coronavirus outbreak called COVID-19 has
been declared a pandemic by World’s Health
Organization in 2020.
Global distribution of confirmed COVID-19 cases. (Map was reproduced from WHO Coronavirus
Disease (COVID-2019)
5. Global Trend
Global trend of confirmed COVID-19 cases and associated
deaths from January 23 through March 9, 2020. (Data were
obtained from WHO Coronavirus Disease (COVID-2019)
Situation Reports
6. Outbreak
The outbreak is likely to have started from
a zoonotic transmission event associated
with a large seafood market that also
traded in live wild animals.
It soon became clear that efficient
person-to-person transmission was also
occurring.
7. The Structure
Coronaviruses (CoVs) are
relatively large viruses
containing a single-stranded
positive-sense RNA genome
encapsulated within a
membrane envelope.
The viral membrane is studded
with glycoprotein spikes that
give coronaviruses their
crown-like appearance
8. Cryo-EM structure analysis has
revealed that the binding affinity of
SARS-CoV-2 S protein to ACE2 is about
10–20 times higher than that of SARS-
CoV S protein.
It is speculated that this may
contribute to the reported higher
transmissibility and contagiousness of
SARS-CoV-2 as compared to SARS-
CoV
9. Pathophysiology
The betacoronavirus genome encodes several structural
proteins, including the glycosylated spike (S) protein that
functions as a major inducer of host immune responses.
This S protein mediates host cell invasion binding to a
receptor protein called angiotensin-converting enzyme
2 (ACE2) located on the surface membrane of host cells.
Priming is facilitated by the host cell-produced serine
protease TMPRSS211
10. The viral genome also encodes several nonstructural proteins including RNA-dependent RNA
polymerase
Upon entrance to the host cells, the viral genome is released as a single-stranded positive
RNA.
Translated into viral polyproteins using host cell protein translation machinery, which are then
cleaved into effector proteins by viral proteinases 3CLpro and Plpro.
Results in Immune suppression
Synthesis of a full-length negative-strand RNA template to be used by RdRp to make more
viral genomic RNA.
The interaction between viral S protein and ACE2 initiate the infection process.
11.
12.
13. Classification
There are four classes of coronaviruses designated
alpha, beta, gamma, and delta.
The betacoronavirus class includes severe acute
respiratory syndrome (SARS) virus (SARS-CoV), Middle
East respiratory syndrome (MERS) virus (MERS-CoV), and
the COVID-19 causative agent SARS-CoV-2.
14. Host
While coronaviruses
infect both humans and
animals, certain types of
animals such as bats that
host the largest variety of
coronaviruses appear to
be immune to
coronavirus-induced
illness.
15. •Recent travel from or residence in an
area with ongoing community spread
of COVID-19 as determined
by CDC or WHO
•Close contact with someone who
has COVID-19 — such as when a family
member or health care worker takes care
of an infected person
RISK FACTORS
16. Causes
It's unclear exactly how contagious the new
coronavirus is.
It appears to spread from person to person
among those in close contact.
It may be spread by respiratory droplets
released when someone with the virus coughs or
sneezes.
It may also be spread if a person touches a
surface with the virus on it and then touches his
or her mouth, nose or eyes.
17. RISK FACTORS
The severity of the disease appears to be
associated with age, with the elderly most
at risk; those over 80 years of age had a
Case Fatality Rate (CFR) of 14.8%.
The CFR was also increased in those with
comorbidities including cardiovascular,
diabetes, chronic respiratory disease,
hypertension, and cancer.
The cause of death is respiratory failure,
shock or multiple organ failure.
18. Incubation period
Incubation period — The incubation period for COVID-19 is thought to be
within 14 days following exposure, with most cases occurring approximately
four to five days after exposure.
Spectrum of illness severity — The spectrum of symptomatic infection ranges
from mild to critical; most infections are not severe
19. Clinical Manifestations/
Clinical Presentation Asymptomatic infection
Mild upper respiratory tract illness, and severe viral
pneumonia
Respiratory failure
Death
Fever(Fever was defined as axillary temperature of at
least 37·3°C)
Dry cough
Dyspnoea
Fatigue
Nasal congestion
Sore throat
Diarrhoea
20.
21. Clinical Investigations
Throat-swab specimens
PCR
ROUTINE BLOOD INVESTIGATIONS LIKE
Complete blood count
Coagulation profile(Coagulopathy was defined as a 3-second extension of
prothrombin time or a 5-second extension of activated partial thromboplastin
time)
Serum biochemical tests (including renal and liver function, creatine kinase,
lactate dehydrogenase, and electrolytes)
myocardial enzymes
interleukin-6 (IL-6), serum ferritin
Procalcitonin
Hypoproteinaemia was defined as blood albumin of less than 25 g/L.
22. Chest CT in patients with COVID-19 most
commonly demonstrates ground-glass
opacification with or without consolidative
abnormalities, consistent with viral pneumonia.
25. WHO and CDC recommend following these precautions for
avoiding COVID-19:
•Avoid large events and mass gatherings.
•Avoid close contact (about 6 feet) with anyone who is sick or has symptoms.
•Keep distance between yourself and others if COVID-19 is spreading in your
community, especially if you have a higher risk of serious illness.
•Wash your hands often with soap and water for at least 20 seconds, or use an
alcohol-based hand sanitizer that contains at least 60% alcohol.
•Cover your mouth and nose with your elbow or a tissue when you cough or
sneeze. Throw away the used tissue.
•Avoid touching your eyes, nose and mouth if your hands aren't clean.
•Avoid sharing dishes, glasses, bedding and other household items if you're
sick.
•Clean and disinfect surfaces you often touch on a daily basis.
•Stay home from work, school and public areas if you're sick, unless you're
going to get medical care. Avoid taking public transportation if you're sick.
26. WHO also recommends that you:
•Avoid eating raw or undercooked meat or animal organs.
•Avoid contact with live animals and surfaces they may
have touched if you're visiting live market areas that have
recently had new coronavirus cases.
CDC doesn't recommend that healthy
people wear a face mask to protect themselves from
respiratory illnesses, including COVID-19. Only wear a
mask if a health care provider tells you to do so.
27. Medical Management
There is no proven treatment at this
early stage but we will doubtless
have more information about this
soon.
It can be assumed that non-
pharmacologic approaches are
effective such as fluid support,
oxygen and ventilatory support.
Extra Corporeal Membrane
Oxygenation (ECMO) is potentially of
benefit.
28. Vaccine and other therapeutics
Phase 1 trials for safety and immunogenicity in human populations
are likely within 3 months.
In terms of therapeutics there is no known effective pharmaceutical
agent.
Putative agents include antivirals; Griffithsin, a spike protein inhibitor,
nucleoside analogues eg. remdesivir, ribavirin and protease inhibitors
such as lopinavir/ritonavir.
Immunomodulatory and other host targeted agents include
interferon, chloroquine and immunoglobulins.
Corticosteroids will potentially have benefit for immune mediated
lung damage late in the course of disease
29. Favipiravir, a purine nucleoside leading to inaccurate viral
RNA synthesis, was originally developed by Toyama
Chemical of Japan, and has recently been approved for a
clinical trial as a drug to treat COVID-19.
Chloroquine, an antimalarial drug, has proven effective in
treating coronavirus in China.
RNA Therapies:
RNA interference (RNAi) is a biological process wherein small
complementary RNA duplexes target and neutralize specific
mRNA molecules, resulting in inhibition of gene expression or
genetic translation
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