The document provides information about COVID-19, including its etiology, clinical presentation, diagnosis, and treatment. It describes how COVID-19 was first identified in Wuhan, China in late 2019 and is caused by the SARS-CoV-2 virus. The main symptoms of COVID-19 are fever, cough, and shortness of breath. Diagnosis can be made through physical examination, CT scans, rapid diagnostic tests, and plasma tests. Treatment involves general supportive care, antiviral medications like remdesivir, and plasma therapy in severe cases. Prevention is through hand washing, social distancing, and disinfecting surfaces.
Innovative Solutions to Combat Spread & Management of Covid-19Sidharth Mehta
As we know, COVID-19 is spreading worldwide and its only treatment is just Prevention from it. However there is no specific Drug/Medicine till available for this disease. In this report I try to demonstrate some Innovative Solutions to Combat Spread & Management of Covid-19. Hope you guys like this report..Please Let me know some suggestions if you have in the comment section below. #STAYHOME #STAYSAFE
covid-19 disease or novel corona virus disease or sars-cov 2 information includes all about virology,patho physiology, taxonomy of virus, taxonomy of intermediary host pangolin,and preventive measures needed to be followed by public etc, in a most possible concised manner illustrated in this presentation.
Innovative Solutions to Combat Spread & Management of Covid-19Sidharth Mehta
As we know, COVID-19 is spreading worldwide and its only treatment is just Prevention from it. However there is no specific Drug/Medicine till available for this disease. In this report I try to demonstrate some Innovative Solutions to Combat Spread & Management of Covid-19. Hope you guys like this report..Please Let me know some suggestions if you have in the comment section below. #STAYHOME #STAYSAFE
covid-19 disease or novel corona virus disease or sars-cov 2 information includes all about virology,patho physiology, taxonomy of virus, taxonomy of intermediary host pangolin,and preventive measures needed to be followed by public etc, in a most possible concised manner illustrated in this presentation.
Covid 19- immunopathogenesis, clinical signs and treatment by Timothy AdegbileTimothy Adegbile
Covid 19- immunopathogenesis, clinical signs and treatment. What we know so far about covid-19 and medications. LNMU. A concise approach to learning about COVID-19.
the Pathophysiology of COVID-19 infection, it's main ways of transmission, Viral loading and shedding, symptoms in addition to it's occupational hazards and it's precautions.
Corona Virus and Reinfection(Second Time Infection)Apurv Charles
You may think that the one “positive” of testing positive for the COVID-19 causing coronavirus (SARS-CoV2) and surviving would be that you won’t get infected by that virus again.
At least not during this pandemic.
Ah, but is this assumption really true? Will you indeed be immune to the SARS-CoV2 after you’ve recovered from a COVID-19 infection?
Some reports out of Japan and China seem to suggest otherwise.
The February 14 article from Caixin, a Beijing, China-based media group, that was entitled “14% of Recovered Covid-19 Patients in Guangdong Tested Positive Again.” Umm, 14% would seem more like an “ooop” than an “ooops.”
"Remember though, these are news reports and not scientific studies yet. "
COVID-19
ALSO USEFUL FOR NEET, CET, JIPMER, AIIMS, OTHER MEDICAL ENTRANCES.
WATCH THE FULL VIDEO ON YOUTUBE:
https://youtu.be/1NQQvLH3xo0
SUBSCRIBE ON YOUTUBE !!
SUB-TOPICS INCLUDED ARE:
Introduction
Structure of SARS-CoV-2
Types of SARS-CoV-2
Transmission of SARS-CoV-2
Viability of the virus
Symptoms of COVID- 19
Diagnosis
Treatment
FOLLOW ON INSTAGRAM:
@stud_e_
https://www.instagram.com/stud_e_/
Corona virus was first identified as a cause of the common cold in 1960. Until 2002, the virus was considered a relatively simple, nonfatal virus.Over the last three decades there have been three attacks of three different coronaviruses, SARS-CoV, MERS CoV and the recent one 2019 novel coronavirus (2019-nCoV).
Covid 19- immunopathogenesis, clinical signs and treatment by Timothy AdegbileTimothy Adegbile
Covid 19- immunopathogenesis, clinical signs and treatment. What we know so far about covid-19 and medications. LNMU. A concise approach to learning about COVID-19.
the Pathophysiology of COVID-19 infection, it's main ways of transmission, Viral loading and shedding, symptoms in addition to it's occupational hazards and it's precautions.
Corona Virus and Reinfection(Second Time Infection)Apurv Charles
You may think that the one “positive” of testing positive for the COVID-19 causing coronavirus (SARS-CoV2) and surviving would be that you won’t get infected by that virus again.
At least not during this pandemic.
Ah, but is this assumption really true? Will you indeed be immune to the SARS-CoV2 after you’ve recovered from a COVID-19 infection?
Some reports out of Japan and China seem to suggest otherwise.
The February 14 article from Caixin, a Beijing, China-based media group, that was entitled “14% of Recovered Covid-19 Patients in Guangdong Tested Positive Again.” Umm, 14% would seem more like an “ooop” than an “ooops.”
"Remember though, these are news reports and not scientific studies yet. "
COVID-19
ALSO USEFUL FOR NEET, CET, JIPMER, AIIMS, OTHER MEDICAL ENTRANCES.
WATCH THE FULL VIDEO ON YOUTUBE:
https://youtu.be/1NQQvLH3xo0
SUBSCRIBE ON YOUTUBE !!
SUB-TOPICS INCLUDED ARE:
Introduction
Structure of SARS-CoV-2
Types of SARS-CoV-2
Transmission of SARS-CoV-2
Viability of the virus
Symptoms of COVID- 19
Diagnosis
Treatment
FOLLOW ON INSTAGRAM:
@stud_e_
https://www.instagram.com/stud_e_/
Corona virus was first identified as a cause of the common cold in 1960. Until 2002, the virus was considered a relatively simple, nonfatal virus.Over the last three decades there have been three attacks of three different coronaviruses, SARS-CoV, MERS CoV and the recent one 2019 novel coronavirus (2019-nCoV).
The whole world is under the threatens of respiratory disease caused by infections of coronavirus. The latest threat to global health is the ongoing outbreak of the respiratory disease that was recently given the name Coronavirus Disease This article trying to focus on the current outbreak of and explores the epidemiology, causes, clinical manifestation and diagnosis, and prevention and control of the novel coronavirus. The aim of this article to provide valid and reliable information and increasing awareness about the COVID 19. Sameer Pawar | Sayali Budhwant | Ketan Shinde | Ashwini Sable "COVID-19: A Scoping Review" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-3 , April 2020, URL: https://www.ijtsrd.com/papers/ijtsrd30567.pdf Paper Url :https://www.ijtsrd.com/pharmacy/other/30567/covid19-a-scoping-review/sameer-pawar
Corona viruses are a group of viruses that infect human & birds. Human corona virus is enveloped, single stranded, positive sense RNA virus. Only seven strain of corona virus are infect man, in which four are circulating in human population.
Novel corona virus 2019 (nCoV2019) is a newly identified human corona virus that has 94% similarity of SARS corona virus. The outbreak of this virus was reported to on 31 December, 2019. The WHO declared the outbreak as a public health emergence of international concern on 23 January. prevention is better than cure.
No vaccine is available.
There is no vaccine available to prevent this infection,
The novel coronavirus disease 2019 (covid 19)overviewMakrani Shaharukh
COVID-19 is a disease caused by a new strain of coronavirus. ‘CO’ stands for corona, ‘VI’ for virus, and ‘D’ for disease. Formerly, this disease was referred to as ‘2019 novel coronavirus’ or ‘2019-nCoV.’The COVID-19 virus is a new virus linked to the same family of viruses as Severe Acute Respiratory Syndrome and some types of common cold. The Coronavirus (COVID-19) was first reported in Wuhan, Hubei, China in December 2019, the outbreak was later recognized as a pandemic by the World Health Organization (WHO) on 11 March 2020. Standard recommendations to prevent infection spread include regular hand washing, covering mouth and nose when coughing and sneezing, Avoid close contact with anyone.
Coronaviruses are important human and animal pathogens. At the end of 2019, a novel coronavirus was identified as the cause of a cluster of pneumonia cases in Wuhan, in the Hubei Province of China. It is rapidly spreading, resulting in an epidemic throughout china, followed by an increasing number of cases in other countries throughout the world. In February 2020, the WHO designated the disease COVID 19, which stands for corona viruses 2019. The virus that causes COVID 19 is designated severe acute respiratory syndrome coronavirus 2 SARS COV 2 previously, it was referred to as 2019 nCoV. Anushka Bharti | Dr. Gaurav Kumar Sharma | Dr. Kaushal Kishore Chandul "COVID-19" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-6 , October 2021, URL: https://www.ijtsrd.com/papers/ijtsrd46439.pdf Paper URL : https://www.ijtsrd.com/pharmacy/pharmaceutics/46439/covid19/anushka-bharti
Corona viruses are a group of RNA viruses. In late December 2019, Patients with pneumonia with unknown etiology was get admitted in health care facilities in Wuhan, China, and resulted in a pandemic disease which affected more than 200 countries and responsible for 182,989 deaths world wide. The disease is officially named as Coronavirus Disease 2019 COVID 19, by WHO on February 11, 2020 . COVID 19 is a potential zoonotic disease with low to moderate estimated 2 -5 mortality rate. Currently, there is no definite treatment for COVID 19 although some trials are under investigation. Hence, appropriate use of PPE, regular hand hygiene, Respiratory and cough etiquettes, social distancing are some key elements to prevent the spread of disease. Ms. Pabalpreet Kaur | Ms. Eenu | Ms. Pooja Jaswal | Dr. (Mrs.) Jyoti Sarin "The Outbreak of COVID-19: An Overview" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-4 , June 2020, URL: https://www.ijtsrd.com/papers/ijtsrd30859.pdf Paper Url :https://www.ijtsrd.com/medicine/nursing/30859/the-outbreak-of-covid19-an-overview/ms-pabalpreet-kaur
Rekha Dehariya (M.Sc nursing 1st year) Bhopal Nursing College, Bhopal
Covid -19 has effected broud number of people all over the world. the health education is necessary to aware people about it.
Covid-19 is an infectious disease caused by SARS-CoV-2. mechsnism, pathogenesis and causes, transmission,symptoms and therapeutic strategies
Published by karuna raghuwanshi,M.pharma II semester (pharmaceutics),Pharmacy department.
Quinine for covid 19 a case presentation for low and middle income economiesBisi Bright
LiveWell Initiative LW, a self funded nonprofit social enterprise which thrives on innovation. (www.livewellng.org) has recommended the use of repurposed Quinine for Moderate to Severe COVID-19 by compiling three (3) sets of STUDY PROTOCOLS in response to the COVID-19 RESPONSE with a goal to arriving at a practical and affordable solution to the pandemic. The Protocols underwent debates and Hypothesis testing among Physicians, Researchers and Virologitsts. They are still undergoing random Physician – Patient Trials at the discretion of Prescribing Clinicians and Clinical Researchers, they are as recommended in a compilation of recent findings by LiveWell Initiative LWI on COVID-19. LiveWell Initiative LWI, a nonprofit organisation, takes no liability for damage from the use of the above suggested STUDY PROTOCOLS FOR COVID-19 RESPONSE. It is a Study Protocol designed to ‘evolve’ as a Solution to COVID-19 Response.
The Protocols strongly suggest the use of Quinine for COVID-19 Treatment in moderate to advanced disease, recommending intravenous infusion of Quinine for critical care in COVID-19. The sample size is small and further studies are recommended but the result is significant. The preliminary results were positive, and posted online even as the concurrent study continues.
In conclusion, Quinine is impactful with positive outcomes for severe or advanced COVID-19 especially after the Cytokine Storm, with 5-7 days total recovery after the onset of the cytokine storm.Due to small preliminary sample size with 100% positive outcome, a full study shoud be commissioned to establish and quantify the impact of Quinine on thousands in a population. This will help to prevent further morbidity in COVID-19 and the cytokine storm will be greatly overcome.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Are There Any Natural Remedies To Treat Syphilis.pdf
Clinical presentation of Covid 19
1. COVID-19
CLINICAL PRESENTATION OF COVID-19
PREPARED BY:
Ms. Shubhangi R. Vinchurkar.
M.Pharm, First year,
KYDSCT’s College of Pharmacy, Sakegaon,
Jalgaon.
2. Presentation by
2014-2018: B. Pharmacy
KVPS, Institute of Pharmaceutical Education, Boradi
(KVPSIPE), Dhule
2019: M.Pharm First yr.
KYDSCT”s College of Pharmacy, Sakegaon, Jalgaon.
Ms Shubhangi R. Vinchurkar
Ms. Shubhangi R. vinchurkar.
shubhangi27897@gmail.com
4. Etiology
As of February 7, 2020, 31,000 human infections with a novel coronavirus
(2019-nCoV) have been confirmed in China with at least 630 reported deaths
and reports continue to increase.
Additional cases have been confirmed in multiple countries including the
United state.
Public health officials and healthcare providers should consider 2019-nCoV
infection as a potential etiology among travelers returning from Wuhan City,
China who present with an acute fever and respiratory illness, particularly if
there was any close contact with a suspected or laboratory confirmed Covid-
19 sick patient.
5. Etiology
On 25 January 2020, the WHO confirmed that the virus was
spread via human‐to‐human transmission.
Some studies shows that it is transmitted through respiratory
droplets & vertical transmission is rare observed.
At the close day on 11th May 2020 the infected people worldwide
was 4,197,459 with the highest number of 1,367,963 patient in
America, 264,663 in Spain and then 219,070 in Italy. Whereas
highest number 80,787 of people died in America.
Taxonomy of Viruses has proposed SARS-CoV-2 as the name of
the virus that causes COVID-19.
6. Covid-19 cases
Median cases with lower mortality rate.
High cases with higher mortality rate.
China
92,918
Iran
1,07603
France
1,76,970
Brazil
1,66,99
UK
2,19,183
USA
13,67,963
India
67,259
Italy
2,19,070
Spain
2,64,633
7. COVID-19
In December 2019, the Centers for Disease Control and Prevention (CDC)
started monitoring the outbreak of a new coronavirus, SARS-CoV-2, which
causes the respiratory illness now recognized as COVID-19 (Corona Virus
Disease 2019).
The first person infected with Covid-19 first identified in Wuhan city of
China.
More than 74,000 people have infected with the virus in China.
8. COVID-19
Health authorities have identified many other people with COVID-19 around
the world, including many in the United States.
On January 31, 2020, the virus passed from one person to another in the
America.
On March 11, 2020 WHO declared Covid-19 as
a Pandemic.
9. INTRODUCTION
Though Covid-19 spread overall countries in the world, it was first detected
in Wuhan City, the capital of Hubei Province, with a population of 11 million.
The origin of the virus remains unknown, and the virus‐host is suspected to
be a species of bat.
COVID-19 disease, is seem to be the largest pandemic since the 1918 H1N1
influenza outbreak.
Similar to severe acute respiratory syndrome coronavirus (SARS-Cov) and
Middle East respiratory syndrome coronavirus (MERS-Cov) infections,
patients exhibited symptoms of viral pneumonia including fever and difficulty
breathing.
10. SARS-COV-2
Corona virus is a single stranded RNA virus belongs to the β Corona virus.
Corona virus belong to the subfamily Coronavirinae in the family Coronaviridae.
11. continued
Scientist identified seven type of Corona virus which are infected human
beings and four are most common:
𝜶 Corona virus (229E).
𝜶 Corona virus (Nl63).
β Corona virus (OC43).
β Corona virus (HKU1).
12. Structure & Genome sequence
• The morphology of coronavirus includes spherical or polymorphic.
• The genome of the coronavirus consists of 6 and 7 open reading frames
(ORFs).
• The ORF 1a and 1b encompass two-third of the viral genome which encodes
the non-structural poly-proteins and the other four ORFs on the
downstream side encode for the structural proteins such as
Envelope protein (E),
Spike protein (S),
Nucleocapsid protein (N), and
Membrane protein (M).
13. continued
• In some coronaviruses, the hemagglutininesterase (HE) gene is present in
the region between ORF 1b and S.
• These structural proteins are folded and entered into the endoplasmic
reticulum (ER) and transported to the Golgi transitional slot.
• During the replication of coronavirus, substantial amounts of structural
proteins are synthesized to assemble the progeny virions.
15. Origin
The first cases were linked to the Huanan
seafood market in Wuhan city of China.
It has been reported that environmental samples
obtained from the marketplace have come back
positive for the SARS-CoV-2, but the specific
animal has not been identified.
More recently, several studies have suggested
that bats could also be the potential natural host
of SARS-CoV-2
16. The SARS-CoV-2 can be
transmitted between humans via
respiratory droplets when an
infected person coughs or sneezes.
It may be possible that a person
can infected with SARS-Cov-2 by
touching a surface or object that
has the virus on it and then
touching their own mouth, nose or
possibly their eyes.
19. Pathogenesis
COVID-19
Binding of the SARS-CoV to the ACE-2 receptors in the
type II pneumocytes in the lungs triggers a cascade of
inflammation in the lower respiratory tract.
These spike and ACE-2 complex proteolytically processed
by adjacent type 2 transmembrane protease TMPRSS2
leading to cleavage of ACE-2 and activation of the spike
protein.
Viral entry and cell infection trigger the host’s immune
response, and the inflammatory cascade by the presence
of antigen, the immune system releasing interleukin 12 to
suppress antigen which are already targeted any cell.
20. Clinical Manifestation
PANDEMIC (COVID-19)
Cough Fever
Shortness
Of Breath
Sore
Throat
Thrombocyto
-penia
01%
Fever
67%
Cough
66%
Dyspnea
07%
Sore
throat
07%
Fatigue
07%
Myalgia
06
Viral pneumonia is an important cause of morbidity and
mortality among human being.
22. Physical Examination
Patients with mild symptoms may not present
positive signs of symptoms.
Patients in severe condition may have shortness of
breath, abnormal rattling sound in lungs, and
increased or decreased tactile speech tremor.
23. Computed Tomography
Computed Tomography (CT) is often found to be
positive when patients with SARS-CoV-2 develop a
persistent cough, fever, and unexplained fatigue.
Typical CT of COVID-19 patients shown bilateral
pulmonary parenchymal ground-glass opacity,
pulmonary consolidation, and nodules, bilateral
diffuse distribution, sometimes with a rounded
morphology, and a peripheral lung distribution.
24. Rapid Diagnostic Test
RDT is further classified in two types.
RDT based on antigen test
RDT based on antibody test
25. RDT based on antigen test
RDT is based on antigen detection test.
RDT detects the presence of viral proteins (antigens) expressed by
the COVID-19 virus in a sample from the respiratory tract of a
person.
Antigen(s) will bind to specific antibodies fixed to a paper strip
enclosed in a plastic casing and generate a visually detectable signal,
typically within 30 minutes.
The antigen(s) detected are expressed only when the virus is actively
replicating; therefore, such tests are best used to identify acute or
early infection
26. RDT based on antibody test
It is another type of rapid detection test based on antibodies
detection in blood of patient supposed to have been infected
with Covid-19.
For clinical diagnosis, however, such tests have limited utility
because they cannot quickly diagnose acute infection to inform
actions needed to determine the course of treatment.
27. Plasma test
02 03 04
01
80 µL plasma
sample was
added into 240
µL of Trizol LS
in the
Biosafety Level
3 laboratory.
Total RNA
was
extracted by
Direct-zol
RNA Miniprep
kit
& 50 µL
elution was
obtained for
sample.
RNA was used
for real-time
RT-PCR, which
targeted the
NP
(Nucleocapsid
protein) gene
using AgPath-
ID One-Step
RT-PCR
Reagent.
RNAaemia was
defined as a
positive result
for real-time
RT-PCR in the
plasma sample.
Real-time RT-PCR was performed using the following conditions: 50°C for 15 min and 95°C for
3 min, 50 cycles of amplification at 95°C for 10 s and 60°C for 45 s.
28. Prevention of infection
Hand washing with soap and water for at least 20 seconds. If soap
and water are not available, use an alcohol-based hand sanitizer.
Avoid touching eyes, nose, and mouth with unwashed hands.
Avoid close contact with people who are sick.
Seek medical attention if you believe you have been exposed and
have symptoms.
Adding sesame oil into the nostrils can prevent the spread of SARS-
CoV-2.
Cover a cough or sneeze with a tissue, then discard the tissue in a
contained trash.
Clean and disinfect frequently touched objects and surfaces.
2
m
30. General Treatment
General treatment includes bed rest and
supportive treatments, securing sufficient
energy intake, maintaining a constant internal
environment (water, electrolytes, and other
internal environment factors) and monitoring
vital signs (heart rate, pulse, blood pressure,
oxygen saturation, respiratory rate).
31. Antiviral treatment
Besides this, with antiviral and medication, the treatment mainly focused on pneumonia caused by Covid-19.
Interferon α
IFNα belonging to І interferon family
suppresses viral infection by directly
interfering with the replication of the
virus and by promoting both innate and
adaptive immune responses.
Lopinavir/Ritonavir
It’s a protease inhibitor & suggests
that they exert an antiviral effect
by inhibiting protein synthesis of
SARS-CoV-2
Ribavirin
It can prevent the replication of RNA
and DNA viruses by suppressing the
activity of inosine monophosphate
dehydrogenase. Ribavirin was widely
used to treat SARS patients.
Chloroquine
It is a widely used antimalarial drug.
Chloroquine phosphate has shown
distinct efficacy in the treatment
of COVID-19 with combination
therapy.
Arbidol
Is an antiviral drug widely used
against influenza infection. Arbidol
mesylate were shown to have a potent
inhibitory effect in reducing the
reproduction of SARS-CoV-2 in vitro.
Remedisivir
It’s a nucleoside analogue & reported
that, the first case of SARS-CoV2
infection in the USA was treated
with IV remdesivir.
32. In a certain study, it is observed that developed antibodies which
are present in already cured Covid-19 patient can utilize to treat
another Covid-19 patient.
The convalescent antibodies present in immune plasma moderate
their therapeutic effect through a variety of mechanisms.
They may bind to the virus and neutralizing their infectivity or may
phagocytic to virus to show therapeutic effect.
But plasma therapy is still objectionable.
Plasma therapy
33. PRACTICE POINTS FROM AN INDIAN PERSPECTIVE
Healthcare providers should take travel history of all patients with
respiratory symptoms, and any international travel within the past 2
weeks .
They & patients ought to use surgical masks themselves while examining
such patients and practice hand hygiene frequently.
Suspected cases should be brought up by government-designated
centers for isolation and testing.
Patients admitted with severe pneumonia and acute respiratory distress
syndrome should be evaluated for travel history and placed under
contact and droplet isolation.
34. Continued
They ought to be tested for etiology using multiplex PCR panels if
logistics permit and if no pathogen is identified, refer the samples
for testing for SARS-CoV-2.
Non-essential international travel should be avoided at this time.
People should stop spreading myths and false information about
the disease and check out to allay the panic and anxiety of the
general public