2. Monsanto Confidential
The World Produces 133 MMT of Vegetable Oils
83% is Consumed for Food
China
India
EU
USA
Indonesia
Brazil
Russia
Japan
Mexico
Turkey
Iran
Malaysia
Argentina
Canada
Thailand
Ukraine
Australia
Philippin…
0
2
4
6
8
10
12
14
16
18
20
2009 Global Vegetable Oil
Consumption in Food
Was 110 MMT
Palm
47 MMT
35%
Soybean
40 MMT
30%
Rapeseed
19 MMT
14%
Sunflower,
11
Coconut, 3
Cotton, 5
Peanut, 5Corn, 2
2009 Global Vegetable Oil
Production
2
3. Improving Soybean Oil Composition Provides
Opportunity to Positively Impact US Diets
• Soybean oil is a major component
of US dietary oils & fats
• For fried foods, baked goods, and
snack products, soybean oil is
hydrogenated to increase shelf life
and flavor stability
• Partial hydrogenation process
creates trans fats
U.S. Edible Oil Consumption
(27 Billion lbs)
Soybean
(65%)
(16.6 B Lbs)
Coconut
Corn
Cottonseed
Lard
Olive
Palm
Palm Kernel
Peanut
Canola
Safflower
Sunflower
Tallow, edible
2008 Soya & Oilseed Bluebook
4. Monsanto Confidential
Mono-
Unsaturated
(Oleic)
Saturated
Fatty Acid
(Palmitic)
Nutritional Recommendations and Actual Intake
0
2
4
6
8
10
12
14
16
Dietary Recommendations
Actual Consumption
Poly-
Unsaturated
(Omega 3/6)
Trans Fat
Hydrogenation
(Linolenic)
(% of energy)
We consume
too little
We consume
too much
Low as
possible
Vegetable Oil Consumption Impacts Nutrition
4
5. Technology Platforms Enable Innovation
from Gene to Seed to Food
Genomics
Food & Nutrition
Crop Analytics
Molecular Breeding
Conventional Breeding
Biotechnology
BREEDING
BIOTECHNOLOGY
Crop
Germplasm
Improved
Seeds
Two R&D pathways linked by shared tools
5Monsanto Confidential5
6. Vistive® Gold Soybean Oil
High Stability, Low Saturated Fat, Zero Trans Fat
Over 12 years development with Processors, Food Co’s and Nutrition Community
OUTPUT TRAIT PRODUCT CONCEPT:
• Consumer health (reduce trans fat & saturated fat)
• Food product performance (increase oxidative stability)
• Sustainable local source (renewable feedstock - food & industrial))
Soybean Oil - Fatty Acid Composition (%)
16:0
Palmitic
18:0
Stearic
18:1
Oleic
18:2
Linoleic
18:3
Linolenic
Commodity Soybean Oil 11 4 20 55 8
Vistive Gold Soybean Oil* 3 3 74 15 < 3.5
Reduce Saturates
(Total 60%, Palm 73%)
Zero TransIncrease StabilityBenefits
Discovery Phase 1
Proof of Concept
Phase 2
Early Development
Phase 3
Adv. Development
Phase 4
Pre-Launch
Launch
Monsanto Company Confidential 6
NEW 2010 Dietary
Guidelines: Reduce
saturated fat from
10% en to 7% en
6
* Target fatty acid composition; final product specification range is contingent upon variety development and environment
6
8. Vistive Gold Technology in the Seed
Lowers Saturated Fat in a Soybean Acre
Each acre of
Vistive Gold
Soybeans
reduces:
•Saturated Fat 60%
•Palmitic Acid 75%
0
10
20
30
40
50
60
70
80
Commodity Soy
15% Sat Fat
Palmitic
Palmitic
Stearic
Stearic
LbsofSaturatedFat/Acre
Vistive Gold Soy
6% Sat Fat
Average annual U.S. per capita consumption of soybean oil is 54 lbs; Average U.S. lifespan is 77.7 years
Monsanto Confidential
Over a persons lifetime Vistive Gold could reduce saturated fat intake 377 LBS
8
9. Vistive Gold Technology in the Seed
Increases Soybean Oil Fry Life 77%
Commodity
Soybean Acre
0
10
20
30
40
50
60
70
80
90
100
51 Hrs
Commodity
Oil
Fry Life
90 Hrs
Vistive
Gold
Oil
Fry Life
HrsofFryLifeinFoodApplication
Vistive Gold
Soybean Acre
Monsanto Confidential
French Fries and Fried Chicken
9
10. Nutrition Facts
Serving Size 114 g
Amount Per Serving
Calories 384 Calories from Fat 183
% daily Value*
Total Fat 20g 31%
Saturated Fat 2.5g
Trans Fat 0g
Nutrition Facts
Serving Size 114 g
Amount Per Serving
Calories 384 Calories from Fat 183
% daily Value*
Total Fat 20g 31%
Saturated Fat 4g
Trans Fat 1g
French Fry in Partial
Hydrogenated Oil
Vistive Gold Delivers Consumer Nutrition Benefit
• Vistive oil reduced saturated fat 43%
and trans fat 98% in french fries
• Vistive oil enables Zero Trans Fat on
nutrition facts label
• Food Co’s striving for “Clean Label’s”
(no trans-fat, no PHSBO, low saturated fat)
10 10
French
Fry
Study
French Fry in
Vistive Gold Oil
0
5
10
15
20
25
30
35
40
Vistive GoldHydrogenated
Source: 2009, Merlin Development and Monsanto
Sat
Fat
23.4%
Trans
Fat
15.7%
Trans
0.3%
Sat
13.2%
Percent
% Trans & Saturated Fat in French Fries
39.1%
13.5%
Monsanto Confidential
11. Soybean Oil - Fatty Acid Composition (%)
16:0
Palmitic
18:0
Stearic
18:1
Oleic
18:2
Linoleic
18:3
Linolenic
18:4ω3
Stearidonic
Commodity Soy 11 4 24 52 8 0
SDA Omega 3 Soy* 11 4 20 24 10 20
Soymega Soybean Oil for Food
(SDA Omega-3 Enriched Soybeans)
Over 12 years development with Processors, Food Co’s and Nutrition Community
OUTPUT TRAIT PRODUCT CONCEPT:
• Consumer nutrition benefit (bioactive omega 3 – heart health)
• Improve food product performance (taste and shelf life)
• Sustainable source of omega 3 in food (renewable supply – non marine)
Increase Omega-3
Discovery Phase 1
Proof of Concept
Phase 2
Early Development
Phase 3
Adv. Development
Phase 4
Pre-Launch
Launch
Monsanto Company Confidential
TM
11
* Target fatty acid composition; final product specification range is contingent upon variety development and environment
12. SDA-Omega 3 Soybean Oil a Better Solution
Dietary EPA has been demonstrated in clinical trials to benefit heart health*
* Yokoyama et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised openlabel, blinded endpoint analysis. Lancet 2007; 369: 1090–98
Algae
Produce
EPA
Marine Route to Omega 3
in Human Diet is via Algae and Fish Oil
20:5
EPA
Omega 3
18:1
Oleic
Mono
18:2
Linoleic
Omega 6
18:3
ALA
Omega 3
18:4
SDA
Omega 3
20:5
EPA
Omega 3
20:5
EPA
Omega 3
Fish consume
algae and deposit
EPA
Humans consume
fish and deposit
EPA
Rate limiting step is ALA conversion
to SDA in fish and mammals
18:1
Oleic
Mono
18:2
Linoleic
Omega 6
18:3
ALA
Omega 3
18:4
SDA
Omega 3
+ Delta-15
desaturase
+ Delta-6
desaturase
Soybeans
Produce
SDA
Biotech Route to Omega 3
in Human Diet is via Soybean Oil
(overcomes rate limiting step)
20:5
SDA
Omega 3
A wide variety of
foods made with
SDA soy oil
20:5
EPA
Omega 3
Humans consume good
tasting SDA foods and
produce their own EPA
12 Monsanto Confidential
13. Monsanto Confidential
SDA Omega-3 Soybean Oil Clinical Study
Confirms Heart Health Benefit
0
0.2
0.4
0.6
0.8
1
1.2
1.4
%EPAINREDBLOODCELLS
Control
12Weeks
Control
12Weeks
Control
12Weeks
Conventional
Soy Oil Diet
EPA Oil
Control Diet
SDA Soy
Oil Diet
*
*
*Per protocol population of 157 subjects; p<0.001 compared to soy oil control; SDA and EPA not different p=0.101
Presented at:
American Heart
Association
Scientific Sessions
Nov. 14, 2009 by
Dr. William Harris
•SDA is GRAS (Generally
Recognized As Safe)
•SDA diet more than
doubles heart healthy EPA
levels compared to
commodity soy
•In addition, SDA diet
exhibited a significant
reduction in triglycerides
• 26-30% reduction versus
control subjects with high
baseline triglycerides
CLINICAL STUDY RESULTS DEMONSTRATE SDA
CONVERSION TO HEART HEALTHY EPA
13
Mean (+ SEM) for per protocol population of 157 subjects
•p<0.001 compared to soy oil control; delta for SDA and EPA not different p=0.101; ANCOVA
13
14. Soymega SDA is Compatible with Food Systems
14 Monsanto Confidential
Soymega flavor profile outperforms
alternative sources of Omega-3
3.5 3.5
4.0
5.0 5.0
7.5
Control
Soy
SDA
Soy
Flax Algal Fish Encapsulated
Fish
0-15 Scale =National Food Laboratory. Nut and Berry Granola
Bar Sensory Results. July 2008.
Low Score
= Better
Taste!
Granola Bar Shelf Life Results
Baking
Breads
Muffins
Cookies/Crackers
Pastries/Cakes
Baked Cereal Bars
Snack Foods
Granola/Cereal Bars
Nutritional Bars
Snacks
Confectionery
Prepared Foods
Processed Meats
Processed Fish
Entrees/Sides
Soups/Sauces
Pet Foods
Beverages
Soy Milk/Smoothies
Fruit Juices/Drinks
Vegetable Juices/Drinks
Enhanced Waters
Dairy Products
Dairy Drinks
Yogurt/Yogurt Drinks
Cheese Products
Sour Cream/Dips
Ice Cream/Frozen Desserts
Non Dairy Creamers
Oil Based Foods
Margarine/Spreads
Shortenings
Mayonnaise
Salad Dressings
Peanut Butter
Broad Range of Food Applications
Excellent Stability and Clean Neutral Flavor
15. * Each salmon icon
represents 100
servings of fish
Omega-3 Soybeans a Path to Sustainable Supply
Just one acre of Omega-3
SDA- enriched soybeans is equal to
~10,000, 3 oz. servings of salmon
Monsanto Company Confidential 151515
16. Monsanto Confidential
Summary: Improving Human Nutrition
with Biotechnology-Derived Soybean Traits
2010 Dietary Guidelines Recommendations
• Avoid industrial trans fat
• Substitute with MUFA and PUFA
• Reduce saturated fat in diet
• Reduce to less than 7% en.
• Substitute with MUFA and PUFA
• Consume LC sources of Omega-3
• Two 4 oz. servings of fatty fish/week
• Average of 250mg LC PUFA/week
16 16
Soymega™
SDA Omega-3
Soybean Oil
Vistive® Gold
Low Saturate
High Oleic
Low Linolenic
Soybean Oil
