Tang nutrition vit a

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Tang nutrition vit a

  1. 1. Using Bio-fortified Crops for Community Intervention Studies Guangwen Tang, Ph.D. Carotenoids and Health Laboratory Jean Mayer USDA Human Nutrition Research Center on Aging Friedman School of Nutrition Science and Policy Tufts University
  2. 2. To combat vitamin A deficiency: • vitamin A capsule supplementation • food fortification • dietary approach (the best and major long-term solution) Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
  3. 3. Food Sources of Vitamin A animal products plant products preformed vitamin A pro-vitamin A carotenoids
  4. 4. CH2OH + ß-carotene retinol in SERUM ß-carotene Provitamin A Carotenoids Can Convert to Vitamin A Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
  5. 5. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University Food matrix Dose Conversion Factor (by wt) Reference carrot n = 7 10 mg b-C 3 mg 2H8 vitamin A 15 : 1 (8 to 25 : 1) Tang, et al. AJCN 2005 spinach n = 14 11 mg b-C 3 mg 2H8vitamin A 21 : 1 (11 to 47 : 1) Tang, et al. AJCN 2005 Conversion Factors of Plant b-Carotene to Retinol Using Isotope Reference Method in Adult Subjects
  6. 6. 21 to 12,500 mg b-carotene 100 mg50 g 50 g 85 mg retinol 50 g 3,000 mg b-carotene 200 mg 15 to 1 200 ml 90 mg retinol 15 g 130 mg retinol 300 mg retinol 305 mg retinolor 30 g RDA: men 900 mg and women 700 mg retinol Children 4 – 8y, 400 mg
  7. 7. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University Subjects Dose Conversion Factor (by wt) Reference Golden Rice 5 Adults 1 – 1.5 mg b-C 0.5 – 1 mg 13C10 vitamin A 3.8 : 1 (2 to 6 : 1) Tang, et al. AJCN 2009 Golden Rice 24 Children 1 mg b-C 0.5 mg 13C10 vitamin A 2.0 : 1 Tang, et al. FASEB J. 2010 Yellow Maize US Women n = 5 0.6 mg maize b-C 250 g porridge 6.5 : 1 ( 3.9 to 13.3 : 1) Li, et al. AJCN 2010 Zimbabwean Men, n = 8 1.2 mg maize b-C 300 g porridge 1 mg 13C8vitamin A (reference dose) 3.2 : 1 (1.5 to 5.3 : 1) Muzhingi et al FASEB J. 2010 Conversion Factors of an Acute Dose of Golden Rice or Maize b-Carotene to Retinol
  8. 8. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University These results indicate that Golden Rice and high b- carotene yellow maize are more bioavailable to provide vitamin A nutrition.
  9. 9. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University Based on the Progress in Nutrition: How do we maximize impact and speed up delivery? Win community support !!! Conduct community studies to feed these staples daily to needed children. It will provide direct evidences on improving vitamin A status with the biofortified staples.
  10. 10. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University Choose right locations Inform and communicate with local government agency School and parent supports Good intervention study practice Large scale intervention trials to evaluate the efficacy
  11. 11. Hengyang, South of Hunan Province
  12. 12. South-west Zhejiang Province
  13. 13. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University A Small Town of Xianju County
  14. 14. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University Recruitment meeting: Local Office, Parent, Teacher, and Scientists
  15. 15. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University Meeting with Parents
  16. 16. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University Presenting the Protocol
  17. 17. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University Asking Questions
  18. 18. Sterilizer Cabinet for Utensils
  19. 19. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University Purchase Foods from Reliable Sources
  20. 20. Distributing Labeled VA Capsules as a Reference Dose Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
  21. 21. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University Providing Healthy Meals
  22. 22. Get Ready for Blood Draw
  23. 23. Before the End of Study Meeting
  24. 24. Gifts for Participation
  25. 25. Putting Gifts Together
  26. 26. Sign to Receive Gifts for Participation
  27. 27. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University Large scale community efficacy intervention trials will bring the new crops to their daily life, gain first-hand health impact information, and promote the acceptance.

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