Talk to OpenForum Academy (Open Forum Europe) about Text and data Mining. Four use cases selected fo non-scientists. Also discussion of latest on Europena copyright reform and TDM exceptions
Automatic Extraction of Knowledge from the LiteratureTheContentMine
Published on May 11, 2016 by PMR
ContentMine tools (and the Harvest alliance) can be used to search the literature for knowledge, especially in biomedicine. All tools are Open and shortly we shall be indexing the complete daily scholarly literature
Published on Jan 29, 2016 by PMR
Keynote talk to LEARN (LERU/H2020 project) for research data management. Emphasizes that problems are cultural not technical. Promotes modern approaches such as Git / continuous Integration, announces DAT. Asserts that the Right to Read in the Right to Mine. Calls for widespread development of content mining (TDM)
Talk to OpenForum Academy (Open Forum Europe) about Text and data Mining. Four use cases selected fo non-scientists. Also discussion of latest on Europena copyright reform and TDM exceptions
Automatic Extraction of Knowledge from the LiteratureTheContentMine
Published on May 11, 2016 by PMR
ContentMine tools (and the Harvest alliance) can be used to search the literature for knowledge, especially in biomedicine. All tools are Open and shortly we shall be indexing the complete daily scholarly literature
Published on Jan 29, 2016 by PMR
Keynote talk to LEARN (LERU/H2020 project) for research data management. Emphasizes that problems are cultural not technical. Promotes modern approaches such as Git / continuous Integration, announces DAT. Asserts that the Right to Read in the Right to Mine. Calls for widespread development of content mining (TDM)
Automatic Extraction of Knowledge from Biomedical literaturepetermurrayrust
a plenary lecture to Cochrane Collaboration in Birmingham, on the value of automatically extracting knowledge. Covers the Why? How? What? Who? and problems and invites collaboration
Published on May 18, 2016 by PMR
Talk to EBI Industry group on Open Software for chemical and pharmaceutical sciences. Covers examples of chemistry , wit demos, and argues that all public knowledge should be Openly accessible
Liberating facts from the scientific literature - Jisc Digifest 2016 TheContentMine
Published on Mar 4, 2016 by PMR
Text and data mining (TDM) techniques can be applied to a wide range of materials, from published research papers, books and theses, to cultural heritage materials, digitised collections, administrative and management reports and documentation, etc. Use cases include academic research, resource discovery and business intelligence.
This workshop will show the value and benefits of TDM techniques and demonstrate how ContentMine aims to liberate 100,000,000 facts from the scientific literature, and ContentMine will provide a hands on demo on a topical and accessible scientific/medical subject.
Automatic Extraction of Knowledge from the Literaturepetermurrayrust
ContentMine tools (and the Harvest alliance) can be used to search the literature for knowledge, especially in biomedicine. All tools are Open and shortly we shall be indexing the complete daily scholarly literature
Amanuens.is HUmans and machines annotating scholarly literature TheContentMine
Published on May 19, 2016 by PMR
about 10,000 scholarly articles ("papers") are published each day. Amanuens.is is a symbiont of ContentMine and Hypothes.is (both Shuttleworth projects/Fellows) which annotates theses using an array of controlled vocabularies ("dictionaries"). The results, in semantic form are used to annotate the original material. The talk had live demos and used plant chemistry as the examples
Open Data and Open Science presented in Rio for Open Science 2014-08-22. I argue that Open Notebook Science is the way forward and will lead to great benefits
Amanuens.is HUmans and machines annotating scholarly literaturepetermurrayrust
about 10,000 scholarly articles ("papers") are published each day. Amanuens.is is a symbiont of ContentMine and Hypothes.is (both Shuttleworth projects/Fellows) which annotates theses using an array of controlled vocabularies ("dictionaries"). The results, in semantic form are used to annotate the original material. The talk had live demos and used plant chemistry as the examples
contentmine.org (funded by Shuttleworth Foundation) has developed tools and workshops to allow anyone to mine scientific content. This 10-minute presentation at Wellcome Trust encourages you to become involved - no previous knowledge required.
Talk to EBI Industry group on Open Software for chemical and pharmaceutical sciences. Covers examples of chemistry , wit demos, and argues that all public knowledge should be Openly accessible
An overview of ContentMining for JISC (the infrastructure provider of UK academia). Examples, details leading to hands-on exercise (http://contentmine.org/workflow
Use of ContentMine tools on the Open Access subset of EuropePubMedCentral to discover new knowledge about the Zika virus.
Three slides have embedded movies - these do not show in slideshare and a first pass of this can be seen as a single file at https://vimeo.com/154705161
High throughput mining of the scholarly literature TheContentMine
Published on Jun 7, 2016 by PMR
Talk given to statisticians in Tilburg, with emphasis on scholarly comms for detecting unusual features. Includes demo of Amanuens.is and image mining
Specimen-level mining: bringing knowledge back 'home' to the Natural History ...Ross Mounce
A talk given at the Geological Society of London, UK on 2016/03/09 as part of the Lyell meeting on Palaeoinformatics. http://www.geolsoc.org.uk/lyell16 #lyell16
Mining the scientific literature for plants and chemistrypetermurrayrust
ContentMine can read the daily scientific literature and extract facts. This talk was given to the OpenPlant project - with whom ContentMine collaborate at a meeting on 2016-07-25/27 in Norwich. Examples of extracted facts are given.
Keynote talk to LEARN (LERU/H2020 project) for research data management. Emphasizes that problems are cultural not technical. Promotes modern approaches such as Git / continuousIntegration, announces DAT. Asserts that the Right to Read in the Right to Mine. Calls for widespread development of contentmining (TDM)
Automatic Extraction of Knowledge from Biomedical literaturepetermurrayrust
a plenary lecture to Cochrane Collaboration in Birmingham, on the value of automatically extracting knowledge. Covers the Why? How? What? Who? and problems and invites collaboration
Published on May 18, 2016 by PMR
Talk to EBI Industry group on Open Software for chemical and pharmaceutical sciences. Covers examples of chemistry , wit demos, and argues that all public knowledge should be Openly accessible
Liberating facts from the scientific literature - Jisc Digifest 2016 TheContentMine
Published on Mar 4, 2016 by PMR
Text and data mining (TDM) techniques can be applied to a wide range of materials, from published research papers, books and theses, to cultural heritage materials, digitised collections, administrative and management reports and documentation, etc. Use cases include academic research, resource discovery and business intelligence.
This workshop will show the value and benefits of TDM techniques and demonstrate how ContentMine aims to liberate 100,000,000 facts from the scientific literature, and ContentMine will provide a hands on demo on a topical and accessible scientific/medical subject.
Automatic Extraction of Knowledge from the Literaturepetermurrayrust
ContentMine tools (and the Harvest alliance) can be used to search the literature for knowledge, especially in biomedicine. All tools are Open and shortly we shall be indexing the complete daily scholarly literature
Amanuens.is HUmans and machines annotating scholarly literature TheContentMine
Published on May 19, 2016 by PMR
about 10,000 scholarly articles ("papers") are published each day. Amanuens.is is a symbiont of ContentMine and Hypothes.is (both Shuttleworth projects/Fellows) which annotates theses using an array of controlled vocabularies ("dictionaries"). The results, in semantic form are used to annotate the original material. The talk had live demos and used plant chemistry as the examples
Open Data and Open Science presented in Rio for Open Science 2014-08-22. I argue that Open Notebook Science is the way forward and will lead to great benefits
Amanuens.is HUmans and machines annotating scholarly literaturepetermurrayrust
about 10,000 scholarly articles ("papers") are published each day. Amanuens.is is a symbiont of ContentMine and Hypothes.is (both Shuttleworth projects/Fellows) which annotates theses using an array of controlled vocabularies ("dictionaries"). The results, in semantic form are used to annotate the original material. The talk had live demos and used plant chemistry as the examples
contentmine.org (funded by Shuttleworth Foundation) has developed tools and workshops to allow anyone to mine scientific content. This 10-minute presentation at Wellcome Trust encourages you to become involved - no previous knowledge required.
Talk to EBI Industry group on Open Software for chemical and pharmaceutical sciences. Covers examples of chemistry , wit demos, and argues that all public knowledge should be Openly accessible
An overview of ContentMining for JISC (the infrastructure provider of UK academia). Examples, details leading to hands-on exercise (http://contentmine.org/workflow
Use of ContentMine tools on the Open Access subset of EuropePubMedCentral to discover new knowledge about the Zika virus.
Three slides have embedded movies - these do not show in slideshare and a first pass of this can be seen as a single file at https://vimeo.com/154705161
High throughput mining of the scholarly literature TheContentMine
Published on Jun 7, 2016 by PMR
Talk given to statisticians in Tilburg, with emphasis on scholarly comms for detecting unusual features. Includes demo of Amanuens.is and image mining
Specimen-level mining: bringing knowledge back 'home' to the Natural History ...Ross Mounce
A talk given at the Geological Society of London, UK on 2016/03/09 as part of the Lyell meeting on Palaeoinformatics. http://www.geolsoc.org.uk/lyell16 #lyell16
Mining the scientific literature for plants and chemistrypetermurrayrust
ContentMine can read the daily scientific literature and extract facts. This talk was given to the OpenPlant project - with whom ContentMine collaborate at a meeting on 2016-07-25/27 in Norwich. Examples of extracted facts are given.
Keynote talk to LEARN (LERU/H2020 project) for research data management. Emphasizes that problems are cultural not technical. Promotes modern approaches such as Git / continuousIntegration, announces DAT. Asserts that the Right to Read in the Right to Mine. Calls for widespread development of contentmining (TDM)
A Global Commons for Scientific Data: Molecules and Wikidatapetermurrayrust
Methods for extracting facts from the scientific literature, and linking them to Wikidata IDs. Wikidata is introduced by an architectural example and bioscience. Then we explore how data can be extracted from text and from images
High throughput mining of the scholarly literature; talk at NIHpetermurrayrust
The scientific and medical literature contains huge amounts of valuable unused information. This talk shows how to discover it, extract, re-use and interpret it. Wikidata is presented as a key new tool and infrastructure. Everyone can become involved. However some of the barriers to use are sociopolitical and these are identified and discussed.
High throughput mining of the plant-science literaturepetermurrayrust
We can now mine the plant science literature for facts, especially species (both plants and others), chemicals, diseases and other agricultural terms. This presentation gives a number of examples and links on how you can do this on the Open Access literature
PhD Theses are normally locked away digitally. They cost 20 billion dollars to create and we waste much of this value. By making them open we can use software to read, index, reuse, compute and add massive value
Copyright is one of the greatest barrier to Open Data. This presentation for insidegovernment UK shows the struggle between those who want to reform copyright and those opposed to reform
ContentMining for France and Europe; Lessons from 2 years in UKpetermurrayrust
I have spend 2 years carrying out Content Mining (aka Text and Data Mining) in the UK under the 2014 "Hargreaves" exception. This talk was given in Paris, to ADBU , after France had passed the law of the numeric Republique. I illustrate what worked in what did not and why and offer ideas to France and Europe
Basics of ContentMining presented to Synthetic Biologists. This was followed by a lively discussion of what components could be extracted from the literature
Published on May 18, 2015 by PMR
Basics of ContentMining presented to Synthetic Biologists. This was followed by a lively discussion of what components could be extracted from the literature
The Culture of Research Data, by Peter Murray-RustLEARN Project
1st LEARN Workshop. Embedding Research Data as part of the research cycle. 29 Jan 2016. Presentation by Peter Murray-Rust, ContentMine.org and University of Cambridge
Published on Aug 22, 2014 by PMR
Open Data and Open Science presented in Rio for Open Science 2014-08-22. I argue that Open Notebook Science is the way forward and will lead to great benefits
ContentMine: Open Data and Social MachinesTheContentMine
Published on Nov 13, 2014 by PMR
Scientific information is often hidden or not published properly. The ContentMine is a Social Machine consisting of semantic software and communities of domain expertise; it aims to liberate all scientific facts from the published literature on a daily basis.
The talk , delivered to the Computational Institute, will be /was followed by a hands-on workshop learning how to use the technology and work as a community.
Paradise Lost and The Right to Read is the Right to Minepetermurrayrust
Presented to UIUC CIRSS seminars to a mixed group of Library, CS, domain scientists with a great contingent of Early Career Researchers. Starts by honouring the creation of the wonderful NCSA Mosaic at UIUC in 1993 and the paradise of knowledge and community it opened. Then shows the gradual and tragic decline of the web into a megacorporate neocolonialist empire, where knowledge is sacrificed for money and power.
You have seen many of the slides before but the words are different and have been recorded.
Automatic Extraction of Science and Medicine from the scholarly literatureTheContentMine
Published on Jun 04, 2015 by PMR
Many scientists have to extract many facts out the scholarly literature - to evaluate other work or to extract useful collections of facts. This shows the approach, especially for systematic reviews of animal or clinical trials
Automatic Extraction of Science and Medicine from the scholarly literaturepetermurrayrust
Many scientists have to extract many facts out the scholarly literature - to evaluate other work or to extract useful collections of facts. This shows the approach, especially for systematic reviews of animal or clinical trials
The scientific scholarly literature now contains many millions of articles. The contain semi-structured information of high quality and veracity. We show how this resource can be converted to a universal Wikicite format and full-text indexed against Wikidata dictionaries. We now have > 5 million bibliographic records and over 200 dictionaries based in Wikidata properties and queriable by SPARQL.
A presentation by Open Climate Knowledge for European Forum for Advanced Practices. Showing how the scientific literature can be searched for knowledge on this multidisciplinary topic.
The Evolution of e-Research: Machines, Methods and MusicDavid De Roure
David De Roure's Inaugural Lecture on 28th October at Oxford e-Research Centre, University of Oxford, UK
10 years ago we saw a few early adopters of e-Science technology; now we see acceleration of research through broader adoption and sharing of tools, techniques and artefacts, both for 'big science' and the 'long tail scientist'.
Will this incremental trend continue or are we seeing glimpses of a phase change ahead, where researchers harness these emerging digital capabilities to address research questions in ways that simply were not possible before?
This talk will describe three generations of e-Research, using the myExperiment social website as a lens to glimpse future research practice, and focusing on a web-scale computational musicology project as an illustration of 3rd generation thinking.
Also available from http://wiki.myexperiment.org/index.php/Presentations
The scientific and medical literature is a vast resource of knowledge, but it needs turning into semantic FAIR form. The ContentMine can do this and we presented a rapid overview of the potential
Can machines understand the scientific literature?petermurrayrust
A presentation to Cambridge MPhil Computational Biology. 2020-11-11 . Presenters Peter Murray-Rust, Shweata Hegde and Ambreen Hamadani from https://github.com/petermr/openvirus .
This chunk is PMR with a large break in the middle for SH and AH talks.
I cover Global Challenges, knowledge equity, semantics of scientific articles, Wikidata, Data Extraction from images, and ethics/politics.
Answer: Yes, technically. No, politically as the Publisher-Academic Complex will block it.
Semantic content created from Open Access papers to help in the fight against viral epidemics. Includes contributions from NIPGR interns, 5 supported by Indian National Young Academy of Scientists.
Overview of openVirus project. Interns in India have worked for 2 months to extract scientific knowledge from the literature about viral epidemics. Covers data science, machine learning and virtual collaboration
Automatic mining of data from materials science literaturepetermurrayrust
The literature on materials science (batteries, etc.) contains huge amounts of scientific facts, but not in easily accessible form. our AMI program has been developed to automatically:
scrape , clean, annotate and display/publish
data for re-use in science.
Examples will be given from electrochemistry, magnetism and other fields . The general principles and (open) tech are applicable to many other disciplines.
XML for science; its huge potential; but are pubiishers preventing it?petermurrayrust
XML can represent almost all well derfined scientific objects. chemistry, plants medcine. But it's not yet widely used. Is this because publishers oppose thr re-use of science?
Early Career Reseachers in Science. Start Early, Be Open , Be Bravepetermurrayrust
Highlights the importance of supporting Early Career Researchers to pursue their own ideas, possibly alongside their main research. Illustrated with biology but applies to all fields of science. This was a 14 min presentation and shows narratives of how ECRs develop and reinforce each other.
Presentation given at NUI, Galway 2019-04-11 for Open Science Week.
An overview of Early Career Researchers, their innovation and contribution towards Open Infrastructure
The ContentMine system (Open Source) can search EuropePMC and download hundreds of articles in seconds. These can be indexed by AMI dictionaries allowing a rapid evaluations and refinement of the search
A 10-minute talk to lovers of early science (e.g. 1600-1900) at the Royal Society. Archivists , computer vision, scientific historical metadata all relevant.
I chose 4 examples of monochrome diagrams that I can extract something from automatically. Some of the methids would scale to larger volumes , e.g. tables for figures, or maps with points
WikiFactMine: Ontology for Everybody and Everythingpetermurrayrust
WikiFactMine https://www.wikidata.org/wiki/Wikidata:WikiFactMine consists of several hundreds dictionaries created from Wikidata. They cover everything from science to medicine to geo to arts. Every item has a unique identifier (Q) and normally has several properties (P) creating a series of triples. Using SPARQL it's possible to create sophiticated queries and run them in seconds
The Publisher -Academic complex is a dystopian cycle where academia gives (mega)publishers manuscripts, reviews and money and the publishers give personal and institutional glory(vanity). This is analysed in its origins, impact and harm. The disruption can come from Advocacy/Activism, Community and Tools. Disruption comes from doing things Better or Novel, not Prices
AUDIO : https://soundcloud.com/damahub/peter-murray-rust-disturbing-the-publisher-academic-complex-210418-british-library
Thanks to DaMaHub
This has now been edited by Ewan McAndrew (Edinburgh Wikimedian in Residence) many thanks - to synchronize the slides with the soundtrack. https://media.ed.ac.uk/media/1_46h85ltt Brilliant
ContentMining (aka Text and Data Mining TDM) is beneficial, legal in the UK and a few other countries. Many groups in Europe are looking to make it legal there as well but there are many vested interests who oppose it.
This short presentation shows the benefits of content mining, some of the technology, and the way that it can be used and promotedby communities of practice. I urge all attendees at CopyCamp and also the wider world to press for liberalization of Copyright
The mining "Revolution"; are Libraries supporting Researchers or Publishers"?petermurrayrust
increasingly we find that mega-corporations have taken control over scholarship. We could use the scholarly literature as a knowledge resource but megacorps try to stop this - and often libraries support them rather than researchers.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Cancer cell metabolism: special Reference to Lactate Pathway
ContentMining in Neuroscience
1. Open Mining of the Bioscience Literature
Peter Murray-Rust,
ContentMine.org and the University of Cambridge
UNAM, MX 2015-10-09
Millions of data points are hidden in the bioscience literature.
ContentMine has Open technology to liberate them automatically.
Using OpenNotebook approaches
The major problem is politico-legal
This is an exploratory talk, looking for ideas and projects
The future depends on young people
4. Some particularly relevant Fellows/Alumni and projects:
• Rufus Pollock: Open Knowledge Foundation
• Mark Surman: Mozilla
• Dan Whaley: Hypothes.is
• Daniel Lombrana-Gonzales: PyBossa/Crowdcrafting
Erin McKiernan, 2015 Flash Award
ContentMine and Peter Murray-Rust are funded by:
5. The Right to Read is the Right to Mine
http://contentmine.org
6. ContentMine Workshops and
Hackdays
Open Science Brazil, 2014-08
Easily distributed software
Get started in 30 mins
Build application
in a morning
Start simple: bagOfWords, Stemming, Regex, templates
8. Why do we publish science?
• Communicate our results
• Archival
• Get feedback from peers.
• Provide material that others can re-use.
• Priority and esteem.
9.
10. http://www.nytimes.com/2015/04/08/opinion/yes-we-were-warned-about-
ebola.html
[Liberian Ministry of Health] were stunned recently when we stumbled across
an article by European researchers in Annals of Virology [1982]: “The results
seem to indicate that Liberia has to be included in the Ebola virus endemic
zone.” In the future, the authors asserted, “medical personnel in Liberian health
centers should be aware of the possibility that they may come across active
cases and thus be prepared to avoid nosocomial epidemics,” referring to
hospital-acquired infection.
Adage in public health: “The road to inaction is paved with research
papers.”
Bernice Dahn (chief medical officer of Liberia’s Ministry of Health)
Vera Mussah (director of county health services)
Cameron Nutt (Ebola response adviser to Partners in Health)
A System Failure of Scholarly Publishing
16. Output of scholarly publishing
[2] https://en.wikipedia.org/wiki/Mont_Blanc#/media/File:Mont_Blanc_depuis_Valmorel.jpg
586,364 Crossref DOIs 201,507 [1] per month
1.5 million (papers + supplemental data) /year [citation needed]*
each 3 mm thick
4500 m high per year [2]
* Most is not Publicly readable
[1] http://www.crossref.org/01company/crossref_indicators.html
17. Scientific and Medical publication (STM)[+]
• World Citizens pay $450,000,000,000…
• … for research in 1,500,000 articles …
• … cost $300,000 each to create …
• … $7000 each to “publish” [*]…
• … $10,000,000,000 from academic libraries …
• … to “publishers” who forbid access to 99.9% of citizens of
the world …
• 85% of medical research is wasted (not published, badly
conceived, duplicated, …) [Lancet 2009]
[+] Figures probably +- 50 %
[*] arXiV preprint server costs $7 USD per paper
19. ContentMine approaches
0. Open software, Open content, Open notebooks
1. Daily liberation of facts which are easy and widely
useful.
– Species (Bacillus subtilis, Okapia johnstoni)
– Genes (BRCA1*, APOE)
– Chemicals (acetone, CH3OH)
– Identifiers (RRIDs, museum specimens, )
1. CMunities of practice with bespoke tools:
– Clinical Trials
– Phylogenetic trees
– Systematic reviews
21. Open Content Mining of FACTs
Machines can interpret chemical reactions
We have done 500,000 patents. There are >
3,000,000 reactions/year. Added value > 1B Eur.
22. C) What’s the problem with this spectrum?
Org. Lett., 2011, 13 (15), pp 4084–4087
Original thanks to ChemBark
28. “adult nonpregnant patients, aged ≥18 years”,
“randomization sequence using a permuted block design with random
block sizes stratified by study center”.
“blinding of the patients and caregivers is not possible”.
“Investigators performing analysis are blinded for the intervention”.
“Continuous normally distributed variables … mean and standard deviation,
counts (n) and percentages (%). … Student’s t-test … or the Mann–Whitney U test
… Categorical … Chi-square test or Fisher's exact tests. Statistical significance is
considered to be at a P value <0.05 …”
Formulaic language in reporting clinical trials
29. Text-based plugins
• Bag of words
(https://en.wikipedia.org/wiki/Bag-of-
words_model)
• https://en.wikipedia.org/wiki/Tf%E2%80%93idf
(Term-frequency, inverse document frequency)
• Templates and regexes (regular expressions).
31. Regular Expressions for Systematic Reviews of Animal Tests
Preceding Text
Following Text
Extracted term
In 30 minutes 6 scientists (most were unfamiliar with regex)
wrote 200 regexes for ARRIVE (NC3R guidelines)
43. Traditional Research and Publication
“Lab” work paper/th
esis
Write
rewrite
Re-experiment
publish
???
Validation??
DATA
output “belongs”
to publisher
45. Open Notebook Content Mining
• “No insider knowledge”
• Anyone can become involved
• All raw non-copyright material on Github
• Planning and discussion on Open Discourse
• All output (however imperfect) on Github CC0
• Immediate upload
• Inspired by Free/Libre/Open Source, Wikipedia,
Open StreetMap.
50. Automatic Open Notebook of computations
Everything is posted to Github before being analyzed
51. Bacillus subtilis [131238]*
Bacteroides fragilis [221817]
Brevibacillus brevis
Cyclobacterium marinum
Escherichia coli [25419]
Filobacillus milosensis
Flectobacillus major [15809775]
Flexibacter flexilis [15809789]
Formosa algae
Gelidibacter algens [16982233]
Halobacillus halophilus
Lentibacillus salicampi [18345921]
Octadecabacter arcticus
Psychroflexus torquis [16988834]
Pseudomonas aeruginosa [31856]
Sagittula stellata [16992371]
Salegentibacter salegens
Sphingobacterium spiritivorum
Terrabacter tumescens
• [Identifier in Wikidata]
• Missing = not found with Wikidata API
20 commonest organisms (in > 30 papers) in trees from IJSEM*
Half do not appear to be in Wikidata
Can the Wikipedia Scientists comment?
*Int. J. Syst. Evol. Microbiol.
70. Prof. Ian Hargreaves (2011): "David Cameron's
exam question”: "Could it be true that laws
designed more than three centuries ago with the
express purpose of creating economic incentives
for innovation by protecting creators' rights are
today obstructing innovation and economic
growth?”
“yes. We have found that the UK's intellectual
property framework, especially with regard to
copyright, is falling behind what is needed.” "Digital
Opportunity" by Prof Ian Hargreaves - http://www.ipo.gov.uk/ipreview.htm. Licensed under CC BY 3.0 via Wikipedia -
https://en.wikipedia.org/wiki/File:Digital_Opportunity.jpg#/media/File:Digital_Opportunity.jpg
Hi, I’m here to talk about AMI; a data extraction framework and tool. First, I just want highlight some of key contributors to the projects; Andy for his work on the ChemistryVisitor and Peter for the overall architecture.
In this talk, I’m going to impress the importance of data in a specific format and its utility to automated machine processing. Then I’m going to demonstrate AMI’s architecture and the transformation of data as it flows through the process. I’m going to dwell a little on a core format used, Scalable Vector Graphics (SVG) before introducing the concept of visitors, which are pluggable context specific data extractors. Next, I’m going to introduce Andy’s ChemVisitor, for extracting semantic chemistry data, along with a few other visitors that can process non-chemistry specific data. Finally, I will demonstrate some uses of the ChemVisitor, within the realm of validation and metabolism.
