Open Data and Open Science presented in Rio for Open Science 2014-08-22. I argue that Open Notebook Science is the way forward and will lead to great benefits
Jean-Claude Bradley was a pioneer of doing Open Science and on 2014-07-14 we held a memorial meeting in Cambridge (see also http://inmemoriamjcb.wikispaces.com/Jean-Claude+Bradley+Memorial+Symposium)
Copyright is one of the greatest barrier to Open Data. This presentation for insidegovernment UK shows the struggle between those who want to reform copyright and those opposed to reform
Scientific information is often hidden or not published properly. The ContentMine is a Social Machine consisting of semantic software and communities of domain expertise; it aims to liberate all scientific facts from the published literature on a daily basis.
The talk , delivered to the Computational Institute, will be /was followed by a hands-on workshop learning how to use the technology and work as a community.
An overview of ContentMining for JISC (the infrastructure provider of UK academia). Examples, details leading to hands-on exercise (http://contentmine.org/workflow
Jean-Claude Bradley was a pioneer of doing Open Science and on 2014-07-14 we held a memorial meeting in Cambridge (see also http://inmemoriamjcb.wikispaces.com/Jean-Claude+Bradley+Memorial+Symposium)
Copyright is one of the greatest barrier to Open Data. This presentation for insidegovernment UK shows the struggle between those who want to reform copyright and those opposed to reform
Scientific information is often hidden or not published properly. The ContentMine is a Social Machine consisting of semantic software and communities of domain expertise; it aims to liberate all scientific facts from the published literature on a daily basis.
The talk , delivered to the Computational Institute, will be /was followed by a hands-on workshop learning how to use the technology and work as a community.
An overview of ContentMining for JISC (the infrastructure provider of UK academia). Examples, details leading to hands-on exercise (http://contentmine.org/workflow
PhD Theses are normally locked away digitally. They cost 20 billion dollars to create and we waste much of this value. By making them open we can use software to read, index, reuse, compute and add massive value
contentmine.org (funded by Shuttleworth Foundation) has developed tools and workshops to allow anyone to mine scientific content. This 10-minute presentation at Wellcome Trust encourages you to become involved - no previous knowledge required.
Followup meeting in London to OpenCon2014, on the need for different models of scholarly communication. I explore the history of 20thC academic student-based revolutions, with special relevance to young people and the scope for action today.
Can Computers understand the scientific literature (includes compscie material)petermurrayrust
With the semantic web machines can autonomously carry out many knowledge-based tasks as well as humans. The main problems are not technical but the prevention of access to information. I advocate automatic downloading and indexing of all scientific information
Published on Aug 22, 2014 by PMR
Open Data and Open Science presented in Rio for Open Science 2014-08-22. I argue that Open Notebook Science is the way forward and will lead to great benefits
Keynote talk to LEARN (LERU/H2020 project) for research data management. Emphasizes that problems are cultural not technical. Promotes modern approaches such as Git / continuousIntegration, announces DAT. Asserts that the Right to Read in the Right to Mine. Calls for widespread development of contentmining (TDM)
Bibliography 2.0: A citeulike case study from the Wellcome Trust Genome CampusDuncan Hull
Abstract: This talk will describe the use of http://www.citeulike.org to manage and share bibliographic references among 1300 scientists and engineers working at the Sanger Institute (http://www.sanger.ac.uk) and European Bioinformatics Insitute (http://www.ebi.ac.uk) based on the Wellcome Trust Genome Campus in Cambridge, UK. Using data from references shared so far, we will illustrate the costs, benefits and adoption of citeulike to create and share bibliographic data on the web.
Presentation from The Influence and Impact of Web 2.0 on Various Applications at the National e-Science Centre, Edinburgh, UK.
Published on Jan 29, 2016 by PMR
Keynote talk to LEARN (LERU/H2020 project) for research data management. Emphasizes that problems are cultural not technical. Promotes modern approaches such as Git / continuous Integration, announces DAT. Asserts that the Right to Read in the Right to Mine. Calls for widespread development of content mining (TDM)
Open scholarship [a FOSTER open science talk]Ross Mounce
A talk by Dr Ross Mounce, given at the FOSTER Open Science event 4th September, King's College London http://www.fosteropenscience.eu/event/foster-discovering-open-practices-pgr-and-early-career-researchers-0
The Publisher -Academic complex is a dystopian cycle where academia gives (mega)publishers manuscripts, reviews and money and the publishers give personal and institutional glory(vanity). This is analysed in its origins, impact and harm. The disruption can come from Advocacy/Activism, Community and Tools. Disruption comes from doing things Better or Novel, not Prices
AUDIO : https://soundcloud.com/damahub/peter-murray-rust-disturbing-the-publisher-academic-complex-210418-british-library
Thanks to DaMaHub
This has now been edited by Ewan McAndrew (Edinburgh Wikimedian in Residence) many thanks - to synchronize the slides with the soundtrack. https://media.ed.ac.uk/media/1_46h85ltt Brilliant
A presentation by Open Climate Knowledge for European Forum for Advanced Practices. Showing how the scientific literature can be searched for knowledge on this multidisciplinary topic.
Open Access for Early Career ResearchersRoss Mounce
My talk for the University of Bath Open Access Week session; 23rd October 2013.
http://www.bath.ac.uk/learningandteaching/rdu/courses/pgskills/modules/RP00335.htm
Slides from the "Author Identity – Creating a new kind of reputation online" session at Science Online London (solo09) with Duncan Hull, Geoffrey Bilder, Michael Habib, Reynold Guida
ResearcherID, Contributor ID, Scopus Author ID, etc. help to connect your scientific record. How do these tools connect to your online identity, and how can OpenID and other tools be integrated? How can we build an online reputation and when should we worry about our privacy?
PhD Theses are normally locked away digitally. They cost 20 billion dollars to create and we waste much of this value. By making them open we can use software to read, index, reuse, compute and add massive value
contentmine.org (funded by Shuttleworth Foundation) has developed tools and workshops to allow anyone to mine scientific content. This 10-minute presentation at Wellcome Trust encourages you to become involved - no previous knowledge required.
Followup meeting in London to OpenCon2014, on the need for different models of scholarly communication. I explore the history of 20thC academic student-based revolutions, with special relevance to young people and the scope for action today.
Can Computers understand the scientific literature (includes compscie material)petermurrayrust
With the semantic web machines can autonomously carry out many knowledge-based tasks as well as humans. The main problems are not technical but the prevention of access to information. I advocate automatic downloading and indexing of all scientific information
Published on Aug 22, 2014 by PMR
Open Data and Open Science presented in Rio for Open Science 2014-08-22. I argue that Open Notebook Science is the way forward and will lead to great benefits
Keynote talk to LEARN (LERU/H2020 project) for research data management. Emphasizes that problems are cultural not technical. Promotes modern approaches such as Git / continuousIntegration, announces DAT. Asserts that the Right to Read in the Right to Mine. Calls for widespread development of contentmining (TDM)
Bibliography 2.0: A citeulike case study from the Wellcome Trust Genome CampusDuncan Hull
Abstract: This talk will describe the use of http://www.citeulike.org to manage and share bibliographic references among 1300 scientists and engineers working at the Sanger Institute (http://www.sanger.ac.uk) and European Bioinformatics Insitute (http://www.ebi.ac.uk) based on the Wellcome Trust Genome Campus in Cambridge, UK. Using data from references shared so far, we will illustrate the costs, benefits and adoption of citeulike to create and share bibliographic data on the web.
Presentation from The Influence and Impact of Web 2.0 on Various Applications at the National e-Science Centre, Edinburgh, UK.
Published on Jan 29, 2016 by PMR
Keynote talk to LEARN (LERU/H2020 project) for research data management. Emphasizes that problems are cultural not technical. Promotes modern approaches such as Git / continuous Integration, announces DAT. Asserts that the Right to Read in the Right to Mine. Calls for widespread development of content mining (TDM)
Open scholarship [a FOSTER open science talk]Ross Mounce
A talk by Dr Ross Mounce, given at the FOSTER Open Science event 4th September, King's College London http://www.fosteropenscience.eu/event/foster-discovering-open-practices-pgr-and-early-career-researchers-0
The Publisher -Academic complex is a dystopian cycle where academia gives (mega)publishers manuscripts, reviews and money and the publishers give personal and institutional glory(vanity). This is analysed in its origins, impact and harm. The disruption can come from Advocacy/Activism, Community and Tools. Disruption comes from doing things Better or Novel, not Prices
AUDIO : https://soundcloud.com/damahub/peter-murray-rust-disturbing-the-publisher-academic-complex-210418-british-library
Thanks to DaMaHub
This has now been edited by Ewan McAndrew (Edinburgh Wikimedian in Residence) many thanks - to synchronize the slides with the soundtrack. https://media.ed.ac.uk/media/1_46h85ltt Brilliant
A presentation by Open Climate Knowledge for European Forum for Advanced Practices. Showing how the scientific literature can be searched for knowledge on this multidisciplinary topic.
Open Access for Early Career ResearchersRoss Mounce
My talk for the University of Bath Open Access Week session; 23rd October 2013.
http://www.bath.ac.uk/learningandteaching/rdu/courses/pgskills/modules/RP00335.htm
Slides from the "Author Identity – Creating a new kind of reputation online" session at Science Online London (solo09) with Duncan Hull, Geoffrey Bilder, Michael Habib, Reynold Guida
ResearcherID, Contributor ID, Scopus Author ID, etc. help to connect your scientific record. How do these tools connect to your online identity, and how can OpenID and other tools be integrated? How can we build an online reputation and when should we worry about our privacy?
Science in the Open - Science Commons Pacific NorthwestCameron Neylon
Slides from talk given at the Science Commons Symposium Pacific Northwest. Includes new material on Panton Principles and simple user interfaces for scientists.
Jean-Claude Bradley presents an overview of Open Notebook Science at a Columbia panel on Open Science on February 19, 2009. The content of this presentation is targeted to a library services audience.
"Open Science, Open Data" training for participants of Software Writing Skills for Your Research - Workshop for Proficient, Helmholtz Centre Potsdam - GFZ German Research Centre for Geosciences, Telegrafenberg, December 16, 2015
Open Science and European Access Policies in H2020 Reme Melero
GEOTEC UJI and FOSTER project organized a training seminar in the context of GEO-C ESR entitled “Open Science and European Open Access policies in H2020”.
The seminar took place in Castellon (Spain), Feb 12th from 9.30 to 14.00.
An introduction to the core concepts of open science and Science 2.0 for informatics grad students. Originally presentation Feb. 18, 20100 to the University of Pittsburgh.
Open Science overview, 5 schools, technical instances, research cultur, obstacles
by
Sascha Friesike (Humboldt institut for internet and society)
and
Sönke Bartling (German Cancer Research Center)
CC-BY if not otherwise stated.
What is Open Science and what role does it play in Development?Leslie Chan
What is Open Science and what role does it play in Development?
The talk begins with a review of current understanding of open science and its alleged role in providing new opportunities for addressing long-standing development challenges. I then introduce the newly launched Open and Collaborative Science in Development Network, funded by IDRC Canada, and in collaboration with iHub Nairobi, Kenya. The rationale, funding modalities, and the short and long term objectives of the network will be discussed.
An internal presentation to the SRI AI Center, to get people up to speed on current goings-on in open science. Tries to cover far too many things, and slides probably aren't very comprehensible by themselves.
Winning research proposals with open scienceIvo Grigorov
Open Science is now mandated by European Commissions Research Framework Programme Horizon 2020, offering pro-active Open Science practioners to be more competitive at research proposals, with respect to Impact.
The presentation offers evidence that Open Science can support economic growth and innovation, and how to place research proposals in context of political directives that shape Horizon2020 evaluation criteria.
The presentation is based on "Winning Horizon 2020 research proposals with Open Science" http://dx.doi.org/10.5281/zenodo.12247
Presentation at the Open Knowledge Festival: Open Research and Education Stream, 20 September 2012, Helsinki; also
Presentation at the DINI-Jahrestagung - Bausteine für Open Science, 24 September 2012, Karlsruhe;
also Belgian Open Access Week: Open Access to Excellence in Research, 22 October 2012, Brussels.
Connecting the dots - e-Infra services for open scienceOpenAIRE
Starting from Open access towards services for open science, we present OpenAIRE, OpenMinTeD and OpenUP, three EU projects that build services to facilitate and accelerate open science.
The Culture of Research Data, by Peter Murray-RustLEARN Project
1st LEARN Workshop. Embedding Research Data as part of the research cycle. 29 Jan 2016. Presentation by Peter Murray-Rust, ContentMine.org and University of Cambridge
Published on Jul 21, 2014 by PMR
Jean-Claude Bradley was a pioneer of doing Open Science and on 2014-07-14 we held a memorial meeting in Cambridge (see also http://inmemoriamjcb.wikispaces.com/Jean-Claude+Bradley+Memorial+Symposium)
What is Open Science / Open Research?; Initiative of the European Union (EU); Elements of Open Science: open research process / cycle; open access (open repositories); open data; open source software; open notebook / lab book; open workflows; open reputation systems; citizen science; relationship between open research and e-research; open science in Africa and South Africa
Open Data in a Big Data World: easy to say, but hard to do?LEARN Project
Presentation at 3rd LEARN workshop on Research Data Management, “Make research data management policies work”
Helsinki, 28 June 2016, by Sarah Callaghan, STFC Rutherford Appleton Laboratory
A open science presentation focusing on the benefits to be gained and basic practices to follow. This was given on behalf of FOSTER at the Open Science Boos(t)camp event at KU Leuven on 24th October 2014.
Automatic Extraction of Science and Medicine from the scholarly literatureTheContentMine
Published on Jun 04, 2015 by PMR
Many scientists have to extract many facts out the scholarly literature - to evaluate other work or to extract useful collections of facts. This shows the approach, especially for systematic reviews of animal or clinical trials
Automatic Extraction of Science and Medicine from the scholarly literaturepetermurrayrust
Many scientists have to extract many facts out the scholarly literature - to evaluate other work or to extract useful collections of facts. This shows the approach, especially for systematic reviews of animal or clinical trials
The ContentMine system (Open Source) can search EuropePMC and download hundreds of articles in seconds. These can be indexed by AMI dictionaries allowing a rapid evaluations and refinement of the search
The slides that will accompany my live webcast for OpenCon 2014 attendees, all about open data in research. The benefits, the how to (both legally & technically), examples, pitfalls, and the future of open research data.
An introduction to open science, why it's important and how to do it. This presentation was given at the European Medical Students Association (EMSA) event, 'Open Access in Action' in Berlin on 14th-15th September 2015
Can machines understand the scientific literature?petermurrayrust
A presentation to Cambridge MPhil Computational Biology. 2020-11-11 . Presenters Peter Murray-Rust, Shweata Hegde and Ambreen Hamadani from https://github.com/petermr/openvirus .
This chunk is PMR with a large break in the middle for SH and AH talks.
I cover Global Challenges, knowledge equity, semantics of scientific articles, Wikidata, Data Extraction from images, and ethics/politics.
Answer: Yes, technically. No, politically as the Publisher-Academic Complex will block it.
Semantic content created from Open Access papers to help in the fight against viral epidemics. Includes contributions from NIPGR interns, 5 supported by Indian National Young Academy of Scientists.
Overview of openVirus project. Interns in India have worked for 2 months to extract scientific knowledge from the literature about viral epidemics. Covers data science, machine learning and virtual collaboration
Automatic mining of data from materials science literaturepetermurrayrust
The literature on materials science (batteries, etc.) contains huge amounts of scientific facts, but not in easily accessible form. our AMI program has been developed to automatically:
scrape , clean, annotate and display/publish
data for re-use in science.
Examples will be given from electrochemistry, magnetism and other fields . The general principles and (open) tech are applicable to many other disciplines.
XML for science; its huge potential; but are pubiishers preventing it?petermurrayrust
XML can represent almost all well derfined scientific objects. chemistry, plants medcine. But it's not yet widely used. Is this because publishers oppose thr re-use of science?
Early Career Reseachers in Science. Start Early, Be Open , Be Bravepetermurrayrust
Highlights the importance of supporting Early Career Researchers to pursue their own ideas, possibly alongside their main research. Illustrated with biology but applies to all fields of science. This was a 14 min presentation and shows narratives of how ECRs develop and reinforce each other.
Presentation given at NUI, Galway 2019-04-11 for Open Science Week.
An overview of Early Career Researchers, their innovation and contribution towards Open Infrastructure
The scientific and medical literature is a vast resource of knowledge, but it needs turning into semantic FAIR form. The ContentMine can do this and we presented a rapid overview of the potential
A 10-minute talk to lovers of early science (e.g. 1600-1900) at the Royal Society. Archivists , computer vision, scientific historical metadata all relevant.
I chose 4 examples of monochrome diagrams that I can extract something from automatically. Some of the methids would scale to larger volumes , e.g. tables for figures, or maps with points
WikiFactMine: Ontology for Everybody and Everythingpetermurrayrust
WikiFactMine https://www.wikidata.org/wiki/Wikidata:WikiFactMine consists of several hundreds dictionaries created from Wikidata. They cover everything from science to medicine to geo to arts. Every item has a unique identifier (Q) and normally has several properties (P) creating a series of triples. Using SPARQL it's possible to create sophiticated queries and run them in seconds
Paradise Lost and The Right to Read is the Right to Minepetermurrayrust
Presented to UIUC CIRSS seminars to a mixed group of Library, CS, domain scientists with a great contingent of Early Career Researchers. Starts by honouring the creation of the wonderful NCSA Mosaic at UIUC in 1993 and the paradise of knowledge and community it opened. Then shows the gradual and tragic decline of the web into a megacorporate neocolonialist empire, where knowledge is sacrificed for money and power.
You have seen many of the slides before but the words are different and have been recorded.
ContentMining (aka Text and Data Mining TDM) is beneficial, legal in the UK and a few other countries. Many groups in Europe are looking to make it legal there as well but there are many vested interests who oppose it.
This short presentation shows the benefits of content mining, some of the technology, and the way that it can be used and promotedby communities of practice. I urge all attendees at CopyCamp and also the wider world to press for liberalization of Copyright
The scientific scholarly literature now contains many millions of articles. The contain semi-structured information of high quality and veracity. We show how this resource can be converted to a universal Wikicite format and full-text indexed against Wikidata dictionaries. We now have > 5 million bibliographic records and over 200 dictionaries based in Wikidata properties and queriable by SPARQL.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
3. Overview
• Most scientific data is lost; costs many billions…
• … AND LIVES.
• Human problem; lack of vision + active
opposition.
• Born-open data and Open Notebook Science
• Jean-Claude Bradley
• Panton Principles and Fellows (OKFN)
• Digital Enlightenment or Digital Darkness?
4. Reasons for Open Data/Science
• Moral: Closed can be unjust
• Ethical: Community norms expect it
• Utilitarian: Greater communal good f
• Personal: Greater personal benefit
5. RCUK
Wellcome
ERC
NSF
FWF…
require
fully OPEN
[at Research Data Alliance, we are entering a new “era of open science”, which will be “good
for citizens, good for scientists and good for society”.
She explicitly highlighted the transformative potential of open access, open data, open
software and open educational resources – mentioning the EU’s policy requiring open access
to all publications and data resulting from EU funded research.
http://blog.okfn.org/2013/03/21/we-are-entering-an-era-of-open-science-says-eu-vp-neelie-kroes/#
sthash.3SWDXDE6.dpuf
6. Scientific and Medical publication (STM)[+]
• World Citizens pay $400,000,000,000…
• … for research in 1,500,000 articles …
• … cost $300,000 each to create …
• … $7000 each to “publish” [*]…
• … $10,000,000,000 from academic libraries …
• … to “publishers” who forbid access to 99.9% of
citizens of the world …
[+] Figures probably +- 50 %
[*] arXiV preprint server costs $7 USD per paper
7. US Taxpayers spend 139 Billion USD / yr
on Scientific Research
4 Billion USD on human genome
yielded 800 Billion USD and 4 M job-years
8. Bad publication wastes science
…three problems—flawed design, non-publication,
and poor reporting—together
meant >85% of research funds were wasted, a
global total loss >100 billion USD per year. [Lancet
2009http://www.thelancet.com/journals/lancet /article/PIIS0140-6736%2809%2960329-
9/fu lltext.]
[Even more] waste clearly occurs after
publication: from poor access, poor
dissemination, and poor uptake of the findings
of research.
[PLOS Medicine 2014-05-27 DOI: 10.1371/journal.pmed.1001651]
13. PM-R writes about
how Open gave him
5 jobs
August 2014
Marcus Hanwell
http://opensource.com/tags/open-science
Ross Mounce
14. Traditional Research and Publication
“Lab” work paper/th
esis
Write
rewrite
Re-experiment
process “belongs”
to publisher
publish
???
Validation??
DATA
output “belongs”
to publisher
Walls of
academia
15. Free/Open Software Development
CODE
REPOSITORY
World
community
CODE
validate
rewrite
CODE
fork
CODE
Re-use
CODE
Re-use
Github, BitBucket
StackOverflow,
Apache
inspires
OSI
NO WALLS
BORN-OPEN-SOURCE
Example: ContentMine at
http://github.com/ContentMine/quickscrape
19. Restrictions on Re-use of Crystallographic data
NOTE: The CCDC is based on data contributed by
scientists as part of publication and validation
20. Elsevier wants to control Open Data
ViceChancellor Cambridge
[asked by Michelle Brook]
21. Licences destroy Content Mining
WE WALKED OUT
• Brit Library
• JISC
• RLUK
• OKFN
• …
• Ross Mounce
• PM-R
STM Publishers Licence
2012_03_15_Sample_Licence_Text_Data_Mining.pdf
(Summary: PMR has NO rights)
• [cannot publish to: ] “libraries, repositories, or archives”
• [cannot] “Make the results of any TDM Output available on an externally facing server or
website”
• “Subscriber shall pay a […] fee”
Heather Piwowar: “negotiating with publishers [made me physically ill]”
22. Human Genome Project
https://en.wikipedia.org/wiki/Bermuda_Principles
• Automatic release of sequence assemblies larger than 1
kb (preferably within 24 hours).
• Immediate publication of finished annotated
sequences.
• Aim to make the entire sequence freely available in the
public domain for both research and development in
order to maximise benefits to society.
23. Panton Principles for Open Data in
science(2010)
• PUBLISH YOUR DATA OPENLY
• …make an explicit and robust statement of your wishes.
• Use a recognized waiver or license that is appropriate for
data.
• open as defined by the Open Knowledge/Data Definition
(… NOT non-commercial)
• Explicit dedication of data … into the public domain via
PDDL or CCZero
Peter Murray-Rust, Cameron Neylon, Rufus Pollock, John
Wilbanks
27. Open notebook science is the practice of
making the entire primary record of a research
project publicly available online as it is
recorded. (WP)
Jean-Claude Bradley was a chemist who
actively promoted Open Science in
chemistry,… He coined the term Open
Notebook Science. … A memorial
symposium was held July 14, 2014 at
Cambridge University, UK.[9]
35. Award of Blue Obelisk
Jean-Claude Bradley Egon Willighagen
36. Realising OpenNotebookScience
When a distinguished but elderly scientist states that something is
possible, he is almost certainly right. When he states that something is
impossible, he is very probably wrong.
http://en.wikipedia.org/wiki/Clarke's_three_laws
Open Inspirations (some are zero budget)
• Open Street Map
• Journal Of Machine Learning Research
• Blue Obelisk
• arXiV
• Protein Data Bank
• Galaxy Zoo
37. Self-benefit drives Open
• I put my data/papers in a repository because I
HAVE TO
• I commit my code to GitHub because I WANT
TO:
– It’s safe
– It’s validated
– I know it works
– There are tools to search it
– Other coders improve and add to it
39. The Polymath project
Tim Gowers and the world
http://polymathprojects.org/2013/11/04/polymath9-pnp/#comments
http://gowers.wordpress.com/2013/11/03/dbd1-initial-post/
40. Open Notebook Science
TOOLS
Open
engineered
repository
INSTRUMENT
World
community
validate
merge
MODEL
CODE
DATA
DATA
knowledge
calibrate
Machines
and humans
Working
together
Problems are solved communally;
Nothing is needlessly duplicated; “publication“ is
continuous ; data are SEMANTIC
42. Open Notebook Science
TOOLS
Open
engineered
repository
INSTRUMENT
World
community
validate
merge
MODEL
CODE
DATA
DATA
knowledge
calibrate
Machines
and humans
Working
together
Problems are solved communally;
Nothing is needlessly duplicated; “publication“ is
continuous ; data are SEMANTIC
43. Benefits of OpenNotebookScience
• Fraud is virtually impossible
• Priority and credit are algorithmically established
• It is difficult to be scooped…
• Data and ideas cannot be lost
• The world discovers you and you the world
• Time to announcement is much advanced
(?years)
• The “publication process” is vastly less onerous
• … but others may use your work in other ways
44. http://www.budapestopenaccessinitiative.org/read
… an unprecedented public good. …
… completely free and unrestricted access to [peer-reviewed
literature] by all scientists, scholars, teachers,
students, and other curious minds. …
…Removing access barriers to this literature will
accelerate research, enrich education, share the
learning of the rich with the poor and the poor with
the rich, make this literature as useful as it can be, and
lay the foundation for uniting humanity in a common
intellectual conversation and quest for knowledge.
(Budapest Open Access Initiative, 2003)
45. Open Notebook Science
TOOLS
ONS
repository
World
community
INSTRUMENT
validate
merge
MODEL
CODE
DATA
DATA
knowledge
calibrate
Machines and
humans
working together
CC-BY
Problems are solved communally;
Nothing is needlessly duplicated; “publication“ is
continuous and immediate
46. Traditional Research and Publication
“Lab” work paper/th
esis
Write
rewrite
Re-experiment
publish
???
Validation??
DATA
output “belongs”
to publisher
Is there anything we can do with this?
47. Open Notebook Science
TOOLS
ONS
repository
World
community
INSTRUMENT
validate
merge
MODEL
CODE
DATA
DATA
knowledge
calibrate
Machines and
humans
working together
CC-BY/0
Problems are solved communally;
Nothing is needlessly duplicated; “publication“ is
continuous and immediate