a plenary lecture to Cochrane Collaboration in Birmingham, on the value of automatically extracting knowledge. Covers the Why? How? What? Who? and problems and invites collaboration
Automatic Extraction of Knowledge from Biomedical literature TheContentMine
Published on Mar 16, 2016 by PMR
A plenary lecture to Cochrane Collaboration in Birmingham, on the value of automatically extracting knowledge. Covers the Why? How? What? Who? and problems and invites collaboration
Automatic Extraction of Knowledge from the Literaturepetermurrayrust
ContentMine tools (and the Harvest alliance) can be used to search the literature for knowledge, especially in biomedicine. All tools are Open and shortly we shall be indexing the complete daily scholarly literature
Amanuens.is HUmans and machines annotating scholarly literaturepetermurrayrust
about 10,000 scholarly articles ("papers") are published each day. Amanuens.is is a symbiont of ContentMine and Hypothes.is (both Shuttleworth projects/Fellows) which annotates theses using an array of controlled vocabularies ("dictionaries"). The results, in semantic form are used to annotate the original material. The talk had live demos and used plant chemistry as the examples
Automatic Extraction of Knowledge from the LiteratureTheContentMine
Published on May 11, 2016 by PMR
ContentMine tools (and the Harvest alliance) can be used to search the literature for knowledge, especially in biomedicine. All tools are Open and shortly we shall be indexing the complete daily scholarly literature
Talk to EBI Industry group on Open Software for chemical and pharmaceutical sciences. Covers examples of chemistry , wit demos, and argues that all public knowledge should be Openly accessible
Liberating facts from the scientific literature - Jisc Digifest 2016 TheContentMine
Published on Mar 4, 2016 by PMR
Text and data mining (TDM) techniques can be applied to a wide range of materials, from published research papers, books and theses, to cultural heritage materials, digitised collections, administrative and management reports and documentation, etc. Use cases include academic research, resource discovery and business intelligence.
This workshop will show the value and benefits of TDM techniques and demonstrate how ContentMine aims to liberate 100,000,000 facts from the scientific literature, and ContentMine will provide a hands on demo on a topical and accessible scientific/medical subject.
Published on May 18, 2016 by PMR
Talk to EBI Industry group on Open Software for chemical and pharmaceutical sciences. Covers examples of chemistry , wit demos, and argues that all public knowledge should be Openly accessible
Automatic Extraction of Knowledge from Biomedical literature TheContentMine
Published on Mar 16, 2016 by PMR
A plenary lecture to Cochrane Collaboration in Birmingham, on the value of automatically extracting knowledge. Covers the Why? How? What? Who? and problems and invites collaboration
Automatic Extraction of Knowledge from the Literaturepetermurrayrust
ContentMine tools (and the Harvest alliance) can be used to search the literature for knowledge, especially in biomedicine. All tools are Open and shortly we shall be indexing the complete daily scholarly literature
Amanuens.is HUmans and machines annotating scholarly literaturepetermurrayrust
about 10,000 scholarly articles ("papers") are published each day. Amanuens.is is a symbiont of ContentMine and Hypothes.is (both Shuttleworth projects/Fellows) which annotates theses using an array of controlled vocabularies ("dictionaries"). The results, in semantic form are used to annotate the original material. The talk had live demos and used plant chemistry as the examples
Automatic Extraction of Knowledge from the LiteratureTheContentMine
Published on May 11, 2016 by PMR
ContentMine tools (and the Harvest alliance) can be used to search the literature for knowledge, especially in biomedicine. All tools are Open and shortly we shall be indexing the complete daily scholarly literature
Talk to EBI Industry group on Open Software for chemical and pharmaceutical sciences. Covers examples of chemistry , wit demos, and argues that all public knowledge should be Openly accessible
Liberating facts from the scientific literature - Jisc Digifest 2016 TheContentMine
Published on Mar 4, 2016 by PMR
Text and data mining (TDM) techniques can be applied to a wide range of materials, from published research papers, books and theses, to cultural heritage materials, digitised collections, administrative and management reports and documentation, etc. Use cases include academic research, resource discovery and business intelligence.
This workshop will show the value and benefits of TDM techniques and demonstrate how ContentMine aims to liberate 100,000,000 facts from the scientific literature, and ContentMine will provide a hands on demo on a topical and accessible scientific/medical subject.
Published on May 18, 2016 by PMR
Talk to EBI Industry group on Open Software for chemical and pharmaceutical sciences. Covers examples of chemistry , wit demos, and argues that all public knowledge should be Openly accessible
High throughput mining of the scholarly literature TheContentMine
Published on Jun 7, 2016 by PMR
Talk given to statisticians in Tilburg, with emphasis on scholarly comms for detecting unusual features. Includes demo of Amanuens.is and image mining
Amanuens.is HUmans and machines annotating scholarly literature TheContentMine
Published on May 19, 2016 by PMR
about 10,000 scholarly articles ("papers") are published each day. Amanuens.is is a symbiont of ContentMine and Hypothes.is (both Shuttleworth projects/Fellows) which annotates theses using an array of controlled vocabularies ("dictionaries"). The results, in semantic form are used to annotate the original material. The talk had live demos and used plant chemistry as the examples
Digital Scholarship: Enlightenment or Devastated Landscape? TheContentMine
Published on Dec 17, 2015 by PMR
Every year 500 Billion USD of public funding is spent on research, but much of this lies hidden in papers that are never read. I describe how machines can help us to read the literature. However there is massive opposition from publishers who are trying to prevent open scholarship and who build walled gardens that they control
Published on Jan 29, 2016 by PMR
Keynote talk to LEARN (LERU/H2020 project) for research data management. Emphasizes that problems are cultural not technical. Promotes modern approaches such as Git / continuous Integration, announces DAT. Asserts that the Right to Read in the Right to Mine. Calls for widespread development of content mining (TDM)
Automatic Extraction of Science and Medicine from the scholarly literaturepetermurrayrust
Many scientists have to extract many facts out the scholarly literature - to evaluate other work or to extract useful collections of facts. This shows the approach, especially for systematic reviews of animal or clinical trials
Use of ContentMine tools on the Open Access subset of EuropePubMedCentral to discover new knowledge about the Zika virus.
Three slides have embedded movies - these do not show in slideshare and a first pass of this can be seen as a single file at https://vimeo.com/154705161
Can Computers understand the scientific literature (includes compscie material)TheContentMine
Published on Jan 24, 2014 by PMR
With the semantic web machines can autonomously carry out many knowledge-based tasks as well as humans. The main problems are not technical but the prevention of access to information. I advocate automatic downloading and indexing of all scientific information
Published on Feb 29, 2016 by PMR
An overview of Text and Data Mining (ContentMining) including live demonstrations. The fundamentals: discover, scrape, normalize , facet/index, analyze, publish are exemplified using the recent Zika outbreak. Mining covers textual and non-textual content and examples of chemistry and phylogenetic tress are given.
Talk to OpenForum Academy (Open Forum Europe) about Text and data Mining. Four use cases selected fo non-scientists. Also discussion of latest on Europena copyright reform and TDM exceptions
Published on Feb 07, 2016 by PMR
Use of ContentMine tools on the Open Access subset of EuropePubMedCentral to discover new knowledge about the Zika virus. Includes clips of the software in action
Mining the scientific literature for plants and chemistrypetermurrayrust
ContentMine can read the daily scientific literature and extract facts. This talk was given to the OpenPlant project - with whom ContentMine collaborate at a meeting on 2016-07-25/27 in Norwich. Examples of extracted facts are given.
An overview of Text and Data Mining (ContentMining) including live demonstrations. The fundamentals: discover, scrape, normalize , facet/index, analyze, publish are exemplified using the recent Zika outbreak. Mining covers textual and non-textual content and examples of chemistry and phylogenetic tress are given.
High throughput mining of the scholarly literature; talk at NIHpetermurrayrust
The scientific and medical literature contains huge amounts of valuable unused information. This talk shows how to discover it, extract, re-use and interpret it. Wikidata is presented as a key new tool and infrastructure. Everyone can become involved. However some of the barriers to use are sociopolitical and these are identified and discussed.
Can machines understand the scientific literaturepetermurrayrust
With over 5000 scientific articles per day we need machines to help us understand the content. This material is to be used at an interactive session for the Science Society at Trinity College Cambridge UK
ContentMining for France and Europe; Lessons from 2 years in UKpetermurrayrust
I have spend 2 years carrying out Content Mining (aka Text and Data Mining) in the UK under the 2014 "Hargreaves" exception. This talk was given in Paris, to ADBU , after France had passed the law of the numeric Republique. I illustrate what worked in what did not and why and offer ideas to France and Europe
High throughput mining of the scholarly literature TheContentMine
Published on Jun 7, 2016 by PMR
Talk given to statisticians in Tilburg, with emphasis on scholarly comms for detecting unusual features. Includes demo of Amanuens.is and image mining
Amanuens.is HUmans and machines annotating scholarly literature TheContentMine
Published on May 19, 2016 by PMR
about 10,000 scholarly articles ("papers") are published each day. Amanuens.is is a symbiont of ContentMine and Hypothes.is (both Shuttleworth projects/Fellows) which annotates theses using an array of controlled vocabularies ("dictionaries"). The results, in semantic form are used to annotate the original material. The talk had live demos and used plant chemistry as the examples
Digital Scholarship: Enlightenment or Devastated Landscape? TheContentMine
Published on Dec 17, 2015 by PMR
Every year 500 Billion USD of public funding is spent on research, but much of this lies hidden in papers that are never read. I describe how machines can help us to read the literature. However there is massive opposition from publishers who are trying to prevent open scholarship and who build walled gardens that they control
Published on Jan 29, 2016 by PMR
Keynote talk to LEARN (LERU/H2020 project) for research data management. Emphasizes that problems are cultural not technical. Promotes modern approaches such as Git / continuous Integration, announces DAT. Asserts that the Right to Read in the Right to Mine. Calls for widespread development of content mining (TDM)
Automatic Extraction of Science and Medicine from the scholarly literaturepetermurrayrust
Many scientists have to extract many facts out the scholarly literature - to evaluate other work or to extract useful collections of facts. This shows the approach, especially for systematic reviews of animal or clinical trials
Use of ContentMine tools on the Open Access subset of EuropePubMedCentral to discover new knowledge about the Zika virus.
Three slides have embedded movies - these do not show in slideshare and a first pass of this can be seen as a single file at https://vimeo.com/154705161
Can Computers understand the scientific literature (includes compscie material)TheContentMine
Published on Jan 24, 2014 by PMR
With the semantic web machines can autonomously carry out many knowledge-based tasks as well as humans. The main problems are not technical but the prevention of access to information. I advocate automatic downloading and indexing of all scientific information
Published on Feb 29, 2016 by PMR
An overview of Text and Data Mining (ContentMining) including live demonstrations. The fundamentals: discover, scrape, normalize , facet/index, analyze, publish are exemplified using the recent Zika outbreak. Mining covers textual and non-textual content and examples of chemistry and phylogenetic tress are given.
Talk to OpenForum Academy (Open Forum Europe) about Text and data Mining. Four use cases selected fo non-scientists. Also discussion of latest on Europena copyright reform and TDM exceptions
Published on Feb 07, 2016 by PMR
Use of ContentMine tools on the Open Access subset of EuropePubMedCentral to discover new knowledge about the Zika virus. Includes clips of the software in action
Mining the scientific literature for plants and chemistrypetermurrayrust
ContentMine can read the daily scientific literature and extract facts. This talk was given to the OpenPlant project - with whom ContentMine collaborate at a meeting on 2016-07-25/27 in Norwich. Examples of extracted facts are given.
An overview of Text and Data Mining (ContentMining) including live demonstrations. The fundamentals: discover, scrape, normalize , facet/index, analyze, publish are exemplified using the recent Zika outbreak. Mining covers textual and non-textual content and examples of chemistry and phylogenetic tress are given.
High throughput mining of the scholarly literature; talk at NIHpetermurrayrust
The scientific and medical literature contains huge amounts of valuable unused information. This talk shows how to discover it, extract, re-use and interpret it. Wikidata is presented as a key new tool and infrastructure. Everyone can become involved. However some of the barriers to use are sociopolitical and these are identified and discussed.
Can machines understand the scientific literaturepetermurrayrust
With over 5000 scientific articles per day we need machines to help us understand the content. This material is to be used at an interactive session for the Science Society at Trinity College Cambridge UK
ContentMining for France and Europe; Lessons from 2 years in UKpetermurrayrust
I have spend 2 years carrying out Content Mining (aka Text and Data Mining) in the UK under the 2014 "Hargreaves" exception. This talk was given in Paris, to ADBU , after France had passed the law of the numeric Republique. I illustrate what worked in what did not and why and offer ideas to France and Europe
Asking the scientific literature to tell us about metabolismpetermurrayrust
Talk to Lhasa Ltd (a world leader in predicting drug metabolism and toxicity. Uses the scientific literature to answer questions on metabolism, chemical transformation. Almost all of the data in a paper can be queried.
Architecture of ContentMine Components contentmine.orgpetermurrayrust
This is the evolving architecture of ContentMine (contentmine.org) architecture. It includes an overview ( slide #2, ) showing getpapers, quickscrape, norma and ami.
The key container is the CTree and the architecture shows where components are added or transformed to this.
These slides are dated and may be out-of-date wrt code. Some diagrams are autogenerated from *.dot files.
Please use http://discuss.contentmine.org/c/software as the main source of up-to-date info. Feel free to ask questions, offer help, critique, etc.
All s/w is Open (BSD, Apache2)
Towards Responsible Content Mining: A Cambridge perspectivepetermurrayrust
ContentMining (Text and Data Mining) is now legal in the UK for non-commercial research. Cambridge UK is a natural centre, with several components:
* a world-class University and Library
* many publishers, both Open Access and conventional
* a digital culture
* ContentMine - a leading proponent and practitioner of mining
Cambridge University Press welcomes content mining and invited PMR to give a talk there. He showed the technology and protocols and proposed a practical way forward in 2017
Asking the scientific literature to tell us about metabolismpetermurrayrust
Talk at Lhasa (https://www.lhasalimited.org/) a leading organization for "in silico prediction and database systems for use in metabolism, toxicology and related sciences". ContentMine software can extract data from papers on compound metabolism in reusable semantic form, including metabolic pathways, pharmacokinetic data.
We have developed image processing techniques to extract data from diagrams used in science and scientific publications. These slides were presented at a workshop session for the Cambridge MPhil in Computational biology. There is an overview of the main techniques for cleaning diagrams, such as thresholding, binarization, edge detection and thinning. Examples are given from plots, phylogenetic trees, chemistry and neuroscience spikes. All software is Open Source and most is Java
Automatic Extraction of Science and Medicine from the scholarly literatureTheContentMine
Published on Jun 04, 2015 by PMR
Many scientists have to extract many facts out the scholarly literature - to evaluate other work or to extract useful collections of facts. This shows the approach, especially for systematic reviews of animal or clinical trials
The Publisher -Academic complex is a dystopian cycle where academia gives (mega)publishers manuscripts, reviews and money and the publishers give personal and institutional glory(vanity). This is analysed in its origins, impact and harm. The disruption can come from Advocacy/Activism, Community and Tools. Disruption comes from doing things Better or Novel, not Prices
AUDIO : https://soundcloud.com/damahub/peter-murray-rust-disturbing-the-publisher-academic-complex-210418-british-library
Thanks to DaMaHub
This has now been edited by Ewan McAndrew (Edinburgh Wikimedian in Residence) many thanks - to synchronize the slides with the soundtrack. https://media.ed.ac.uk/media/1_46h85ltt Brilliant
The scientific and medical literature is a vast resource of knowledge, but it needs turning into semantic FAIR form. The ContentMine can do this and we presented a rapid overview of the potential
The ContentMine system (Open Source) can search EuropePMC and download hundreds of articles in seconds. These can be indexed by AMI dictionaries allowing a rapid evaluations and refinement of the search
Keynote talk to LEARN (LERU/H2020 project) for research data management. Emphasizes that problems are cultural not technical. Promotes modern approaches such as Git / continuousIntegration, announces DAT. Asserts that the Right to Read in the Right to Mine. Calls for widespread development of contentmining (TDM)
Publishing your research: Open Access (introduction & overview)Jamie Bisset
Open Access: what is it and what do I need to do? (November 2013) slides. Delivered as part of the Durham University Researcher Development Programme. Further Training available at https://www.dur.ac.uk/library/research/training/
searching tips and tools, recommendations, getting the most from databases, finding RCTs, EBP, evidence based practice, hospital library, DeepWeb, Grey Literature, Altmetrics,
10 Years Experience in Pioneering Open Access Publishing in Health Informatic...Gunther Eysenbach
Peer-reviewed journals remain important vehicles for knowledge transfer and dissemination in health informatics, yet, their format, processes and business models are changing only slowly. Up to the end of last century, it was common for individual researchers and scientific organizations to leave the business of knowledge transfer to professional publishers, signing away their rights to the works in the process, which in turn impeded wider dissemination. Traditional medical informatics journals are poorly cited and the visibility and uptake of articles beyond the medical informatics community remain limited. In 1999, the Journal of Medical Internet Research (JMIR; http://www.jmir.org) was launched, featuring several innovations including 1) ownership and copyright retained by the authors, 2) electronic-only, "lean" non-for-profit publishing, 3) openly accessible articles with a reversed business model (author pays instead of reader pays), 4) technological innovations such as automatic XML tagging and reference checking, on-the-fly PDF generation from XML, etc., enabling wide distribution in various bibliographic and full-text databases. In the past 10 years, despite limited resources, the journal has emerged as a leading journal in health informatics, and is presently ranked the top journal in the medical informatics and health services research categories by impact factor. The paper summarizes some of the features of the Journal, and uses bibliometric and access data to compare the influence of the Journal on the discipline of medical informatics and other disciplines. While traditional medical informatics journals are primarily cited by other Medical Informatics journals (33%-46% of citations), JMIR papers are to a more often cited by "end-users" (policy, public health, clinical journals), which may be partly attributable to the "open access advantage".
This presentation was given at Medinfo 2010 (13th World Congress on Medical and Health Informatics) in Cape Town in September 2010.
A self-archived full paper is available on Scribd:
http://tinyurl.com/jmir10yrs
Please cite as:
Eysenbach G. 10 years experience with pioneering open access publishing in health informatics: the Journal of Medical Internet Research (JMIR). Stud Health Technol Inform. 2010;160(Pt 2):1329-3
(cc-by) can be freely distributed under the Creative Commons Attribution License
Presentation given at NUI, Galway 2019-04-11 for Open Science Week.
An overview of Early Career Researchers, their innovation and contribution towards Open Infrastructure
Basics of ContentMining presented to Synthetic Biologists. This was followed by a lively discussion of what components could be extracted from the literature
Published on May 18, 2015 by PMR
Basics of ContentMining presented to Synthetic Biologists. This was followed by a lively discussion of what components could be extracted from the literature
The scientific scholarly literature now contains many millions of articles. The contain semi-structured information of high quality and veracity. We show how this resource can be converted to a universal Wikicite format and full-text indexed against Wikidata dictionaries. We now have > 5 million bibliographic records and over 200 dictionaries based in Wikidata properties and queriable by SPARQL.
Published on Jul 10, 2015 by PMR
Scholarly Publishing wastes huge amounts of valuable science. This presentation to the Public Library of Science suggests how we can work together to put this right
Similar to Automatic Extraction of Knowledge from Biomedical literature (20)
Can machines understand the scientific literature?petermurrayrust
A presentation to Cambridge MPhil Computational Biology. 2020-11-11 . Presenters Peter Murray-Rust, Shweata Hegde and Ambreen Hamadani from https://github.com/petermr/openvirus .
This chunk is PMR with a large break in the middle for SH and AH talks.
I cover Global Challenges, knowledge equity, semantics of scientific articles, Wikidata, Data Extraction from images, and ethics/politics.
Answer: Yes, technically. No, politically as the Publisher-Academic Complex will block it.
Semantic content created from Open Access papers to help in the fight against viral epidemics. Includes contributions from NIPGR interns, 5 supported by Indian National Young Academy of Scientists.
Overview of openVirus project. Interns in India have worked for 2 months to extract scientific knowledge from the literature about viral epidemics. Covers data science, machine learning and virtual collaboration
Automatic mining of data from materials science literaturepetermurrayrust
The literature on materials science (batteries, etc.) contains huge amounts of scientific facts, but not in easily accessible form. our AMI program has been developed to automatically:
scrape , clean, annotate and display/publish
data for re-use in science.
Examples will be given from electrochemistry, magnetism and other fields . The general principles and (open) tech are applicable to many other disciplines.
A presentation by Open Climate Knowledge for European Forum for Advanced Practices. Showing how the scientific literature can be searched for knowledge on this multidisciplinary topic.
XML for science; its huge potential; but are pubiishers preventing it?petermurrayrust
XML can represent almost all well derfined scientific objects. chemistry, plants medcine. But it's not yet widely used. Is this because publishers oppose thr re-use of science?
Early Career Reseachers in Science. Start Early, Be Open , Be Bravepetermurrayrust
Highlights the importance of supporting Early Career Researchers to pursue their own ideas, possibly alongside their main research. Illustrated with biology but applies to all fields of science. This was a 14 min presentation and shows narratives of how ECRs develop and reinforce each other.
A 10-minute talk to lovers of early science (e.g. 1600-1900) at the Royal Society. Archivists , computer vision, scientific historical metadata all relevant.
I chose 4 examples of monochrome diagrams that I can extract something from automatically. Some of the methids would scale to larger volumes , e.g. tables for figures, or maps with points
WikiFactMine: Ontology for Everybody and Everythingpetermurrayrust
WikiFactMine https://www.wikidata.org/wiki/Wikidata:WikiFactMine consists of several hundreds dictionaries created from Wikidata. They cover everything from science to medicine to geo to arts. Every item has a unique identifier (Q) and normally has several properties (P) creating a series of triples. Using SPARQL it's possible to create sophiticated queries and run them in seconds
Paradise Lost and The Right to Read is the Right to Minepetermurrayrust
Presented to UIUC CIRSS seminars to a mixed group of Library, CS, domain scientists with a great contingent of Early Career Researchers. Starts by honouring the creation of the wonderful NCSA Mosaic at UIUC in 1993 and the paradise of knowledge and community it opened. Then shows the gradual and tragic decline of the web into a megacorporate neocolonialist empire, where knowledge is sacrificed for money and power.
You have seen many of the slides before but the words are different and have been recorded.
ContentMining (aka Text and Data Mining TDM) is beneficial, legal in the UK and a few other countries. Many groups in Europe are looking to make it legal there as well but there are many vested interests who oppose it.
This short presentation shows the benefits of content mining, some of the technology, and the way that it can be used and promotedby communities of practice. I urge all attendees at CopyCamp and also the wider world to press for liberalization of Copyright
The mining "Revolution"; are Libraries supporting Researchers or Publishers"?petermurrayrust
increasingly we find that mega-corporations have taken control over scholarship. We could use the scholarly literature as a knowledge resource but megacorps try to stop this - and often libraries support them rather than researchers.
WikiFactMine uses dictionaries created directly from Wikidata to search the scientific literature. The example given is for papers which contain mention of conifers and terpenes (volatile plant organic compounds). Traditional queries and content are expanded by the system to be much broader and more precise than traditional keyword searchers of abstract
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
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Automatic Extraction of Knowledge from Biomedical literature
1. Cochrane UK & Ireland
Symposium 2016,
Birmingham, UK, 2016-03-16
Automated Extraction of
Knowledge from Biomedical
Literature
Peter Murray-Rust1,2
[1]University of Cambridge
[2]TheContentMine
pm286 AT cam DOT ac DOT uk
Simple, Universal,
Knowledge creation and re-use
Our tools and minds are Open.
How can we help Cochrane?
2. Overview
Content Mining:
• Why we need it
• What it is
• How WE can do it
• The next steps
• PM-R has worked in Glaxo Group Research on drug discovery, with
WHO on adverse events and ICD-10, FDA on NDAs, EPO on patents,
etc.
3. The Right to Read is the Right to Mine**PeterMurray-Rust, 2011
http://contentmine.org
Not-for-private Profit
5. Output of scholarly publishing
[2] https://en.wikipedia.org/wiki/Mont_Blanc#/media/File:Mont_Blanc_depuis_Valmorel.jpg
586,364 Crossref DOIs 201507 [1] per month
1.5 million (papers + supplemental data) /year [citation needed]*
each 3 mm thick
4500 m high per year [2]
* Most is not Publicly readable
[1] http://www.crossref.org/01company/crossref_indicators.html
6. Scientific and Medical publication (STM)[+]
• World Citizens pay $450,000,000,000…
• … for research in 1,500,000 articles …
• … cost $300,000 each to create …
• … $7000 each to “publish” [*]…
• … $10,000,000,000 from academic libraries …
• … to “publishers” who forbid access to 99.9% of citizens of
the world …
• 85% of medical research is wasted (not published, badly
conceived, duplicated, …) [Lancet 2009]
[+] Figures probably +- 50 %
[*] arXiV preprint server costs $7 USD per paper
7. http://www.nytimes.com/2015/04/08/opinion/yes-we-were-warned-about-
ebola.html
We were stunned recently when we stumbled across an article by European
researchers in Annals of Virology [1982]: “The results seem to indicate that
Liberia has to be included in the Ebola virus endemic zone.” In the future,
the authors asserted, “medical personnel in Liberian health centers should be
aware of the possibility that they may come across active cases and thus be
prepared to avoid nosocomial epidemics,” referring to hospital-acquired
infection.
Adage in public health: “The road to inaction is paved with research
papers.”
Bernice Dahn (chief medical officer of Liberia’s Ministry of Health)
Vera Mussah (director of county health services)
Cameron Nutt (Ebola response adviser to Partners in Health)
A System Failure of Scholarly Publishing
10. WE pay for scholarly
publications that WE
can’t read
[1] The Military-Industrial-Academic complex (1961)
(Dwight D Eisenhower, US President)
Publishers Academia
Glory+?
$$, MS
review
Taxpayer
Student
Researcher
$$ $$
in-kind
The Publisher-Academic complex[1]
12. Prof. Ian Hargreaves (2011): "David Cameron's
exam question”: "Could it be true that laws
designed more than three centuries ago with the
express purpose of creating economic incentives
for innovation by protecting creators' rights are
today obstructing innovation and economic
growth?”
“yes. We have found that the UK's intellectual
property framework, especially with regard to
copyright, is falling behind what is needed.” "Digital
Opportunity" by Prof Ian Hargreaves - http://www.ipo.gov.uk/ipreview.htm. Licensed under CC BY 3.0 via Wikipedia -
https://en.wikipedia.org/wiki/File:Digital_Opportunity.jpg#/media/File:Digital_Opportunity.jpg
13.
14. Resources
• Europe PubMedCentral http://europepmc.org/
• ContentMine toolkit https://github.com/ContentMine/
• Wikidata:
https://www.wikidata.org/wiki/Wikidata:Main_Page
• Hypothes.is https://hypothes.is/ [1]
• Etherpad: http://pads.cottagelabs.com/p/cochrane2016
• Note: early adopters can obtain our (Open) software and
run it at home…
• [1] Not used in CochraneBham workshop
24. Open Content Mining of FACTs
Machines can interpret chemical reactions
We have done 500,000 patents. There are >
3,000,000 reactions/year. Added value > 1B Eur.
25. Dictionaries
• Simplest approach to knowledge extraction
and management.
We’d love to help integrate your dictionaries and
Open authorities
26. Disease Dictionary (ICD-10)
<dictionary title="disease">
<entry term="1p36 deletion syndrome"/>
<entry term="1q21.1 deletion syndrome"/>
<entry term="1q21.1 duplication syndrome"/>
<entry term="3-methylglutaconic aciduria"/>
<entry term="3mc syndrome”
<entry term="corpus luteum cyst”/>
<entry term="cortical blindness" />
SELECT DISTINCT ?thingLabel WHERE {
?thing wdt:P494 ?wd .
?thing wdt:P279 wd:Q12136 .
SERVICE wikibase:label {
bd:serviceParam wikibase:language "en" }
}
wdt:P494 = ICD-10 (P494) identifier
wd:Q12136 = disease (Q12136) abnormal condition that
affects the body of an organism
Wikidata ontology for disease
27. • ChEBI (chemicals at EBI)
ftp://ftp.ebi.ac.uk/pub/databases/chebi/Flat_file_tab_delimited/names_3star.tsv.gz)
• combined with WIKIDATA: World Health Organisation International Nonproprietary Name
(P2275)
* => 4947 items in the dictionary (inn.xml)
DRUGS
<dictionary title="inn">
<entry term="(r)-fenfluramine"/>
<entry term="abacavir"/>
<entry term="abafungin"/>
<entry term="abafungina"/>
<entry term="abafungine"/>
<entry term="abafunginum"/>
<entry term="abamectin"/>
<entry term="abarelix"/>
<entry term="abatacept"/>
28. <dictionary title="funders">
<!— from http://help.crossref.org/funder-registry with
thanks -->
<entry id="http://dx.doi.org/10.13039/100001436"
term="1675 Foundation"/>
<entry id="http://dx.doi.org/10.13039/100004343"
term="3M"/>
<entry id=“http://dx.doi.org/10.13039/501100005957”
term="8020 Promotion Foundation"/>
<entry id="http://dx.doi.org/10.13039/501100007139"
term="A Richer Life Foundation"/>
<entry id="http://dx.doi.org/10.13039/100006543"
term="A World Celiac Community Foundation"/>
<entry id="http://dx.doi.org/10.13039/100001962"
term="A-T Children's Project"/>
<entry id="http://dx.doi.org/10.13039/100008456"
term="A. Alfred Taubman Medical Research Institute"/>
11566 entries
Funders Dictionary
39. Systematic Reviews
Can we:
• eliminate true negatives automatically?
• extract data from formulaic language?
• mine diagrams?
• Annotate existing sources?
• forward-reference clinical trials?
40. Polly has 20 seconds to read this paper…
…and 10,000 more
41. ContentMine software can do this in a few minutes
Polly: “there were 10,000 abstracts and due
to time pressures, we split this between 6
researchers. It took about 2-3 days of work
(working only on this) to get through
~1,600 papers each. So, at a minimum this
equates to 12 days of full-time work (and
would normally be done over several weeks
under normal time pressures).”
42. 400,000 Clinical Trials
In 10 government registries
Mapping trials => papers
http://www.trialsjournal.com/content/16/1/80
2009 => 2015. What’s
happened in last 6 years??
Search the whole scientific literature
For “2009-0100068-41”
57. @Senficon (Julia Reda) :Text & Data mining in times of
#copyright maximalism:
"Elsevier stopped me doing my research"
http://onsnetwork.org/chartgerink/2015/11/16/elsevi
er-stopped-me-doing-my-research/ … #opencon #TDM
Elsevier stopped me doing my research
Chris Hartgerink
58. I am a statistician interested in detecting potentially problematic research such as data fabrication,
which results in unreliable findings and can harm policy-making, confound funding decisions, and
hampers research progress.
To this end, I am content mining results reported in the psychology literature. Content mining the
literature is a valuable avenue of investigating research questions with innovative methods. For
example, our research group has written an automated program to mine research papers for errors in
the reported results and found that 1/8 papers (of 30,000) contains at least one result that could
directly influence the substantive conclusion [1].
In new research, I am trying to extract test results, figures, tables, and other information reported in
papers throughout the majority of the psychology literature. As such, I need the research papers
published in psychology that I can mine for these data. To this end, I started ‘bulk’ downloading research
papers from, for instance, Sciencedirect. I was doing this for scholarly purposes and took into account
potential server load by limiting the amount of papers I downloaded per minute to 9. I had no intention
to redistribute the downloaded materials, had legal access to them because my university pays a
subscription, and I only wanted to extract facts from these papers.
Full disclosure, I downloaded approximately 30GB of data from Sciencedirect in approximately 10 days.
This boils down to a server load of 0.0021GB/[min], 0.125GB/h, 3GB/day.
Approximately two weeks after I started downloading psychology research papers, Elsevier notified my
university that this was a violation of the access contract, that this could be considered stealing of
content, and that they wanted it to stop. My librarian explicitly instructed me to stop downloading
(which I did immediately), otherwise Elsevier would cut all access to Sciencedirect for my university.
I am now not able to mine a substantial part of the literature, and because of this Elsevier is directly
hampering me in my research.
[1] Nuijten, M. B., Hartgerink, C. H. J., van Assen, M. A. L. M., Epskamp, S., & Wicherts, J. M. (2015). The
prevalence of statistical reporting errors in psychology (1985–2013). Behavior Research Methods, 1–22.
doi: 10.3758/s13428-015-0664-2
Chris Hartgerink’s blog post
59. WILEY … “new security feature… to prevent systematic download of content
“[limit of] 100 papers per day”
“essential security feature … to protect both parties (sic)”
CAPTCHA
User has to type words
60. http://onsnetwork.org/chartgerink/2016/02/23/wiley-also-stopped-my-doing-my-research/
Wiley also stopped me (Chris Hartgerink) doing my research
In November, I wrote about how Elsevier wanted me to stop downloading scientific articles for my research. Today, Wiley
also ordered me to stop downloading.
As a quick recapitulation: I am a statistician doing research into detecting
potentially problematic research such as data fabrication and
estimating how often it occurs. For this, I need to download many scientific articles, because my research
applies content mining methods that extract facts from them (e.g., test statistics). These facts serve as my data to answer my research
questions. If I cannot download these research articles, I cannot collect the data I need to do my research.
I was downloading psychology research articles from the Wiley library, with a maximum of 5 per minute. I did this using the tool quickscrape,
developed by the ContentMine organization. With this, I have downloaded approximately 18,680 research articles from the Wiley library,
which I was downloading solely for research purposes.
Wiley noticed my downloading and notified my university library that they detected a compromised proxy, which they
had immediately restricted. They called it “illegally downloading copyrighted content
licensed by your institution”. However, at no point was there any investigation into whether my user credentials were
actually compromised (they were not). Whether I had legitimate reasons to download these articles was never discussed.
The original email from Wiley is available here.
As a result of Wiley denying me to download these research articles, I cannot collect data from
another one of the big publishers, alongside Elsevier. Wiley is more strict than Elsevier by immediately condemning the
downloading as illegal, whereas Elsevier offers an (inadequate) API with additional terms of use (while legitimate access
has already been obtained). I am really confused about what the publisher’s stance on content mining is, because Sage
and Springer seemingly allow it; I have downloaded 150,210 research articles from Springer
and 12,971 from Sage and they never complained about it.
61.
62. ContentMine can Offer
• Collaboration
• Prototyping. YOU design the rules and system
• Rapid knowledge creation and analysis tools accessible to
EVERYONE and controlled by ANYONE.
• Access to ALL daily scientific/medical FACTs
ContentMine needs
• Joint projects with narratives
• Support in kind (code, content) and cash.
• http://contentmine.org
63. ContentMine can Offer
• Collaboration
• Prototyping
• Rapid knowledge creation and analysis tools accessible to
EVERYONE and controlled by ANYONE.
• Access to ALL daily scientific/medical FACTs
ContentMine needs
• Joint projects with narratives
• Support in kind (code, content) and cash.
• http://contentmine.org
KNOWLEDGE
SAVES
LIVES