The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
patient positioning in operative room.pptxmohsinyeshar
Lecture about tips and tricks for proper patient positioning in operative room
Description of common positions
Possible complications
And how to prevent complications
According to recent guidelines and references
Regional Blocks of the Upper Limb and Thorax RRTRanjith Thampi
Blocks of the UL and Thorax made easy. Most methods mentioned here are modifications and not classical methods used that maybe be required for examination writing purpose.
Acute management and decision making in spinal cord injury by dr ss sharmadrshyamsundersharma
These slides made by references of spinal cord medicine books for information,education and communication of physicians,paramedics and peoples by which early appropriate, accessible measures can be taken for mandatory spine cord injury care and management.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
patient positioning in operative room.pptxmohsinyeshar
Lecture about tips and tricks for proper patient positioning in operative room
Description of common positions
Possible complications
And how to prevent complications
According to recent guidelines and references
Regional Blocks of the Upper Limb and Thorax RRTRanjith Thampi
Blocks of the UL and Thorax made easy. Most methods mentioned here are modifications and not classical methods used that maybe be required for examination writing purpose.
Acute management and decision making in spinal cord injury by dr ss sharmadrshyamsundersharma
These slides made by references of spinal cord medicine books for information,education and communication of physicians,paramedics and peoples by which early appropriate, accessible measures can be taken for mandatory spine cord injury care and management.
Introduction:
Patients in any healthcare setting can quickly become acutely unwell, and assessment and management of the airway is always the priority in any clinical situation (Resuscitation Council UK, 2021). When patients are critically unwell, there is a high risk of respiratory deterioration, and many patients require an artificial airway to facilitate their treatment. Knowing how to assess and manage the airway is a key skill for the nurse working in critical care.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
The hemodynamic and autonomic determinants of elevated blood pressure in obes...
Complications of Prone Position For Anesthetized Patient - Copy.pptx
1. Complications of Prone Position For Patient under General Anesthesia
Mohamed Khelifa, AT, CPSO
Al Wakra Hospital – June 2022
2. I have no conflict of interest to declare regarding this presentation
3. The prone position has been described, used, and developed as a result of the requirement for
surgical access. However, pioneers of spinal surgery in the 1930s and 1940s were hampered
because no effort was made to avoid abdominal compression when positioning the patient.
Prone position (PP) has been used since the 1970s to treat severe hypoxemia
in patients with ARDS because of its effectiveness in improving gas exchange.
Historical development
4. INTRODUCTION
• Prone positioning is a common position used for access to the posterior head, neck, and spine
during spinal surgery Access to the retroperitoneum and upper urinary tracts and access to posterior
structures when required during plastic surgery.
• Prone positioning is associated with several important and potentially catastrophic complications which can
result in permanent disability.
• Complications include hemodynamic changes resulting in hypoperfusion, a range of ophthalmologic
conditions, central nervous system lesions, peripheral nerve compression injuries, compartment syndrome,
and pressure ulcers.
• Other complications include airway swelling and peripheral arterial compression.
5. Benefits of Prone Positioning
Improve V/Q mismatch
Increased ventilation independent areas
Decreases physiologic shunt
Improved ventilation in areas where perfusion remains the same
Decreases compression/Increases FRC Cardiac
Prevent ventilator-associated lung injury
Enhances mobilization of secretions
6. Anesthesia for Prone Position
Induction and Intubation in supine position
Turn prone as a single unit requiring at least 4 people
Neck should be in a neutral position
Head may be turned to the side not exceeding the patient’s normal range of motion or
face down On a cushioned holder
Arms should be at the sides in a comfortable position with the elbow flexed (avoiding
excessive Adduction at the shoulder)
Chest should rest on parallel rolls (foams) or special supports (frame)to facilitate
ventilation
Check oral endotracheal tube, ckt, and other attachments.
Check breath sounds bilaterally
7. Complications
Complications that occur from poor positioning cause morbidity, and in some cases mortality.
Knowledge of the potential problems allows the practitioner to pay particular attention to
risk
1- Pressure Injuries
Pressure injuries are caused either directly by pressure on the affected tissue or directly
By pressure to the vascular supply and drainage of the injured area.
Pressure ulcer at the edge of
the endotracheal tube holder
8. Facial pressure ulcer from use of the Andrews frame
An unusual cause of unilateral facial
injuries caused by horseshoe ...
Pressure ulcer appearing to reflect
the shape of the endotracheal tube
holder
11. 2- Ophthalmic Complications
o Ophthalmic complications range from abrasions to devastating postoperative visual loss.
o There are two mechanisms, with differing aetiology. The direct pressure on the eye can lead to central retinal artery
whereas ischaemic optic neuropathy can occur without any pressure on the globe or orbit
Periorbital Edema
Periorbital Edema
Corneal Abrasion
12. 3- Peripheral Nervous System
Injuries to the peripheral nervous system are one of the most common complications and
all superficial peripheral nerves should be considered at risk. It is widely believed that poor positioning
and compression or stretch of the nerve within its narrow bony canal (ulnar nerve
at the elbow) or from external compression (common peroneal nerve by straps/pads below the knee) is
responsible for the development of neuropathy.
13. 4- Central Nervous System
it is also important to take care not to over-extend or flex the cervical spine. Those patients
with an unstable spine should be log rolled and it is our practice (once the airway has been
secured) to transfer care of the head and neck during positioning to the surgeon in this
group.
14. 5- Accidental Extubation
Accidental tracheal extubation with the patient in the prone position can be a catastrophic
complication. Even if tracheal intubation was performed easily in the supine position, this
represents a challenging airway scenario for several reasons. First, there is less time to re-establish
the airway because oxygen reserves may be limited, particularly if the FiO2 has been below 0.6).
Second, anaesthesiologists are not accustomed to performing bag-mask ventilation or attempting
airway manoeuvres with the patient prone.
15. 6 - Cardiac Arrest
Cardiac arrest in the prone position is a rare event. case reports have described
successful resuscitation and defibrillation in the prone position. This has allowed
immediate commencement of cardiopulmonary resuscitation while preparing to turn
supine. Chest compressions have been performed using several methods including
placing a hand over each scapula, compressions over the thoracic spine with or without
counter-pressure on the sternum, or open cardiac compressions if surgery already
involves a thoracotomy.
16. Practicalities
Six members of staff are needed to position a patient prone: one person (usually the anesthetist, except in
of unstable spine injury) at the head, one moving the feet, and two on either side of the patient. Additional
members of staff may be required for obese patients or patients with unstable spines requiring ‘log-rolling’.
Alternatively, specialized equipment such as the Jackson table can be used to turn the patient, see the
our practice to disconnect monitoring, infusions, and the breathing system while turning the patient to
the risk of accidentally dislodging lines or the tracheal tube (TT). As soon as the patient is prone all lines,
monitoring, and the breathing circuit are reconnected.
23. Prone Position Protocol
Use the best practices when implementing prone positioning of patients with ARDS
Obtain an order for prone positioning
Assess the hemodynamic status and oxygenation to determine his or her eligibility
Administer sedation and neuromuscular blocking agents as ordered.
Provide eye care/lubrication, and tape eyelids if indicated.
Ensure that the patient’s tongue is inside the mouth, insert a bite block if needed, and provide oral
care as needed
Secure the airway/endotracheal tube and suction as necessary.
Perform anterior skincare, and place hydrocolloid dressing on bony prominences, chin, and
forehead.
Position the patient’s face away from the ventilator to prevent tube kinking, and reposition the
patient’s head hourly to prevent skin breakdown.
Empty any drainage bag
Place ECG electrodes on the patient’s posterior chest.
Assign interprofessional team members to reposition responsibilities.
Monitor the patient’s response to prone positioning.
Obtain arterial blood gas.
24. Aesthetic Problems for Prone Position
I –AIRWAY
- ETT tube kinking or dislodgement
- edema of the upper airway in prolonged cases
II – BLOOD VESSELS
- Arterial or veinous occlusion of the upper extremity
- Kinking of the femoral vein with marked flexion of the hips
- Augmentation of abdominal pressure.
- Augmentation of epidural veinous pressure can cause bleeding because frames elevates.
25. III – PRESSURE NECROSIS
- Nose
- Ear
- Forehead
- Breast ( females)
- Genitals ( males)
IV – MONITORS
- The disconnection of the monitors is hard to avoid, it should be managed carefully
26. V -
NERVES
- Brachial plexus stretch or compression.
- Ulnar nerf N compression: pressure of the olecranon
- Lateral femoral cutaneous N trauma: pressure over the iliac crest
VI – HEAD & NECK
- Gross hyperflexion or hyperextension of the neck .
- External pressure over the eyes: retinal injury.
- Lack of lubrication or coverage of eyes.
- Head rest may cause pressure injury of supraorbital N
- Excessive rotation of the neck can cause brachial plexus problems.
- L- Spine excessive lordosis may lead to neurologic injury.
27. 40/M w/h/o C-spine whiplash injury s/p C4-5-6
discectomy underwent excision of soft tissue mass in the prone position under GA
C-spine stabilization, awake fiber optic intubation, horseshoe headrest
PACU c/o dizziness, headache, painful numbness of the right face, slurred speech, and myoclonic,
spasms of left side extremities
MRA Rt vertebral artery stenosis? Lateral medullary syndrome
Causes excessive rotation or extension of the head during positioning, hypoperfusion under GA?
exacerbated vertebral arterial insufficiency.
Case Report
Thoracic disc herniation: An
unusual complication after
prone positioning in spinal
surgery
28. Conclusion
Increased age, elevated body mass index, the presence of comorbidities, and the long duration of surgery
to be the most important risk factors for complications associated
with prone positioning. We recommend a structured team approach and careful selection of equipment
to the patient and surgery. The systematic use of checklists is recommended to guide operating room teams
reduce prone to position-related complications. Anaesthesiologists should be prepared to manage major
intraoperative emergencies (accidental extubation) and anticipate postoperative complications ( airway
and visual loss).
29. Summary
•Discuss the indication of proning
•Increased awareness of the physiological effects proning has on patients.
•Identified the contraindications to proning
•Injury can occur to all organ systems (including the eyes), due to direct or indirect
pressure effects.
•For most cases, a securely fastened tracheal tube is the airway device of choice.
•In the event of a cardiac arrest, chest compressions and defibrillation can be commenced
in the prone position.
•All the team members should be familiar with possible risks to maintain patient safety.
• Check with the anaesthesia provider to move the patient.
•Use slow movements and do not drag the patient, move with a team approach.
30. objectives
1. Identify the various types of equipment used in prone positioning, including their indications,
advantage and disadvantages.
2. Understand the potential complications that can occur with prone positioning and describe
techniques to prevent or manage them.
3. Formulate a strategy for planned extubating after prolonged prone positioning.
4. Describe the management of accidental extubating during prone positioning.
5. Discuss strategies to improve the safety of patients undergoing surgery in prone positions.
31. 1. Akhavan A, Gainsburg DM, Stock JA. Complications associated with patient positioning in urologic
surgery. Urology. 2010;76(6):1309–1316. [PubMed] [Google Scholar]
2. St-Arnaud A, Paquin MJ. Safe positioning for neurosurgical patients. AORN J. 2008;87(6):1156–
1168. [PubMed] [Google Scholar]
3. Grisell M, Place H. Face tissue pressure in prone positioning. Spine. 2008;33(26):2938–2941. [PubMed] [Google
Scholar]
4. Tabara Y, Tachibana-Iimori R, Yamamoto M, Abe M, Kondo I, Miki T, Kohara K. Hypotension associated
with prone body position: a possible overlooked postural hypotension. Hypertens Res. 2005;28:741–
746. [PubMed] [Google Scholar]
References
32. Thank You
1- Anesthesia for trauma patient
2- Pediatric Anesthesia
3- Postoperative Pain Management
4- Pediatric Cardiac Arrest
5- Anesthesia for Liver Transplant
6- Antibiotic Prophylaxis for surgical procedures
7- High Alert Medication
8- Arterial & Central lines Monitoring
9- Patient Safety in Anesthesia
10- Anesthesia Concern for Covid-19 Patient
11- Presentation of new airway Management device (TUBAIR) in innovation symposium
12- Complications of Prone Position under GA
For Attending My 12 Presentations in HMC