COMPLETE BLOOD COUNT

1. Guided By :- Prepared By :-
Mr. Md Sohel Akhter Abu Raihan Shams
Associate Professor(Jr. ) Pharm. D , 2nd
1700100350

2. TOPIC
COMPLETE BLOOD COUNT

3. Introduction
 A CBC is a series of tests used to evaluate the
composition and concentration of the cellular
components of blood.
 It is a blood panel requested by a doctor or other
medical professional that gives information about the
cell in patient blood such as cell count of each blood cell,
type, cell size , shape and concentration.
 It is also known as full blood exam.

4. The cells that circulate in the blood stream are generally of
three types:-
RBC [erythrocyte]
WBC[leukocyte]
Platelets [thrombocyte]
Abnormally high or low count may indicate the presence
of many form of disease.

5. Why it is done
 CBCs are done to monitor overall health to screen for some
diseases ,to confirm a diagnosis of sone medical condition,
and to monitor changes in the body caused by medical
treatments.
 It can reflect acute or chronic infections , allergies and
problems with clotting, etc..

6. Common components of CBC
 RBC Count
 Hemoglobin (Hb)
 Packed Cell Volume (PCV)
 Mean Corpuscular Volume (MCV)
 Mean Cospuscular Hb (MCH) & Mean Corpuscular Hb
Concentration (MCHC)
 WBC Count
 Platelet Count

7. RBC Count
Normal Range
Male:- 4.7-6.1 Million/microliter
Female:- 4.2-5.4 Million/mircoliter
 High RBC count indicates
Polycythemia , Dehydration, Pulmonary disease, Kidney
& other tumour that produces erythropoietin.
 Low RBC count indicates
Anemia like Hemolytic anemia or Aplastic anemia ,
Acute or chronic bleeding , Bonemarrow
disorder/damage, Kidney failure.

8. Hemoglobin
Normal Range
Male:- 13-18 g/dl
Female:- 11.5-16.5 g/dl
 High Hb indicates
COPD(Chronic Obstructive Pulmonary Disease) ,
Emphysema , Polycythemia.
 Low Hb indicates
It is due to low RBC, Aplastic anemia, Iron-deficiency
anemia, cancer , Lead poisoning, Multiple myeloma ,
Myelodysplastic syndrome.

9. Packed Cell Volume(PCV)
It is % of RBC circulating in blood.
Normal Range
Male:- 45%
Female:- 40%
 High PCV indicates
Polycythemia , COPD, Dehydration, Capillary Leak
syndrome / Clarkson’s Disease.
 Low PCV indicates
Anemia , Vitamin & Mineral Deficiency , Heavy Blood Loss

10. Mean Corpuscular Volume(MCV)
In this we measure average size of RBC.
Normal Range
80.00-100.00 fL(femtoliter)
 High MCV indicates
Vitamin B12 or Follic acid deficiency anemia
 Low MCV indicates
Thalassamia, Lead Poisoning, Sickle cell anemia, Iron
deficiency anemia

11. Mean Corpuscular Hb(MCH) & Mean
Corpuscular Hb concentration (MCHC)
MCH is amount of HB present in one RBC.
Normal Range:- 27-32 pg (picogram)
MCHC is proportion of each cell taken by Hb.
Normal Range:- 32-35 g/dl
 High MCH & MCHC
Sickle cell anemia
 Low MCH & MCHC
Microlytic anemia

12. WBC Count
Normal Range
4 thousand – 11 thousand/ microliter
 High WBC count(Leukocytosis) indicates
Acute or Chronic Lymphocytic leukemia, Bacterial & Viral
infection, Rheumatoid arthritis, Myelofibrosis(A
Bonemarrow disorder)
 Low WBC count (Leukopenia) indicates
Due to acute viral infection like Cold or Influenza , Aplastic
anaemia, AIDS, Cancer , Typhoid, Malaria , Tuberculosis,
Dengue, Lyme disease(it is a bacterial disease caused by
Borrelia burgdorferi)

13. Platelet Count
Normal Range
1,50,000 – 4,00,000/ microliter
 High Platelet count(Thrombocytosis) indicates
Chronic inflammation, Malignancy/Cancer, Iron deficiency,
Acute Blood loss, Myeloproliferative Disorder,
Inflammatory Bowel Disease, Rheumatoid arthritis
 Low Platelet count(Thrombocytopenia) indicates
Dengue, Beberiosis, Chemotherapy, Radiotherapy,
Splenomegaly , Gaucher’s disease, HELLP syndrome ,
Aplastic anemia, Laukemia , Lymphoma

14. REFERENCES
https://en.wikipedia.org/wiki/Complete_blood_count
www.Slideshare.net
https://www.mayoclinic.org/tests-
procedures/complete-blood-count/about/pac-
20384919
Buttarello, M.Plebani, M(Jul 2008). Automated blood
cell counts: statemof the art, American Journal of
Clinical Pathology, 130(1) 140-16.