This document discusses the importance of maintaining a cold chain for vaccine storage and transportation. It outlines how vaccines must be kept within specific temperature ranges to maintain potency from the manufacturer to the point of use. Several types of cold storage equipment are described, including walk-in cold rooms, deep freezers, and ice-lined refrigerators. Proper vaccine handling and storage is essential to ensure vaccines are effective and public health programs maintain public confidence.

1. PRESENTED BY,
MR. KAILASH NAGAR
ASSIST. PROF.
DEPT. OF COMMUNITY HEALTH NSG.
DINSHA PATEL COLLEGE OF NURSING, NADIAD

2. Cold Chain
The ‘cold chain’ is the system of
transporting and storing vaccines at
recommended temperature from the
point of manufacture to the point of use.
Manufacturer
Distributor
Vaccine
Depots
Provider
office
Client

3. Why is the cold chain important ?
1. Vaccines are:
 Biological products
 lose potency with time
 Process irreversible and
accelerated if proper storage
conditions are not adhered to.
3. Ensuring maximum benefit
from immunisations
Responsibility not to waste
scarce NHS resources
Reduce wastage from errors
2. Assurance in potent
product and vaccine
programmes
 Professional responsibility
 Confident the vaccines you give
will be effective
 Public Health responsibility
 Public confidence in
immunisation programmes
4.Compliance with
SPC/Manufacturer
Any vaccine that has not been
stored at a temperature of 2-8ºC as
per its licensing conditions is no
longer a licensed product

4. • Cold chain storage equipment
Walk in
cold rooms
Deep
freezers
Ice lined
refrigerators

5. 1.Walk in cold rooms(WIC)
At district & PHC levels
Temp :- -15oc to -25oc
At PHC, used only for the
preparation of ice packs
At regional level
Storage up to 3 months
2.Deep freezers

6. 3.Ice lined refrigerators(ILR)
Both at district and PHC
levels
Temp :- +2oc to +8oc
ILR’s are top opening,
can hold cold air inside
better than front opening
refrigerators

7. Vaccine Stability
Sensitivity to HEAT
BCG
Varicella
MMR
MenC
Hepatitis B
DT and/or aP/IPV/HIB
HepB and combination
DTand/or aP/IPV/HIB
Influenza
MenC
*MMR
*Varicella
*BCG
(*Freeze dried)
MOST
SENSITIVE Sensitivity to COLD
Temperature must be
dial thermometer
LEAST
recorded twice in a day with SENSITIVE

8. Immunisation Department, Centre forInfections
Light Sensitive
Sensitive to strong light, sunlight, ultraviolet,
fluorescents (neon)
BCG
MMR
Varicella
Meningococcal C Conjugate
Most DTaP containing vaccines
Vaccines should
always be stored
in their original
packaging until
point of use to
protect them from
light

9. Vaccine Storage
Use a dedicated vaccine fridge
Safeguard electricity supply
No more than 50% full
Place vaccines in clearly
labelled plastic mesh baskets
Group vaccines by type
(Paediatric, Adult, Adolescent)
Defrost/calibrate fridge regularly
Ensure back up facilities are
available in the event of fridge
failing
X Do not place fridge in
direct sunlight or near heat
source
X Do not store vaccines for
more than 1 month at PHC.
X Do not store vaccines in
fridge doors or in solid
plastic trays/containers
within the fridge
X Keep vaccines away from
fridge walls and cold air
vents
Picture taken fromwww.medisave.co.uk
DO’sDON’T’s
X No food or medical
specimens

10. Transporting Equipment
Cold
boxes
Vaccine
carriers
Day
carriers

11. 1.Cold boxes Used for transport of vaccines
Fully frozen ice packs placed
at the bottom and sides
DPT, TT, DT should not be kept
in direct contact
2.Vaccine
carriers
Used to carry small quantity of
vaccines(16 to 20 vials)
For out of reach sessions
4 icepacks are used

12. 3.Day carriers
Used to carry very small quantities
of vaccines(6 to 8 vials)
For anear by session
2 icepacks areused
For only 2 hours period

13. Use of diluentsSpecifically designed to reconstitute
the vaccines with respect to volume,
pH and other chemical properties
Store at +2oc to +8oc in ILR
Only use vaccines suppled and
packaged by manufacturer

14. Vaccine Vial Monitor(VVM)
VVM is a label containing heat sensitive
material that is placed on a vaccine vial
to register heat exposure over time
Vaccine vial
monitor

15. Stage 1
• Inner square
lighter than
outer circle
Stage 2
• Inner square
still lighter than
outer circle
Stage 3
• Color of inner
square matches
the outer circle
Stage 4
• Color of inner
square darker
than outer circle
Combined effects of time and
temperature cause the inner square
to darken gradually and irreversibly
VVM does not directly measure the
vaccine potency but gives info about
the main factor that affects potency

16. Immunization is the
process whereby a
person is made
immune to an
infectious disease,
typically by the
administration of a
vaccine.
Controlling and eliminating life-threatening infectious diseases
Estimated to avert between 2 and 3 million deaths each year.
 One of the most cost-effective health investments
Accessible to even the most hard-to-reach and vulnerable
populations.
Immunization
schedule

17. Strengthen routine
immunization to
meet vaccination
coverage targets
and improved
vaccines
Spur research and
development for
the next generation
of vaccines and
technologies
Accelerate control
of vaccine-
preventable
diseases
Objectives of
WHO in
immunization
Introduce new
Active immunization/vaccination
has been named one of the
"Ten Great Public Health
Achievements in the 20th Century"

18. Immunization
Schedule