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DEPARTMENT OF ENTOMOLOGY, COLLEGE OF AGRICULTURE, PJTSAU ,HYDERABAD
CLASSIFICATION OF INSECTICIDES AND THEIR MODE OF
ACTION
N.RAMYA SRI
RAD/ 2017-12
PURPOSE
• The IRAC Mode of Action (MoA) classification provides growers,
advisors, extension staff, consultants and crop protection
professionals with a guide to the selection of acaricides or
insecticides for use in an effective and sustainable acaricide or
insecticide resistance management (IRM) strategy.
• Rules for inclusion of a compound in the MoA list
• Names To be included in the active list, compounds must have,
or be very close to having, a minimum of one registered use in
at least one country.
• when more than one active ingredient in that chemical sub-
group is registered for use, the chemical sub-group name is
used.
• when only one active ingredient is registered for use, the name
of that exemplifying active ingredient may be use
CLASSIFICATION OF INSECTICIDES AND THEIR MODE
OF ACTION
CLASSIFICATION OF INSECTICIDES AND THEIR MODE OF
ACTION
Main Group and
Primary Site of Action
Chemical Sub-group or
exemplifying Active
Ingredient
Active Ingredients
1. Acetylcholinesterase
(AChE) inhibitors
Nerve action
1A
Carbamates
Aldicarb, Bendiocarb,,
Carbaryl, Carbofuran,
Carbosulfan etc
1B
Organophosphates
Acephate, Chlorpyrifos,
Dichlorvos,
Monocrotophos,
Triazophos
2 .GABA-gated chloride
channel blockers
Nerve action
2A
Cyclodiene
Organochlorines
Chlordane, Endosulfan
2B
Phenylpyrazoles
(Fiproles)
Ethiprole, Fipronil
MODE OF ACTION OF (ACHE) INHIBITORS
Main Group and
Primary Site of Action
Chemical Sub-group or
exemplifying Active
Ingredient
Active Ingredients
3 .Sodium channel modulators
Nerve action
3A
Pyrethroids
Pyrethrins
Allethrin,
Bifenthrin,
Cypermethrin,
3B
DDT
Methoxychlor
DDT
Methoxychlor
4.Nicotinic acetylcholine receptor
(nAChR) competitive modulators
Nerve action
4A
Neonicotinoids
Acetamiprid,,
Imidacloprid,
Thiamethoxam,
4B
Nicotine
Nicotine
4C
Sulfoximines
Sulfoxaflor
4D
Butenolides
Flupyradifurone
4E
Mesoionics
Triflumezopyrim
Main Group and
Primary Site of Action
Chemical Sub-group or
exemplifying Active
Ingredient
Active Ingredients
5. Nicotinic acetylcholine
receptor (nAChR)
allosteric modulators
Nerve action
Spinosyns Spinetoram, Spinosad
6 .Glutamate-gated
chloride channel
(GluCl) allosteric
modulators
Nerve and muscle action
Avermectins,
Milbemycins
Abamectin, Emamectin
benzoate, Lepimectin,
Milbemectin
7. Juvenile hormone
mimics
Growth regulation
7A
Juvenile hormone
analogues
Hydroprene, Kinoprene,
Methoprene
7B
Fenoxycarb
Fenoxycarb
7C
Pyriproxyfen
Pyriproxyfen
Main Group and
Primary Site of Action
Chemical Sub-group or
exemplifying Active
Ingredient
Active Ingredients
8 .Miscellaneous nonspecific
(multi-site)
inhibitors
8A
Alkyl halides
Methyl bromide and other
alkyl halides
8B
Chloropicrin
Chloropicrin
8C
Fluorides
Cryolite (Sodium aluminum
fluoride), Sulfuryl fluoride
8D
Borates
Borax, Boric acid, Sodium
borate
8E
Tartar emetic
Tartar emetic
8F
Methyl isothiocyanate
generators
Dazomet, Metam
Main Group and
Primary Site of Action
Chemical Sub-group
or
exemplifying Active
Ingredient
Active Ingredients
9.Chordotonal organ
TRPV channel
modulators
Nerve action
9B
Pyridine azomethine
derivatives
Pymetrozine, Pyrifluquinazon
10.Mite growth inhibitors
Growth regulation
10A
Clofentezine
Diflovidazin
Hexythiazox
Clofentezine, Diflovidazin, Hexythiazox
10B
Etoxazole
Etoxazole
11.Microbial disruptors
of insect midgut
membranes
11A
Bacillus thuringiensis
and the insecticidal
proteins they
produce
Bacillus thuringiensis subsp. israelensis
Bacillus thuringiensis subsp. aizawai
Bacillus thuringiensis subsp. kurstaki
Bacillus thuringiensis subsp. tenebrionis
11B
Bacillus sphaericus
Bacillus sphaericus
Main Group and
Primary Site of Action
Chemical Sub-group or
exemplifying Active
Ingredient
Active Ingredients
12.Inhibitors of mitochondrial
ATP synthase(Energy metabolism)
12A
Diafenthiuron
Diafenthiuron
12B
Organotin miticides
Azocyclotin, Cyhexatin,
Fenbutatin oxide
12C
Propargite
Propargite
12D
Tetradifon
Tetradifon
13.Uncouplers of Oxidative
phosphorylation via disruption of
the proton gradient
Energy metabolism
Pyrroles Chlorfenapyr
Dinitrophenols DNOC
Sulfluramid Sulfluramid
Main Group and
Primary Site of Action
Chemical Sub-group or
exemplifying Active
Ingredient
Active Ingredients
14. Nicotinic
acetylcholine
receptor (nAChR) channel
blockers Nerve action
Nereistoxin analogues Bensultap, Cartap
hydrochloride, Thiocyclam,
Thiosultap-sodium
15.Inhibitors of chitin
biosynthesis, type 0
Growth regulation
Benzoylureas Chlorfluazuron,Diflubenzuon,
Flucycloxuron
16.Inhibitors of chitin
biosynthesis, type 1
Growth regulation
Buprofezin Buprofezin
17.Moulting disruptors,
Dipteran
Growth regulation
Cyromazine Cyromazine
Main Group and
Primary Site of Action
Chemical Sub-group or
exemplifying Active
Ingredient
Active Ingredients
18.Ecdysone receptor
antagonists
Growth regulation
Diacylhydrazines Chromafenozide,
Halofenozide,
Methoxyfenozide,
Tebufenozide
19.Octopamine receptor
Agonists (Nerve action)
Amitraz Amitraz
20.Mitochondrial complex
III electron transport
inhibitors
(Energy metabolism)
20A
Hydramethylnon
Hydramethylnon
20B
Acequinocyl
Acequinocyl
20C
Fluacrypyrim
Fluacrypyrim
20D
Bifenazate
Bifenazate
Main Group and
Primary Site of Action
Chemical Sub-group or
exemplifying Active
Ingredient
Active Ingredients
21.Mitochondrial complex
I electron transport
Inhibitors Energy
metabolism
21A
METI acaricides and
insecticides
Fenazaquin,
Fenpyroximate, Pyridaben,
Pyrimidifen,
Tebufenpyrad, Tolfenpyrad
21B
Rotenone
Rotenone (Derris)
22.Voltage-dependent
sodium channel blockers
Nerve action
22A
Oxadiazines
Indoxacarb
22B
Semicarbazones
Metaflumizone
23.Inhibitors of acetyl CoA
carboxylase
Lipid synthesis, growth
regulation
Tetronic and Tetramic
acid derivatives
Spirodiclofen,
Spiromesifen,
Spirotetramat
Main Group and
Primary Site of Action
Chemical Sub-group or
exemplifying Active
Ingredient
Active Ingredients
24
Mitochondrial complex
IV electron transport
inhibitors
Energy metabolism
24A
Phosphides
Aluminium phosphide,
Calcium phosphide,
Phosphine, Zinc phosphide
24B
Cyanides
Calcium cyanide,
Potassium cyanide, Sodium
cyanide
25.Mitochondrial complex
II electron transport
inhibitors
Energy metabolism
25A
Beta-ketonitrile
derivatives
Cyenopyrafen,
Cyflumetofen
25B
Carboxanilides
Pyflubumide
28.Ryanodine receptor
modulators
Nerve and muscle action
Diamides Chlorantraniliprole,
Cyantraniliprole,
Flubendiamide
Main Group and
Primary Site of Action
Chemical Sub-group or
exemplifying Active
Ingredient
Active Ingredients
29.Chordotonal organ
Modulators - undefined
target site
Nerve action
Flonicamid Flonicamid
 CLASSIFICATION OF INSECTICIDES AND  THEIR MODE OF ACTION

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CLASSIFICATION OF INSECTICIDES AND THEIR MODE OF ACTION

  • 1. WELCOME DEPARTMENT OF ENTOMOLOGY, COLLEGE OF AGRICULTURE, PJTSAU ,HYDERABAD CLASSIFICATION OF INSECTICIDES AND THEIR MODE OF ACTION N.RAMYA SRI RAD/ 2017-12
  • 2. PURPOSE • The IRAC Mode of Action (MoA) classification provides growers, advisors, extension staff, consultants and crop protection professionals with a guide to the selection of acaricides or insecticides for use in an effective and sustainable acaricide or insecticide resistance management (IRM) strategy. • Rules for inclusion of a compound in the MoA list • Names To be included in the active list, compounds must have, or be very close to having, a minimum of one registered use in at least one country. • when more than one active ingredient in that chemical sub- group is registered for use, the chemical sub-group name is used. • when only one active ingredient is registered for use, the name of that exemplifying active ingredient may be use CLASSIFICATION OF INSECTICIDES AND THEIR MODE OF ACTION
  • 3. CLASSIFICATION OF INSECTICIDES AND THEIR MODE OF ACTION Main Group and Primary Site of Action Chemical Sub-group or exemplifying Active Ingredient Active Ingredients 1. Acetylcholinesterase (AChE) inhibitors Nerve action 1A Carbamates Aldicarb, Bendiocarb,, Carbaryl, Carbofuran, Carbosulfan etc 1B Organophosphates Acephate, Chlorpyrifos, Dichlorvos, Monocrotophos, Triazophos 2 .GABA-gated chloride channel blockers Nerve action 2A Cyclodiene Organochlorines Chlordane, Endosulfan 2B Phenylpyrazoles (Fiproles) Ethiprole, Fipronil
  • 4. MODE OF ACTION OF (ACHE) INHIBITORS
  • 5.
  • 6. Main Group and Primary Site of Action Chemical Sub-group or exemplifying Active Ingredient Active Ingredients 3 .Sodium channel modulators Nerve action 3A Pyrethroids Pyrethrins Allethrin, Bifenthrin, Cypermethrin, 3B DDT Methoxychlor DDT Methoxychlor 4.Nicotinic acetylcholine receptor (nAChR) competitive modulators Nerve action 4A Neonicotinoids Acetamiprid,, Imidacloprid, Thiamethoxam, 4B Nicotine Nicotine 4C Sulfoximines Sulfoxaflor 4D Butenolides Flupyradifurone 4E Mesoionics Triflumezopyrim
  • 7.
  • 8. Main Group and Primary Site of Action Chemical Sub-group or exemplifying Active Ingredient Active Ingredients 5. Nicotinic acetylcholine receptor (nAChR) allosteric modulators Nerve action Spinosyns Spinetoram, Spinosad 6 .Glutamate-gated chloride channel (GluCl) allosteric modulators Nerve and muscle action Avermectins, Milbemycins Abamectin, Emamectin benzoate, Lepimectin, Milbemectin 7. Juvenile hormone mimics Growth regulation 7A Juvenile hormone analogues Hydroprene, Kinoprene, Methoprene 7B Fenoxycarb Fenoxycarb 7C Pyriproxyfen Pyriproxyfen
  • 9.
  • 10. Main Group and Primary Site of Action Chemical Sub-group or exemplifying Active Ingredient Active Ingredients 8 .Miscellaneous nonspecific (multi-site) inhibitors 8A Alkyl halides Methyl bromide and other alkyl halides 8B Chloropicrin Chloropicrin 8C Fluorides Cryolite (Sodium aluminum fluoride), Sulfuryl fluoride 8D Borates Borax, Boric acid, Sodium borate 8E Tartar emetic Tartar emetic 8F Methyl isothiocyanate generators Dazomet, Metam
  • 11. Main Group and Primary Site of Action Chemical Sub-group or exemplifying Active Ingredient Active Ingredients 9.Chordotonal organ TRPV channel modulators Nerve action 9B Pyridine azomethine derivatives Pymetrozine, Pyrifluquinazon 10.Mite growth inhibitors Growth regulation 10A Clofentezine Diflovidazin Hexythiazox Clofentezine, Diflovidazin, Hexythiazox 10B Etoxazole Etoxazole 11.Microbial disruptors of insect midgut membranes 11A Bacillus thuringiensis and the insecticidal proteins they produce Bacillus thuringiensis subsp. israelensis Bacillus thuringiensis subsp. aizawai Bacillus thuringiensis subsp. kurstaki Bacillus thuringiensis subsp. tenebrionis 11B Bacillus sphaericus Bacillus sphaericus
  • 12.
  • 13. Main Group and Primary Site of Action Chemical Sub-group or exemplifying Active Ingredient Active Ingredients 12.Inhibitors of mitochondrial ATP synthase(Energy metabolism) 12A Diafenthiuron Diafenthiuron 12B Organotin miticides Azocyclotin, Cyhexatin, Fenbutatin oxide 12C Propargite Propargite 12D Tetradifon Tetradifon 13.Uncouplers of Oxidative phosphorylation via disruption of the proton gradient Energy metabolism Pyrroles Chlorfenapyr Dinitrophenols DNOC Sulfluramid Sulfluramid
  • 14.
  • 15. Main Group and Primary Site of Action Chemical Sub-group or exemplifying Active Ingredient Active Ingredients 14. Nicotinic acetylcholine receptor (nAChR) channel blockers Nerve action Nereistoxin analogues Bensultap, Cartap hydrochloride, Thiocyclam, Thiosultap-sodium 15.Inhibitors of chitin biosynthesis, type 0 Growth regulation Benzoylureas Chlorfluazuron,Diflubenzuon, Flucycloxuron 16.Inhibitors of chitin biosynthesis, type 1 Growth regulation Buprofezin Buprofezin 17.Moulting disruptors, Dipteran Growth regulation Cyromazine Cyromazine
  • 16. Main Group and Primary Site of Action Chemical Sub-group or exemplifying Active Ingredient Active Ingredients 18.Ecdysone receptor antagonists Growth regulation Diacylhydrazines Chromafenozide, Halofenozide, Methoxyfenozide, Tebufenozide 19.Octopamine receptor Agonists (Nerve action) Amitraz Amitraz 20.Mitochondrial complex III electron transport inhibitors (Energy metabolism) 20A Hydramethylnon Hydramethylnon 20B Acequinocyl Acequinocyl 20C Fluacrypyrim Fluacrypyrim 20D Bifenazate Bifenazate
  • 17. Main Group and Primary Site of Action Chemical Sub-group or exemplifying Active Ingredient Active Ingredients 21.Mitochondrial complex I electron transport Inhibitors Energy metabolism 21A METI acaricides and insecticides Fenazaquin, Fenpyroximate, Pyridaben, Pyrimidifen, Tebufenpyrad, Tolfenpyrad 21B Rotenone Rotenone (Derris) 22.Voltage-dependent sodium channel blockers Nerve action 22A Oxadiazines Indoxacarb 22B Semicarbazones Metaflumizone 23.Inhibitors of acetyl CoA carboxylase Lipid synthesis, growth regulation Tetronic and Tetramic acid derivatives Spirodiclofen, Spiromesifen, Spirotetramat
  • 18. Main Group and Primary Site of Action Chemical Sub-group or exemplifying Active Ingredient Active Ingredients 24 Mitochondrial complex IV electron transport inhibitors Energy metabolism 24A Phosphides Aluminium phosphide, Calcium phosphide, Phosphine, Zinc phosphide 24B Cyanides Calcium cyanide, Potassium cyanide, Sodium cyanide 25.Mitochondrial complex II electron transport inhibitors Energy metabolism 25A Beta-ketonitrile derivatives Cyenopyrafen, Cyflumetofen 25B Carboxanilides Pyflubumide 28.Ryanodine receptor modulators Nerve and muscle action Diamides Chlorantraniliprole, Cyantraniliprole, Flubendiamide
  • 19. Main Group and Primary Site of Action Chemical Sub-group or exemplifying Active Ingredient Active Ingredients 29.Chordotonal organ Modulators - undefined target site Nerve action Flonicamid Flonicamid