1. The document discusses androgens and their role in male physiology and pharmacology. It describes hormones like testosterone and their effects on tissues like the testes, prostate, and muscles.
2. Various androgen therapies are mentioned for conditions like hypogonadism, breast cancer, and osteoporosis. Antiandrogen drugs are also summarized that block androgen receptors for prostate cancer.
3. Biosynthesis and metabolism of testosterone is outlined. Side effects of androgen therapies and indications for antiandrogens are provided. Erectile dysfunction treatments like sildenafil are also briefly described.
A power point presentation on thyroid hormones and thyroid inhibitors on subject of pharmacology suitable for reading by undergraduate medical students.
These slides contain the information about Estrogen, its basic pharmacology, its synthesis in human body, Functions of estrogen, role in female puberty, Agonists of estrogen and antagonists of estrogen, also contain detail of the receptors associated with the estrogen functioning.
Points:
Male Sex Hormone - Androgens (Mainly Testosterone)
Synthesis, Regulation & metabolism (By both Hypothalamus & Pituitory gland)
Various Action/ Physiological roles over:
1. Sex organs and secondary sex characters (Androgenic)
2. Testes
3. Skeleton and skeletal muscles (Anabolic)
4. Erythropoiesis
Anabolic Steroids & their uses
Antiandrogens (Classification, MOA & Uses)
Drugs for erectile dysfunction (MOA & Uses)
Main Male Sex Hormone is Testosterone which converts into its highly active form i.e. dihydrotestosteron (DHT).
Main Female Sex Hormones are Estrogen & Progesterone.
sex-hormones belong to the steroid class of compounds and are produced in the gonads, i.e., testes in the male and ovaries in the female. In fact, their activity seems to be controlled and monitored by the hormones that are produced in the interior.
Detailed information of all terms like Thyroid gland, Thyroxine, Triidothyronine, Calcitonine, growth and development , propylthiouracil, Calorigenesis, tadpole to frog, Oligomenorrhoea, snehal chakorkar, pharmacology, Cretinism, Myxoedema coma, Graves disease, Thiocynates, Perchlorate, Nitrates.
Radioactive iodine, I131
A power point presentation on thyroid hormones and thyroid inhibitors on subject of pharmacology suitable for reading by undergraduate medical students.
These slides contain the information about Estrogen, its basic pharmacology, its synthesis in human body, Functions of estrogen, role in female puberty, Agonists of estrogen and antagonists of estrogen, also contain detail of the receptors associated with the estrogen functioning.
Points:
Male Sex Hormone - Androgens (Mainly Testosterone)
Synthesis, Regulation & metabolism (By both Hypothalamus & Pituitory gland)
Various Action/ Physiological roles over:
1. Sex organs and secondary sex characters (Androgenic)
2. Testes
3. Skeleton and skeletal muscles (Anabolic)
4. Erythropoiesis
Anabolic Steroids & their uses
Antiandrogens (Classification, MOA & Uses)
Drugs for erectile dysfunction (MOA & Uses)
Main Male Sex Hormone is Testosterone which converts into its highly active form i.e. dihydrotestosteron (DHT).
Main Female Sex Hormones are Estrogen & Progesterone.
sex-hormones belong to the steroid class of compounds and are produced in the gonads, i.e., testes in the male and ovaries in the female. In fact, their activity seems to be controlled and monitored by the hormones that are produced in the interior.
Detailed information of all terms like Thyroid gland, Thyroxine, Triidothyronine, Calcitonine, growth and development , propylthiouracil, Calorigenesis, tadpole to frog, Oligomenorrhoea, snehal chakorkar, pharmacology, Cretinism, Myxoedema coma, Graves disease, Thiocynates, Perchlorate, Nitrates.
Radioactive iodine, I131
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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1. Dr. RAGHU PRASADA M S
MBBS,MD
ASSISTANT PROFESSOR
DEPT. OF PHARMACOLOGY
SSIMS & RC.
2. GnRH-gonadotropin release hormone
LH-ICSH-Interstitial cell stimulating hormone
FSH-inhibin- supresses FSH
activin- stimulates FSH synthesis
FSH in males-spermatogensis, sertoli cells
LH in males-androgen and testosterone in leydig cells
SERTOLI cells-gonadal peptides- Inhibin- b and activin
FSH germ cell proliferation and maturation in
semniferous tubules
3. Naturally occurring androgenic hormones are:
1. Testosterone, the principal androgenic hormone
produced by the Leydig cells of testis.
2. Dehydroepiandrosterone (DHEA) (Adrenal cortex
produces DHEA)
3. Androstenedione
The testis produce other hormones like 1) Small
quantities of Estradiol 2) Inhibin and 3) Activin
4. Testosterone preparations:
Use for androgen replacement:
- Testosterone I.M; S.C
- Testosterone propionate I.M, S.L
- Testosterone cypionate I.M; depo I.M
- Methyltestosterone O; S.L
- Fluoxymestrone O
Use for breast cancer:
Testolactone (progesterone derivative and aromatase
inhibitor)
5. Use for anabolism (osteoporosis):
Androgen:anabolic ratio=1:2 or 1:3 (promote + ve
anabolism and muscular growth but little effect on
sex)
- Ethylestrenol O
- Stanozolol O
- Oxandrolone O
- Nandrolone decanoate I.M
- Methandienone O
8. Androgens Antagonists
NH
CF3
S
F
CN
O O O
CH3OH
NH
CF3
O
CH3
NO2
CH3
O
CH3
CH3
OH
CH
N
CH3
CH3
N
H
O
O
N
H
CH3
CH3
CH3
H
Danazol
(endometriosis)
Finesteride
(baldness)
Bicalutamide
(prostate cancer)
Flutamide
(prostate cancer)
9. Biosynthesis and Metabolism of Testosterone
CH3
CH3
OH
CH3
CH3
CH3
O
OH
CH3
CH3
OH
O
CH3
O
CH3
O
CH3
OH
O
CH3
H
CH3
CH3
H
OH
OH
Cholesterol Pregnenolone Testosterone
Androstendione5a-DHTOther metabolites
11. Androgenic Steroids – Physiological Activities
Androgenic Activity
Growth and development of male sex organs
• Important for male sex drive and performance
• Development of secondary sexual characteristics
• Important role in spermatogenesis
Anabolic Activity
• Development of muscle mass
• Reverse catabolic or tissue-depleting processes
12. Transport & MOA of androgens:
SHBG
5α-reductase
Testosterone 5α-dihydrotestosterone (sex
organs)
(skeletal muscles)
cytosolic; nuclear receptors
increase transcription of a specific protein
androgen effects
DHT is 10 times more potent than testosterone and
mediates effects of testosterone on skin and sexual
organs (prostate; seminal vesicle, epididymis…)
14. O
CH3
CH3
O
O
H
HH
Testolactone - Teslac®
TESTOLACTONE
Indications: palliative therapy in advanced disseminated
breast cancer
MOA: irreversible inhibitor of the enzyme steroid
aromatase that is responsible for the synthesis of
estrone from androstenedione
Hepatic metabolism
Most commonly used androgen for breast cancer.
Few or no androgenic side effects - hirsutism
Adrenal estrogen depletion – post menopausal women
Contraindicated in male breast cancer
15. Mild androgenic, anabolic and progestational activity
Treatment of endometriosis, fibrocystic disease of breast
and premenstrual tension syndrome
Used to prevent the attacks of hereditary angioneurotic
oedema recurrent oedema of skin and larynx these
patients lack endogenous inhibitor of activated first
component of complement danazol increases serum
conc of C1
Danazol withdrawl after 3-4 monthsrebound fertility
Used in hemophiliaproco-agulant factor VIII increased
S/E-hot flushes, muscle cramps, teratogenic
16. 1. Replacement therapy in men: hypogonadism,
impotency; ↓ libido; aging, infertility
2. Anemia: aplastic or other anemia, leukemia;
lymphoma (largely replaced by recombinant
erythropoietin)
3. Protein anabolic steroids-METHANDIENONE,
NANDROLONE, OXYMETHOLONE, STANOZOLOL
4. Osteoporosis(either alone or in conjunction with
estrogens. Replaced by bisphosphonates)
5. Angioneurotic edema-danazol
6. Endometriosis and fibrocystic disease of breast-
Danazol
17. 1. Virilization (masculinization)
2. Hirsutism; acne; menstrual disorders
3. Precocious puberty & hirsutism in children
4. Salt & water retention
5. Jaundice; gall bladder stones (methyltestosterone)
6. Enlargement of prostate
7. Liver cancer
20. OSTARINE-
Customized response-selective anabolic effect on
bones and muscles except androgenic effect on
prostate and testis(10:1)
-females-increase bone mas and libido without causing
virilization, devoid of hepatotoxicity
HERSHBERGER ASSAY-for determining the androgen
and anabolic ratio(ventral prostate and levator ani
muscle of male rats)
21. - Carcinoma prostate
- Benign hyperplasia of the prostate (Finasteride)
- Severe acne and hirsutism (Spironolactone;
Cyproterone acetate)
- Precocious puberty
- Antifertility agents ( contraceptive) (Gossypol)
- baldness (Cyoctol=topical antiandrogen; Finasteride)
- Female disorders: dysfunctional uterine bleeding,
endometriosis advanced breast and ovarian cancers-
GnRH agonists and antoagonists
-
Antiandrogens side effects:
↓ libido; impotency; ↓ spermatogenesis; ↓ ejaculate
22. CH3
N
H
NO2
CF3
O
CH3
Flutamide - Eulexin®
FLUTAMIDE
Indications: metastatic carcinoma of the prostate
MOA: non-steroidal anti-androgen inhibits cellular
uptake of androgen steroids and inhibits nuclear
binding of androgens to their receptors – adrenal
hepatic metabolism with renal excretion, 96% protein
bound
Used with LHRH (GnRH) agonists
DEMERITS-photosensitivity,
Urine color changes
23. NILUTAMIDE-Indications: For use in treatment
with surgical castration for metastatic carcinoma
of the prostate
MOA: non-steroidal anti-androgen that inhibits
cellular uptake of testosterone and inhibits
nuclear binding to its receptor - adrenal
Hepatic metabolism of methyl group produces
two enantiomers in which one is major active
compound
Inhibits a variety of CYP enzymes
24. N
H
CF3
O
CH3
CN
OH
SO2
Bicalutamide - Casodex®
F
Indications: Advanced prostate cancer
MOA: a non-steroidal competitive inhibitor of the
cytosolic androgen receptors - adrenal
Prostatic carcinoma is androgen sensitive
Mixture of enantiomers - stereospecific metabolism
occurs; R-enantiomer of the drug is predominate
serum drug
Drug must be taken in combination with luteinizing-
hormone releasing hormone (LHRH)
25. pregnant women, infants and young children
(somatotropin is more appropriate to produce a
growth spurt).
male patients with carcinoma of the prostate or
breast.
renal or cardiac disease predisposed to edema
Caution: Several cases of hepatocellular carcinoma
have been reported in patients with aplastic anemia
treated with androgen anabolic therapy.
Erythropoietin and colony-stimulating factors should
be used instead.
27. NO activates guanylyl cyclase which forms cGMP from
GTP produces smooth muscle relaxation leading to
erection
Sildenafil inhibits PD-5 enzyme increases cGMP levels
Erectile dysfunction due to organic and psychogenic
causes
25-50mg taken 1 hour prior to anticipated sexual activity
and beneficial effects lasts for 4hrs after administration
P/K-oral bioavailability-40%
- Plasma protein binding-95%
28. Metabolite-N-desmethyl sildenafil is about 50% potent
Elimination –biliary
Adverse effects- headache, nasal congesiton, decrease in
BP, disturbance in colour vision
Drug interaction-concurrent organic nitrates (angina, MI,
hypertension)
CYP inhibitors such as ketoconazole,
itraconazole, cimetidine and erythromycin increase
plasma levels of drug
Carbamazepine and rifampicin decrease levels of drug
Contra-indication- Retinitis Pigmentosa
30. Most useful method for ED before sildenafil
Needs repeated self injection into penis- painful
Alprostadil-PGE1 analogue , can also be placed in
urethra as mini- suppository
S/E- low incidence of priapism and fibrosis
Triple therapy ( Alprostidil + Papavarine +
Phentolamine)- less side effects